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  1. Article ; Online: Collaborative Strategies for Antimicrobial Stewardship Programs: Navigating Financial and Regulatory Landscapes.

    Swartz, Talia H / Aberg, Judith A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  

    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad723
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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  2. Article ; Online: Preserving the Future of Infectious Diseases: Why We Must Address the Decline in Compensation for Clinicians and Researchers.

    Swartz, Talia H / Aberg, Judith A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 10, Page(s) 1387–1394

    Abstract: Infectious diseases (ID) physicians play a pivotal role in patient care and public health, yet concerns are mounting about their under-compensation compared with other medical specialties. This trend sees ID physicians, including new graduates, receiving ...

    Abstract Infectious diseases (ID) physicians play a pivotal role in patient care and public health, yet concerns are mounting about their under-compensation compared with other medical specialties. This trend sees ID physicians, including new graduates, receiving lower remuneration than their general and hospital medicine peers, despite their significant contributions. The persistent disparity in compensation has been identified as a key factor behind the declining interest in the ID specialty among medical students and residents, potentially threatening patient care quality, research advancement, and diversity within the ID workforce. This viewpoint underscores the urgent need for the ID community to rally behind the Infectious Diseases Society of America in advocating for fair compensation for ID physicians and researchers. While focusing on wellness and work-life balance is vital, it is critical to address compensation, a significant source of distress for physicians. Failure to confront the issue of under-compensation promptly may jeopardize the future growth and sustainability of the ID specialty.
    MeSH term(s) Humans ; Communicable Diseases ; Patient Care ; Physicians ; Infectious Disease Medicine ; Public Health
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad416
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  3. Article ; Online: Aging and HIV infection: focus on cardiovascular disease risk.

    Aberg, Judith A

    Topics in antiviral medicine

    2020  Volume 27, Issue 4, Page(s) 102–105

    Abstract: ... a presentation by Judith A. Aberg, MD, at the International Antiviral Society-USA (IAS-USA) annual ...

    Abstract Effective antiretroviral therapy has extended life expectancy for individuals with HIV. Estimates from 2015 indicate that 47% of persons with HIV in the US were older than 50 years of age and 16% were older than 65 years. These older patients are at increased risk of age-related diseases and conditions. Further, there is substantial evidence that patients with HIV infection accumulate age-related conditions earlier than do those in the general population. There is risk for increased comorbidities and polypharmacy in the aging HIV-infected population. Specific measures for assessing and reducing the risk of cardiovascular disease and other age-related conditions in the aging HIV population are needed. This article summarizes a presentation by Judith A. Aberg, MD, at the International Antiviral Society-USA (IAS-USA) annual continuing education program held in Chicago, Illinois, in May 2019.
    MeSH term(s) Aged ; Aging/immunology ; Aging/physiology ; Anti-HIV Agents/immunology ; Anti-HIV Agents/therapeutic use ; Cardiovascular Diseases/prevention & control ; Comorbidity/trends ; Female ; HIV Infections/drug therapy ; HIV Infections/immunology ; Humans ; Male ; Middle Aged ; Risk Factors
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2656632-1
    ISSN 2161-5853 ; 2161-5861
    ISSN (online) 2161-5853
    ISSN 2161-5861
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  4. Article ; Online: Viral Persistence in the Gut-Associated Lymphoid Tissue and Barriers to HIV Cure.

    Cossarini, Francesca / Aberg, Judith A / Chen, Benjamin K / Mehandru, Saurabh

    AIDS research and human retroviruses

    2023  

    Abstract: More than 40 years after the first reported cases of what then became known as acquired immunodeficiency syndrome (AIDS), tremendous progress has been achieved in transforming the disease from almost universally fatal to a chronic manageable condition. ... ...

    Abstract More than 40 years after the first reported cases of what then became known as acquired immunodeficiency syndrome (AIDS), tremendous progress has been achieved in transforming the disease from almost universally fatal to a chronic manageable condition. Nonetheless, the efforts to find a preventative vaccine or a cure for the underlying infection with Human Immunodeficiency Virus (HIV) remain largely unsuccessful. Many challenges intrinsic to the virus characteristics and host response need to be overcome for either goal to be achieved. This article will review the obstacles to an effective HIV cure, specifically the steps involved in the generation of HIV latency, focusing on the role of the gut-associated lymphoid tissue, which has received less attention compared with the peripheral blood, despite being the largest repository of lymphoid tissue in the human body, and a large site for HIV persistence.
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2022.0180
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  5. Article ; Online: Convalescent plasma in patients hospitalised with COVID-19.

    Liu, Sean T H / Aberg, Judith A

    Lancet (London, England)

    2021  Volume 397, Issue 10289, Page(s) 2024–2025

    MeSH term(s) COVID-19/therapy ; Coronavirus Infections ; Hospitals ; Humans ; Immunization, Passive ; SARS-CoV-2 ; COVID-19 Serotherapy
    Language English
    Publishing date 2021-05-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)01064-3
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  6. Article ; Online: The evolution of clinical study design in heavily treatment-experienced persons with HIV: A critical review.

    Aberg, Judith A / Mills, Anthony / Moreno, Santiago / Slater, Jill / Prakash, Manyu / Clark, Andrew

    Antiviral therapy

    2023  Volume 28, Issue 3, Page(s) 13596535231174774

    Abstract: Heavily treatment-experienced (HTE) persons with HIV have limited options for antiretroviral therapy and face many challenges, complicating their disease management. There is an ongoing need for new antiretrovirals and treatment strategies for this ... ...

    Abstract Heavily treatment-experienced (HTE) persons with HIV have limited options for antiretroviral therapy and face many challenges, complicating their disease management. There is an ongoing need for new antiretrovirals and treatment strategies for this population. We reviewed the study designs, baseline characteristics, and results of clinical trials that enrolled HTE persons with HIV. A PubMed literature search retrieved articles published between 1995 and 2020, which were grouped by trial start date (1995-2009,
    MeSH term(s) Humans ; Anti-HIV Agents/therapeutic use ; HIV Infections/drug therapy ; Anti-Retroviral Agents/therapeutic use ; Viral Load
    Chemical Substances Anti-HIV Agents ; Anti-Retroviral Agents
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1339842-8
    ISSN 2040-2058 ; 1359-6535
    ISSN (online) 2040-2058
    ISSN 1359-6535
    DOI 10.1177/13596535231174774
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    Zs.MO 174: Show issues

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  7. Article: Informative Censoring-A Cause of Bias in Estimating COVID-19 Mortality Using Hospital Data.

    Lin, Hung-Mo / Liu, Sean T H / Levin, Matthew A / Williamson, John / Bouvier, Nicole M / Aberg, Judith A / Reich, David / Egorova, Natalia

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 1

    Abstract: 1) Background: Several retrospective observational analyzed treatment outcomes for COVID-19; (2) Methods: Inverse probability of censoring weighting (IPCW) was applied to correct for bias due to informative censoring in database of hospitalized patients ...

    Abstract (1) Background: Several retrospective observational analyzed treatment outcomes for COVID-19; (2) Methods: Inverse probability of censoring weighting (IPCW) was applied to correct for bias due to informative censoring in database of hospitalized patients who did and did not receive convalescent plasma; (3) Results: When compared with an IPCW analysis, overall mortality was overestimated using an unadjusted Kaplan-Meier curve, and hazard ratios for the older age group compared to the youngest were underestimated using the Cox proportional hazard models and 30-day mortality; (4) Conclusions: An IPCW analysis provided stabilizing weights by hospital admission.
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13010210
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  8. Article ; Online: Aging, inflammation, and HIV infection.

    Aberg, Judith A

    Topics in antiviral medicine

    2012  Volume 20, Issue 3, Page(s) 101–105

    Abstract: ... immune activation in HIV infection. This article summarizes a presentation by Judith A. Aberg, MD, at the IAS-USA ...

    Abstract Prolonged survival in HIV infection is accompanied by an increased frequency of non-HIV-related comorbidities. A number of age-related comorbidities occur earlier in HIV-infected patients than in individuals without HIV infection. This "accelerated aging" appears to be largely related to chronic inflammation, chronic immune activation, and immunosenescence in HIV infection. Levels of markers of inflammation and coagulopathy are elevated in HIV-infected patients, and elevations in markers such as high-sensitivity C-reactive protein, D-dimer, and interleukin 6 (IL-6) have been associated with increased risk for cardiovascular disease, opportunistic conditions, or all-cause mortality. In both HIV infection and aging, immunosenescence is marked by an increased proportion of CD28-, CD57+ memory CD8+ T cells with reduced capacity to produce interleukin 2 (IL-2), increased production of IL-6, resistance to apoptosis, and shortened telomeres. A number of AIDS Clinical Trials Group studies are under way to examine treatment aimed at reducing chronic inflammation and immune activation in HIV infection. This article summarizes a presentation by Judith A. Aberg, MD, at the IAS-USA live continuing medical education course held in New York City in October 2011.
    MeSH term(s) Aging ; CD28 Antigens/immunology ; CD57 Antigens/immunology ; CD8-Positive T-Lymphocytes/chemistry ; CD8-Positive T-Lymphocytes/immunology ; Chronic Disease ; Comorbidity ; HIV Infections/complications ; HIV Infections/immunology ; HIV Infections/mortality ; HIV Infections/pathology ; Humans ; Immunologic Memory ; Inflammation/pathology ; Interleukin-2/metabolism ; Interleukin-6/metabolism ; New York City ; T-Lymphocyte Subsets/chemistry ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; Telomere ; United States
    Chemical Substances CD28 Antigens ; CD57 Antigens ; Interleukin-2 ; Interleukin-6
    Language English
    Publishing date 2012-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2656632-1
    ISSN 2161-5853 ; 2161-5853
    ISSN (online) 2161-5853
    ISSN 2161-5853
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  9. Article ; Online: Effect of tesamorelin in people with HIV with and without dorsocervical fat

    Farah Rahman / Taryn McLaughlin / Pedro Mesquita / Josee Morin / Diane Potvin / Marilyn De Chantal / Judith A. Aberg

    Journal of Clinical and Translational Science, Vol

    Post hoc analysis of phase III double-blind placebo-controlled trial

    2023  Volume 7

    Abstract: Tesamorelin, a synthetic growth hormone-releasing hormone, is indicated for the reduction of visceral adipose tissue (VAT) in people with HIV. Here, we performed a post hoc analysis of participants receiving tesamorelin for 26 weeks in a phase III ... ...

    Abstract Tesamorelin, a synthetic growth hormone-releasing hormone, is indicated for the reduction of visceral adipose tissue (VAT) in people with HIV. Here, we performed a post hoc analysis of participants receiving tesamorelin for 26 weeks in a phase III clinical trial. Efficacy data were compared between individuals with and without dorsocervical fat, stratified by tesamorelin response. Among tesamorelin responders, VAT and waist circumference (WC) decreased in both dorsocervical fat groups and did not statistically differ (VAT P = 0.657, WC P = 0.093). These data demonstrate that tesamorelin is equally effective and should be considered in the treatment of excess VAT regardless of the presence of dorsocervical fat.
    Keywords HIV ; antiretrovirals ; lipohypertrophy ; growth hormone-releasing hormone ; tesamorelin ; Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Effect of tesamorelin in people with HIV with and without dorsocervical fat: Post hoc analysis of phase III double-blind placebo-controlled trial.

    Rahman, Farah / McLaughlin, Taryn / Mesquita, Pedro / Morin, Josee / Potvin, Diane / De Chantal, Marilyn / Aberg, Judith A

    Journal of clinical and translational science

    2022  Volume 7, Issue 1, Page(s) e40

    Abstract: Tesamorelin, a synthetic growth hormone-releasing hormone, is indicated for the reduction of visceral adipose tissue (VAT) in people with HIV. Here, we performed a post hoc analysis of participants receiving tesamorelin for 26 weeks in a phase III ... ...

    Abstract Tesamorelin, a synthetic growth hormone-releasing hormone, is indicated for the reduction of visceral adipose tissue (VAT) in people with HIV. Here, we performed a post hoc analysis of participants receiving tesamorelin for 26 weeks in a phase III clinical trial. Efficacy data were compared between individuals with and without dorsocervical fat, stratified by tesamorelin response. Among tesamorelin responders, VAT and waist circumference (WC) decreased in both dorsocervical fat groups and did not statistically differ (VAT
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2022.515
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