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  1. Article ; Online: Unsuccessful ban on gutkha in India needs authentication - Authors' reply.

    Arakeri, Gururaj / Rao Us, Vishal / Dhananjay, K V / Chaturvedi, Pankaj / Brennan, Peter A

    Lancet (London, England)

    2024  Volume 403, Issue 10433, Page(s) 1238–1239

    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01893-7
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  2. Article ; Online: Unsuccessful ban on gutkha and need for tobacco control in India.

    Arakeri, Gururaj / Us, Vishal Rao / Patil, Shekar / Brennan, Peter A

    Lancet (London, England)

    2023  Volume 401, Issue 10383, Page(s) 1154

    MeSH term(s) Humans ; Tobacco Control ; Mouth Neoplasms ; India ; Tobacco, Smokeless ; Tobacco Products ; Tobacco Industry
    Language English
    Publishing date 2023-04-07
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00406-3
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  3. Article ; Online: Methylene blue as an anti-COVID-19 mouthwash in dental practice.

    Arakeri, Gururaj / Rao Us, Vishal

    The British journal of oral & maxillofacial surgery

    2020  Volume 59, Issue 1, Page(s) 135–136

    MeSH term(s) COVID-19 ; Dentistry ; Humans ; Methylene Blue ; Mouthwashes ; SARS-CoV-2
    Chemical Substances Mouthwashes ; Methylene Blue (T42P99266K)
    Keywords covid19
    Language English
    Publishing date 2020-09-17
    Publishing country Scotland
    Document type Letter ; Comment
    ZDB-ID 605685-4
    ISSN 1532-1940 ; 0266-4356
    ISSN (online) 1532-1940
    ISSN 0266-4356
    DOI 10.1016/j.bjoms.2020.09.018
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  4. Article ; Online: SARS-CoV-2 variants in India: a call for genomic surveillance.

    Rao Us, Vishal / Arakeri, Gururaj / Amaral Mendes, Rui

    BMJ (Clinical research ed.)

    2021  Volume 373, Page(s) n1426

    Language English
    Publishing date 2021-06-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n1426
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  5. Article ; Online: We need to optimise genome surveillance and tracing of SARS-CoV-2 variants.

    Rao Us, Vishal / Arakeri, Gururaj / Rao, Ujjwal / Chandru, Vijay / Amaral Mendes, Rui

    BMJ (Clinical research ed.)

    2022  Volume 376, Page(s) o601

    MeSH term(s) COVID-19/epidemiology ; Humans ; Mutation ; SARS-CoV-2/genetics
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.o601
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  6. Article ; Online: Evaluation of possible role of fluoride in pathogenesis of oral submucous fibrosis: A pilot study.

    Arakeri, Gururaj / Rao Us, Vishal / Patil, Shekar / Kunigal, Sateesh / Reddy, Roopa / Krishnan, Murugesan / Hale, Beverley / Brennan, Peter A

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

    2024  Volume 53, Issue 3, Page(s) 226–231

    Abstract: Background: Oral submucous fibrosis (OSMF) is a potentially malignant disorder. Although areca nut chewing is an established risk factor, its low prevalence among nut chewers indicates additional factors likely facilitates pathogenesis. We recently ... ...

    Abstract Background: Oral submucous fibrosis (OSMF) is a potentially malignant disorder. Although areca nut chewing is an established risk factor, its low prevalence among nut chewers indicates additional factors likely facilitates pathogenesis. We recently demonstrated high fluoride levels in smokeless tobacco products and hypothesized a potential pathological role of fluoride in OSMF. Further exploring this novel role, this study compared fluoride levels in tissue, serum, and saliva samples from OSMF patients and healthy controls.
    Methods: The ethically approved study included 25 clinically confirmed OSMF patients and 25 healthy matched controls. OSMF cases underwent buccal mucosal incisional biopsy, while controls had buccal mucosa tissue sampling during third molar removal. Fasting venous blood and unstimulated saliva were collected. Fluoride levels were analysed using ion chromatography and expressed as median (IQR).
    Results: OSMF cases showed significantly higher fluoride concentrations compared with controls in tissue biopsies (30.1 vs. 0 mg/kg, p < 0.0001), serum (0.4 vs. 0 mg/L, p = 0.005) and saliva (1.3 vs. 0 mg/L, p < 0.0001). Majority (68%) of controls had undetectable fluoride levels across all samples. Tissue fluoride weakly correlated with OSMF severity (r = -0.158, p = 0.334).
    Conclusion: The preliminary findings demonstrated increased tissue fluoride levels in OSMF patients compared with healthy controls. Along with a previous study showing high fluoride content in smokeless tobacco products, these findings provided early evidence suggesting fluoride could play a contributory role in OSMF pathogenesis. Further large-scale investigation is warranted to definitively establish whether the association between fluoride exposure and OSMF is indicative of causation.
    MeSH term(s) Humans ; Oral Submucous Fibrosis/pathology ; Fluorides/adverse effects ; Pilot Projects ; Mouth Mucosa/pathology ; Tobacco, Smokeless/adverse effects
    Chemical Substances Fluorides (Q80VPU408O)
    Language English
    Publishing date 2024-02-28
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1021270-x
    ISSN 1600-0714 ; 0904-2512
    ISSN (online) 1600-0714
    ISSN 0904-2512
    DOI 10.1111/jop.13527
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  7. Article ; Online: Methylene blue as an anti-COVID-19 mouthwash in dental practice

    Arakeri, Gururaj / Rao US, Vishal

    British Journal of Oral and Maxillofacial Surgery ; ISSN 0266-4356

    2020  

    Keywords Surgery ; Oral Surgery ; Otorhinolaryngology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.bjoms.2020.09.018
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  8. Article ; Online: Evaluation of fluoride levels in areca nut, tobacco, and commercial smokeless tobacco products: a pilot study.

    Arakeri, Gururaj / Vishal Rao, U S / Patil, Shekar / Patil, Shankargouda / Krishnamurthy, M V S R / Krishnan, Murugesan / Brennan, Peter A

    The British journal of oral & maxillofacial surgery

    2023  Volume 62, Issue 1, Page(s) 76–82

    Abstract: Oral submucous fibrosis (OSMF) is a premalignant condition associated with chewing areca nut and tobacco products. We observed increased fluoride levels in some OSMF-endemic regions,and the observation suggested that fluoride exposure may contribute to ... ...

    Abstract Oral submucous fibrosis (OSMF) is a premalignant condition associated with chewing areca nut and tobacco products. We observed increased fluoride levels in some OSMF-endemic regions,and the observation suggested that fluoride exposure may contribute to its pathogenesis. This study aimed to assess the fluoride content of various smokeless tobacco items as a potential influencing source. Fluoride concentration was analysed in commercial areca nut products, including gutkha, pan masala, and raw areca nut, along with tobacco, slaked lime, and catechu samples from Karnataka, India. Fluoride was measured using alkali fusion and the ion selective electrode method. All products showed high fluoride, with catechu having the highest mean concentration at 51.20 mg/kg, followed by tobacco, gutkha, pan masala, processed areca nut, and raw areca nut. Fluoride was also elevated in soil, but not in water. The findings demonstrate substantial fluoride levels in popular types of smokeless tobacco, and highlight an overlooked source of exposure among consumers of gutkha, pan masala and similar oral tobacco-products. The fluoride content warrants an investigation of potential links with the occurrence and severity of OSMF.
    MeSH term(s) Humans ; Tobacco, Smokeless ; Fluorides ; Areca ; Pilot Projects ; Nuts ; India ; Oral Submucous Fibrosis
    Chemical Substances Fluorides (Q80VPU408O)
    Language English
    Publishing date 2023-11-17
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 605685-4
    ISSN 1532-1940 ; 0266-4356
    ISSN (online) 1532-1940
    ISSN 0266-4356
    DOI 10.1016/j.bjoms.2023.11.002
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  9. Article ; Online: COVID-associated mucormycosis (CAM): is the Delta variant a cause?

    Arakeri, Gururaj / Rao Us, Vishal / Amaral Mendes, Rui / Oeppen, Rachel S / Brennan, Peter A

    The British journal of oral & maxillofacial surgery

    2021  Volume 60, Issue 4, Page(s) e529–e530

    MeSH term(s) COVID-19 ; Humans ; Mucormycosis/complications ; SARS-CoV-2
    Language English
    Publishing date 2021-09-16
    Publishing country Scotland
    Document type Letter ; Comment
    ZDB-ID 605685-4
    ISSN 1532-1940 ; 0266-4356
    ISSN (online) 1532-1940
    ISSN 0266-4356
    DOI 10.1016/j.bjoms.2021.08.009
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  10. Article ; Online: RE: Impact of radical treatments on survival in locally advanced T4a and T4b buccal mucosa cancers: Selected surgically treated T4b cancers have similar control rates as T4a.

    Shetty, Sameep S / Vishal Rao, U S

    Oral oncology

    2019  Volume 90, Page(s) 122

    MeSH term(s) Humans ; Mouth Mucosa ; Mouth Neoplasms ; Neoplasm Staging
    Language English
    Publishing date 2019-01-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2019.01.008
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