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  1. Article ; Online: Bacterial DNAemia in Alzheimer’s Disease and Mild Cognitive Impairment

    Robertina Giacconi / Patrizia D’Aquila / Marta Balietti / Cinzia Giuli / Marco Malavolta / Francesco Piacenza / Laura Costarelli / Demetrio Postacchini / Giuseppe Passarino / Dina Bellizzi / Mauro Provinciali

    International Journal of Molecular Sciences, Vol 24, Iss 1, p

    Association with Cognitive Decline, Plasma BDNF Levels, and Inflammatory Response

    2022  Volume 78

    Abstract: ... whose alterations contribute to the etiopathogenesis of Alzheimer’s disease (AD). The purpose of this study is ...

    Abstract Microbial dysbiosis (MD) provokes gut barrier alterations and bacterial translocation in the bloodstream. The increased blood bacterial DNA (BB-DNA) may promote peripheral- and neuro-inflammation, contributing to cognitive impairment. MD also influences brain-derived neurotrophic factor (BDNF) production, whose alterations contribute to the etiopathogenesis of Alzheimer’s disease (AD). The purpose of this study is to measure BB-DNA in healthy elderly controls (EC), and in patients with mild cognitive impairment (MCI) and AD to explore the effect on plasma BDNF levels (pBDNF), the inflammatory response, and the association with cognitive decline during a two-year follow-up. Baseline BB-DNA and pBDNF were significantly higher in MCI and AD than in EC. BB-DNA was positively correlated with pBDNF in AD, plasma Tumor necrosis factor-alpha (TNF-α), and Interleukin-10 (IL-10) levels in MCI. AD patients with BB-DNA values above the 50th percentile had lower baseline Mini-Mental State Examination (MMSE). After a two-year follow-up, AD patients with the highest BB-DNA tertile had a worse cognitive decline, while higher BB-DNA levels were associated with higher TNF-α and lower IL-10 in MCI. Our study demonstrates that, in early AD, the higher the BB-DNA levels, the higher the pBDNF levels, suggesting a defensive attempt; BB-DNA seems to play a role in the AD severity/progression; in MCI, higher BB-DNA may trigger an increased inflammatory response.
    Keywords circulating bacterial DNA ; inflammation ; BDNF ; Alzheimer’s disease ; mild cognitive impairment ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Colon cancer screening in U.S. adults aged 65 and older according to life expectancy and age.

    Schonberg, Mara A / Breslau, Erica S / Hamel, Mary Beth / Bellizzi, Keith M / McCarthy, Ellen P

    Journal of the American Geriatrics Society

    2015  Volume 63, Issue 4, Page(s) 750–756

    Abstract: Objectives: To examine receipt of colorectal cancer (CRC) screening according to age and life expectancy (LE) in adults aged 65 and older.: Design: Population-based survey.: Setting: United States.: Participants: Community dwelling adults aged ... ...

    Abstract Objectives: To examine receipt of colorectal cancer (CRC) screening according to age and life expectancy (LE) in adults aged 65 and older.
    Design: Population-based survey.
    Setting: United States.
    Participants: Community dwelling adults aged 65 and older who participated in the 2008 or 2010 National Health Interview Survey (N = 7,747).
    Measurements: Receipt of CRC screening (e.g., colonoscopy within 10 years) was examined according to age and LE (≥10 and <10 years), adjusting for sociodemographic characteristics and survey year. Frequency of CRC screening was also examined according to age and LE at time of screening (e.g., age at colonoscopy rather than at interview). Participants screened when they were aged 75 and older or had less than a 10-year LE were considered to have received screening inconsistent with guidelines.
    Results: Overall, 38.5% of participants had less than a 10-year LE; 40.2% were aged 75 and older, and 56.3% had received recent CRC screening (90.1% by colonoscopy). CRC screening was higher in 2010 (58.9%) than 2008 (53.7%, P <.001) and was associated with longer LE and younger age, although 51.1% of adults aged 75 and older reported receiving CRC screening, as did 50.9% of adults with less than a 10-year LE. Based on age and LE at time of screening (rather than at interview), 28.4% of CRC screening of adults aged 65 and older was targeted to those aged 75 and older and those with less than a 10-year LE. Of adults aged 65 to 75 with a 10-year LE or more (adults recommended for screening by guidelines), 39.2% had not recently been screened.
    Conclusion: Older adults with little chance of benefit because of limited LE commonly undergo CRC screening, whereas many adults aged 65 to 75 with a 10-year LE or greater are not screened.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Data Collection ; Early Detection of Cancer/trends ; Female ; Humans ; Life Expectancy ; Male ; Practice Guidelines as Topic ; United States
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.13335
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  3. Article: Letter to the Editor: Violence Against Women and Persistent Harmful Social Norms.

    Bellizzi, Saverio / Nivoli, Alessandra

    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

    2024  Volume 46, Issue 1, Page(s) 102254

    MeSH term(s) Humans ; Social Norms ; Gender-Based Violence ; Women ; Female
    Language English
    Publishing date 2024-02-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2171082-X
    ISSN 1701-2163
    ISSN 1701-2163
    DOI 10.1016/j.jogc.2023.102254
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  4. Article ; Online: An Algorithmic Immunohistochemical Approach to Define Tumor Type and Assign Site of Origin.

    Bellizzi, Andrew M

    Advances in anatomic pathology

    2021  Volume 27, Issue 3, Page(s) 114–163

    Abstract: ... CD45/S-100-"triple-negative" neoplasm. ...

    Abstract Immunohistochemistry represents an indispensable complement to an epidemiology and morphology-driven approach to tumor diagnosis and site of origin assignment. This review reflects the state of my current practice, based on 15-years' experience in Pathology and a deep-dive into the literature, always striving to be better equipped to answer the age old questions, "What is it, and where is it from?" The tables and figures in this manuscript are the ones I "pull up on the computer" when I am teaching at the microscope and turn to myself when I am (frequently) stuck. This field is so exciting because I firmly believe that, through the application of next-generation immunohistochemistry, we can provide better answers than ever before. Specific topics covered in this review include (1) broad tumor classification and associated screening markers; (2) the role of cancer epidemiology in determining pretest probability; (3) broad-spectrum epithelial markers; (4) noncanonical expression of broad tumor class screening markers; (5) a morphologic pattern-based approach to poorly to undifferentiated malignant neoplasms; (6) a morphologic and immunohistochemical approach to define 4 main carcinoma types; (7) CK7/CK20 coordinate expression; (8) added value of semiquantitative immunohistochemical stain assessment; algorithmic immunohistochemical approaches to (9) "garden variety" adenocarcinomas presenting in the liver, (10) large polygonal cell adenocarcinomas, (11) the distinction of primary surface ovarian epithelial tumors with mucinous features from metastasis, (12) tumors presenting at alternative anatomic sites, (13) squamous cell carcinoma versus urothelial carcinoma, and neuroendocrine neoplasms, including (14) the distinction of pheochromocytoma/paraganglioma from well-differentiated neuroendocrine tumor, site of origin assignment in (15) well-differentiated neuroendocrine tumor and (16) poorly differentiated neuroendocrine carcinoma, and (17) the distinction of well-differentiated neuroendocrine tumor G3 from poorly differentiated neuroendocrine carcinoma; it concludes with (18) a discussion of diagnostic considerations in the broad-spectrum keratin/CD45/S-100-"triple-negative" neoplasm.
    MeSH term(s) Algorithms ; Biomarkers, Tumor/analysis ; Humans ; Immunohistochemistry/methods ; Neoplasms/diagnosis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1212493-x
    ISSN 1533-4031 ; 1072-4109
    ISSN (online) 1533-4031
    ISSN 1072-4109
    DOI 10.1097/PAP.0000000000000256
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  5. Article ; Online: Refugees and migrants at the heart of the synergies between universal health coverage, health security and health promotion.

    Bellizzi, Saverio / Severoni, Santino

    Journal of travel medicine

    2023  Volume 31, Issue 1

    MeSH term(s) Humans ; Refugees ; Transients and Migrants ; Universal Health Insurance ; Health Promotion ; Health Services Accessibility
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taad137
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  6. Article ; Online: Interconnection between reproductive and migrant health rights.

    Bellizzi, Saverio / Nivoli, Alessandra

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2023  Volume 163, Issue 2, Page(s) 705–706

    MeSH term(s) Humans ; Health Services Accessibility ; Human Rights ; Reproductive Health ; Right to Health ; Transients and Migrants
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.15095
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  7. Article ; Online: Gender discrimination in nationality laws: A systemic type of violence against women.

    Bellizzi, Saverio / Nivoli, Alessandra

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2023  Volume 163, Issue 1, Page(s) 323–324

    MeSH term(s) Female ; Humans ; Sexism ; Ethnicity ; Violence ; Human Rights ; Domestic Violence
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.14986
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  8. Article ; Online: The critical issue of bride kidnapping in Kyrgyzstan.

    Bellizzi, Saverio / Nivoli, Alessandra

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2023  Volume 161, Issue 3, Page(s) 1094–1095

    MeSH term(s) Humans ; Kyrgyzstan/epidemiology ; Crime ; Intimate Partner Violence
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.14730
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  9. Article ; Online: Potential of artificial intelligence in public health disaster and emergency management.

    Ali Maher, O / Panu Napodano, C M / Bellizzi, S

    Public health

    2024  

    Language English
    Publishing date 2024-04-20
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 427333-3
    ISSN 1476-5616 ; 0033-3506
    ISSN (online) 1476-5616
    ISSN 0033-3506
    DOI 10.1016/j.puhe.2024.03.017
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  10. Article ; Online: RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner.

    Hagen, Jussara / Muniz, Viviane P / Falls, Kelly C / Reed, Sara M / Taghiyev, Agshin F / Quelle, Frederick W / Gourronc, Francoise A / Klingelhutz, Aloysius J / Major, Heather J / Askeland, Ryan W / Sherman, Scott K / O'Dorisio, Thomas M / Bellizzi, Andrew M / Howe, James R / Darbro, Benjamin W / Quelle, Dawn E

    Cancer research

    2014  Volume 74, Issue 22, Page(s) 6661–6670

    Abstract: ... By comparison, Rb1 inactivation partially restored G1 to S phase progression in RABL6A-knockdown cells ...

    Abstract Mechanisms of neuroendocrine tumor (NET) proliferation are poorly understood, and therapies that effectively control NET progression and metastatic disease are limited. We found amplification of a putative oncogene, RABL6A, in primary human pancreatic NETs (PNET) that correlated with high-level RABL6A protein expression. Consistent with those results, stable silencing of RABL6A in cultured BON-1 PNET cells revealed that it is essential for their proliferation and survival. Cells lacking RABL6A predominantly arrested in G1 phase with a moderate mitotic block. Pathway analysis of microarray data suggested activation of the p53 and retinoblastoma (Rb1) tumor-suppressor pathways in the arrested cells. Loss of p53 had no effect on the RABL6A knockdown phenotype, indicating that RABL6A functions independent of p53 in this setting. By comparison, Rb1 inactivation partially restored G1 to S phase progression in RABL6A-knockdown cells, although it was insufficient to override the mitotic arrest and cell death caused by RABL6A loss. Thus, RABL6A promotes G1 progression in PNET cells by inactivating Rb1, an established suppressor of PNET proliferation and development. This work identifies RABL6A as a novel negative regulator of Rb1 that is essential for PNET proliferation and survival. We suggest RABL6A is a new potential biomarker and target for anticancer therapy in PNET patients.
    MeSH term(s) Cell Line, Tumor ; Cell Proliferation ; G1 Phase ; Humans ; Mitosis ; Neuroendocrine Tumors/pathology ; Oncogene Proteins/physiology ; Pancreatic Neoplasms/pathology ; Retinoblastoma Protein/physiology ; S Phase ; rab GTP-Binding Proteins/physiology
    Chemical Substances Oncogene Proteins ; Retinoblastoma Protein ; RABL6A protein, human (EC 3.6.1.-) ; rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2014-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-13-3742
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