LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article: Drug monographs: belinostat and idelalisib.

    Piper, Whitney L / Waddell, J Aubrey / Solimando, Dominic A

    Hospital pharmacy

    2015  Volume 49, Issue 11, Page(s) 1009–1013

    Abstract: The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and ... ...

    Abstract The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast.net; or J. Aubrey Waddell, Professor, University of Tennessee College of Pharmacy; Oncology Pharmacist, Pharmacy Department, Blount Memorial Hospital, 907 E. Lamar Alexander Parkway, Maryville, TN 37804, e-mail: waddfour@charter.net.
    Language English
    Publishing date 2015-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1468893-1
    ISSN 0018-5787
    ISSN 0018-5787
    DOI 10.1310/hjp4911-1009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1758: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 21: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Standards for the care of people with cystic fibrosis (CF); recognising and addressing CF health issues.

    Burgel, Pierre-Régis / Southern, Kevin W / Addy, Charlotte / Battezzati, Alberto / Berry, Claire / Bouchara, Jean-Philippe / Brokaar, Edwin / Brown, Whitney / Azevedo, Pilar / Durieu, Isabelle / Ekkelenkamp, Miquel / Finlayson, Felicity / Forton, Julian / Gardecki, Johanna / Hodkova, Pavla / Hong, Gina / Lowdon, Jacqueline / Madge, Su / Martin, Clémence /
    McKone, Edward / Munck, Anne / Ooi, Chee Y / Perrem, Lucy / Piper, Amanda / Prayle, Andrew / Ratjen, Felix / Rosenfeld, Margaret / Sanders, Don B / Schwarz, Carsten / Taccetti, Giovanni / Wainwright, Claire / West, Natalie E / Wilschanski, Michael / Bevan, Amanda / Castellani, Carlo / Drevinek, Pavel / Gartner, Silvia / Gramegna, Andrea / Lammertyn, Elise / Landau, Eddie Edwina C / Plant, Barry J / Smyth, Alan R / van Koningsbruggen-Rietschel, Silke / Middleton, Peter G

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2024  

    Abstract: This is the third in a series of four papers updating the European Cystic Fibrosis Society (ECFS) standards for the care of people with CF. This paper focuses on recognising and addressing CF health issues. The guidance was produced with wide stakeholder ...

    Abstract This is the third in a series of four papers updating the European Cystic Fibrosis Society (ECFS) standards for the care of people with CF. This paper focuses on recognising and addressing CF health issues. The guidance was produced with wide stakeholder engagement, including people from the CF community, using an evidence-based framework. Authors contributed sections, and summary statements which were reviewed by a Delphi consultation. Monitoring and treating airway infection, inflammation and pulmonary exacerbations remains important, despite the widespread availability of CFTR modulators and their accompanying health improvements. Extrapulmonary CF-specific health issues persist, such as diabetes, liver disease, bone disease, stones and other renal issues, and intestinal obstruction. These health issues require multidisciplinary care with input from the relevant specialists. Cancer is more common in people with CF compared to the general population, and requires regular screening. The CF life journey requires mental and emotional adaptation to psychosocial and physical challenges, with support from the CF team and the CF psychologist. This is particularly important when life gets challenging, with disease progression requiring increased treatments, breathing support and potentially transplantation. Planning for end of life remains a necessary aspect of care and should be discussed openly, honestly, with sensitivity and compassion for the person with CF and their family. CF teams should proactively recognise and address CF-specific health issues, and support mental and emotional wellbeing while accompanying people with CF and their families on their life journey.
    Language English
    Publishing date 2024-01-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6028: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 459: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Predictors of Traumatic Suicide Attempts in Youth Presenting to Hospitals with Level I Trauma Centers.

    Barczyk, Amanda N / Gillon, Jason T / Piper, Karen / Crocker, Catherine L / Christie, LeeAnn M / Lawson, Karla A

    The Journal of emergency medicine

    2020  Volume 59, Issue 2, Page(s) 178–185

    Abstract: ... information. We used the Mann-Whitney U test to examine the association between traumatic suicide attempts and ...

    Abstract Background: Limited research exists examining the predictors of suicide attempts by mechanism.
    Objective: The purpose of this study was to examine predictors of traumatic suicide attempts in youth.
    Methods: Data came from patients 5-18 years of age presenting because of a suicide attempt at 2 hospitals in Central Texas with level I trauma centers. Univariate logistic regression examined the association between traumatic suicide attempts and variables describing the patient's demographic, mental health, and social information. We used the Mann-Whitney U test to examine the association between traumatic suicide attempts and the continuous variable of age.
    Results: Of 231 patients included in this study, most were female (75.8%), non-Hispanic white (48.1%), and had a median age of 15.0 years (interquartile range 14-16). Compared with patients presenting because of an intentional overdose, patients presenting because of traumatic suicide attempts were associated with a reported criminal history (odds ratio [OR] 14.50 [95% confidence interval {CI} 3.84-54.82]), reported Child Protective Services history (OR 3.26 [95% CI 0.99-10.77]), being publicly insured or uninsured (OR 1.80 [95% CI 1.02-3.19]), male (OR 2.37 [95% CI 1.28-4.38]), and identifying as Hispanic (OR 2.01 [95% CI 1.10-3.68).
    Conclusions: Our findings inform targeted preventative resources and education efforts to populations of greatest need.
    MeSH term(s) Adolescent ; Child ; Female ; Hospitals ; Humans ; Logistic Models ; Male ; Risk Factors ; Suicide, Attempted ; Texas/epidemiology ; Trauma Centers
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2020.02.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1895: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Validity of arterialised-venous P CO2, pH and bicarbonate in obesity hypoventilation syndrome.

    Hollier, Carly A / Maxwell, Lyndal J / Harmer, Alison R / Menadue, Collette / Piper, Amanda J / Black, Deborah A / Willson, Grant N / Alison, Jennifer A

    Respiratory physiology & neurobiology

    2013  Volume 188, Issue 2, Page(s) 165–171

    Abstract: ... group differences were assessed with independent t-tests or Mann-Whitney U tests. Forty-two viable ... HCO3(-): MD -0.3 mmol L(-1) (-1.0%), LOA -1.8-1.2 mmol L(-1) (± 5.3%). AVBG provides valid measures ...

    Abstract This prospective study investigated the validity of arterialised-venous blood gases (AVBG) for estimating arterial carbon dioxide P CO2, pH and bicarbonate (HCO3(-)) in people with obesity hypoventilation syndrome (OHS). AVBGs were obtained from an upper limb vein, after heating the skin at 42-46°C. Arterial blood gas (ABG) and AVBG samples were taken simultaneously and compared using Bland Altman analysis. Between-group differences were assessed with independent t-tests or Mann-Whitney U tests. Forty-two viable paired samples were analysed, including 27 paired samples from 15 OHS participants, and 15 paired samples from 16 controls. AVBG-ABG agreement was not different between groups, or between dorsal hand, forearm and antecubital AVBG sampling sites, and was clinically acceptable for P Co2: mean difference (MD) 0.4 mmHg (0.9%), limits of agreement (LOA) -2.7-3.6 mmHg (± 6.6%); pH: MD -0.008 (-0.1%), LOA -0.023-0.008 (± 0.2%); and HCO3(-): MD -0.3 mmol L(-1) (-1.0%), LOA -1.8-1.2 mmol L(-1) (± 5.3%). AVBG provides valid measures of [Formula: see text] , pH, and HCO3(-) in OHS.
    MeSH term(s) Adult ; Arteries ; Bicarbonates/blood ; Blood Gas Analysis ; Carbon Dioxide/blood ; Female ; Humans ; Hydrogen-Ion Concentration ; Male ; Middle Aged ; Obesity Hypoventilation Syndrome/blood ; Reproducibility of Results ; Statistics, Nonparametric ; Veins
    Chemical Substances Bicarbonates ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2013-08-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2077867-3
    ISSN 1878-1519 ; 1569-9048
    ISSN (online) 1878-1519
    ISSN 1569-9048
    DOI 10.1016/j.resp.2013.05.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Fast 3D Near-infrared breast imaging using indocyanine green for detection and characterization of breast lesions.

    Schneider, P / Piper, S / Schmitz, C H / Schreiter, N F / Volkwein, N / Lüdemann, L / Malzahn, U / Poellinger, A

    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

    2011  Volume 183, Issue 10, Page(s) 956–963

    Abstract: ... the malignant group (Mann-Whitney U-test, p < 0.05). Breasts with malignant lesions showed higher peaks at early ...

    Abstract Purpose: To evaluate fast 3D near-infrared breast imaging using the optical contrast agent indocyanine green (ICG) for the detection and characterization of breast lesions.
    Materials and methods: 30 patients with suspicious breast lesions on mammography and/or ultrasound underwent fast 2 Hz 3D optical mammography before, during, and after administration of a 25 mg ICG bolus prior to needle biopsy. The bolus kinetics is analyzed using two perfusion parameters and a derived parameter: "peak amplitude" (PA), "time-to-peak" (TTP) and "peak-time grouped amplitude" (PTA). A receiver operating characteristic curve (ROC) analysis was performed to define a PTA cut-off for reader-independent differentiation of benign and malignant lesions. 8 patients had to be excluded from data analysis. Overall 14 breasts bearing a malignant lesion, 8 breasts bearing a benign lesion and 3 healthy breasts were analyzed.
    Results: The cut-off-based PTA analysis allowed correct detection for 12 of 14 malignant lesions (tumor size: 8 - 80 mm; sensitivity = 85.7 %). Two malignant lesions were missed. In the benign study group only one fibroadenoma was detected (specificity = 87.5 %). The PTA values differed significantly between the benign group and the malignant group (Mann-Whitney U-test, p < 0.05). Breasts with malignant lesions showed higher peaks at early time-points in ICG perfusion.
    Conclusion: Early perfusion analysis of ICG-enhanced 3D fast optical mammography revealed different enhancement patterns for benign and malignant lesions. This approach might help with the detection of malignant breast lesions and the differentiation from benign lesions.
    MeSH term(s) Adult ; Aged ; Biopsy, Needle ; Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Carcinoma/diagnosis ; Carcinoma/pathology ; Carcinoma, Ductal, Breast/diagnosis ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Intraductal, Noninfiltrating/diagnosis ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Lobular/diagnosis ; Carcinoma, Lobular/pathology ; Contrast Media/administration & dosage ; Diagnosis, Differential ; Diagnostic Imaging/instrumentation ; Equipment Design ; Female ; Fibroadenoma/diagnosis ; Fibroadenoma/pathology ; Fibrocystic Breast Disease/diagnosis ; Fibrocystic Breast Disease/pathology ; Humans ; Image Processing, Computer-Assisted/instrumentation ; Imaging, Three-Dimensional/instrumentation ; Indocyanine Green ; Mammography/instrumentation ; Middle Aged ; Sensitivity and Specificity ; Tomography, Optical/instrumentation ; Ultrasonography, Mammary/instrumentation
    Chemical Substances Contrast Media ; Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2011-10
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    ISSN (online) 1438-9010
    ISSN 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    DOI 10.1055/s-0031-1281726
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.12: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Fast 3D Near-Infrared Breast Imaging Using Indocyanine Green for Detection and Characterization of Breast Lesions

    Schneider, P. / Piper, S. / Schmitz, C. H. / Schreiter, N. F. / Volkwein, N. / Lüdemann, L. / Malzahn, U. / Poellinger, A.

    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

    2011  Volume 183, Issue 10, Page(s) 956–963

    Abstract: ... Studiengruppe (Mann-Whitney U Test, p < 0,05). Brüste mit malignen Läsionen zeigten höhere Peaks zu früheren ...

    Abstract ZIEL: Evaluierung eines schnellen 3-D-Nah-Infrarot-Bildgebungsverfahrens unter Verwendung von Indocyaningrün (ICG) für die Detektion und Charakterisierung von Brustläsionen. MATERIAL UND METHODEN: 30 Patientinnen mit mammografisch und/oder sonografisch detektierten suspekten Brustläsionen wurden mit einem schnellen optischen 2 Hz 3-D-Mammografen vor, während und nach Gabe eines 25 mg ICG-Bolus vor histologischer Sicherung mittels Stanzbiopsie untersucht. Die Boluskinetik wurde mithilfe von zwei Perfusionsparametern und einem abgeleiteten Parameter analysiert: „peak amplitude” (PA), „time to peak” (TTP) und „peak-time grouped amplitude” (PTA). Mithilfe einer Receiver-operating-characteristic(ROC)-Analyse wurde ein PTA-Cut-off-Wert für eine untersucherunabhängige Differenzierung zwischen benignen und malignen Läsionen festgelegt. Acht Patientinnen mussten von der Datenauswertung ausgeschlossen werden. Insgesamt wurden 14 Brüste mit malignen Läsionen, 8 Brüste mit benignen Läsionen und drei gesunde Brüste analysiert. ERGEBNISSE: Die cut-off-basierte PTA-Analyse führte zur korrekten Detektion bei 12 von 14 malignen Läsionen (Tumorgröße 8 – 80 mm; Sensitivität = 85,7 %). Zwei maligne Läsionen wurden nicht erkannt. In der benignen Studiengruppe wurde lediglich ein Fibroadenom detektiert (Spezifität = 87.5 %). PTA-Werte unterschieden sich signifikant für benigne und maligne Studiengruppe (Mann-Whitney U Test, p < 0,05). Brüste mit malignen Läsionen zeigten höhere Peaks zu früheren Zeitpunkten in der ICG-Perfusion. SCHLUSSFOLGERUNG: Die frühe Perfusionsanalyse in der ICG-gestützten optischen 3-D-Mammografie konnte unterschiedliche Muster der Kontrastmittelaufnahme in benignen und malignen Läsionen aufzeigen. Dieser Ansatz könnte der Detektion maligner Brustläsionen und der Abgrenzung zu benignen Herden dienen.
    Keywords breast ; laser ; contrast agents ; technical aspects
    Language English
    Publishing date 2011-10-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/s-0031-1281726
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.12: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Schnelle 3-D-Nah-Infrarot-Bildgebung der Brust unter Verwendung von Indocyaningrün für die Detektion and Charakterisierung von Läsionen in der weiblichen Brust

    Schneider, P / Piper, S / Schmitz, C. H / Schreiter, N. F / Volkwein, N / Lüdemann, L / Malzahn, U / Poellinger, A

    RöFo

    2011  Volume 183, Issue 10, Page(s) 956–963

    Abstract: ... Studiengruppe (Mann-Whitney U Test, p < 0,05). Brüste mit malignen Läsionen zeigten höhere Peaks zu früheren ...

    Abstract ZIEL: Evaluierung eines schnellen 3-D-Nah-Infrarot-Bildgebungsverfahrens unter Verwendung von Indocyaningrün (ICG) für die Detektion und Charakterisierung von Brustläsionen. MATERIAL UND METHODEN: 30 Patientinnen mit mammografisch und/oder sonografisch detektierten suspekten Brustläsionen wurden mit einem schnellen optischen 2 Hz 3-D-Mammografen vor, während und nach Gabe eines 25 mg ICG-Bolus vor histologischer Sicherung mittels Stanzbiopsie untersucht. Die Boluskinetik wurde mithilfe von zwei Perfusionsparametern und einem abgeleiteten Parameter analysiert: „peak amplitude” (PA), „time to peak” (TTP) und „peak-time grouped amplitude” (PTA). Mithilfe einer Receiver-operating-characteristic(ROC)-Analyse wurde ein PTA-Cut-off-Wert für eine untersucherunabhängige Differenzierung zwischen benignen und malignen Läsionen festgelegt. Acht Patientinnen mussten von der Datenauswertung ausgeschlossen werden. Insgesamt wurden 14 Brüste mit malignen Läsionen, 8 Brüste mit benignen Läsionen und drei gesunde Brüste analysiert. ERGEBNISSE: Die cut-off-basierte PTA-Analyse führte zur korrekten Detektion bei 12 von 14 malignen Läsionen (Tumorgröße 8 – 80 mm; Sensitivität = 85,7 %). Zwei maligne Läsionen wurden nicht erkannt. In der benignen Studiengruppe wurde lediglich ein Fibroadenom detektiert (Spezifität = 87.5 %). PTA-Werte unterschieden sich signifikant für benigne und maligne Studiengruppe (Mann-Whitney U Test, p < 0,05). Brüste mit malignen Läsionen zeigten höhere Peaks zu früheren Zeitpunkten in der ICG-Perfusion. SCHLUSSFOLGERUNG: Die frühe Perfusionsanalyse in der ICG-gestützten optischen 3-D-Mammografie konnte unterschiedliche Muster der Kontrastmittelaufnahme in benignen und malignen Läsionen aufzeigen. Dieser Ansatz könnte der Detektion maligner Brustläsionen und der Abgrenzung zu benignen Herden dienen.
    Keywords Alkoholkonsum und Mortalität ; Primärrekonstruktion ; Hiatus sacralis ; Trisomie 13
    Language German
    Document type Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    ISSN (online) 1438-9010
    ISSN 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    DOI 10.1055/s-0031-1281726
    Database bibnet.org

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.12: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top