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  1. Article ; Online: Drug-Induced Liver Injury and COVID-19 Infection: The Rules Remain the Same.

    Olry, Alexandre / Meunier, Lucy / Délire, Bénédicte / Larrey, Dominique / Horsmans, Yves / Le Louët, Hervé

    Drug safety

    2020  Volume 43, Issue 7, Page(s) 615–617

    MeSH term(s) Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Betacoronavirus/isolation & purification ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/therapy ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Humans ; Liver Function Tests/methods ; Medicine, Traditional/adverse effects ; Medicine, Traditional/methods ; Pandemics ; Pharmacovigilance ; Pneumonia, Viral/blood ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Symptom Assessment/methods ; Withholding Treatment
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country New Zealand
    Document type Editorial
    ZDB-ID 1018059-x
    ISSN 1179-1942 ; 0114-5916
    ISSN (online) 1179-1942
    ISSN 0114-5916
    DOI 10.1007/s40264-020-00954-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2127: Show issues Location:
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  2. Article ; Online: Educational Strategies to Reduce Physician Shortages in Underserved Areas: A Systematic Review.

    Figueiredo, Alexandre Medeiros de / Labry Lima, Antonio Olry de / Figueiredo, Daniela Cristina Moreira Marculino de / Neto, Alexandre José de Melo / Rocha, Erika Maria Sampaio / Azevedo, George Dantas de

    International journal of environmental research and public health

    2023  Volume 20, Issue 11

    Abstract: The shortage of physicians in rural and underserved areas is an obstacle to the implementation of Universal Health Coverage (UHC). We carried out a systematic review to analyze the effectiveness of initiatives in medical education aimed to increase the ... ...

    Abstract The shortage of physicians in rural and underserved areas is an obstacle to the implementation of Universal Health Coverage (UHC). We carried out a systematic review to analyze the effectiveness of initiatives in medical education aimed to increase the supply of physicians in rural or underserved areas. We searched for studies published between 1999 and 2019 in six databases, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Interventional or observational controlled studies were defined as inclusion criteria. A total of 955 relevant unique records were selected for inclusion, which resulted in the identification of 17 articles for analysis. The admission of students from rural areas associated with a rural curriculum represented 52.95% of the interventions. Medical practice after graduation in rural or underserved areas was the most evaluated outcome, representing 12 publications (70.59%). Participants of these educational initiatives were more likely to work in rural or underserved areas or to choose family medicine, with significant differences between the groups in 82.35% of the studies. Educational strategies in undergraduate and medical residencies are effective. However, it is necessary to expand these interventions to ensure the supply of physicians in rural or urban underserved areas.
    MeSH term(s) Humans ; Medically Underserved Area ; Physicians ; Family Practice ; Curriculum ; Students ; Rural Health Services
    Language English
    Publishing date 2023-05-29
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20115983
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  3. Article ; Online: Identification and Quantification of Coumarins by UHPLC-MS in

    Perkowska, Izabela / Siwinska, Joanna / Olry, Alexandre / Grosjean, Jérémy / Hehn, Alain / Bourgaud, Frédéric / Lojkowska, Ewa / Ihnatowicz, Anna

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 6

    Abstract: Coumarins are phytochemicals occurring in the plant kingdom, which biosynthesis is induced under various stress factors. They belong to the wide class of specialized metabolites well known for their beneficial properties. Due to their high and wide ... ...

    Abstract Coumarins are phytochemicals occurring in the plant kingdom, which biosynthesis is induced under various stress factors. They belong to the wide class of specialized metabolites well known for their beneficial properties. Due to their high and wide biological activities, coumarins are important not only for the survival of plants in changing environmental conditions, but are of great importance in the pharmaceutical industry and are an active source for drug development. The identification of coumarins from natural sources has been reported for different plant species including a model plant
    MeSH term(s) Arabidopsis/metabolism ; Chromatography, High Pressure Liquid ; Coumarins/analysis ; Coumarins/metabolism ; Mass Spectrometry ; Plant Roots/metabolism
    Chemical Substances Coumarins
    Language English
    Publishing date 2021-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26061804
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    Zs.MO 81: Show issues

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  4. Article: Drug-Induced Liver Injury and COVID-19 Infection: The Rules Remain the Same

    Olry, Alexandre / Meunier, Lucy / Délire, Bénédicte / Larrey, Dominique / Horsmans, Yves / Le Louët, Hervé

    Drug Saf

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #574890
    Database COVID19

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  5. Article ; Online: Drug-Induced Liver Injury and COVID-19 Infection

    Olry, Alexandre / Meunier, Lucy / Délire, Bénédicte / Larrey, Dominique / Horsmans, Yves / Le Louët, Hervé

    Drug Safety

    The Rules Remain the Same

    2020  Volume 43, Issue 7, Page(s) 615–617

    Keywords Toxicology ; Pharmacology (medical) ; Pharmacology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1018059-x
    ISSN 1179-1942 ; 0114-5916
    ISSN (online) 1179-1942
    ISSN 0114-5916
    DOI 10.1007/s40264-020-00954-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Identification and Quantification of Coumarins by UHPLC-MS in Arabidopsis Thaliana Natural Populations

    Izabela Perkowska / Joanna Siwinska / Alexandre Olry / Jérémy Grosjean / Alain Hehn / Frédéric Bourgaud / Ewa Lojkowska / Anna Ihnatowicz

    Molecules, Vol 26, Iss 1804, p

    2021  Volume 1804

    Abstract: Coumarins are phytochemicals occurring in the plant kingdom, which biosynthesis is induced under various stress factors. They belong to the wide class of specialized metabolites well known for their beneficial properties. Due to their high and wide ... ...

    Abstract Coumarins are phytochemicals occurring in the plant kingdom, which biosynthesis is induced under various stress factors. They belong to the wide class of specialized metabolites well known for their beneficial properties. Due to their high and wide biological activities, coumarins are important not only for the survival of plants in changing environmental conditions, but are of great importance in the pharmaceutical industry and are an active source for drug development. The identification of coumarins from natural sources has been reported for different plant species including a model plant Arabidopsis thaliana . In our previous work, we demonstrated a presence of naturally occurring intraspecies variation in the concentrations of scopoletin and its glycoside, scopolin, the major coumarins accumulating in Arabidopsis roots. Here, we expanded this work by examining a larger group of 28 Arabidopsis natural populations (called accessions) and by extracting and analysing coumarins from two different types of tissues–roots and leaves. In the current work, by quantifying the coumarin content in plant extracts with ultra-high-performance liquid chromatography coupled with a mass spectrometry analysis (UHPLC-MS), we detected a significant natural variation in the content of simple coumarins like scopoletin, umbelliferone and esculetin together with their glycosides: scopolin, skimmin and esculin, respectively. Increasing our knowledge of coumarin accumulation in Arabidopsis natural populations, might be beneficial for the future discovery of physiological mechanisms of action of various alleles involved in their biosynthesis. A better understanding of biosynthetic pathways of biologically active compounds is the prerequisite step in undertaking a metabolic engineering research.
    Keywords analytical methods ; model plant ; natural genetic variation ; natural products ; simple coumarins ; Organic chemistry ; QD241-441
    Subject code 580
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Convergent evolution leading to the appearance of furanocoumarins in citrus plants.

    Limones-Mendez, Mariana / Dugrand-Judek, Audray / Villard, Cloé / Coqueret, Victoire / Froelicher, Yann / Bourgaud, Frédéric / Olry, Alexandre / Hehn, Alain

    Plant science : an international journal of experimental plant biology

    2019  Volume 292, Page(s) 110392

    Abstract: Furanocoumarins are defense molecules mainly described in four plant families that are phylogenetically distant. Molecular characterization of the biosynthetic pathway has been started for many years in Apiaceae and Rutaceae. The results obtained thus ... ...

    Abstract Furanocoumarins are defense molecules mainly described in four plant families that are phylogenetically distant. Molecular characterization of the biosynthetic pathway has been started for many years in Apiaceae and Rutaceae. The results obtained thus far in Apiaceae indicated a major role of cytochromes P450 (P450s) in the CYP71 family. In the present work, we describe the importance of another subfamily of P450s, CYP82D, identified by using a deep analysis of the citrus (Rutaceae) genome and microarray database. CYP82D64 is able to hydroxylate xanthotoxin to generate 5-OH-xanthotoxin. Minor and limited amino acid changes in the CYP82D64 coding sequence between Citrus paradisi and Citrus hystrix provide the enzyme in the latter with the ability to hydroxylate herniarin, but with low efficiency. The kinetic constants of the enzyme are consistent with those of other enzymes of this type in plants and indicate that it may be the physiological substrate. The activity of the enzyme is identical to that of CYP71AZ6 identified in parsnip, showing possible evolutionary convergence between these two families of plants. It is highly possible that these molecules are derived from the synthesis of ubiquitous coumarins throughout the plant kingdom.
    MeSH term(s) Amino Acid Sequence ; Citrus/chemistry ; Citrus/genetics ; Cytochrome P-450 Enzyme System/chemistry ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Evolution, Molecular ; Furocoumarins/chemistry ; Furocoumarins/genetics ; Phylogeny ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Plant Proteins/metabolism
    Chemical Substances Furocoumarins ; Plant Proteins ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2019-12-31
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 742010-9
    ISSN 1873-2259 ; 0168-9452
    ISSN (online) 1873-2259
    ISSN 0168-9452
    DOI 10.1016/j.plantsci.2019.110392
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    In stock of ZB MED Bonn / Germany

    Z 77/717: Show issues

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  8. Book ; Online: Teaching and learning in the age of artificial intelligence

    Romero, Margarida / Heiser, Laurent / Lepage, Alexandre / Gagnebien, Anne / Bonjour, Audrey / Lagarrigue, Aurélie / Palaude, Axel / Boulord, Caroline / Gagneur, Charles-Antoine / Mercier, Chloé / Caucheteux, Christelle / Guidoni-Stoltz, Dominique / Tressols, Florence / Alexandre, Frédéric / Céci, Jean-François / Metral, Jean-François / Camponovo, Jérémy / Henry, Julie / Fouché, Laurent /
    Hodgkins, Lianne-Blue / Comte, Marie-Hélène / Durampart, Michel / Corieri, Patricia / Olry, Paul / Reboul, Pauline / Bonfils, Philippe / Amor, Sami Ben / Collin, Simon / Ciavaldini-Cartaut, Solange / Viéville, Thierry / Batifol, Victoire / Borgne, Yann-Aël Le

    2023  

    Abstract: ... by Margarida Romero, Laurent Heiser and Alexandre Lepage aims to provide the various educational actors ...

    Abstract As part of the Digital Working Group (GTnum) #Scol_IA "Renewal of digital practices and creative uses of digital and AI" we are pleased to present the white paper "Teaching and learning in the era of Artificial Intelligence, Acculturation, integration and creative uses of AI in education". The white paper edited by Margarida Romero, Laurent Heiser and Alexandre Lepage aims to provide the various educational actors with a diversified perspective both on the issues of acculturation and training in AI and on the resources and feedback from the various research teams and organisations. of scientific culture in the French-speaking countries. A multidisciplinary approach makes it possible to consider the perspectives of researchers in computer science as well as those of education and training sciences, information and communication sciences and the expertise of teaching professionals. and scientific mediation.

    Comment: in French language
    Keywords Computer Science - Human-Computer Interaction
    Language French
    Publishing date 2023-03-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Author Correction: A GDSL lipase-like from Ipomoea batatas catalyzes efficient production of 3,5-diCQA when expressed in Pichia pastoris.

    Miguel, Sissi / Legrand, Guillaume / Duriot, Léonor / Delporte, Marianne / Menin, Barbara / Michel, Cindy / Olry, Alexandre / Chataigné, Gabrielle / Salwinski, Aleksander / Bygdell, Joakim / Vercaigne, Dominique / Wingsle, Gunnar / Hilbert, Jean Louis / Bourgaud, Frédéric / Hehn, Alain / Gagneul, David

    Communications biology

    2020  Volume 3, Issue 1, Page(s) 746

    Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s42003-020-01488-x. ...

    Abstract A Correction to this paper has been published: https://doi.org/10.1038/s42003-020-01488-x.
    Language English
    Publishing date 2020-12-02
    Publishing country England
    Document type Published Erratum
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-020-01488-x
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  10. Article ; Online: Parallel evolution of UbiA superfamily proteins into aromatic

    Munakata, Ryosuke / Olry, Alexandre / Takemura, Tomoya / Tatsumi, Kanade / Ichino, Takuji / Villard, Cloé / Kageyama, Joji / Kurata, Tetsuya / Nakayasu, Masaru / Jacob, Florence / Koeduka, Takao / Yamamoto, Hirobumi / Moriyoshi, Eiko / Matsukawa, Tetsuya / Grosjean, Jérémy / Krieger, Célia / Sugiyama, Akifumi / Mizutani, Masaharu / Bourgaud, Frédéric /
    Hehn, Alain / Yazaki, Kazufumi

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 17

    Abstract: Plants produce ∼300 aromatic compounds enzymatically linked to prenyl side chains via C-O bonds. ... ...

    Abstract Plants produce ∼300 aromatic compounds enzymatically linked to prenyl side chains via C-O bonds. These
    MeSH term(s) Angelica/genetics ; Angelica/metabolism ; Citrus paradisi/genetics ; Citrus paradisi/metabolism ; Evolution, Molecular ; Furocoumarins/biosynthesis ; Phylogeny ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Prenylation
    Chemical Substances Furocoumarins ; Plant Proteins ; bergamottin (JMU611YFRB)
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2022294118
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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