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  1. Article ; Online: Is a high baseline inflammatory burden the major driver in causing daptomycin-induced eosinophilic pneumonia and muscular toxicity?

    Gatti, Milo / Pea, Federico

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae017
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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  2. Article ; Online: Comment on: pharmacokinetics/pharmacodynamics and therapeutic drug monitoring of ceftazidime/avibactam administered by continuous infusion in patients with MDR Gram-negative bacterial infections.

    Gatti, Milo / Pea, Federico

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 6, Page(s) 1556–1557

    MeSH term(s) Humans ; Ceftazidime/pharmacology ; Drug Monitoring ; Anti-Bacterial Agents/pharmacology ; Azabicyclo Compounds/pharmacology ; Gram-Negative Bacterial Infections/drug therapy ; Drug Combinations
    Chemical Substances Ceftazidime (9M416Z9QNR) ; avibactam (7352665165) ; Anti-Bacterial Agents ; Azabicyclo Compounds ; Drug Combinations
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad108
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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  3. Article ; Online: Is intrathecal or intraventricular therapy with polymyxins or aminoglycosides still needed for improving the outcome of post-neurosurgical extensively/multi drug-resistant (XDR/MDR) Gram-negative bacteria (-GNB) related meningitis/ventriculitis in the current era of novel beta-lactams beta-lactam/beta-lactamase inhibitor combinations?

    Gatti, Milo / Virgili, Giulio / Viale, Pierluigi / Pea, Federico

    International journal of antimicrobial agents

    2024  , Page(s) 107177

    Language English
    Publishing date 2024-04-19
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2024.107177
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    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  4. Article ; Online: Pharmacokinetic analysis investigating gentamicin dosing in a major burned patient complicated by septic shock.

    Gatti, Milo

    Journal of chemotherapy (Florence, Italy)

    2020  Volume 32, Issue 4, Page(s) 208–212

    Abstract: Profound pharmacokinetic alterations involving volume of distribution and clearance may impair the achievement of adequate antimicrobial serum concentrations in major burn patients. Gentamicin pharmacokinetic analysis was performed in a major burn victim ...

    Abstract Profound pharmacokinetic alterations involving volume of distribution and clearance may impair the achievement of adequate antimicrobial serum concentrations in major burn patients. Gentamicin pharmacokinetic analysis was performed in a major burn victim with 90% of total body surface area affected and complicated by septic shock due to
    MeSH term(s) Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/therapeutic use ; Burns/complications ; Burns/drug therapy ; Drug Monitoring ; Gentamicins/pharmacokinetics ; Gentamicins/therapeutic use ; Humans ; Male ; Metabolic Clearance Rate ; Middle Aged ; Serratia marcescens ; Shock, Septic/complications ; Shock, Septic/microbiology
    Chemical Substances Anti-Bacterial Agents ; Gentamicins
    Language English
    Publishing date 2020-03-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1036294-0
    ISSN 1973-9478 ; 1120-009X
    ISSN (online) 1973-9478
    ISSN 1120-009X
    DOI 10.1080/1120009X.2020.1733335
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    Zs.A 2701: Show issues Location:
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    Zs.MO 387: Show issues

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  5. Article ; Online: In reply to the Letter to the Editor regarding "Clinical efficacy of cefiderocol-based regimens in patients with carbapenem-resistant Acinetobacter baumannii infections: A systematic review with meta-analysis".

    Gatti, Milo / Cosentino, Federica / Giannella, Maddalena / Viale, Pierluigi / Pea, Federico

    International journal of antimicrobial agents

    2024  , Page(s) 107168

    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2024.107168
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    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  6. Article ; Online: The expert clinical pharmacological advice program for tailoring on real-time antimicrobial therapies with emerging TDM candidates in special populations: how the ugly duckling turned into a swan.

    Gatti, Milo / Pea, Federico

    Expert review of clinical pharmacology

    2023  Volume 16, Issue 11, Page(s) 1035–1051

    Abstract: Introduction: The growing spread of infections caused by multidrug-resistant pathogens makes the need of tailoring antimicrobial therapies by means of a 'patient-centered' approach fundamental. In this scenario, therapeutic drug monitoring (TDM) of ... ...

    Abstract Introduction: The growing spread of infections caused by multidrug-resistant pathogens makes the need of tailoring antimicrobial therapies by means of a 'patient-centered' approach fundamental. In this scenario, therapeutic drug monitoring (TDM) of emerging antimicrobial candidates may be a valuable approach, but expert interpretation of TDM results should be granted for making them more clinically useful. The MD Clinical Pharmacologist may take over this task since this specialist may couple PK/PD expertise on drugs with a medical background and may provide expert interpretation of TDM results of antimicrobials for tailoring therapy on real-time in each single patient based on specific both drug/pathogen issues and patient issues.
    Areas covered: This article aims to highlight the main key-points and organizational aspects for implementing a successful TDM-based expert clinical pharmacological advice (ECPA) program for tailoring antimicrobial therapies on real-time in different hospitalized patient special populations.
    Expert opinion: TDM-based ECPA programs lead by the MD Clinical Pharmacologist may represent a way forward for maximizing clinical efficacy and for minimizing the risk of resistance developments and/or toxicity of antimicrobials. Stakeholders should be aware of the fact that this innovative approach may be cost-effective.
    MeSH term(s) Humans ; Animals ; Drug Monitoring/methods ; Anti-Infective Agents/adverse effects ; Pharmacology, Clinical ; Anseriformes
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2023.2274984
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  7. Article ; Online: Continuous versus intermittent infusion of antibiotics in Gram-negative multidrug-resistant infections.

    Gatti, Milo / Pea, Federico

    Current opinion in infectious diseases

    2023  Volume 34, Issue 6, Page(s) 737–747

    Abstract: Purpose of review: The aim of this review was to perform a critical reappraisal of the real-world evidence supporting administration by prolonged infusion of novel beta-lactams for the management of multidrug-resistant Gram-negative infections.: ... ...

    Abstract Purpose of review: The aim of this review was to perform a critical reappraisal of the real-world evidence supporting administration by prolonged infusion of novel beta-lactams for the management of multidrug-resistant Gram-negative infections.
    Recent findings: Real-world evidence support the use of novel beta-lactams by prolonged infusion over intermittent infusion in terms of achieving aggressive pharmacokinetic/pharmacodynamic (PK/PD) target for either maximizing efficacy and clinical outcome or suppressing the emergence of resistance development. Continuous infusion of ceftolozane-tazobactam showed a marked superiority toward both intermittent and extended infusion (EI) in achieving a PK/PD target of 100%fT> 4 X MIC in infections caused by less-susceptible Pseudomonas aeruginosa isolates. No resistance development was found in critically ill or immunocompromised patients treated with EI ceftolozane-tazobactam compared to intermittent infusion. Prolonged infusion of ceftazidime-avibactam was negatively associated with mortality in patients affected by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae infections. Different challenging scenarios (patients showing augmented renal clearance of affected by deep-seated infections) could benefit from prolonged infusion to optimize the efficacy of novel agents.
    Summary: Although available data are still limited, real-world evidence regarding mainly ceftolozane-tazobactam and ceftazidime-avibactam could support the administration of novel beta-lactams by prolonged infusion in some specific scenarios in which achievement of aggressive PK/PD target is quite challenging.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Cephalosporins ; Critical Illness ; Drug Combinations ; Humans ; Klebsiella pneumoniae ; Microbial Sensitivity Tests ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins ; Drug Combinations
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000755
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    Zs.A 2462: Show issues Location:
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  8. Article ; Online: Jumping into the future: overcoming pharmacokinetic/pharmacodynamic hurdles to optimize the treatment of severe difficult to treat-Gram-negative infections with novel beta-lactams.

    Gatti, Milo / Pea, Federico

    Expert review of anti-infective therapy

    2023  Volume 21, Issue 2, Page(s) 149–166

    Abstract: Introduction: The choice of best therapeutic strategy for difficult-to-treat resistance (DTR) Gram-negative infections currently represents an unmet clinical need.: Areas covered: This review provides a critical reappraisal of real-world evidence ... ...

    Abstract Introduction: The choice of best therapeutic strategy for difficult-to-treat resistance (DTR) Gram-negative infections currently represents an unmet clinical need.
    Areas covered: This review provides a critical reappraisal of real-world evidence supporting the role of pharmacokinetic/pharmacodynamic (PK/PD) optimization of novel beta-lactams in the management of DTR Gram-negative infections. The aim was to focus on prolonged and/or continuous infusion administration, penetration rates into deep-seated infections, and maximization of PK/PD targets in special renal patient populations. Retrieved findings were applied to the three most critical clinical scenarios of Gram-negative resistance phenotypes (i.e. carbapenem-resistant
    Expert opinion: Several studies supported the role of PK/PD optimization of beta-lactams in the management of DTR Gram-negative infections for both maximizing clinical efficacy and preventing resistance emergence. Optimizing antimicrobial therapy with novel beta-lactams based on the so called 'antimicrobial therapy puzzle' PK/PD concepts may represent a definitive jump into the future toward a personalized patient management of DTR Gram negative infections. Establishing a dedicated and coordinated multidisciplinary team and implementing a real-time TDM-guided personalized antimicrobial exposure optimization of novel beta-lactams based on expert clinical pharmacological interpretation, could represent crucial cornerstones for the proper management of DTR Gram-negative infections.
    MeSH term(s) Humans ; Anti-Bacterial Agents ; beta-Lactams/pharmacology ; beta-Lactams/therapeutic use ; Drug Resistance, Multiple, Bacterial ; Drug Combinations ; Carbapenems/pharmacology ; Microbial Sensitivity Tests ; Gram-Negative Bacteria ; Cephalosporins/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams ; Drug Combinations ; Carbapenems ; Cephalosporins
    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2023.2169131
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    Zs.A 6106: Show issues Location:
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  9. Article ; Online: Impact of attaining aggressive vs. conservative PK/PD target on the clinical efficacy of beta-lactams for the treatment of Gram-negative infections in the critically ill patients: a systematic review and meta-analysis.

    Gatti, Milo / Cojutti, Pier Giorgio / Pea, Federico

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 123

    Abstract: Background: To perform a systematic review with meta-analysis with the dual intent of assessing the impact of attaining aggressive vs. conservative beta-lactams PK/PD target on the clinical efficacy for treating Gram-negative infections in critical ... ...

    Abstract Background: To perform a systematic review with meta-analysis with the dual intent of assessing the impact of attaining aggressive vs. conservative beta-lactams PK/PD target on the clinical efficacy for treating Gram-negative infections in critical patients, and of identifying predictive factors of failure in attaining aggressive PK/PD targets.
    Methods: Two authors independently searched PubMed-MEDLINE and Scopus database from inception to 23rd December 2023, to retrieve studies comparing the impact of attaining aggressive vs. conservative PK/PD targets on clinical efficacy of beta-lactams. Independent predictive factors of failure in attaining aggressive PK/PD targets were also assessed. Aggressive PK/PD target was considered a100%fT
    Results: A total of 20,364 articles were screened, and 21 observational studies were included in the meta-analysis (N = 4833; 2193 aggressive vs. 2640 conservative PK/PD target). Attaining aggressive PK/PD target was significantly associated with higher clinical cure rate (OR 1.69; 95% CI 1.15-2.49) and lower risk of beta-lactam resistance development (OR 0.06; 95% CI 0.01-0.29). Male gender, body mass index > 30 kg/m
    Conclusions: Attaining aggressive beta-lactams PK/PD targets provided significant clinical benefits in critical patients. Our analysis could be useful to stratify patients at high-risk of failure in attaining aggressive PK/PD targets.
    MeSH term(s) Humans ; Male ; beta-Lactams/pharmacology ; beta-Lactams/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Critical Illness/therapy ; Treatment Outcome ; Infusions, Intravenous
    Chemical Substances beta-Lactams ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-024-04911-5
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    Zs.A 5517: Show issues Location:
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  10. Article ; Online: Feasibility of FreeStyle Libre Flash Glucose Monitoring System in pregnant woman affected by type 1 diabetes.

    Gatti, Milo

    Acta diabetologica

    2018  Volume 56, Issue 4, Page(s) 481–483

    MeSH term(s) Adult ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring/instrumentation ; Blood Glucose Self-Monitoring/methods ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/drug therapy ; Feasibility Studies ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Pregnancy ; Pregnancy in Diabetics/blood ; Pregnancy in Diabetics/drug therapy ; Wearable Electronic Devices
    Chemical Substances Blood Glucose ; Hypoglycemic Agents
    Language English
    Publishing date 2018-11-11
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-018-1252-6
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