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Article ; Online: Spatial distribution of drinking and irrigation water quality in different climatic zones of Baluchistan, Pakistan.

Ahmad, Zeeshan / Fatima, Shehla Batool / Masood, Noshin / Ullah, Fath / Kamal, Simi / Farooqi, Abida

Environmental science and pollution research international

2023 Volume 30, Issue 47, Page(s) 103801–103822

Abstract: Baluchistan's water profile was developed by dividing it into seven zones (Northern Highlands-NH, Southern Highlands-SH, Quetta Valley-QV, Desert-D, Sibbi Plains-SP, Coastal Lasbella-CL, Coastal Gwadar-CG) based on geography, water availability, and ... ...

Abstract	Baluchistan's water profile was developed by dividing it into seven zones (Northern Highlands-NH, Southern Highlands-SH, Quetta Valley-QV, Desert-D, Sibbi Plains-SP, Coastal Lasbella-CL, Coastal Gwadar-CG) based on geography, water availability, and climate of the area. A total of 106 water samples were collected from karaiz, spring water, and tube wells. Spatial distribution of EC, TDS, TH, SO
MeSH term(s)	Water Quality ; Environmental Monitoring ; Pakistan ; Drinking Water ; Agricultural Irrigation ; Groundwater ; Water Pollutants, Chemical/analysis
Chemical Substances	Drinking Water ; Water Pollutants, Chemical
Language	English
Publishing date	2023-09-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-29251-9
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Article ; Online: Exogenous application of Atonik (sodium nitrophenolate) under skip irrigation regimes modulated the physiology, growth and productivity of Zea mays L

Batool, Zarina / Ishfaq, Muhammad / Akbar, Nadeem / Zulfiqar, Usman / Anjum, Shakeel Ahmad / Shafiq, Muhammad / Nazir, Shahid / Aziz, Abida

Archives of Agronomy and Soil Science. 2023 Oct. 15, v. 69, no. 12 p.2325-2339

2023

Abstract: Foliar application of Atonik (sodium nitrophenolate) at crop critical growth stages is expected to improve crop physiology, morphology, and productivity. The present field study was conducted at the University of Agriculture, Faisalabad in autumn season ... ...

Abstract	Foliar application of Atonik (sodium nitrophenolate) at crop critical growth stages is expected to improve crop physiology, morphology, and productivity. The present field study was conducted at the University of Agriculture, Faisalabad in autumn season of 2018 and 2019. Water deficit conditions were imposed by skip irrigation method. Plants were treated with foliar application of Atonik 10 (mg L⁻¹) to evaluate the physiological, morphological, yield, and yield causative attributes of maize grown under deficit irrigation treatments. Randomized complete block design (RCBD) with split plots arrangement was used to layout the experiment having three replications. It was revealed that application of Atonik improved the crop’s physiological attributes: relative leaf water contents (RLWC by 10%), chlorophyll contents (14%), and carotenoids content (15%) under water deficit conditions. Similarly, Atonik application augmented the leaf length at maturity, the number of green leaves at harvesting, and the number of grains row⁻¹ of maize by 7%, 20% and 12%, respectively. Moreover, the application of Atonik amended the 100-grains weight, grain yield, and biological yield by 8%, 9% and 20%, respectively. In crux, application of Atonik is an excellent strategy to alleviate the detrimental influence of water deficit on physiological, morphological, and yield causative attributes of maize.
Keywords	Zea mays ; agricultural colleges ; agronomy ; autumn ; carotenoids ; chlorophyll ; corn ; deficit irrigation ; foliar application ; grain yield ; leaf length ; leaves ; physiology ; sodium ; Atonik ; chlorophyll contents ; stem diameter ; water deficit ; yield
Language	English
Dates of publication	2023-1015
Size	p. 2325-2339.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1132910-5
ISSN	1476-3567 ; 0365-0340
ISSN (online)	1476-3567
ISSN	0365-0340
DOI	10.1080/03650340.2022.2152011
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Article ; Online: Drug designing against NSP15 of SARS-COV2 via high throughput computational screening and structural dynamics approach.

Batool, Abida / Bibi, Nousheen / Amin, Farhat / Kamal, Mohammad Amjad

European journal of pharmacology

2020 Volume 892, Page(s) 173779

Abstract: The rapid outbreak of the COVID-19 also known as SARS-CoV2 has been declared pandemic with serious global concern. As there is no effective therapeutic against COVID-19, there is an urgent need for explicit treatment against it. The focused objective of ... ...

Abstract	The rapid outbreak of the COVID-19 also known as SARS-CoV2 has been declared pandemic with serious global concern. As there is no effective therapeutic against COVID-19, there is an urgent need for explicit treatment against it. The focused objective of the current study is to propose promising drug candidates against the newly identified potential therapeutic target (endonuclease, NSP15) of SARS-CoV2. NSP15 is an attractive druggable target due to its critical role in SARS-CoV2 replication and virulence in addition to interference with the host immune system. Here in the present study, we integrated the high throughput computational screening and dynamic simulation approach to identify the most promising candidate lead compound against NSP15.5-fluoro-2-oxo-1H-pyrazine-3-carboxamide (favipiravir), (3R,4R, 5R)-3,4-Bis(benzyloxy)-5-((benzyloxy) methyl) dihydrofuran-2(3H)-one) remedesivir, 1,3-thiazol-5-ylmethyl N-[(2S,3S, 5S)-3-hydroxy-5-[[(2 S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate (ritonavir), ethyl (3R,4R, 5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate (oseltamivir), and (2 S)-N-[(2S,4S, 5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide (lopinavir) were chosen as a training set to generate the pharmacophore model. A dataset of ~140,000 compounds library was screened against the designed pharmacophore model and 10 unique compounds were selected that passed successfully through geometry constraints, Lipinski Rule of 5, and ADME/Tox filters along with a strong binding affinity for NSP15 binding cavity. The best fit compound was selected for dynamic simulation to have detailed structural features critical for binding with the NSP15 protein. Given our detailed integrative computational analysis, a Small molecule (3,3-Dimethyl-N-[4-(1-piperidinylcarbonyl) phenyl] butanamide) with drug-like properties and high binding affinity with the NSP15 is proposed as a most promising potential drug against COVID-19. The current computational integrative approach may complement high-throughput screening and the shortlisted small molecule may contribute to selective targeting of NSP15 to stop the replication of SARS-CoV2.
MeSH term(s)	Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Antiviral Agents/toxicity ; Benzamides/pharmacokinetics ; Benzamides/pharmacology ; COVID-19/metabolism ; Drug Design ; Endoribonucleases/chemistry ; Endoribonucleases/metabolism ; High-Throughput Screening Assays ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Piperidines/pharmacokinetics ; Piperidines/pharmacology ; SARS-CoV-2 ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism
Chemical Substances	3,3-dimethyl-N-(4-(1-piperidinylcarbonyl)phenyl)butanamide ; Antiviral Agents ; Benzamides ; Piperidines ; Viral Nonstructural Proteins ; Endoribonucleases (EC 3.1.-) ; nidoviral uridylate-specific endoribonuclease (EC 3.1.-)
Language	English
Publishing date	2020-12-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2020.173779
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Article ; Online: Inhibitory Mechanism of An Anticancer Drug, Bexarotene Against Amyloid β Peptide Aggregation: Repurposing Via Neuroinformatics Approach.

Bibi, Nousheen / Rizvi, Syed M D / Batool, Abida / Kamal, Mohammad A

Current pharmaceutical design

2019 Volume 25, Issue 27, Page(s) 2989–2995

Abstract: Background: Aggregation of Amyloid β (Aβ) peptide is a crucial feature of Alzheimer disease (AD) pathogenesis. In fact, Aβ peptides are misfolded and aggregated to frame Amyloid fibrils, which is considered as one of the major contributing events in the ...

Abstract	Background: Aggregation of Amyloid β (Aβ) peptide is a crucial feature of Alzheimer disease (AD) pathogenesis. In fact, Aβ peptides are misfolded and aggregated to frame Amyloid fibrils, which is considered as one of the major contributing events in the onset of AD. All these observations have prompted the researchers to design therapeutic molecules with robust anti-Aβ aggregation potential. Interestingly, in the last few decades, drug repurposing has turned into a fruitful and savvy approach for the treatment of several diseases. Bexarotene is an anticancer drug that has been under consideration for its ability to suppress Aβ-peptide aggregation. However, the exact mechanistic aspect of suppression of Aβ-peptide accumulation has not yet been completely revealed. Methods: In the present study, we have attempted to decipher the mechanistic aspects of the anti-aggregation potential of bexarotene by using the computational biology approach. Results: We have observed the effect of 'Aβ-bexarotene' interaction on the aggregation ability of the Aβ-peptide and decoded the involvement of receptor for advanced glycation end products (RAGE) and beta-secretase (BACE-1). A deep structural analysis of Aβ upon binding with bexarotene revealed critical binding sites and structural twists involved in Aβ aggregation. It is evident from the present that bexarotene could significantly restrain the process of primary nucleation of Aβ. In addition, bexarotene showed a strong interaction with RAGE and BACE-1, suggesting them as plausible targets for the neuro-therapeutic action of bexarotene. Conclusion: Hence, we could safely suggest that bexarotene is a potent drug candidate that could reduce Aβ- peptide aggregation by applying different mechanistic pathways. These results might boost the portfolio of pharmaceutical companies looking for the development of new chemical entities against AD.
MeSH term(s)	Alzheimer Disease ; Amyloid beta-Peptides/antagonists & inhibitors ; Antineoplastic Agents/pharmacology ; Bexarotene/pharmacology ; Drug Repositioning ; Humans ; Peptide Fragments
Chemical Substances	Amyloid beta-Peptides ; Antineoplastic Agents ; Peptide Fragments ; Bexarotene (A61RXM4375)
Language	English
Publishing date	2019-08-29
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612825666190801123235
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Article: Ciprofloxacin-Loaded Gold Nanoparticles against Antimicrobial Resistance: An In Vivo Assessment.

Nawaz, Afrah / Ali, Syed Mohsin / Rana, Nosheen Fatima / Tanweer, Tahreem / Batool, Amna / Webster, Thomas J / Menaa, Farid / Riaz, Sundus / Rehman, Zahra / Batool, Farhat / Fatima, Misha / Maryam, Tuba / Shafique, Iqra / Saleem, Abida / Iqbal, Arfa

Nanomaterials (Basel, Switzerland)

2021 Volume 11, Issue 11

Abstract: Metallic nanoparticles, such as gold nanoparticles (AuNPs), have been extensively studied as drug delivery systems for various therapeutic applications. However, drug-loaded-AuNPs have been rarely explored in vivo for their effect on bacteria residing ... ...

Abstract	Metallic nanoparticles, such as gold nanoparticles (AuNPs), have been extensively studied as drug delivery systems for various therapeutic applications. However, drug-loaded-AuNPs have been rarely explored in vivo for their effect on bacteria residing inside tissues. Ciprofloxacin (CIP) is a second-generation fluoroquinolone with a broad-spectrum of antibiotic properties devoid of developing bacteria resistance. This research is focused on the synthesis and physical characterization of Ciprofloxacin-loaded gold nanoparticles (CIP-AuNPs) and their effect on the colonization of
Language	English
Publishing date	2021-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano11113152
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Article: Anatomical adaptations and ionic homeostasis in aquatic halophyte

Mumtaz, Sahar / Saleem, Muhammad Hamzah / Hameed, Mansoor / Batool, Fatima / Parveen, Abida / Amjad, Syeda Fasiha / Mahmood, Athar / Arfan, Muhammad / Ahmed, Shakeel / Yasmin, Humaira / Alsahli, Abdulaziz Abdullah / Alyemeni, Mohammed Nasser

Saudi journal of biological sciences

2021 Volume 28, Issue 5, Page(s) 2655–2666

Abstract: Salinity is extremely hazardous to agriculture worldwide and its expanding constantly. Soil of almost 100 countries facing salinity problem including Pakistan. ...

Abstract	Salinity is extremely hazardous to agriculture worldwide and its expanding constantly. Soil of almost 100 countries facing salinity problem including Pakistan.
Language	English
Publishing date	2021-03-13
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2021.03.002
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Article ; Online: Topical Discoveries on Multi-Target Approach to Manage Alzheimer's Disease.

Batool, Abida / Kamal, Mohammad Amjad / Rizvi, Syed Mohd Danish / Rashid, Sajid

Current drug metabolism

2018 Volume 19, Issue 8, Page(s) 704–713

Abstract: Background: Alzheimer's disease (AD) is recognized as progressive multifaceted and multi-factorial neurodegenerative disorder which causes dementia among elderly people. Although, researchers in this field have put considerable efforts for the ... ...

Abstract	Background: Alzheimer's disease (AD) is recognized as progressive multifaceted and multi-factorial neurodegenerative disorder which causes dementia among elderly people. Although, researchers in this field have put considerable efforts for the investigation of novel and appropriate therapeutic measures towards the cure of AD, unfortunately, no effective prevention therapy for this disease is available till date. In fact, various aspects involved in the onset and progression of AD are still disputed or uncovered. However, to achieve definite and direct cure of AD, researcher's attention has been drawn towards exploration of new therapeutics targets. In this review, we have discussed the current progress of various aspects of pathophysiological mechanisms behind AD, together with recent investigational therapeutic approaches and present tools with an emphasis on Multi Target Directed Drugs approach. Method: We have scrutinized numerous peer-reviewed research articles to assemble and discuss significant research findings and success achieved in the last decade pertinent to the application of Multi-Target Directed Drugs in the treatment of AD. Results: The main emphasis of the review was to understand the various aspects of pathophysiological mechanisms involved in AD, along with the recent developments on potential AD targets and application of Multi-Target Directed Drugs approach against AD. In addition, a brief overview of major drawbacks of conventional anti-AD drugs has also been included. We found that several strategies including in silico approach could be used for multi-target drug designing against AD. However, various synthetic/natural compounds and nano-formulations have the ability to be developed as multi-target drugs for AD. Conclusion: The present review comprises imperative information regarding AD pathology and disease process along with recent researches going on to develop treatment strategies against AD. Thus, this review might be helpful for physician, neurologist and scientist in understanding the diverse roots of AD for designing primary cure skills and scaffold of pharmacological treatment to manage AD.
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/etiology ; Alzheimer Disease/pathology ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Brain/blood supply ; Brain/drug effects ; Brain/pathology ; Cognition/drug effects ; Computer Simulation ; Drug Delivery Systems/methods ; Drug Design ; Humans ; Molecular Targeted Therapy/methods ; Nootropic Agents/pharmacology ; Nootropic Agents/therapeutic use ; Treatment Outcome
Chemical Substances	Nootropic Agents
Language	English
Publishing date	2018-03-07
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2064815-7
ISSN	1875-5453 ; 1389-2002
ISSN (online)	1875-5453
ISSN	1389-2002
DOI	10.2174/1389200219666180305152553
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Article ; Online: Impact of COVID-19 on the wellbeing of micro and small entrepreneurs of rural Pakistan.

Khan, Wajid / Zahid, R M Ammar / Ullah, Ikram / Chuadhry, Muhammad Asif / Malik, Saqib Yaqoob / Mughal, Yasir Hayat / Batool, Nazia / Begum, Abida / Han, Heesup / Mohamed, Abdullah

Frontiers in public health

2022 Volume 10, Page(s) 993412

Abstract: According to the constitution of Pakistan, the state is responsible for the provision of necessities of life to its citizens whenever their livelihood is permanently or temporarily threatened. COVID-19 and its associated lockdowns were a series of events ...

Abstract	According to the constitution of Pakistan, the state is responsible for the provision of necessities of life to its citizens whenever their livelihood is permanently or temporarily threatened. COVID-19 and its associated lockdowns were a series of events where amenities of life around the world were seriously endangered. Especially, hard hit were the small- and medium-sized entrepreneurs (SMEs) of rural Pakistan. To quantitatively assess the social and economic impact of COVID-19, we interviewed the local microenterprise owners in rural Pakistan from January to February 2021 and then June 2021. Mean comparison tests were estimated for pre- and post-COVID-19 periods. Results reveal that the COVID-19 pandemic has significantly and negatively affected wellbeing of micro and small entrepreneurs in the regions as the income of most of the sampled entrepreneurs significantly decreased during the pandemic. Disaggregated consumption analysis however revealed that nominal consumption of food, clothing, energy, health, and education all increased, except for communication, during the pandemic. Furthermore, the regression analysis revealed that changes in income, occupation, borrowing during COVID-19, and family type of the respondents were significant factors in mitigating the effects of COVID-19. Based on the findings, policy recommendations are also spelled out in the last section.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Pandemics ; Pakistan/epidemiology ; Communicable Disease Control ; Rural Population
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.993412
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Article ; Online: Relationship between resilience and quality of life in diabetics.

Nawaz, Abida / Malik, Jamil A / Batool, Azra

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2014 Volume 24, Issue 9, Page(s) 670–675

Abstract: Objective: To determine the relationship between resilience and quality of life of diabetes patients controlling the effect of personal level (i.e., gender, age, and income) and disease-specific (i.e., duration of disease, and current glucose level) ... ...

Abstract	Objective: To determine the relationship between resilience and quality of life of diabetes patients controlling the effect of personal level (i.e., gender, age, and income) and disease-specific (i.e., duration of disease, and current glucose level) demographics. Study design: Analytical study. Place and duration of study: Outpatient Departments of various hospitals in Islamabad and Rawalpindi, from October to November 2012. Methodology: Patients diagnosed with diabetes taking treatment in an outdoor patients' facility were included. Patients with a major diabetes complications causing or coexistent with a physical disability, medical condition or psychiatric comorbidity were excluded. Informed consent was taken from patients before administration of questionnaires. The patients were asked to respond to a demographic sheet, State-Trait resilience inventory, and WHO-Quality of Life BREF. Statistical testing was conducting using bivariate correlation, Mann-Whitney U-test, and multiple linear regression analysis for moderation testing. Results: There were 242 patients including (n=108, 44% females; and n=134, 56% males) aged 17 - 85 years with mean of 44.56 ± 16.56 years. Trait resilience predicted all aspects of quality of life of diabetic patients (b range = 0.30 to 0.42, p < .01) and explained 17% variance in physical functioning, 29% in psychological functioning, 17% in environmental functioning, 30% in social dimension, and 29% in overall quality of life. Duration of diabetes moderated effect of state resilience on all aspects of quality of life (b interaction range = 0.20 to 0.26, p < .05) and explained an additional 4% variance in physical functioning, 5% in psychological functioning, 3% in environmental functioning, 5% in social dimension, and 4% in overall quality of life of diabetics. Conclusion: Trait resilience has unconditional positive effect on all aspect of quality of life. Long standing diabetics may benefit from intervention addressing state resilience.
MeSH term(s)	Adaptation, Psychological ; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Diabetes Mellitus, Type 2/psychology ; Educational Status ; Female ; Humans ; Income ; Male ; Middle Aged ; Personality Inventory ; Quality of Life ; Regression Analysis ; Resilience, Psychological ; Sex Factors ; Social Support ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2014-09
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	09.2014/JCPSP.670675
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Article ; Online: Ciprofloxacin-Loaded Gold Nanoparticles against Antimicrobial Resistance

Afrah Nawaz / Syed Mohsin Ali / Nosheen Fatima Rana / Tahreem Tanweer / Amna Batool / Thomas J. Webster / Farid Menaa / Sundus Riaz / Zahra Rehman / Farhat Batool / Misha Fatima / Tuba Maryam / Iqra Shafique / Abida Saleem / Arfa Iqbal

Nanomaterials, Vol 11, Iss 3152, p

An In Vivo Assessment

2021 Volume 3152

Abstract	Metallic nanoparticles, such as gold nanoparticles (AuNPs), have been extensively studied as drug delivery systems for various therapeutic applications. However, drug-loaded-AuNPs have been rarely explored in vivo for their effect on bacteria residing inside tissues. Ciprofloxacin (CIP) is a second-generation fluoroquinolone with a broad-spectrum of antibiotic properties devoid of developing bacteria resistance. This research is focused on the synthesis and physical characterization of Ciprofloxacin-loaded gold nanoparticles (CIP-AuNPs) and their effect on the colonization of Enterococcus faecalis in the liver and kidneys of mice. The successfully prepared CIP-AuNPs were stable and exerted enhanced in vitro antibacterial activity against E. faecalis compared with free CIP. The optimized CIP-AuNPs were administered (500 µg/Kg) once a day via tail vein to infected mice for eight days and were found to be effective in eradicating E. faecalis from the host tissues. Moreover, unlike CIP, CIP-AuNPs were non-hemolytic. In summary, this study demonstrated that CIP-AuNPs are promising and biocompatible alternative therapeutics for E.-faecalis -induced infections resistant to conventional drugs (e.g., beta-lactams and vancomycin) and should be further investigated.
Keywords	drug delivery ; antibiotics ; antimicrobial resistance ; gold nanoparticles ; ciprofloxacin ; Enterococcus faecalis ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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