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Article ; Online: Recognition of cognitive dysfunction in hospitalised older patients: a flash mob study.

Visser, Fleur C W / van Eersel, Marlise E A / Hempenius, Liesbeth / Verwey, Nicolaas A / Band, Caterina / van der Bol, Jessica M / Boudestein, Kris / van Dijk, Suzanne C / Gobbens, Robbert / van der Hooft, Cornelis S / Kamper, Adriaan M / Ruiter, Rikje / Sipers, Walther / Spoelstra, Birgit N A / Stoffels, Josephine / Stolwijk-Woudstra, Dyane J / van Stralen, Karlijn J / van Strien, Astrid M / Wijngaarden, Marjolein A /

Winters, Marian / Strijkert, Fijanne / van Munster, Barbara C

BMC geriatrics

2024 Volume 24, Issue 1, Page(s) 66

Abstract: Background: It is important that healthcare professionals recognise cognitive dysfunction in hospitalised older patients in order to address associated care needs, such as enhanced involvement of relatives and extra cognitive and functional support. ... ...

Abstract	Background: It is important that healthcare professionals recognise cognitive dysfunction in hospitalised older patients in order to address associated care needs, such as enhanced involvement of relatives and extra cognitive and functional support. However, studies analysing medical records suggest that healthcare professionals have low awareness of cognitive dysfunction in hospitalised older patients. In this study, we investigated the prevalence of cognitive dysfunction in hospitalised older patients, the percentage of patients in which cognitive dysfunction was recognised by healthcare professionals, and which variables were associated with recognition. Methods: A multicentre, nationwide, cross-sectional observational study was conducted on a single day using a flash mob study design in thirteen university and general hospitals in the Netherlands. Cognitive function was assessed in hospitalised patients aged ≥ 65 years old, who were admitted to medical and surgical wards. A Mini-Cog score of < 3 out of 5 indicated cognitive dysfunction. The attending nurses and physicians were asked whether they suspected cognitive dysfunction in their patient. Variables associated with recognition of cognitive dysfunction were assessed using multilevel and multivariable logistic regression analyses. Results: 347 of 757 enrolled patients (46%) showed cognitive dysfunction. Cognitive dysfunction was recognised by attending nurses in 137 of 323 patients (42%) and by physicians in 156 patients (48%). In 135 patients (42%), cognitive dysfunction was not recognised by either the attending nurse or physician. Recognition of cognitive dysfunction was better at a lower Mini-Cog score, with the best recognition in patients with the lowest scores. Patients with a Mini-Cog score < 3 were best recognised in the geriatric department (69% by nurses and 72% by physicians). Conclusion: Cognitive dysfunction is common in hospitalised older patients and is poorly recognised by healthcare professionals. This study highlights the need to improve recognition of cognitive dysfunction in hospitalised older patients, particularly in individuals with less apparent cognitive dysfunction. The high proportion of older patients with cognitive dysfunction suggests that it may be beneficial to provide care tailored to cognitive dysfunction for all hospitalised older patients.
MeSH term(s)	Humans ; Aged ; Delirium ; Cross-Sectional Studies ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/complications ; Patients ; Hospitalization
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-023-04588-5
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Article ; Online: The Dutch Pancreas Biobank Within the Parelsnoer Institute: A Nationwide Biobank of Pancreatic and Periampullary Diseases.

Strijker, Marin / Gerritsen, Arja / van Hilst, Jony / Bijlsma, Maarten F / Bonsing, Bert A / Brosens, Lodewijk A / Bruno, Marco J / van Dam, Ronald M / Dijk, Frederike / van Eijck, Casper H / Farina Sarasqueta, Arantza / Fockens, Paul / Gerhards, Michael F / Groot Koerkamp, Bas / van der Harst, Erwin / de Hingh, Ignace H / van Hooft, Jeanin E / Huysentruyt, Clément J / Kazemier, Geert /

Klaase, Joost M / van Laarhoven, Cornelis J / van Laarhoven, Hanneke W / Liem, Mike S / de Meijer, Vincent E / van Rijssen, L Bengt / van Santvoort, Hjalmar C / Suker, Mustafa / Verhagen, Judith H / Verheij, Joanne / Verspaget, Hein W / Wennink, Roos A / Wilmink, Johanna W / Molenaar, I Quintus / Boermeester, Marja A / Busch, Olivier R / Besselink, Marc G

Pancreas

2018 Volume 47, Issue 4, Page(s) 495–501

Abstract: Objectives: Large biobanks with uniform collection of biomaterials and associated clinical data are essential for translational research. The Netherlands has traditionally been well organized in multicenter clinical research on pancreatic diseases, ... ...

Abstract	Objectives: Large biobanks with uniform collection of biomaterials and associated clinical data are essential for translational research. The Netherlands has traditionally been well organized in multicenter clinical research on pancreatic diseases, including the nationwide multidisciplinary Dutch Pancreatic Cancer Group and Dutch Pancreatitis Study Group. To enable high-quality translational research on pancreatic and periampullary diseases, these groups established the Dutch Pancreas Biobank. Methods: The Dutch Pancreas Biobank is part of the Parelsnoer Institute and involves all 8 Dutch university medical centers and 5 nonacademic hospitals. Adult patients undergoing pancreatic surgery (all indications) are eligible for inclusion. Preoperative blood samples, tumor tissue from resected specimens, pancreatic cyst fluid, and follow-up blood samples are collected. Clinical parameters are collected in conjunction with the mandatory Dutch Pancreatic Cancer Audit. Results: Between January 2015 and May 2017, 488 patients were included in the first 5 participating centers: 4 university medical centers and 1 nonacademic hospital. Over 2500 samples were collected: 1308 preoperative blood samples, 864 tissue samples, and 366 follow-up blood samples. Conclusions: Prospective collection of biomaterials and associated clinical data has started in the Dutch Pancreas Biobank. Subsequent translational research will aim to improve treatment decisions based on disease characteristics.
MeSH term(s)	Academic Medical Centers ; Aged ; Ampulla of Vater/pathology ; Biological Specimen Banks ; Female ; Humans ; Male ; Middle Aged ; Netherlands ; Pancreas/pathology ; Pancreas/surgery ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Prospective Studies ; Tissue and Organ Procurement/methods ; Translational Medical Research/methods
Language	English
Publishing date	2018-05-11
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000001018
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Zs.A 2160: Show issues

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Article: Adverse drug reaction-related hospitalisations: a nationwide study in The Netherlands.

van der Hooft, Cornelis S / Sturkenboom, Miriam C J M / van Grootheest, Kees / Kingma, Herre J / Stricker, Bruno H Ch

Drug safety

2006 Volume 29, Issue 2, Page(s) 161–168

Abstract: Background: The incidence of adverse drug reaction (ADR)-related hospitalisations has usually been assessed within hospitals. Because of the variability in results and methodology, it is difficult to extrapolate these results to a national level.: ... ...

Abstract	Background: The incidence of adverse drug reaction (ADR)-related hospitalisations has usually been assessed within hospitals. Because of the variability in results and methodology, it is difficult to extrapolate these results to a national level. Objectives: To evaluate the incidence and characteristics of ADR-related hospitalisations in The Netherlands in 2001. Methods: We conducted a nationwide study of all hospital admissions in 2001. Data were retrieved from a nationwide computer database for hospital discharge records. All acute, non-planned admissions to all Dutch academic and general hospitals in 2001 were included in the study (n = 668 714). From these admissions we selected all hospitalisations that were coded as drug-related, but intended forms of overdose, errors in administration and therapeutic failures were excluded. Hence, we extracted all ADR-related hospitalisations. We compared age, sex and the risk of a fatal outcome between patients admitted with ADRs and patients admitted for other reasons, as well as the most frequent main diagnoses in ADR-related hospitalisations and which drugs most frequently caused the ADRs. In addition, we evaluated to what extent these ADRs were reported to the Netherlands Pharmacovigilance Centre Lareb for spontaneous ADR reporting. Results: In 2001, 12 249 hospitalisations were coded as ADR related. This was 1.83% of all acute hospital admissions in The Netherlands (95% CI 1.80, 1.86). The proportion increased with age from 0.8% (95% CI 0.75, 0.85) in the <18 years group to 3.2% in the >/=80 years group (95% CI 3.08, 3.32). The most frequent ADR-related diagnoses of hospitalisations were bleeding (n = 1048), non-specified 'unintended effect of drug' (n = 438), hypoglycaemia (n = 375) and fever (n = 347). The drugs most commonly associated with ADR-related hospitalisations were anticoagulants (n = 2185), cytostatics and immunosuppressives (n = 1809) and diuretics (n = 979). Six percent of the ADR-related hospitalisations had a fatal outcome (n = 734). Older age and female gender were associated with ADR-related hospitalisations. Only approximately 1% of the coded ADRs causing hospitalisation were reported to our national centre for spontaneous ADR reporting. Conclusion: The proportion of ADR-related hospitalisations is substantial, especially considering the fact that not all ADRs may be recognised or mentioned in discharge letters. Under-reporting of ADRs that result in hospital admission to our national centre for spontaneous ADR reporting was considerable.
MeSH term(s)	Adolescent ; Adult ; Adverse Drug Reaction Reporting Systems ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Databases, Factual ; Drug-Related Side Effects and Adverse Reactions ; Female ; Health Surveys ; Hospitalization/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Netherlands ; Patient Admission/statistics & numerical data ; Prospective Studies
Language	English
Publishing date	2006-01-16
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	1018059-x
ISSN	1179-1942 ; 0114-5916
ISSN (online)	1179-1942
ISSN	0114-5916
DOI	10.2165/00002018-200629020-00006
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Zs.A 2127: Show issues

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Article: Drug-induced atrial fibrillation.

van der Hooft, Cornelis S / Heeringa, Jan / van Herpen, Gerard / Kors, Jan A / Kingma, J Herre / Stricker, Bruno H Ch

Journal of the American College of Cardiology

2004 Volume 44, Issue 11, Page(s) 2117–2124

Abstract: Atrial fibrillation (AF) is the most common sustained rhythm disorder observed in clinical practice and predominantly associated with cardiovascular disorders such as coronary heart disease and hypertension. However, several classes of drugs may induce ... ...

Abstract	Atrial fibrillation (AF) is the most common sustained rhythm disorder observed in clinical practice and predominantly associated with cardiovascular disorders such as coronary heart disease and hypertension. However, several classes of drugs may induce AF in patients without apparent heart disease or may precipitate the onset of AF in patients with preexisting heart disease. We reviewed the literature on drug-induced AF, using the PubMed/Medline and Micromedex databases and lateral references. Successively, we discuss the potential role in the onset of AF of cardiovascular drugs, respiratory system drugs, cytostatics, central nervous system drugs, genitourinary system drugs, and some miscellaneous agents. Drug-induced AF may play a role in only a minority of the patients presenting with AF. Nevertheless, it is important to recognize drugs or other agents as a potential cause, especially in the elderly, because increasing age is associated with multiple drug use and a high incidence of AF. This may contribute to timely diagnosis and management of drug-induced AF.
MeSH term(s)	Anti-Arrhythmia Agents/pharmacology ; Antineoplastic Agents/adverse effects ; Atrial Fibrillation/chemically induced ; Atrial Fibrillation/etiology ; Atrial Fibrillation/physiopathology ; Cardiovascular Agents/adverse effects ; Central Nervous System Agents/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Erectile Dysfunction/drug therapy ; Humans ; Male ; Respiratory System Agents/adverse effects ; Tocolytic Agents/adverse effects
Chemical Substances	Anti-Arrhythmia Agents ; Antineoplastic Agents ; Cardiovascular Agents ; Central Nervous System Agents ; Respiratory System Agents ; Tocolytic Agents
Language	English
Publishing date	2004-12-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2004.08.053
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: Adverse drug reaction-related hospitalisations: a population-based cohort study.

van der Hooft, Cornelis S / Dieleman, Jeanne P / Siemes, Claire / Aarnoudse, Albert-Jan L H J / Verhamme, Katia M C / Stricker, Bruno H C H / Sturkenboom, Miriam C J M

Pharmacoepidemiology and drug safety

2008 Volume 17, Issue 4, Page(s) 365–371

Abstract: Purpose: To evaluate the extent, characteristics and determinants of adverse drug reaction (ADR)-related hospitalisations on a population-based level in 2003.: Methods: We performed a cohort study in the Integrated Primary Care Information (IPCI) ... ...

Abstract	Purpose: To evaluate the extent, characteristics and determinants of adverse drug reaction (ADR)-related hospitalisations on a population-based level in 2003. Methods: We performed a cohort study in the Integrated Primary Care Information (IPCI) database, a general practitioners (GPs) research database with longitudinal data from electronic patient records of a group of 150 GP throughout the Netherlands. Hospital discharge letters and patient records were reviewed to evaluate ADR-related hospitalisations applying WHO causality criteria. The prevalence of ADR-related hospitalisations per total admissions and the incidence per drug group were calculated. Avoidability and seriousness of the ADRs causing admission were assessed applying the algorithm from Hallas. Results: We identified 3515 hospital admissions, 1277 elective and 2238 acute. Of the acute admissions, 115 were caused by an ADR giving a prevalence of 5.1% (95% confidence intervals (CI): 4.3-6.1%). The prevalence of ADR-related acute admissions increased with age up to 9.8% (95%CI: 7.5-12.7) for persons >75 years. The ADRs that most frequently caused hospitalisations were gastro-intestinal bleeding with anti-thrombotics, bradycardia/hypotension with cardiovascular drugs and neutropenic fever with cytostatics. The incidence rate of ADR-related hospitalisations per drug group was highest for anti-thrombotics and anti-infectives and was relatively low for cardiovascular drugs. Fatality as a direct consequence of the ADR-related admission was 0.31%. In elderly patients 40% of the ADRs causing hospitalisation were judged to be avoidable. Conclusions: The extent and potential avoidability of ADR-related hospitalisations is still substantial, especially in elderly patients. Measures need to be put into place to reduce the burden of ADRs.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cohort Studies ; Drug-Related Side Effects and Adverse Reactions ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Medical Records Systems, Computerized ; Middle Aged ; Netherlands/epidemiology ; Pharmacoepidemiology ; Population Surveillance/methods ; Prevalence
Language	English
Publishing date	2008-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099748-9
ISSN	1099-1557 ; 1053-8569
ISSN (online)	1099-1557
ISSN	1053-8569
DOI	10.1002/pds.1565
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Zs.A 3395: Show issues

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Article ; Online: Inappropriate benzodiazepine use in older adults and the risk of fracture.

van der Hooft, Cornelis S / Schoofs, Mariëtte W C J / Ziere, Gijsbertus / Hofman, Albert / Pols, Huibert A P / Sturkenboom, Miriam C J M / Stricker, Bruno H Ch

British journal of clinical pharmacology

2008 Volume 66, Issue 2, Page(s) 276–282

Abstract: Aims: The Beers criteria for prescribing in elderly are well known and used for many drug utilization studies. We investigated the clinical value of the Beers criteria for benzodiazepine use, notably the association between inappropriate use and risk of ...

Abstract	Aims: The Beers criteria for prescribing in elderly are well known and used for many drug utilization studies. We investigated the clinical value of the Beers criteria for benzodiazepine use, notably the association between inappropriate use and risk of fracture. Methods: We performed a nested case-control study within the Rotterdam Study, a population-based cohort study in 7983 elderly. The proportion of 'inappropriate' benzodiazepine use according to the Beers criteria was compared between fracture patients and controls. 'Inappropriate' use for elderly implies use of some long-acting benzodiazepines and some intermediate/short-acting ones exceeding a suggested maximum daily dose. Also, alternative criteria were applied to compare the risk of fracture. Cases were defined as persons with incident fracture between 1991 and 2002 who were current benzodiazepine users on the fracture date. Controls were matched on fracture date and were also current benzodiazepine users. Results: The risk of fracture in 'inappropriate' benzodiazepine users according to the Beers criteria was not significantly different from 'appropriate' users [odds ratio (OR) 1.07, 95% confidence interval (CI) 0.72, 1.60]. However, a significantly higher risk of fracture was found in 'high dose' users and a longer duration of use (14-90 days), irrespective of the type of benzodiazepine (OR 3.45, 95% CI 1.38, 8.59). Conclusions: These findings suggest that inappropriate benzodiazepine use according to the Beers criteria is not associated with increased risk of fracture. Daily dose and longer duration of use (>14 days) is associated with higher risk of fracture, irrespective of the type of benzodiazepine prescribed.
MeSH term(s)	Aged ; Benzodiazepines/adverse effects ; Confounding Factors, Epidemiologic ; Dose-Response Relationship, Drug ; Drug Prescriptions ; Drug Utilization Review ; Epidemiologic Methods ; Female ; Fractures, Bone/chemically induced ; Health Services Misuse ; Humans ; Male ; Medication Errors/statistics & numerical data ; Practice Patterns, Physicians'/standards ; Treatment Outcome
Chemical Substances	Benzodiazepines (12794-10-4)
Language	English
Publishing date	2008-05-06
Publishing country	England
Document type	Journal Article
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/j.1365-2125.2008.03185.x
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Zs.A 1118: Show issues

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Article: Inappropriate drug prescribing in older adults: the updated 2002 Beers criteria--a population-based cohort study.

van der Hooft, Cornelis S / Jong, Geert W 't / Dieleman, Jeanne P / Verhamme, Katia M C / van der Cammen, Tischa J M / Stricker, Bruno H Ch / Sturkenboom, Miriam C J M

British journal of clinical pharmacology

2005 Volume 60, Issue 2, Page(s) 137–144

Abstract: Background: In 1997, Beers and colleagues developed explicit criteria for potentially inappropriate drug prescribing in ambulatory older adults aged 65 years and over. Several studies have been performed to estimate the prevalence of inappropriate drug ... ...

Abstract	Background: In 1997, Beers and colleagues developed explicit criteria for potentially inappropriate drug prescribing in ambulatory older adults aged 65 years and over. Several studies have been performed to estimate the prevalence of inappropriate drug prescribing based on these criteria. In 2002, the criteria were updated. Aims: To examine the extent and trend of inappropriate drug prescribing to ambulatory older adults in the Netherlands between 1997 and 2001, according to the 1997 and the updated Beers criteria. Methods: Data were retrieved from the Integrated Primary Care Information (IPCI) project, a general practice research database with data from computer-based patient records of a group of 150 general practitioners in the Netherlands. All subjects aged 65 and over were included. Prescriptions were classified as inappropriate if they fulfilled the Beers criteria of prescriptions that generally should be avoided in older adults because of a high risk of adverse effects, while also considering dose and comorbidity. Results: Between 1997 and 2001, the 1-year risk of receiving at least one inappropriate drug prescription for older adults ranged between 16.8% (95% CI: 16.3-17.3%) and 18.5% (18.3-18.7%) according to the 1997 criteria and between 19.1% (18.6-19.6%) and 20.0% (19.5-20.5%) according to the updated Beers criteria. According to the updated criteria, the most frequently prescribed inappropriate drugs were nitrofurantoin, long-acting benzodiazepines, amitriptyline, promethazine and cimetidine. Temazepam and zolpidem were mostly prescribed in supratherapeutic dose. Conventional NSAIDs in persons with a history of gastric/duodenal ulcer were the most frequently prescribed contra-indicated drugs. Conclusions: Prescribing potentially inappropriate prescriptions to ambulatory older people in the Netherlands is substantial. Compared with other studies using the 1997 Beers criteria, inappropriate prescribing to the elderly is lower than in the USA but similar to Finland. Despite a restrictive medication policy and a growing attention for medication surveillance in Europe, inappropriate drug prescribing is still a substantial problem.
MeSH term(s)	Aged ; Amitriptyline/adverse effects ; Amitriptyline/therapeutic use ; Anti-Infective Agents, Urinary/adverse effects ; Anti-Infective Agents, Urinary/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antidepressive Agents, Tricyclic/adverse effects ; Antidepressive Agents, Tricyclic/therapeutic use ; Antipruritics/adverse effects ; Antipruritics/therapeutic use ; Benzodiazepines/adverse effects ; Benzodiazepines/therapeutic use ; Cimetidine/adverse effects ; Cimetidine/therapeutic use ; Cohort Studies ; Comorbidity ; Drug Prescriptions ; Drug Therapy, Combination ; Enzyme Inhibitors/adverse effects ; Enzyme Inhibitors/therapeutic use ; Female ; Humans ; Hypnotics and Sedatives/adverse effects ; Hypnotics and Sedatives/therapeutic use ; Male ; Medication Errors ; Netherlands/epidemiology ; Nitrofurantoin/adverse effects ; Nitrofurantoin/therapeutic use ; Promethazine/adverse effects ; Promethazine/therapeutic use ; Pyridines/adverse effects ; Pyridines/therapeutic use ; Risk Assessment/methods
Chemical Substances	Anti-Infective Agents, Urinary ; Anti-Inflammatory Agents, Non-Steroidal ; Antidepressive Agents, Tricyclic ; Antipruritics ; Enzyme Inhibitors ; Hypnotics and Sedatives ; Pyridines ; Benzodiazepines (12794-10-4) ; Amitriptyline (1806D8D52K) ; zolpidem (7K383OQI23) ; Cimetidine (80061L1WGD) ; Nitrofurantoin (927AH8112L) ; Promethazine (FF28EJQ494)
Language	English
Publishing date	2005-08
Publishing country	England
Document type	Journal Article
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/j.1365-2125.2005.02391.x
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Article: Corticosteroids and the risk of atrial fibrillation.

van der Hooft, Cornelis S / Heeringa, Jan / Brusselle, Guy G / Hofman, Albert / Witteman, Jacqueline C M / Kingma, J Herre / Sturkenboom, Miriam C J M / Stricker, Bruno H Ch

Archives of internal medicine

2006 Volume 166, Issue 9, Page(s) 1016–1020

Abstract: Background: High-dose (pulse) corticosteroid therapy has been associated with the development of atrial fibrillation. This association, however, is mainly based on case reports.: Methods: To test the hypothesis that high-dose corticosteroid exposure ... ...

Abstract	Background: High-dose (pulse) corticosteroid therapy has been associated with the development of atrial fibrillation. This association, however, is mainly based on case reports. Methods: To test the hypothesis that high-dose corticosteroid exposure increases the risk of new-onset atrial fibrillation, we performed a nested case-control study within the Rotterdam Study, a population-based cohort study among 7983 older adults. Cases were defined as persons with incident atrial fibrillation between July 1, 1991, and January 1, 2000. Their date of diagnosis was defined as the index date. All noncases within the Rotterdam Study who were alive and eligible on this index date were used as controls. Subsequently, we compared the proportion of cases and controls that received a corticosteroid prescription within 1 month preceding the index date. Corticosteroid exposure was categorized into high-dose exposure (oral or parenteral steroid at a daily dose > or =7.5 mg of prednisone equivalents) and low-intermediate-dose exposure (<7.5 mg of prednisone equivalents or inhaled corticosteroids). Results: There were 385 eligible cases of new-onset atrial fibrillation during the study period. The risk of new-onset atrial fibrillation was significantly higher for persons who received a corticosteroid prescription within 1 month before the index date than for those without (odds ratio [OR], 3.75; 95% confidence interval [CI], 2.38-5.87). However, only high-dose corticosteroid use was associated with an increased risk (OR, 6.07; 95% CI, 3.90-9.42), whereas low-intermediate-dose use was not (OR, 1.42; 95% CI, 0.72-2.82). The association of atrial fibrillation with high-dose corticosteroid use was largely independent of the indication for corticosteroid therapy, since the risk of new-onset atrial fibrillation was not only increased in patients with asthma or chronic obstructive pulmonary disease (OR, 4.02; 95% CI, 2.07-7.81) but also in patients with rheumatic, allergic, or malignant hematologic diseases (OR, 7.90; 95% CI, 4.47-13.98). Conclusion: Our findings strongly suggest that patients receiving high-dose corticosteroid therapy are at increased risk of developing atrial fibrillation.
MeSH term(s)	Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/adverse effects ; Adult ; Aged ; Asthma/drug therapy ; Atrial Fibrillation/chemically induced ; Case-Control Studies ; Drug Administration Schedule ; Female ; Hematologic Neoplasms/drug therapy ; Humans ; Hypersensitivity/drug therapy ; Male ; Middle Aged ; Odds Ratio ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Rheumatic Diseases/drug therapy ; Risk Assessment ; Risk Factors
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2006-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	211575-x
ISSN	1538-3679 ; 0003-9926 ; 0888-2479 ; 0730-188X
ISSN (online)	1538-3679
ISSN	0003-9926 ; 0888-2479 ; 0730-188X
DOI	10.1001/archinte.166.9.1016
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Article ; Online: Prolonged QTc interval and risk of sudden cardiac death in a population of older adults.

Straus, Sabine M J M / Kors, Jan A / De Bruin, Marie L / van der Hooft, Cornelis S / Hofman, Albert / Heeringa, Jan / Deckers, Jaap W / Kingma, J Herre / Sturkenboom, Miriam C J M / Stricker, Bruno H Ch / Witteman, Jacqueline C M

Journal of the American College of Cardiology

2006 Volume 47, Issue 2, Page(s) 362–367

Abstract: Objectives: This study sought to investigate whether prolongation of the heart rate-corrected QT (QTc) interval is a risk factor for sudden cardiac death in the general population.: Background: In developed countries, sudden cardiac death is a major ... ...

Abstract	Objectives: This study sought to investigate whether prolongation of the heart rate-corrected QT (QTc) interval is a risk factor for sudden cardiac death in the general population. Background: In developed countries, sudden cardiac death is a major cause of cardiovascular mortality. Prolongation of the QTc interval has been associated with ventricular arrhythmias, but in most population-based studies no consistent association was found between QTc prolongation and total or cardiovascular mortality. Only very few of these studies specifically addressed sudden cardiac death. Methods: This study was conducted as part of the Rotterdam Study, a prospective population-based cohort study that comprises 3,105 men and 4,878 women aged 55 years and older. The QTc interval on the electrocardiogram was determined during the baseline visit (1990 to 1993) and the first follow-up examination (1993 to 1995). The association between a prolonged QTc interval and sudden cardiac death was estimated using Cox proportional hazards analysis. Results: During an average follow-up period of 6.7 years (standard deviation, 2.3 years) 125 patients died of sudden cardiac death. An abnormally prolonged QTc interval (>450 ms in men, >470 ms in women) was associated with a three-fold increased risk of sudden cardiac death (hazard ratio, 2.5; 95% confidence interval, 1.3 to 4.7), after adjustment for age, gender, body mass index, hypertension, cholesterol/high-density lipoprotein ratio, diabetes mellitus, myocardial infarction, heart failure, and heart rate. In patients with an age below the median of 68 years, the corresponding relative risk was 8.0 (95% confidence interval 2.1 to 31.3). Conclusions: Abnormal QTc prolongation on the electrocardiogram should be viewed as an independent risk factor for sudden cardiac death.
MeSH term(s)	Aged ; Confounding Factors (Epidemiology) ; Death, Sudden, Cardiac/epidemiology ; Electrocardiography ; Female ; Heart Conduction System/physiopathology ; Humans ; Male ; Middle Aged ; Netherlands/epidemiology ; Proportional Hazards Models ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2006-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2005.08.067
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Article ; Online: Neoadjuvant Chemoradiotherapy Versus Upfront Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Long-Term Results of the Dutch Randomized PREOPANC Trial.

Versteijne, Eva / van Dam, Jacob L / Suker, Mustafa / Janssen, Quisette P / Groothuis, Karin / Akkermans-Vogelaar, Janine M / Besselink, Marc G / Bonsing, Bert A / Buijsen, Jeroen / Busch, Olivier R / Creemers, Geert-Jan M / van Dam, Ronald M / Eskens, Ferry A L M / Festen, Sebastiaan / de Groot, Jan Willem B / Groot Koerkamp, Bas / de Hingh, Ignace H / Homs, Marjolein Y V / van Hooft, Jeanin E /

Kerver, Emile D / Luelmo, Saskia A C / Neelis, Karen J / Nuyttens, Joost / Paardekooper, Gabriel M R M / Patijn, Gijs A / van der Sangen, Maurice J C / de Vos-Geelen, Judith / Wilmink, Johanna W / Zwinderman, Aeilko H / Punt, Cornelis J / van Tienhoven, Geertjan / van Eijck, Casper H J

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2022 Volume 40, Issue 11, Page(s) 1220–1230

Abstract: Purpose: The benefit of neoadjuvant chemoradiotherapy in resectable and borderline resectable pancreatic cancer remains controversial. Initial results of the PREOPANC trial failed to demonstrate a statistically significant overall survival (OS) benefit. ...

Abstract	Purpose: The benefit of neoadjuvant chemoradiotherapy in resectable and borderline resectable pancreatic cancer remains controversial. Initial results of the PREOPANC trial failed to demonstrate a statistically significant overall survival (OS) benefit. The long-term results are reported. Methods: In this multicenter, phase III trial, patients with resectable and borderline resectable pancreatic cancer were randomly assigned (1:1) to neoadjuvant chemoradiotherapy or upfront surgery in 16 Dutch centers. Neoadjuvant chemoradiotherapy consisted of three cycles of gemcitabine combined with 36 Gy radiotherapy in 15 fractions during the second cycle. After restaging, patients underwent surgery followed by four cycles of adjuvant gemcitabine. Patients in the upfront surgery group underwent surgery followed by six cycles of adjuvant gemcitabine. The primary outcome was OS by intention-to-treat. No safety data were collected beyond the initial report of the trial. Results: Between April 24, 2013, and July 25, 2017, 246 eligible patients were randomly assigned to neoadjuvant chemoradiotherapy (n = 119) and upfront surgery (n = 127). At a median follow-up of 59 months, the OS was better in the neoadjuvant chemoradiotherapy group than in the upfront surgery group (hazard ratio, 0.73; 95% CI, 0.56 to 0.96; Conclusion: Neoadjuvant gemcitabine-based chemoradiotherapy followed by surgery and adjuvant gemcitabine improves OS compared with upfront surgery and adjuvant gemcitabine in resectable and borderline resectable pancreatic cancer.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemoradiotherapy/methods ; Humans ; Neoadjuvant Therapy ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/surgery ; Survival Rate ; Pancreatic Neoplasms
Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.21.02233
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