LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 21

Search options

  1. Article ; Online: Correction: Comparison of the efficacy of pioglitazone and metformin on ultrasound grade and liver enzymes level in patients with non-alcoholic fatty liver disease: A randomized controlled clinical trial.

    Khoshbaten, Manouchehr / Beheshtirouy, Samineh / Shayanrad, Shahrzad / Gharekhani, Afshin / Rezaee, Haleh

    Drug research

    2023  Volume 73, Issue 4, Page(s) e1

    Language English
    Publishing date 2023-06-27
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-2109-9465
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Comparison of the efficacy of pioglitazone and metformin on ultrasound grade and liver enzymes level in patients with non-alcoholic fatty liver disease: A randomized controlled clinical trial.

    Khoshbaten, Manouchehr / Beheshtirouy, Samineh / Shayanrad, Shahrzad / Gharekhani, Afshin / Rezaee, Haleh

    Drug research

    2023  Volume 73, Issue 4, Page(s) 232–237

    Abstract: Background: This study aimed to evaluate the effectiveness of metformin and pioglitazone in combination with vitamin E on sonography grade and liver enzymes level in patients with non-alcoholic fatty liver disease.: Methods: A randomized controlled ... ...

    Abstract Background: This study aimed to evaluate the effectiveness of metformin and pioglitazone in combination with vitamin E on sonography grade and liver enzymes level in patients with non-alcoholic fatty liver disease.
    Methods: A randomized controlled clinical trial was designed with 68 patients diagnosed with non-alcoholic fatty liver disease by sonography and clinical examinations. Sixty-eight patients were randomly divided into two groups; 34 were assigned to receive 15 mg of pioglitazone per day and 34 were assigned to receive 1000 mg of metformin per day for 6 months. All of the patients received vitamin E at a dose of 800 IU daily for six months. The sonography grade of fatty liver and the levels of alanine aminotransferase and aspartate aminotransferase of patients were evaluated at baseline, and within three and six months after initiation of the intervention.
    Results: The use of metformin or pioglitazone in combination with vitamin E decreased the sonography grade of non-alcoholic fatty liver disease patients after 6 months of treatment (p-value<0.05); however, patients in metformin group benefit more compared to pioglitazone group. Patients who received metformin and vitamin E had a significant reduction in the levels of alanine aminotransferase and aspartate aminotransferase (p-value<0.05). There were no significant changes in the liver enzymes level of the patients who received pioglitazone and vitamin E (p-value>0.05).
    Major conclusion: The concomitant use of metformin and vitamin E significantly improves the sonography grade of fatty liver and the level of liver enzymes in patients with non-alcoholic fatty liver disease.
    MeSH term(s) Humans ; Metformin/therapeutic use ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/drug therapy ; Pioglitazone ; Hypoglycemic Agents/therapeutic use ; Alanine Transaminase ; Vitamin E/therapeutic use ; Aspartate Aminotransferases
    Chemical Substances Metformin (9100L32L2N) ; Pioglitazone (X4OV71U42S) ; Hypoglycemic Agents ; Alanine Transaminase (EC 2.6.1.2) ; Vitamin E (1406-18-4) ; Aspartate Aminotransferases (EC 2.6.1.1)
    Language English
    Publishing date 2023-02-15
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-1997-0401
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Angiotensin 1-7: A Novel Strategy in COVID-19 Treatment.

    Imanpour, Hamed / Rezaee, Haleh / Nouri-Vaskeh, Masoud

    Advanced pharmaceutical bulletin

    2020  Volume 10, Issue 4, Page(s) 488–489

    Keywords covid19
    Language English
    Publishing date 2020-08-09
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 3018440-X
    ISSN 2251-7308 ; 2228-5881
    ISSN (online) 2251-7308
    ISSN 2228-5881
    DOI 10.34172/apb.2020.068
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Molnupiravir: A new candidate for COVID-19 treatment.

    Pourkarim, Fariba / Pourtaghi-Anvarian, Samira / Rezaee, Haleh

    Pharmacology research & perspectives

    2021  Volume 10, Issue 1, Page(s) e00909

    Abstract: The novel coronavirus disease 2019 (COVID-19) emerged in late December 2019 in china and has rapidly spread to many countries around the world. The effective pharmacotherapy can reduce the mortality of COVID-19. Antiviral medications are the candidate ... ...

    Abstract The novel coronavirus disease 2019 (COVID-19) emerged in late December 2019 in china and has rapidly spread to many countries around the world. The effective pharmacotherapy can reduce the mortality of COVID-19. Antiviral medications are the candidate therapies for the management of COVID-19. Molnupiravir is an antiviral drug with anti-RNA polymerase activity and currently is under investigation for the treatment of patients with COVID-19. This review focuses on summarizing published literature for the mechanism of action, safety, efficacy, and clinical trials of molnupiravir in the treatment of COVID-19 patients.
    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Clinical Trials as Topic ; Cytidine/analogs & derivatives ; Cytidine/therapeutic use ; Drug Interactions ; Humans ; Hydroxylamines/therapeutic use ; SARS-CoV-2/isolation & purification
    Chemical Substances Antiviral Agents ; Hydroxylamines ; Cytidine (5CSZ8459RP) ; molnupiravir (YA84KI1VEW)
    Language English
    Publishing date 2021-12-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.909
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Angiotensin 1-7

    Hamed Imanpour / Haleh Rezaee / Masoud Nouri-Vaskeh

    Advanced Pharmaceutical Bulletin, Vol 10, Iss 4, Pp 488-

    A Novel Strategy in COVID-19 Treatment

    2020  Volume 489

    Keywords Therapeutics. Pharmacology ; RM1-950 ; covid19
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Tabriz University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: [No title information]

    Khoshbaten, Manouchehr / Beheshtirouy, Samineh / Shayanrad, Shahrzad / Gharekhani, Afshin / Rezaee, Haleh

    Drug Research

    2023  Volume 73, Issue 04, Page(s) 232–237

    Abstract: Background: This study aimed to evaluate the effectiveness of metformin and pioglitazone in combination with vitamin E on sonography grade and liver enzymes level in patients with non-alcoholic fatty liver disease. ...

    Abstract Background: This study aimed to evaluate the effectiveness of metformin and pioglitazone in combination with vitamin E on sonography grade and liver enzymes level in patients with non-alcoholic fatty liver disease.
    Methods: A randomized controlled clinical trial was designed with 68 patients diagnosed with non-alcoholic fatty liver disease by sonography and clinical examinations. Sixty-eight patients were randomly divided into two groups; 34 were assigned to receive 15 mg of pioglitazone per day and 34 were assigned to receive 1000 mg of metformin per day for 6 months. All of the patients received vitamin E at a dose of 800 IU daily for six months. The sonography grade of fatty liver and the levels of alanine aminotransferase and aspartate aminotransferase of patients were evaluated at baseline, and within three and six months after initiation of the intervention.
    Results: The use of metformin or pioglitazone in combination with vitamin E decreased the sonography grade of non-alcoholic fatty liver disease patients after 6 months of treatment (p-value<0.05); however, patients in metformin group benefit more compared to pioglitazone group. Patients who received metformin and vitamin E had a significant reduction in the levels of alanine aminotransferase and aspartate aminotransferase (p-value<0.05). There were no significant changes in the liver enzymes level of the patients who received pioglitazone and vitamin E (p-value>0.05).
    Major conclusion: The concomitant use of metformin and vitamin E significantly improves the sonography grade of fatty liver and the level of liver enzymes in patients with non-alcoholic fatty liver disease.
    Keywords Non-alcoholic fatty liver disease ; NAFLD ; pioglitazone ; metformin ; ALT ; AST
    Language English
    Publishing date 2023-02-15
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-1997-0401
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: The Effect of Treating Vitamin D Deficiency or Insufficiency on Serum Adiponectin, Leptin and Insulin Resistance of Type 2 Diabetes Mellitus Patients: A Pilot Study.

    Gharekhani, Afshin / Najafipour, Farzad / Baradaran, Hananeh / Tagharrobi, Parisa / Rezaee, Haleh

    Iranian journal of pharmaceutical research : IJPR

    2021  Volume 19, Issue 3, Page(s) 86–94

    Abstract: Vitamin D deficiency is considered as one of the most prevalent healthcare problems in the world. Vitamin D contributes to insulin synthesis and secretion. Deficiency of vitamin D leads to insulin resistance which is the major cause of type 2 diabetes ... ...

    Abstract Vitamin D deficiency is considered as one of the most prevalent healthcare problems in the world. Vitamin D contributes to insulin synthesis and secretion. Deficiency of vitamin D leads to insulin resistance which is the major cause of type 2 diabetes mellitus. We aim to evaluate the effect of treating vitamin D deficiency or insufficiency on serum adiponectin, leptin, and leptin to adiponectin ratio (LAR) of type 2 diabetes mellitus patients. Forty patients with type 2 diabetes mellitus were included according to the inclusion criteria of the study. Fasting venous blood samples were obtained and evaluated before and after the treatment of vitamin D deficiency or insufficiency. Then, blood levels of leptin, adiponectin, and LAR (an indicator of insulin resistance) were measured. The results of study indicate a significant decline in circulating leptin and adiponectin after vitamin D treatment, but it doesn't cause a noteworthy change in LAR. Furthermore, the study demonstrates that female gender, higher body mass index, and triglyceride levels increase LAR significantly. It was concluded that the treatment of vitamin D deficiency or insufficiency doesn't change insulin resistance in diabetic patients. Moreover, we concluded that LAR is not a reliable method to compare insulin resistance between men and women due to sex-related differences in adipose tissue.
    Language English
    Publishing date 2021-01-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2578271-X
    ISSN 1735-0328 ; 1726-6890
    ISSN 1735-0328 ; 1726-6890
    DOI 10.22037/ijpr.2020.112067.13512
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Angiotensin 1-7

    Imanpour, Hamed / Rezaee, Haleh / Nouri-Vaskeh, Masoud

    Advanced Pharmaceutical Bulletin

    A Novel Strategy in COVID-19 Treatment

    2020  Volume 10, Issue 4, Page(s) 488–489

    Keywords General Pharmacology, Toxicology and Pharmaceutics ; covid19
    Language English
    Publisher Maad Rayan Publishing Company
    Publishing country de
    Document type Article ; Online
    ZDB-ID 3018440-X
    ISSN 2251-7308 ; 2228-5881
    ISSN (online) 2251-7308
    ISSN 2228-5881
    DOI 10.34172/apb.2020.068
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Angiotensin 1-7: A Novel Strategy in COVID-19 Treatment

    Imanpour, Hamed / Rezaee, Haleh / Nouri-Vaskeh, Masoud

    Advanced Pharmaceutical Bulletin

    Abstract: The renin-angiotensin-aldosterone system plays a critical role in COVID-19 pathogenesis 1 The sex difference in the mortality rate and complications of COVID-19, and also the more favorable prognosis of children leads to new hypotheses regarding the ... ...

    Abstract The renin-angiotensin-aldosterone system plays a critical role in COVID-19 pathogenesis 1 The sex difference in the mortality rate and complications of COVID-19, and also the more favorable prognosis of children leads to new hypotheses regarding the protective and harmful factors in the treatment of these patients 2,3 Angiotensin-converting enzyme (ACE) plays a role in innate and adaptive immune responses as well as converting angiotensin and affecting different physiological functions 4 Understanding the expression of ACE on myeloid cells can be helpful in the treatment of infections [ ]to adults, children have a higher level of ACE 4 Although SARS-CoV-2 binds to ACE2 for entering the host cells, children are more immune against this virus;this is possibly due to a high level of ACE in children and its effects on immune responses 4 Moreover, although children have a higher level of renin, angiotensin, and aldosterone compared with adults and also a higher amount of fluid in their bodies, they have lower blood pressures5;one of the reasons behind this is the high level of angiotensin 1-7 that acts as a vasodilator and anti-inflammatory agent against angiotensin 2 By injecting angiotensin 1-7, the renin-angiotensin-aldosterone axis will become active to prevent a further drop in blood pressure, the ACE level will rise, and the ACE2 level will reduce owing to the accumulation of angiotensin 1-7 8 This means that providing high levels of angiotensin 1-7 and ACE while reducing inflammatory bradykinin will be protective against ACE2, the entry site of the virus into the host cells 8 Finally, the controlled injection of angiotensin 1-7 as a modulator of the renin-angiotensin-aldosterone system and the compensation of a possible drop in blood pressure by infusion of intravenous fluids and alpha agonists may be able to reduce the severity of COVID-19 infection since the host is given an opportunity to induce specific immunity
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #860161
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Drug-drug interactions with candidate medications used for COVID-19 treatment: An overview.

    Rezaee, Haleh / Pourkarim, Fariba / Pourtaghi-Anvarian, Samira / Entezari-Maleki, Taher / Asvadi-Kermani, Touraj / Nouri-Vaskeh, Masoud

    Pharmacology research & perspectives

    2021  Volume 9, Issue 1, Page(s) e00705

    Abstract: Drug-drug interaction (DDI) is a common clinical problem that has occurred as a result of the concomitant use of multiple drugs. DDI may occur in patients under treatment with medications used for coronavirus disease 2019 (COVID-19; i.e., chloroquine, ... ...

    Abstract Drug-drug interaction (DDI) is a common clinical problem that has occurred as a result of the concomitant use of multiple drugs. DDI may occur in patients under treatment with medications used for coronavirus disease 2019 (COVID-19; i.e., chloroquine, lopinavir/ritonavir, ribavirin, tocilizumab, and remdesivir) and increase the risk of serious adverse reactions such as QT-prolongation, retinopathy, increased risk of infection, and hepatotoxicity. This review focuses on summarizing DDIs for candidate medications used for COVID-19 in order to minimize the adverse reactions.
    MeSH term(s) Animals ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antiviral Agents/therapeutic use ; Chloroquine/therapeutic use ; Drug Interactions ; Humans ; Lopinavir/therapeutic use ; Ribavirin/therapeutic use ; Ritonavir/therapeutic use ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antiviral Agents ; Lopinavir (2494G1JF75) ; Ribavirin (49717AWG6K) ; Chloroquine (886U3H6UFF) ; tocilizumab (I031V2H011) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2021-01-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.705
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top