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  1. Article ; Online: Light People: Professor Cheng-Wei Qiu.

    Sun, Tingting

    Light, science & applications

    2023  Volume 12, Issue 1, Page(s) 91

    Abstract: ... control". We are greatly honored to invite Prof. Cheng-Wei Qiu from National University of Singapore ... an exclusive interview. Prof. Cheng-Wei Qiu showed us the profound interpretation of his research works and ...

    Abstract EDITORIAL: "Mind-controlled information transmission" is one of human's ultimate fantasies for the development of science and technology. On June 11, 2022, eLight Journal simultaneously published two research papers on brainwave-based metasurfaces, and proposed a new concept of metasurface controlled by mind for the first time in the world. This major scientific breakthrough rushed up to the hot search list of public media. It was read more than ten million times, and the related video has been played 600,000 times, which aroused the audience's strong interest and discussion, and really made a significant leap toward "mind control". We are greatly honored to invite Prof. Cheng-Wei Qiu from National University of Singapore, the corresponding author of both above-mentioned articles and the co-Editor-in-Chief of eLight Journal, to have an exclusive interview. Prof. Cheng-Wei Qiu showed us the profound interpretation of his research works and shared his unique insights on journal development and talent cultivation.
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2662628-7
    ISSN 2047-7538 ; 2047-7538
    ISSN (online) 2047-7538
    ISSN 2047-7538
    DOI 10.1038/s41377-023-01138-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.

    Wang, Yin / Gao, Junfeng / Sun, Liqiao / Li, Qi / Kang, Ning / Gao, Chen / Li, Tong

    Journal of ethnopharmacology

    2023  Volume 306, Page(s) 116180

    Abstract: ... to add herbs and improve them into an external dosage form, called Jia-Wei-Si-Miao-Yong-An Fang (JWSMYA ...

    Abstract Ethnopharmacological relevance: A famous traditional oral Chinese medicine formula, Si-Miao-Yong-An decoction, has been used to treat thromboangiitis obliterans from the Qing Dynasty. Because its therapeutic principles including clearing away heat, detoxification, accelerating blood circulation and relieving pains are consistent with acute radiation-induced cutaneous wounds in traditional Chinese medicine, we tried to add herbs and improve them into an external dosage form, called Jia-Wei-Si-Miao-Yong-An Fang (JWSMYA). However, its mechanism on radiation-induced cutaneous wounds is still unknown.
    Aim of the study: This study evaluated the therapeutic effect of JWSMYA and investigated the mechanism of repair and anti-fibrosis on acute radiation-induced cutaneous wounds with JWSMYA.
    Materials and methods: Firstly, we prepared JWSMYA, and determined the composition through UHPLC LC-MS/MS. Then we used ionizing radiation to make a cutaneous wound model of rats, and observed wound healing through their skin injury score, wound contraction percentage and histological staining. In addition, immunohistochemical staining, Western blot analysis, qRT-PCR and Elisa were used to explore wound rehabilitation and anti-fibrosis mechanisms.
    Results: An in vivo assay revealed that JWSMYA promoted the repairment of acute radiation-induced cutaneous wounds, facilitated MAPK/ERK phosphorylation, inhibited PI3K/AKT activation, reduced the level of alpha-smooth muscle actin (a-sma), collagen type-I alpha 2 (Col1a2) and transforming growth factor-beta 1 (TGF-β1) in cutaneous tissues. However, no statistical difference was found in vascular endothelial growth factor (VEGF).
    Conclusion: JWSMYA accelerated the repair of acute radiation-induced cutaneous wounds, which might be associated with the MAPK/ERK pathway. In addition, PI3K/AKT might be associated with the inhibition of fibrosis and the promotion of high-quality wound healing.
    MeSH term(s) Rats ; Animals ; MAP Kinase Signaling System ; Proto-Oncogene Proteins c-akt/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Fibrosis
    Chemical Substances Collagen Type I, alpha2 Subunit ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Vascular Endothelial Growth Factor A ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2023-01-21
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116180
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    Zs.A 1494: Show issues Location:
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  3. Article ; Online: Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway.

    Xie, Dong / Wu, Chao / Wang, Dan / Nisma Lena, Bahaji Azami / Liu, Ningning / Ye, Guan / Sun, Mingyu

    Journal of ethnopharmacology

    2023  Volume 318, Issue Pt B, Page(s) 117020

    Abstract: Ethnopharmacological relevance: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis ( ... ...

    Abstract Ethnopharmacological relevance: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous lesions in China clinically. This study aimed to investigate the efficacy and potential mechanism of WFC in treating Gastric intestinal metaplasia (GIM) and Gastric dysplasia (GDys).
    Materials and methods: Rat GIM and GDys established by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) combined with hot paste, ethanol injury, and intermittent fasting were intervened by WFC. Body weight, histopathology, pH of gastric acid, pepsin activity, intestinal metaplasia index and inflammation were detected. Rat bone marrow derived macrophages (BMDMs) pretreated with WFC were stimulated by LPS. Inflammatory factors and the nuclear factor-kappa B (NF-κB) pathway were assessed. GES-1 cells pretreated by WFC were stimulated by MNNG and TNF-α, intestinal metaplasia index, the NF-κB pathway and interaction between P65 and CDX2 were detected.
    Results: WFC improved rat body weight, histopathology, pH value of gastric acid, activity of gastric pepsin, intestinal metaplasia (CDX2), inflammation (IL-1β, IL-6 and TNF-α), macrophage aggregation (CD68) in gastric mucosa in rat GIM and GDys. WFC inhibited inflammation (IL-1β and TNF-α) by inactivating the NF-κB pathway. WFC reduced the expression of CDX2 by inhibiting the binding of CDX2 promoter TSS upstream region with p65.
    Conclusion: WFC blocked GIM and GDys associated with inflammation by regulating the NF-κB pathway.
    MeSH term(s) Rats ; Animals ; NF-kappa B/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Methylnitronitrosoguanidine ; Pepsin A/metabolism ; Inflammation/pathology ; Precancerous Conditions/drug therapy ; Hyperplasia/pathology ; Stomach Neoplasms/pathology ; Metaplasia/metabolism ; Metaplasia/pathology ; Gastric Mucosa/pathology
    Chemical Substances NF-kappa B ; Tumor Necrosis Factor-alpha ; Methylnitronitrosoguanidine (12H3O2UGSF) ; Pepsin A (EC 3.4.23.1)
    Language English
    Publishing date 2023-08-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117020
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  4. Article ; Online: Wei Chang An pill regulates gastrointestinal motility in a bidirectional manner.

    Jia, Sitong / Chai, Lijuan / Zhang, Jing / Zhang, Min / Li, Lin / Qi, Yaxin / Pang, Yafen / Chen, Xi / Fan, Nana / Wang, Lin / Wang, Yujing / Song, Jixiang / Sun, Yingjie / Wang, Yi / Miao, Lin / Zhang, Han

    Pharmaceutical biology

    2021  Volume 59, Issue 1, Page(s) 1452–1463

    Abstract: Context: Wei Chang An (WCA) is a commercial prescription developed for the coordination ...

    Abstract Context: Wei Chang An (WCA) is a commercial prescription developed for the coordination of gastrointestinal movement.
    Objective: To investigate the role of WCA in the regulation of diarrhoea and constipation in rats.
    Material and methods: The diarrhoea and constipation models were prepared by gavage of
    Results: Data from Bristol stool form scale, diarrhoea index, visceral sensitivity, defaecation time, and intestinal propulsive rate showed that WCA protected rats against diarrhoea and constipation (
    Conclusions: WCA has both antidiarrhea and anti-constipation effects, suggesting its bidirectional role in gastrointestinal modulation, and providing evidence of WCA for irritable bowel syndrome treatment.
    MeSH term(s) Animals ; Constipation/drug therapy ; Constipation/physiopathology ; Diarrhea/drug therapy ; Diarrhea/physiopathology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Gastrointestinal Motility/drug effects ; Irritable Bowel Syndrome/drug therapy ; Irritable Bowel Syndrome/physiopathology ; Male ; Myosin-Light-Chain Kinase/genetics ; Rats ; Rats, Wistar ; rho-Associated Kinases/genetics
    Chemical Substances Drugs, Chinese Herbal ; Weichang'an ; ROCK1 protein, rat (EC 2.7.11.1) ; rho-Associated Kinases (EC 2.7.11.1) ; Myosin-Light-Chain Kinase (EC 2.7.11.18)
    Language English
    Publishing date 2021-10-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2021.1991383
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  5. Article ; Online: Jia-Wei-Kai-Xin-San Treatment Alleviated Mild Cognitive Impairment through Anti-Inflammatory and Antiapoptotic Mechanisms in SAMP8 Mice.

    Zhang, Xiaolu / Sun, Yingxin / Yu, Qun / Zeng, Wenyun / Zhang, Yue / Zeng, Miao / Pang, Kexin / Yu, Yifei / Gan, Jiali / Li, Huhu / Yang, Lin / Jiang, Xijuan

    Mediators of inflammation

    2023  Volume 2023, Page(s) 7807302

    Abstract: ... of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism ...

    Abstract Background: Alleviating mild cognitive impairment (MCI) is crucial to delay the progression of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism of JWKXS in the treatment of MCI is unclear. Thus, this study aimed to investigate the effect and mechanism of JWKXS in SAMP8 mice models of MCI.
    Methods: MCI models were established to examine learning and memory ability and explore the pathomechanisms in brain of SAMP8 mice at 4, 6, and 8 months. The mice were treated for 8 weeks and the effects of JWKXS on MCI were characterized through Morris water maze and HE/Nissl's/immunohistochemical staining. Its mechanism was predicted by the combination of UPLC-Q-TOF/MS and system pharmacology analysis, further verified with SAMP8 mice, BV2 microglial cells, and PC12 cells.
    Results: It was found that 4-month-old SAMP8 mice exhibited MCI. Two months of JWKXS treatment improved the learning and memory ability, alleviated the hippocampal tissue and neuron damage. Through network pharmacology, four key signaling pathways were found to be involved in treatment of MCI by JWKXS, including TLR4/NF-
    Conclusion: JWKXS treatment improved the learning and memory ability and conferred neuroprotective effects against MCI by inducing anti-inflammation and antiapoptosis.
    MeSH term(s) Rats ; Mice ; Animals ; Inflammasomes/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Toll-Like Receptor 4/metabolism ; Cognitive Dysfunction/drug therapy ; Alzheimer Disease/drug therapy ; Anti-Inflammatory Agents/therapeutic use
    Chemical Substances Kai-Xin-San ; Inflammasomes ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Toll-Like Receptor 4 ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2023/7807302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3575: Show issues Location:
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  6. Article ; Online: Identification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress.

    Shan, Chenxiao / Li, Jia / Sun, Bo / Zhou, Runze / Xu, Min / Zhao, Qiulong / Ren, Ping / Wen, Hongmei / Huang, Xi

    RSC advances

    2022  Volume 12, Issue 8, Page(s) 4455–4468

    Abstract: Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia ...

    Abstract Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and pharmacokinetic profiles. Thus, in the present study, a sensitive, precise, and rapid procedure for the identification of absorbed compounds (Cs) in the plasma of depressed rats together with a pharmacokinetic analysis was established with the help of ultra-flow liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF MS/MS) and ultra-flow liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-QQQ MS/MS). Based on the characteristic fragmentation, neutral loss, mass defect filter, relevant literature and reference standards, 225 Cs in the XYSJW extract and 20 Cs in the plasma of the depressed rats were tentatively recognized
    Language English
    Publishing date 2022-02-04
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra08778a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Molluscicidal effectiveness of Luo-Wei, a novel plant-derived molluscicide, against Oncomelania hupensis, Biomphalaria alexandrina and Bulinus truncatus.

    Jia, Tie-Wu / Wang, Wei / Sun, Le-Ping / Lv, Shan / Yang, Kun / Zhang, Neng-Min / Huang, Xi-Bao / Liu, Jian-Bing / Liu, Han-Cheng / Liu, Rui-Hua / Gawish, Fathia A / Habib, Mohamed R / El-Emam, Mohamed A / King, Charles H / Zhou, Xiao-Nong

    Infectious diseases of poverty

    2019  Volume 8, Issue 1, Page(s) 27

    Abstract: ... molluscicidal activity, and a new compound Luo-Wei, also named tea-seed distilled saponin (TDS), was developed ...

    Abstract Background: Control of snail intermediate hosts has been proved to be a fast and efficient approach for interrupting the transmission of schistosomiasis. Some plant extracts have shown obvious molluscicidal activity, and a new compound Luo-Wei, also named tea-seed distilled saponin (TDS), was developed based on the saponins extracted from Camellia oleifera seeds. We aimed to test the molluscicidal activity of 4% TDS against the intermediate host snails in China and Egypt, and evaluate its environmental safety to non-target organisms.
    Methods: In the laboratory, Oncomelania hupensis, Biomphalaria alexandrina and Bulinus truncatus were exposed to 4% TDS, and the median lethal concentration (LC
    Results: In the laboratory, the LC
    Conclusions: 4% TDS is active against O. hupensis, B. alexandrina and B. truncatus under laboratory and field conditions, and it may be a candidate molluscicide of plant origin.
    MeSH term(s) Animals ; Biomphalaria ; Bulinus ; China ; Egypt ; Lethal Dose 50 ; Molluscacides/administration & dosage ; Molluscacides/toxicity ; Plant Extracts ; Quail ; Schistosoma/drug effects ; Schistosomiasis/prevention & control ; Snails/drug effects ; Snails/parasitology ; Toxicity Tests
    Chemical Substances Molluscacides ; Plant Extracts
    Language English
    Publishing date 2019-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2689396-4
    ISSN 2049-9957 ; 2049-9957
    ISSN (online) 2049-9957
    ISSN 2049-9957
    DOI 10.1186/s40249-019-0535-7
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  8. Article: A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of Wei-Fu-Chun Tablet in the Treatment of Precancerous Lesions of Gastric Cancer.

    Wang, Huijun / Wu, Ruoming / Xie, Dong / Ding, Liqin / Lv, Xing / Bian, Yanqin / Chen, Xi / Nisma Lena, Bahaji Azami / Wang, Shunchun / Li, Kun / Chen, Wei / Ye, Guan / Sun, Mingyu

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 558471

    Abstract: Wei-Fu-Chun (WFC) tablet is a commercial medicinal product approved by China ...

    Abstract Wei-Fu-Chun (WFC) tablet is a commercial medicinal product approved by China Food and Drug Administration, which is made of
    Language English
    Publishing date 2020-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.558471
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  9. Article ; Online: Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway

    Xie, Dong / Wu, Chao / Wang, Dan / Nisma Lena, Bahaji Azami / Liu, Ningning / Ye, Guan / Sun, Mingyu

    Journal of Ethnopharmacology. 2023 Aug. 09, p.117020-

    2023  , Page(s) 117020–

    Abstract: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous ... ...

    Abstract Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous lesions in China clinically. This study aimed to investigate the efficacy and potential mechanism of WFC in treating Gastric intestinal metaplasia (GIM) and Gastric dysplasia (GDys). Rat GIM and GDys established by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) combined with hot paste, ethanol injury, and intermittent fasting were intervened by WFC. Body weight, histopathology, pH of gastric acid, pepsin activity, intestinal metaplasia index and inflammation were detected. Rat bone marrow derived macrophages (BMDMs) pretreated with WFC were stimulated by LPS. Inflammatory factors and the nuclear factor-kappa B (NF-κB) pathway were assessed. GES-1 cells pretreated by WFC were stimulated by MNNG and TNF-α, intestinal metaplasia index, the NF-κB pathway and interaction between P65 and CDX2 were detected. WFC improved rat body weight, histopathology, pH value of gastric acid, activity of gastric pepsin, intestinal metaplasia (CDX2), inflammation (IL-1β, IL-6 and TNF-α), macrophage aggregation (CD68) in gastric mucosa in rat GIM and GDys. WFC inhibited inflammation (IL-1β and TNF-α) by inactivating the NF-κB pathway. WFC reduced the expression of CDX2 by inhibiting the binding of CDX2 promoter TSS upstream region with p65. WFC blocked GIM and GDys associated with inflammation by regulating the NF-κB pathway.
    Keywords Food and Drug Administration ; body weight ; bone marrow ; ethanol ; fasting ; gastric acid ; gastric mucosa ; gastritis ; herbal medicines ; histopathology ; inflammation ; interleukin-6 ; intestines ; macrophages ; metaplasia ; pH ; pepsin ; rats ; traditional medicine ; transcription factor NF-kappa B ; China ; Wei-fu-chun tablet ; Gastric intestinal metaplasia ; Gastric dysplasia ; NF-κB pathway
    Language English
    Dates of publication 2023-0809
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117020
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  10. Article ; Online: Proteomics analysis reveals suppression of IL-17 signaling pathways contributed to the therapeutic effects of Jia-Wei Bu-Shen-Yi-Qi formula in a murine asthma model.

    Qin, Jingjing / Wuniqiemu, Tulake / Wei, Ying / Teng, Fangzhou / Cui, Jie / Sun, Jing / Yi, La / Tang, Weifeng / Zhu, Xueyi / Xu, Weifang / Dong, Jingcheng

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2021  Volume 95, Page(s) 153803

    Abstract: Background: Jia-Wei Bu-Shen-Yi-Qi formula (JWBSYQF), a Chinese herbal formula, is a commonly used ...

    Abstract Background: Jia-Wei Bu-Shen-Yi-Qi formula (JWBSYQF), a Chinese herbal formula, is a commonly used prescription for treating asthma patients. However, the targeted proteins associated with JWBSYQF treatment remain unknown.
    Purpose: Present study aims to evaluate the therapeutic efficacy of JWBSYQF and identify the targeted proteins in addition to functional pathways.
    Study design: The ovalbumin (OVA)-induced murine asthma model was established to explore the therapeutic effect of JWBSYQF treatment. Proteomic profiling and quantifications were performed using data-independent acquisition (DIA) methods. Differentially expressed proteins (DEPs) were validated via western blot (WB) and immunohistochemistry (IHC).
    Methods: A murine asthma model was made by OVA sensitization and challenge, and JWBSYQF (2.25, 4.50, 9,00 g/kg body weight) or dexamethasone (1 mg/ kg body weight) were administered orally. Airway hyperresponsiveness (AHR) to methacholine (Mch), inflammatory cell counts and classification in bronchoalveolar lavage fluid (BALF), lung histopathology, and cytokine levels were measured. Furthermore, DIA proteomic analyses were performed to explore the DEPs targeted by JWBSYQF and were further validated by WB and IHC.
    Results: Our results exhibited that JWBSYQF attenuated AHR which was mirrored by decreased airway resistance and increased lung compliance. In addition, JWBSYQF-treated mice showed reduced inflammatory score, mucus hypersecretion, as well as reduced the number of BALF leukocytes along with decreased content of BALF Th2 inflammatory cytokines (IL-4, IL-5, IL-13) and serum IgE. Proteomics analysis identified 704 DEPs between the asthmatic mice and control group (MOD vs CON), and 120 DEPs between the JWBSYQF-treatment and the asthmatic mice (JWB-M vs MOD). A total of 33 overlapped DEPs were identified among the three groups. Pathway enrichment analysis showed that DEPs were significantly enriched in IL-17 signaling pathway, in which DEPs, Lcn2, TGF-β1, Gngt2, and Ppp2r5e were common DEPs between three experimental groups. WB and IHC results further validated expressional levels and tendency of these proteins. Our results also showed that JWBSYQF affects mitogen activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways, that are activated by IL-17 signaling.
    Conclusion: The present study suggested that JWBSYQF could attenuate AHR and airway inflammation in OVA-induced asthmatic mice. In addition, proteomics analysis revealed that suppression of IL-17 signaling pathways contributes to the therapeutic effects of JWBSYQF.
    MeSH term(s) Animals ; Asthma/drug therapy ; Bronchoalveolar Lavage Fluid ; Cytokines ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Interleukin-17 ; Lung ; Mice ; Mice, Inbred BALB C ; Ovalbumin ; Proteomics ; Signal Transduction
    Chemical Substances Cytokines ; Drugs, Chinese Herbal ; Interleukin-17 ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2021-10-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2021.153803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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