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Article ; Online: Biological Effects and Mechanisms of Taurine in Various Therapeutics.

Sharma, Shikha / Sahoo, Biswa Mohan / Banik, Bimal Krishna

Current drug discovery technologies

2023 Volume 20, Issue 6, Page(s) 60–78

Abstract: More than two hundred years ago, taurine was first isolated from materials derived from animals. It is abundantly found in a wide range of mammalian and non-mammalian tissues and diverse environments. Taurine was discovered to be a by-product of the ... ...

Abstract	More than two hundred years ago, taurine was first isolated from materials derived from animals. It is abundantly found in a wide range of mammalian and non-mammalian tissues and diverse environments. Taurine was discovered to be a by-product of the metabolism of sulfur only a little over a century and a half ago. Recently, there has been a renewed academic interest in researching and exploring various uses of the amino acid taurine, and recent research has indicated that it may be useful in the treatment of a variety of disorders, including seizures, high blood pressure, cardiac infarction, neurodegeneration, and diabetes. Taurine is currently authorised for the therapy of congestive heart failure in Japan, and it has shown promising results in the management of several other illnesses as well. Moreover, it was found to be effective in some clinical trials, and hence it was patented for the same. This review compiles the research data that supports the prospective usage of taurine as an antibacterial, antioxidant, anti-inflammatory, diabetic, retinal protective, and membrane stabilizing agent, amongst other applications.
Language	English
Publishing date	2023-05-22
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6220
ISSN (online)	1875-6220
DOI	10.2174/1570163820666230525101353
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Article ; Online: Development And Validation Of Rp-Hplc Method For The Estimation Of Tenofovir And Emtricitabine In Bulk And Pharmaceutical Dosage Form.

Sahoo, Biswa Mohan / Rao, Pallepogu Venkateswara / Rao, Naidu Srinivasa

Current drug research reviews

2023

Abstract: Background: A novel, simple, efficient, rapid, and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed for the estimation of Tenofovir and Emtricitabine in the bulk and pharmaceutical dosage form. The currently ... ...

Abstract	Background: A novel, simple, efficient, rapid, and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed for the estimation of Tenofovir and Emtricitabine in the bulk and pharmaceutical dosage form. The currently developed method was subsequently validated according to ICH guidelines in terms of linearity, accuracy, precision, the limit of detection, the limit of quantification, robustness, etc. Methods: The separation of the selected drugs was optimized after several trials including change of mobile phase and its composition, stationary phase, flow rate, column temperature, etc. The separation was performed by using an Inertsil ODS C18 column (250 mm x 4.6 mm, 5μ) and UV absorption was measured at 231 nm. Methanol: Acetonitrile: Water was selected as the mobile phase in the ratio of 50:20:30 (V/V/V) at a flow rate of 1 mL/min. As per International Conference on Harmonization (ICH) Q2 R1 guidelines, several validation parameters were evaluated which include specificity, linearity, precision, accuracy, the limit of detection (LOD), and the limit of quantitation (LOQ). Results: The acceptable degree of linearity range was found to be 40-100 µg/mL. The standard solution exhibited retention times of 3.06 minutes and 5.07 minutes for Tenofovir and Emtricitabine respectively. The LOD and LOQ obtained were 0.05µg/ml and 0.02µg/mL, 15µg/mL, and 0.08µg/mL for Tenofovir and Emtricitabine respectively. The percent recovery was found to be 98 to 102%. Conclusion: Hence, the proposed method is simple, selective, and specifically meets the requirements of ICH guidelines for the validation of the analytical method.
Language	English
Publishing date	2023-06-02
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2589-9783
ISSN (online)	2589-9783
DOI	10.2174/2589977515666230602151222
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Article ; Online: Applications of nanotechnology-mediated herbal nanosystems for ophthalmic drug.

Shree, Dipthi / Patra, Chinam Niranjan / Sahoo, Biswa Mohan

Pharmaceutical nanotechnology

2023

Abstract: In recent years, herbal nanomedicines have gained tremendous popularity for novel drug discovery. Nanotechnology has provided several advances in the healthcare sector, emerging several novel nanocarriers that potentiate the bioavailability and ... ...

Abstract	In recent years, herbal nanomedicines have gained tremendous popularity for novel drug discovery. Nanotechnology has provided several advances in the healthcare sector, emerging several novel nanocarriers that potentiate the bioavailability and therapeutic efficacy of the herbal drug. The recent advances in nanotechnology with accelerated strategies of ophthalmic nanosystems have paved a new path for overcoming the limitations associated with ocular drug delivery systems, such as low bioavailability, poor absorption, stability, and precorneal drug loss. Ophthalmic drug delivery is challenging due to anatomical and physiological barriers. Due to the presence of these barriers, the herbal drug entry into the eyes can be affected when administered by following multiple routes, i.e., topical, injectables, or systemic. However, the advancement of nanotechnology with intelligent systems enables the herbal active constituent to successfully entrap within the system, which is usually difficult to reach employing conventional herbal formulations. Herbal-loaded nanocarrier drug delivery systems demonstrated enhanced herbal drug permeation and prolonged herbal drug delivery. In this current manuscript, an extensive search is conducted for original research papers using databases Viz., PubMed, Google Scholar, Science Direct, Web of Science, etc. Further painstaking efforts are made to compile and update the novel herbal nanocarriers such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructure lipid carriers, micelles, niosomes, nanoemulsions, dendrimers, etc., which are mostly used for ophthalmic drug delivery system. This article presents a comprehensive survey of diverse applications used for the preventative measures and treatment therapy of varied eye disorders. Further, this article highlights the recent findings that the innovators are exclusively working on ophthalmic nanosystems for herbal drug delivery systems. The nanocarriers are promising drug delivery systems that enable an effective and supreme therapeutic potential circumventing the limitations associated with conventional ocular drug delivery systems. The nanotechnology-based approach is useful to encapsulate the herbal bioactive and prevent them from degradation and therefore providing them for controlled and sustained release with enhanced herbal drug permeation. Extensive research is still being carried out in the field of herbal nanotechnology to design an ophthalmic nanosystem with improved.
Language	English
Publishing date	2023-08-16
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2211-7393
ISSN (online)	2211-7393
DOI	10.2174/2211738511666230816090046
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Article ; Online: Mechanistic Role of Tempol: Synthesis, Catalysed Reactions and Therapeutic Potential.

Tiwari, Abhishek / Tiwari, Varsha / Banik, Bimal Krishna / Sahoo, Biswa Mohan

Medicinal chemistry (Shariqah (United Arab Emirates))

2023 Volume 19, Issue 9, Page(s) 859–878

Abstract: Tempol (TP) was introduced in 1960 by Lebedev and Kazarnovskii and is an excellent catalyst extensively used in the synthesis and oxidation of various reagents. 4-Hydroxy-2,2,6,6- tetramethylpiperidin-1-oxyl (TP) has also been explored against various ... ...

Abstract	Tempol (TP) was introduced in 1960 by Lebedev and Kazarnovskii and is an excellent catalyst extensively used in the synthesis and oxidation of various reagents. 4-Hydroxy-2,2,6,6- tetramethylpiperidin-1-oxyl (TP) has also been explored against various disorders like inflammation, superoxide anion-influenced molecular linked behavioural modifications, radical capturing, cardioprotective, protective ocular damage, against skin burns, fibrocystic diseases, breast cancer prevention, respiratory infections, alopecia, and cerebral malaria, etc. This review article comprises five major aspects of TP namely (a) Approx. 25 different Synthesis schemes of TP (b) major reactions catalysed by TP (c) Therapeutic potential of TP. It also provides scientific information that supports the use of TP which may be proven as a "MIRACLE" drug for the treatment of numerous disorders namely in reducing the reactive oxygen species, superoxide mutases, vision disorders, cancer as well as in covid. It also possesses a significant role in minimising side effects in combination therapy. This review will be beneficial to researchers, healthcare, and academic professionals for further research.
MeSH term(s)	Humans ; COVID-19 ; Spin Labels ; Cyclic N-Oxides/pharmacology ; Cyclic N-Oxides/therapeutic use ; Superoxides
Chemical Substances	tempol (U78ZX2F65X) ; Spin Labels ; Cyclic N-Oxides ; Superoxides (11062-77-4)
Language	English
Publishing date	2023-06-07
Publishing country	Netherlands
Document type	Review ; Journal Article
ISSN	1875-6638
ISSN (online)	1875-6638
DOI	10.2174/1573406419666230505150020
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Article ; Online: Novel Herbal Nanocarriers for Treatment of Dermatological Disorders.

Shree, Dipthi / Patra, Chinam Niranjan / Sahoo, Biswa Mohan

Pharmaceutical nanotechnology

2022 Volume 10, Issue 4, Page(s) 246–256

Abstract: Background and objective: In the present scenario, the use of novel nanocarriers to provide a better therapy regimen is noteworthy. Nanotechnology with the advanced system enables the herbs for encapsulation within the smart carrier and boosts the ... ...

Abstract	Background and objective: In the present scenario, the use of novel nanocarriers to provide a better therapy regimen is noteworthy. Nanotechnology with the advanced system enables the herbs for encapsulation within the smart carrier and boosts the nanotherapeutic. These emerging innovations of herbal nanocarriers have paved the way for dermal targeting by eliciting the desired response for particular diseases. Methods: In this current manuscript, an extensive search is conducted for the original research papers using databases, viz., Google Scholar, PubMed, Science Direct, etc. Furthermore, painstaking efforts are made to compile and update the novel herbal nanocarriers, such as liposomes, ethosomes, transferosomes, niosomes, nanoemulsions, nanogels, nanostructured lipid carriers, solid lipid carriers, etc., which are mostly used for the treatment of several skin maladies, viz., eczema, psoriasis, acne, etc. This article highlights the recent findings that the innovators are exclusively working on herbal drug delivery systems for dermal targeting, and these are enumerated in the form of tables. Conclusion: Herbal formulations employing a suitable nanocarrier could be a promising approach for the treatment of several pathological conditions, including skin ailments. Therefore, scientific research is still being carried out in this specific area for a better perspective in herbal drug delivery and targeting.
MeSH term(s)	Drug Delivery Systems ; Skin ; Liposomes ; Nanostructures ; Lipids
Chemical Substances	Liposomes ; Lipids
Language	English
Publishing date	2022-06-22
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2211-7393
ISSN (online)	2211-7393
DOI	10.2174/2211738510666220622123019
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Article ; Online: Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes.

Mahapatra, Manoj Kumar / Karuppasamy, Muthukumar / Sahoo, Biswa Mohan

Reviews in endocrine & metabolic disorders

2022 Volume 23, Issue 3, Page(s) 521–539

Abstract: Semaglutide, a glucagon like peptide-1 (GLP-1) receptor agonist, is available as monotherapy in both subcutaneous as well as oral dosage form (first approved oral GLP-1 receptor agonist). It has been approved as a second line treatment option for better ... ...

Abstract	Semaglutide, a glucagon like peptide-1 (GLP-1) receptor agonist, is available as monotherapy in both subcutaneous as well as oral dosage form (first approved oral GLP-1 receptor agonist). It has been approved as a second line treatment option for better glycaemic control in type 2 diabetes and currently under scrutiny for anti-obesity purpose. Semaglutide has been proved to be safe in adults and elderly patients with renal or hepatic disorders demanding no dose modification. Cardiovascular (CV) outcome trials established that it can reduce various CV risk factors in patients with established CV disorders. Semaglutide is well tolerated with no risk of hypoglycaemia in monotherapy but suffers from gastrointestinal adverse effects. A large population affected with COVID-19 infection were diabetic; therefore use of semaglutide in diabetes as well as CV patients would be very much supportive in maintaining health care system during this pandemic situation. Hence, this peptidic drug can be truly considered as a quintessential of GLP-1 agonists for management of type 2 diabetes.
MeSH term(s)	Aged ; COVID-19/drug therapy ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/therapeutic use ; Glucagon-Like Peptides ; Humans ; Hypoglycemic Agents/therapeutic use
Chemical Substances	Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; semaglutide (53AXN4NNHX) ; Glucagon-Like Peptides (62340-29-8) ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2022-01-07
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2185718-0
ISSN	1573-2606 ; 1389-9155
ISSN (online)	1573-2606
ISSN	1389-9155
DOI	10.1007/s11154-021-09699-1
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Article ; Online: Green Chemistry Approach for the Synthesis of Isoxazole Derivatives and Evaluation of their Anti-epileptic Activity.

Panda, Krishna Chandra / Varaha Bera, Ravi Kumar Venkata / Sahoo, Biswa Mohan / Swain, Parijat

Current drug discovery technologies

2023 Volume 20, Issue 3, Page(s) e150223213697

Abstract: Background: Green strategy involves the design, synthesis, processing, and use of chemical substances by eliminating the generation of chemical hazards. This approach focuses on atom economy, use of safer solvents or chemicals, consumption of energy, ... ...

Abstract	Background: Green strategy involves the design, synthesis, processing, and use of chemical substances by eliminating the generation of chemical hazards. This approach focuses on atom economy, use of safer solvents or chemicals, consumption of energy, and decomposition of the chemical substances to non-toxic materials which are eco-friendly. Objective: So, the microwave irradiated heating method is considered a green and sustainable technique for the development of novel heterocyclic scaffold-like isoxazole derivatives via chalcones. Isoxazole derivatives play a vital role due to their diverse pharmacological activities such as antibiotic (Sulfamethoxazole, Cloxacillin, Flucloxacillin, Cycloserine), anti-fungal (Drazoxolon), Antirheumatic (Leflunomide), antidepressant (Isocarboxazid), antineoplastic (Acivicin), anticonvulsant (Zonisamide), antipsychotic (Risperidone) and anti-inflammatory drugs (Valdecoxib), etc. Methods: The isoxazole derivatives were synthesized with the help of microwave irradiation that follows green chemistry protocol. Results: The titled compounds were subjected to antiepileptic evaluation to determine their therapeutic potential. Conclusion: The use of microwave radiation enhances the rate of the reaction which leads to high selectivity with improved product yields in comparison with the traditional heating methods. The tested compounds exhibited promising antiepileptic activity as compared to the standard drug (Phenytoin).
MeSH term(s)	Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Isoxazoles/pharmacology ; Isoxazoles/therapeutic use ; Isoxazoles/chemistry ; Chalcones/chemistry ; Anti-Bacterial Agents/pharmacology ; Solvents
Chemical Substances	Anticonvulsants ; Isoxazoles ; Chalcones ; Anti-Bacterial Agents ; Solvents
Language	English
Publishing date	2023-01-26
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6220
ISSN (online)	1875-6220
DOI	10.2174/1570163820666230215125043
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Article ; Online: NOX-2 Inhibitors may be Potential Drug Candidates for the Management of COVID-19 Complications.

Chowdhury, Bimalendu / Sahoo, Biswa Mohan / Jena, Akankshya / Hiramani, K / Behera, Amulyaratna / Acharya, Biswajeet

Current drug research reviews

2023

Abstract: COVID-19 is an RNA virus that attacks the targeting organs, which express angiotensin-converting enzyme-2 (ACE-2), such as the lungs, heart, renal system, and gastrointestinal tract. The virus that enters the cell by endocytosis triggers ROS production ... ...

Abstract	COVID-19 is an RNA virus that attacks the targeting organs, which express angiotensin-converting enzyme-2 (ACE-2), such as the lungs, heart, renal system, and gastrointestinal tract. The virus that enters the cell by endocytosis triggers ROS production within the confines of endosomes via a NOX-2 containing NADPH-oxidase. Various isoforms of NADPH oxidase are expressed in airways and alveolar epithelial cells, endothelial and vascular smooth muscle cells, and inflammatory cells, such as alveolar macrophages, monocytes, neutrophils, and T-lymphocytes. The key NOX isoform expressed in macrophages and neutrophils is the NOX-2 oxidase, whereas, in airways and alveolar epithelial cells, it appears to be NOX-1 and NOX-2. The respiratory RNA viruses induce NOX-2-mediated ROS production in the endosomes of alveolar macrophages. The mitochondrial and NADPH oxidase (NOX) generated ROS can enhance TGF-β signaling to promote fibrosis of the lungs. The endothelium-derived ROS and platelet-derived ROS, due to activation of the NADPH-oxidase enzyme, play a crucial role in platelet activation. It has been observed that NOX-2 is generally activated in COVID-19 patients. The post-COVID complications like pulmonary fibrosis and platelet aggregation may be due to the activation of NOX-2. NOX-2 inhibitors may be a useful drug candidate to prevent COVID-19 complications like pulmonary fibrosis and platelet aggregation.
Language	English
Publishing date	2023-07-06
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2589-9783
ISSN (online)	2589-9783
DOI	10.2174/2589977515666230706114812
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Article ; Online: Carbapenem Antibiotics: Recent Update on Synthesis and Pharmacological Activities.

Tiwari, Abhishek / Tiwari, Varsha / Sahoo, Biswa Mohan / Banik, Bimal Krishna / Kumar, Manish / Verma, Navneet

Current drug research reviews

2022 Volume 15, Issue 1, Page(s) 35–61

Abstract: Right from the breakthrough of carbapenems since 1976, many schemes on synthesis, structure-activity relationship (SAR), and biological activities have been carried out, and several carbapenems have been developed, including parentally active carbapenems ...

Abstract	Right from the breakthrough of carbapenems since 1976, many schemes on synthesis, structure-activity relationship (SAR), and biological activities have been carried out, and several carbapenems have been developed, including parentally active carbapenems like imipenem, doripenem, biapenem, meropenem, ertapenem, panipenem, razupenem, tomopenem, and cilastatin, whereas orally active carbapenems like GV-118819, GV-104326, CS-834, L-084, DZ-2640, CL 191, 121, L-646, 591, S-4661, ER-35768, MK-826. Prodrugs of carbapenem with increased bioavailability include temopenem, tebipenem, sanfetrinem, LK-157, and CP 5484. Merck, Glaxo Welcome Research Group, Johnson & Johnson, Sankyo Group and Dai-ichi Group, and Wyeth-Ayerst Group were among the businesses that produced carbapenems. In this review Witting reaction, Mitsunobu reaction, Dieckmann reaction, palladium-catalyzed hydrogenolysis, E. coli-based cloned synthesis, as well as biosynthetic enzymes such as carbapenem synthetase (carA), carboxymethylproline synthase (carB), carbapenem synthase (carC) are included. Carbapenems are biologically mainly active in the infections like urinary tract infections, bloodstream infections, tuberculosis, intra-abdominal infections, and pathogens like anaerobes, gram-positive and gram-negative bacteria.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Escherichia coli ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Carbapenems/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Carbapenems
Language	English
Publishing date	2022-09-01
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ISSN	2589-9783
ISSN (online)	2589-9783
DOI	10.2174/2589977514666220907141939
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Article ; Online: Reactive Oxygen Species (ROS): Key Components in Cancer Therapies.

Sahoo, Biswa Mohan / Banik, Bimal Krishna / Borah, Preetismita / Jain, Adya

Anti-cancer agents in medicinal chemistry

2021 Volume 22, Issue 2, Page(s) 215–222

Abstract: Reactive Oxygen Species (ROS) refers to the highly reactive substances which contain oxygen radicals. Hypochlorous acid, peroxides, superoxide, singlet oxygen, alpha-oxygen, and hydroxyl radicals are the major examples of ROS. Generally, the reduction of ...

Abstract	Reactive Oxygen Species (ROS) refers to the highly reactive substances which contain oxygen radicals. Hypochlorous acid, peroxides, superoxide, singlet oxygen, alpha-oxygen, and hydroxyl radicals are the major examples of ROS. Generally, the reduction of oxygen (O2) in molecular form produces superoxide (•O2 -) anion. ROS are produced during a variety of biochemical reactions within the cell organelles, such as endoplasmic reticulum, mitochondria, and peroxisome. Naturally, ROS are also formed as a byproduct of the normal metabolism of oxygen. The production of ROS can be induced by various factors such as heavy metals, tobacco, smoke, drugs, xenobiotics, pollutants, and radiation. From various experimental studies, it is reported that ROS acts as either a tumor-suppressing or a tumor-promoting agent. The elevated level of ROS can arrest the growth of tumors through the persistent increase in cell cycle inhibition. The increased level of ROS can induce apoptosis by both intrinsic and extrinsic pathways. ROS is considered to be a tumor-suppressing agent as the production of ROS is due to the use of most of the chemotherapeutic agents in order to activate cell death. The cytotoxic effect of ROS provides impetus towards apoptosis, but in higher levels, ROS can cause initiation of malignancy that leads to uncontrolled cell death in cancer cells. In contrast, some species of ROS can influence various activities at the cellular level, including cell proliferation. This review highlights the genesis of ROS within cells by various routes and their role in cancer therapies.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Humans ; Molecular Structure ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Reactive Oxygen Species/analysis ; Reactive Oxygen Species/metabolism
Chemical Substances	Antineoplastic Agents ; Reactive Oxygen Species
Language	English
Publishing date	2021-06-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/1871520621666210608095512
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