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  1. Article: Rheocarna

    Nakamura, Yasuhito / Kumada, Yoshitaka / Kawai, Norikazu / Ishida, Narihiro

    SAGE open medicine

    2023  Volume 11, Page(s) 20503121231192813

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/20503121231192813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Endometrial Receptivity Array (ERA) Test in a 32-Year-Old Female With Refractory Infertility: A Case Report.

    Imoto, Sayaka / Funabiki, Miyako / Nakamura, Yoshitaka / Taguchi, Sagiri

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55703

    Abstract: We report a successful case for the clinical efficacy of the endometrial receptivity array (ERA) test for a 32-year-old female patient with refractory infertility. After our careful treatment, the patient gave birth to a male baby (3390 g) in November ... ...

    Abstract We report a successful case for the clinical efficacy of the endometrial receptivity array (ERA) test for a 32-year-old female patient with refractory infertility. After our careful treatment, the patient gave birth to a male baby (3390 g) in November 2021. To our knowledge, though the clinical efficacy of the ERA test is controversial until March 2024, we think that the age of the patients, the number of IVF cycles, and the racial differences may have an impact on the clinical efficacy of the ERA test.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55703
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  3. Article ; Online: Steroid Producing Cells during Ovarian Differentiation of the Tilapia, Sarotherodon niloticus: (ovarian differentiation/female germ cell/steroid producing cell/ultrastructure/tilapia).

    Nakamura, Masaru / Nagahama, Yoshitaka

    Development, growth & differentiation

    2023  Volume 27, Issue 6, Page(s) 701–708

    Abstract: In order to examine the initial appearance and development of the steroid producing cells (SPCs) during the process of ovarian differentiation, histology and ultrastructure of tilapia (Sarotherodon niloticus) ovaries were investigated from 10 to 50 days ... ...

    Abstract In order to examine the initial appearance and development of the steroid producing cells (SPCs) during the process of ovarian differentiation, histology and ultrastructure of tilapia (Sarotherodon niloticus) ovaries were investigated from 10 to 50 days after hatching. In gonads of fry at 23-26 days after hatching, initial ovarian differentiation was confirmed by the differentiation of stromal aggregations in the proximal and distal region of the gonad on the side facing the lateral wall. This represents the initial formation of the ovarian cavity. At the same time as ovarian differentiation, a few large cells appeared initially in the vicinity of blood vessels. They have some of the ultrastructural features characteristic of SPCs such as a moderate number of mitochondria with tubular cristae, a large amount of smooth endoplasmic reticulum and many free ribosomes. Based on these ultrastructural criteria, together with the present finding that these cells further differentiated into the typical SPCs at older stages, these cells were identified as SPCs. Thereafter, by 30-50 days, SPCs increased gradually in number in the area enclosing the blood vessels of ovaries. The increase in SPCs coincided with the development of germ cells, including the multiplication of oogonia and the transformation from oogonia to oocytes.
    Language English
    Publishing date 2023-06-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1111/j.1440-169X.1985.00701.x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 194: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Book ; Online: Mössbauer study at DSDP Hole 95-612, supplementary data to: Minai, Yoshitaka; Nakamura, Yuii; Tominaga, Takeshi (1987): A Mössbauer study of oceanic sediments from Site 612, Deep Sea Drilling Project Leg 95. In: Poag, CW; Watts, AB; et al. (eds.), Initial Reports of the Deep Sea Drilling Project (U.S. Govt. Printing Office), 95, 641-645

    Minai, Yoshitaka / Nakamura, Yuii / Tominaga, Takeshi

    1987  

    Abstract: 57Fe Mössbauer spectra of 15 oceanic sediment samples collected from Site 612 (Deep Sea Drilling Project Leg 95) were recorded. These spectra showed that most of the iron in the sediments was present as high-spin, paramagnetic Fe2+ and Fe3+. The ferrous ... ...

    Abstract 57Fe Mössbauer spectra of 15 oceanic sediment samples collected from Site 612 (Deep Sea Drilling Project Leg 95) were recorded. These spectra showed that most of the iron in the sediments was present as high-spin, paramagnetic Fe2+ and Fe3+. The ferrous iron was mainly distributed in terrigenous clays and biogenic carbonates. The variation of the Mössbauer parameters for Fe2+ with sub-bottom depth suggests that the main Fe2+-bearing component changed with geologic time. The amount of iron in each iron-bearing phase as estimated from the corresponding peak areas in the spectra also changed with depth. These variations in the Mössbauer parameters and peak areas are correlated with lithologic changes in the sediment column.
    Language English
    Dates of publication 1987-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.2973/dsdp.proc.95.126.1987
    DOI 10.1594/PANGAEA.788510
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article ; Online: Enantioselective total syntheses of (S)-phosphonothrixin and unexpected cyclic derivative (S)-cyclic phosphonothrixin via enzymatic resolution.

    Nakamura, Koki / Matsushima, Yoshitaka

    Bioscience, biotechnology, and biochemistry

    2022  Volume 87, Issue 2, Page(s) 138–147

    Abstract: S)-Phosphonothrixin is a phosphonate natural product produced by Saccharothrix sp. ST-888 that exhibits herbicidal activity. The previously reported asymmetric synthesis of (S)-phosphonothrixin is laborious and difficult to reproduce. In this study, we ... ...

    Abstract (S)-Phosphonothrixin is a phosphonate natural product produced by Saccharothrix sp. ST-888 that exhibits herbicidal activity. The previously reported asymmetric synthesis of (S)-phosphonothrixin is laborious and difficult to reproduce. In this study, we developed a scalable and concise enantioselective total synthesis of (S)-phosphonothrixin via two different synthetic routes by the enzymatic resolution of a known racemic epoxy alcohol. The second-generation synthesis was more efficient in terms of the overall yield (15%) and the number of steps (7) and afforded a unique cyclic phosphonate (phostone) as the product of the C-P bond formation reaction, which was converted to (S)-cyclic phosphonothrixin. Both (S)-phosphonothrixin and (S)-cyclic phosphonothrixin induced chlorosis in the plant Arabidopsis thaliana. However, (S)-cyclic phosphonothrixin exhibited lower activity than (S)-phosphonothrixin owing to its fixed conformation, as evidenced by a structure-activity relationship study. This study paves the way for the elucidation of the detailed mode of action of (S)-phosphonothrixin.
    MeSH term(s) Stereoisomerism ; Structure-Activity Relationship ; Organophosphonates/chemistry ; Ethanol
    Chemical Substances phosphonothrixin ; Organophosphonates ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2022-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1093/bbb/zbac188
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4647: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue.

    Okano, Yuji / Kase, Yoshitaka / Suematsu, Yu / Nakamura, Masaya / Okano, Hideyuki

    Inflammation and regeneration

    2024  Volume 44, Issue 1, Page(s) 10

    Abstract: Inflammatory responses are known to suppress neural regeneration in patients receiving stem cell-based regenerative therapy for spinal cord injury (SCI). Consequently, pathways involved in neurogenesis and immunomodulation, such as the hepatocyte growth ... ...

    Abstract Inflammatory responses are known to suppress neural regeneration in patients receiving stem cell-based regenerative therapy for spinal cord injury (SCI). Consequently, pathways involved in neurogenesis and immunomodulation, such as the hepatocyte growth factor (HGF)/MET signaling cascade, have garnered significant attention. Notably, various studies, including our own, have highlighted the enhanced recovery of locomotor functions achieved in SCI animal models by combining HGF pretreatment and human induced stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC) transplantation. However, these studies implicitly hypothesized that the functionality of HGF in SCI would be time consistent and did not elucidate its dynamics. In the present article, we investigated the time-course of the effect of HGF on SCI, aiming to uncover a more precise mechanism for HGF administration, which is indispensable for developing crystallizing protocols for combination therapy. To this end, we performed a detailed investigation of the temporal variation of HGF using the RNA-seq data we obtained in our most recent study. Leveraging the time-series design of the data, which we did not fully exploit previously, we identified three components in the effects of HGF that operate at different times: early effects, continuous effects, and delayed effects. Our findings suggested a concept where the three components together contribute to the acceleration of neurogenesis and immunomodulation, which reinforce the legitimacy of empirically fine-tuned protocols for HGF administration and advocate the novel possibility that the time-inconsistent effects of HGF progressively augment the efficacy of combined therapy.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-024-00322-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2929: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Protocol to combine brain sections from multiple mice into a single block for spatial transcriptomic analyses.

    Sei, Yoshitaka J / Chaumeil, Myriam M / Nakamura, Ken

    STAR protocols

    2023  Volume 4, Issue 4, Page(s) 102617

    Abstract: Spatial transcriptomics couples visual spatial markers with gene expression levels, but slide space and cost limit the number of samples that can be processed. Here, we present a protocol for mounting brains from multiple mice onto a single capture area ... ...

    Abstract Spatial transcriptomics couples visual spatial markers with gene expression levels, but slide space and cost limit the number of samples that can be processed. Here, we present a protocol for mounting brains from multiple mice onto a single capture area of a spatial transcriptomics slide. We describe steps for conjoining frozen hippocampal sections from different brains into a single cryostat block, reducing the quantity of reagents required. This protocol is applicable to a range of existing spatial genomics platforms. For complete details on the use and execution of this protocol, please refer to Li et al. (2023).
    MeSH term(s) Animals ; Mice ; Gene Expression Profiling ; Transcriptome/genetics ; Brain ; Genomics ; Hippocampus
    Language English
    Publishing date 2023-09-23
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102617
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  8. Article ; Online: Direct effect of 2-palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal-derived astrocytes.

    Tsuboi, Misato / Nakamura, Yoshitaka / Sakuma, Hiroshi

    FEBS open bio

    2023  Volume 13, Issue 7, Page(s) 1320–1332

    Abstract: Breast milk contains constituents, such as 1,3-dioleoyl-2-palmitoylglycerol (OPO), that are beneficial for infants. Herein, we hypothesized that 2-palmitoyl glycerol (2-PG), a derivative of OPO, is advantageous to infants' development. Gamma aminobutyric ...

    Abstract Breast milk contains constituents, such as 1,3-dioleoyl-2-palmitoylglycerol (OPO), that are beneficial for infants. Herein, we hypothesized that 2-palmitoyl glycerol (2-PG), a derivative of OPO, is advantageous to infants' development. Gamma aminobutyric acid (GABA) is a major neurotransmitter involved in neural development. Although GABA is generally known to be produced in neurons, astrocytes can also produce it in immature brains. In this study, we used expression analysis techniques to show that 2-PG upregulates the mRNA and protein expression of glutamate decarboxylases (GAD1 and GAD2) in normal human fetal-derived astrocytes. Our data suggest that 2-PG promotes GABA synthesis in astrocytes, which may contribute to brain development because GABA is involved in neural development in the developing brain. This may help to elucidate the mechanism by which breast milk affects infant brain development.
    MeSH term(s) Infant ; Female ; Humans ; Pregnancy ; Astrocytes/metabolism ; Neurons/metabolism ; Brain/metabolism ; gamma-Aminobutyric Acid/pharmacology ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances palmitoyl glycerol (U9H9OM3S75) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2651702-4
    ISSN 2211-5463 ; 2211-5463
    ISSN (online) 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.13649
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  9. Article ; Online: Protocol to combine brain sections from multiple mice into a single block for spatial transcriptomic analyses

    Yoshitaka J. Sei / Myriam M. Chaumeil / Ken Nakamura

    STAR Protocols, Vol 4, Iss 4, Pp 102617- (2023)

    2023  

    Abstract: Summary: Spatial transcriptomics couples visual spatial markers with gene expression levels, but slide space and cost limit the number of samples that can be processed. Here, we present a protocol for mounting brains from multiple mice onto a single ... ...

    Abstract Summary: Spatial transcriptomics couples visual spatial markers with gene expression levels, but slide space and cost limit the number of samples that can be processed. Here, we present a protocol for mounting brains from multiple mice onto a single capture area of a spatial transcriptomics slide. We describe steps for conjoining frozen hippocampal sections from different brains into a single cryostat block, reducing the quantity of reagents required. This protocol is applicable to a range of existing spatial genomics platforms.For complete details on the use and execution of this protocol, please refer to Li et al. (2023).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
    Keywords Genomics ; Neuroscience ; Biotechnology and Bioengineering ; Science (General) ; Q1-390
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Direct effect of 2‐palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal‐derived astrocytes

    Misato Tsuboi / Yoshitaka Nakamura / Hiroshi Sakuma

    FEBS Open Bio, Vol 13, Iss 7, Pp 1320-

    2023  Volume 1332

    Abstract: Breast milk contains constituents, such as 1,3‐dioleoyl‐2‐palmitoylglycerol (OPO), that are beneficial for infants. Herein, we hypothesized that 2‐palmitoyl glycerol (2‐PG), a derivative of OPO, is advantageous to infants' development. Gamma aminobutyric ...

    Abstract Breast milk contains constituents, such as 1,3‐dioleoyl‐2‐palmitoylglycerol (OPO), that are beneficial for infants. Herein, we hypothesized that 2‐palmitoyl glycerol (2‐PG), a derivative of OPO, is advantageous to infants' development. Gamma aminobutyric acid (GABA) is a major neurotransmitter involved in neural development. Although GABA is generally known to be produced in neurons, astrocytes can also produce it in immature brains. In this study, we used expression analysis techniques to show that 2‐PG upregulates the mRNA and protein expression of glutamate decarboxylases (GAD1 and GAD2) in normal human fetal‐derived astrocytes. Our data suggest that 2‐PG promotes GABA synthesis in astrocytes, which may contribute to brain development because GABA is involved in neural development in the developing brain. This may help to elucidate the mechanism by which breast milk affects infant brain development.
    Keywords 1,3‐dioleoyl‐2‐palmitoylglycerol ; astrocytes ; brain development ; breast milk ; gamma aminobutyric acid metabolism ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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