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Article: Development and characterization of microsatellites in Vanda varieties

LIM, A / YUE, G.H / LIM-HO, C.L / HONG, Y

Molecular ecology notes. 2007 May, v. 7, no. 3

2007

Abstract: The orchid genus Vanda includes more than 70 monopodial species and numerous hybrids. The aim ... microsatellite markers were isolated from the variety Vanda Miss Joaquim and were characterized in four Vanda ... species, 11 Vanda hybrids, and one Aranda intergenus hybrid. Populations from three species were also ...

Abstract	The orchid genus Vanda includes more than 70 monopodial species and numerous hybrids. The aim of this study was to develop microsatellite markers for this horticultural valuable genus. Thirteen polymorphic microsatellite markers were isolated from the variety Vanda Miss Joaquim and were characterized in four Vanda species, 11 Vanda hybrids, and one Aranda intergenus hybrid. Populations from three species were also analysed. Number of alleles ranged from two to 19. For the V. sumatrana population, the expected heterozygosity ranged from 0 to 0.76 (mean 0.31) and the observed heterozygosity ranged from 0 to 1 (mean 0.36). All the varieties tested were distinct from one another (similarity index < 0.8). These microsatellites could be used for studying genetic diversity and population structure of wild populations within the orchid genus Vanda, as well as for distinguishing cultured Vanda varieties.
Keywords	Orchidaceae ; genetic variation ; microsatellite repeats ; Vanda
Language	English
Dates of publication	2007-05
Size	p. 461-463.
Publisher	Blackwell Publishing Ltd
Publishing place	Oxford, UK
Document type	Article
ZDB-ID	2051527-3
ISSN	1471-8278
ISSN	1471-8278
DOI	10.1111/j.1471-8286.2006.01618.x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Acceptability of Digital Technology and Tele-Exercise in the Age of COVID-19: Cross-sectional Study.

Ho, Vanda / Merchant, Reshma A

JMIR aging

2022 Volume 5, Issue 2, Page(s) e33165

Abstract: Background: With the COVID-19 pandemic, telehealth has been increasingly used to offset the negative outcomes of social isolation and functional decline in older adults. Crucial to the success of telehealth is end user adoption.: Objective: This ... ...

Abstract	Background: With the COVID-19 pandemic, telehealth has been increasingly used to offset the negative outcomes of social isolation and functional decline in older adults. Crucial to the success of telehealth is end user adoption. Objective: This study aims to investigate perception and acceptability of digital technology among Asian older adults. Methods: The Healthy Ageing Promotion Program for You (HAPPY) dual-task exercise was conducted virtually to participants aged ≥60 years. Questionnaires were administered digitally and collected data on demographics, perceptions of digital technology and evaluation of HAPPY, the 6-item Lubben Social Network Scale, intrinsic capacity using the Integrated Care for Older People tool, and a functional screening with the FRAIL scale and five chair rises. Descriptive analysis was used. Results: A total of 42 participants were digitally interviewed. The mean age was 69.1 (4.7) years. Hearing, vision, and 3-item recall difficulty were present in 14% (n=6), 12% (n=5), and 24% (n=10) of participants, respectively. Of the participants, 29% (n=12) had possible sarcopenia and 14% (n=6) were prefrail. Around 24% (n=10) were at risk of social isolation. Most of the participants (n=38, 91%) agreed that technology is good, and 79% (n=33) agreed that technology would allow them to be independent for longer. Over three-quarters of participants (n=33, 79%) agreed that they have the necessary knowledge, and 91% (n=38) had technological assistance available. However, 57% (n=24) were still apprehensive about using technology. Despite 71% (n=30) of older adults owning their devices, 36% (n=15) felt finances were limiting. Through digital HAPPY, 45% (n=19) of participants reported feeling stronger, 48% (n=20) had improved spirits, and 40% (n=17) and 38% (n=16) had improved mood and memory, respectively. Conclusions: The majority of older adults in this study believed in digital technology and had the necessary knowledge and help, but almost half still felt apprehensive and had financial barriers to adopting technology. A digitally administered exercise program especially in a group setting is a feasible option to enhance intrinsic capacity in older adults. However, more work is needed in elucidating sources of apprehension and financial barriers to adopting technology.
Language	English
Publishing date	2022-04-13
Publishing country	Canada
Document type	Journal Article
ISSN	2561-7605
ISSN (online)	2561-7605
DOI	10.2196/33165
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Article ; Online: Patterns of improvement in functional ability and predictors of responders to dual-task exercise: A latent class analysis.

Ho, Vanda / Chan, Yiong Huak / Merchant, Reshma Aziz

Frontiers in public health

2023 Volume 10, Page(s) 1069970

Abstract: Background: Exercise is the pillar for healthy aging. "Non-responders" may be due to a mismatch in exercise prescription. A latent cluster analysis (LCA) profile can be useful to uncover subpopulations sharing similar profiles or outcomes. We aim to use ...

Abstract	Background: Exercise is the pillar for healthy aging. "Non-responders" may be due to a mismatch in exercise prescription. A latent cluster analysis (LCA) profile can be useful to uncover subpopulations sharing similar profiles or outcomes. We aim to use the LCA to develop a response prediction model for older adults who would benefit from The Healthy Aging Promotion Program for You, a community-embedded dual-task exercise program. Methods: A total of 197 participants completed the 3-month follow-up, and the complete data were available for 136 community-dwelling older adults. Inclusion criteria were age ≥60 years, pre-frail or frail and ambulant, mild cognitive impairment, and ability to provide consent. Data collected include demographics, education, falls, physical function (Katz ADL scale and Lawton's IADL scale), physical activity (rapid assessment of physical activity), cognition (Montreal Cognitive Assessment; MoCA), frailty (FRAIL scale), and perceived health, pain, anxiety/depression, fear of falling, and social isolation (Lubben Social Network Scale). The body mass index (BMI), handgrip strength, and short physical performance battery (SPPB) were measured. Those who improved in frailty, anxiety/depression, pain, Lubben, MoCA, SPPB, fear-of-falling, physical activity, falls, and HGS were classified as responders. Results: The mean age was 74.7 years, BMI 23.5 kg/m Conclusion: Response to dual-task exercise was influenced by age, SPPB, BMI, and cognition. Prospective longitudinal studies are needed to validate this LCA model and guide the development of public health strategies.
MeSH term(s)	Humans ; Male ; Aged ; Middle Aged ; Female ; Frailty ; Frail Elderly/psychology ; Hand Strength ; Latent Class Analysis ; Prospective Studies ; Accidental Falls/prevention & control ; Fear ; Exercise/psychology
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.1069970
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Article ; Online: Reproductive factors and risk of physical frailty among Chinese women living in Singapore.

Ho, Vanda W T / Chua, Kevin Yiqiang / Song, Xingyue / Jin, Aizhen / Koh, Woon-Puay

The journal of nutrition, health & aging

2024 Volume 28, Issue 6, Page(s) 100226

Abstract: Setting: Although age at menopause has been linked to higher risk of physical frailty in later life, little is known about other reproductive factors.: Objectives: Our study aimed to investigate the associations between 1) age at menarche, 2) age at ... ...

Abstract	Setting: Although age at menopause has been linked to higher risk of physical frailty in later life, little is known about other reproductive factors. Objectives: Our study aimed to investigate the associations between 1) age at menarche, 2) age at natural menopause, 3) duration of reproductive period, 4) number of children, 5) use of oral contraceptives (OCP), and 6) use of hormone replacement therapy (HRT) with the risk of physical frailty in late life. Design: We used data from 5934 women of the Singapore Chinese Health Study who experienced natural menopause, and participated in the third follow-up interviews when physical frailty was assessed. Logistic regression was used to evaluate association of reproductive factors evaluated during baseline and prior follow-up interviews with physical frailty at follow-up 3. Participants: Community-dwelling Chinese women living in Singapore. Participants had a mean age of 52.6 years at baseline (1993-1998), and a mean age of 72.8 years during the third follow-up (2014-2017). Measurements: Sociodemographic characteristics, level of education, smoking history, physical activity, and history of physician-diagnosed comorbidities were collected. Participants' weight and height were self-reported. We used a modified Cardiovascular Health Study phenotype to assess physical frailty. Results: Age at menarche was inversely associated with the likelihood of physical frailty (P Conclusions: In our population-based cohort of Chinese women, younger ages at menarche and menopause were associated with higher likelihood of physical frailty in later life.
Language	English
Publishing date	2024-04-08
Publishing country	France
Document type	Journal Article
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1016/j.jnha.2024.100226
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Article ; Online: Digitally administered SARC-F or the 5-time chair rise: Which is better?

Ho, Vanda Wen-Teng / Merchant, Reshma A

Geriatrics & gerontology international

2021 Volume 21, Issue 10, Page(s) 964–966

MeSH term(s)	Aged ; Cross-Sectional Studies ; Geriatric Assessment ; Humans ; Mass Screening ; Sarcopenia ; Surveys and Questionnaires
Language	English
Publishing date	2021-08-11
Publishing country	Japan
Document type	Letter
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14261
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The "Iron Tale"- iron indices and handgrip strength in community-dwelling adults.

Ho, Vanda / Lee, Chun-Tsu / Merchant, Reshma A

Aging clinical and experimental research

2022 Volume 34, Issue 12, Page(s) 3025–3032

Abstract: Sarcopenia is a precursor for physical frailty and is associated with adverse outcomes. Low handgrip strength (HGS) is one of the diagnostic criteria for sarcopenia. Multiple factors can influence muscle quality, including muscle composition, ... ...

Abstract	Sarcopenia is a precursor for physical frailty and is associated with adverse outcomes. Low handgrip strength (HGS) is one of the diagnostic criteria for sarcopenia. Multiple factors can influence muscle quality, including muscle composition, architecture, fat infiltration, fibrosis, excessive iron deposition, and neural activation. There is limited evidence on the association of iron and HGS in community-dwelling older adults. We aim to examine the association of HGS with iron indices and inflammation. The Healthy Older People Everyday study is a subset of the Singapore Population Health Studies cohort. Complete cross-sectional data and iron indices were available for 477 participants. Sociodemographics, comorbidities, and final scores of the FRAIL scale, Barthel Index, Lawton Scale, HGS, and timed-up-and-go were collected and analyzed. Laboratory parameters including hemoglobin, hsCRP and iron indices were measured. The mean age of the participants was 70.9 ± 5.0 years, 258(54.1%) were females, and most were of Chinese(85.3%) ethnicity. Amongst the participants, 6.9% were frail, 39.4% were pre-frailt, and 53.7% were robust. Mean HGS was 22.2 ± 7.0 kg. Low HGS was prevalent in 47.8%, the highest amongst Indians. Prevalence of diabetes, chronic kidney disease, and ischaemic heart disease were significantly higher in those with low HGS. In multivariate regression adjusting for age, sex, comorbidities and Hb, ferritin (β = 0.004 95%CI 0.0002-0.007, p = 0.04), transferrin saturation (β = 0.06 95%CI 0.01-0.10, p = 0.02) and hsCRP (β = - 0.15 95%CI - 0.26 to - 0.04, p < 0.01) were significantly associated with HGS. CRP was negatively associated with HGS, whereas ferritin and transferrin saturation were positively associated with HGS. Older people with iron deficiency should be assessed for sarcopenia, and vice versa, as both can occur in multisystemic disorder, and need to be managed concurrently. Prospective longitudinal studies and clinical trials may be required to establish the causal effect of iron deficiency on muscle strength and sarcopenia and the benefits of iron therapy to improve function and quality of life.
MeSH term(s)	Female ; Humans ; Aged ; Male ; Hand Strength/physiology ; Sarcopenia ; Independent Living ; Cross-Sectional Studies ; Prospective Studies ; Iron ; Quality of Life ; C-Reactive Protein ; Muscle Strength ; Ferritins ; Hemoglobins ; Transferrins
Chemical Substances	Iron (E1UOL152H7) ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) ; Hemoglobins ; Transferrins
Language	English
Publishing date	2022-09-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-022-02242-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Patterns of improvement in functional ability and predictors of responders to dual-task exercise

Ho, Vanda / Chan, Yiong Huak / Merchant, Reshma Aziz

Front Public Health

A latent class analysis

2023

Abstract: BACKGROUND: Exercise is the pillar for healthy aging. “Non-responders” may be due to a mismatch in exercise prescription. A latent cluster analysis (LCA) profile can be useful to uncover subpopulations sharing similar profiles or outcomes. We aim to use ... ...

Abstract	BACKGROUND: Exercise is the pillar for healthy aging. “Non-responders” may be due to a mismatch in exercise prescription. A latent cluster analysis (LCA) profile can be useful to uncover subpopulations sharing similar profiles or outcomes. We aim to use the LCA to develop a response prediction model for older adults who would benefit from The Healthy Aging Promotion Program for You, a community-embedded dual-task exercise program. METHODS: A total of 197 participants completed the 3-month follow-up, and the complete data were available for 136 community-dwelling older adults. Inclusion criteria were age ≥60 years, pre-frail or frail and ambulant, mild cognitive impairment, and ability to provide consent. Data collected include demographics, education, falls, physical function (Katz ADL scale and Lawton's IADL scale), physical activity (rapid assessment of physical activity), cognition (Montreal Cognitive Assessment; MoCA), frailty (FRAIL scale), and perceived health, pain, anxiety/depression, fear of falling, and social isolation (Lubben Social Network Scale). The body mass index (BMI), handgrip strength, and short physical performance battery (SPPB) were measured. Those who improved in frailty, anxiety/depression, pain, Lubben, MoCA, SPPB, fear-of-falling, physical activity, falls, and HGS were classified as responders. RESULTS: The mean age was 74.7 years, BMI 23.5 kg/m(2), 23.5% were male, 96.3% were of Chinese ethnicity, 61% were pre-frail, education level of 4.3 years, and the MoCA score of 23.3 ± 4.8. Two clusters were identified: non-responders (61.8%) and responders (38.2%). Responders had significant improvement in cognition (44.2% vs. 0, p < 0.001) and SPPB (gait:28.8% vs. 0, p < 0.001; balance:42.3% vs. 15.5%, p = 0.001; chair-stand:65.4% vs. 4.8%, p < 0.001). Responders were significantly older (76.9 vs. 73.3 years, p = 0.005), had higher BMI (24.8 vs. 22.8 kg/m(2), p = 0.007), lower education (3.4 vs. 4.9 years, p = 0.021), lower MoCA scores (21.8 vs. 24.3, p = 0.002), and lower SPPB scores ...
Keywords	Public Health
Subject code	796
Language	English
Publishing date	2023-01-09
Publisher	Frontiers Media S.A.
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Drug interactions with potential antivirals used for COVID-19 in older persons.

Ho, Vanda / Tee, Caroline / See, Kay Choong

Geriatrics & gerontology international

2020 Volume 20, Issue 7, Page(s) 737–739

MeSH term(s)	Aged ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Betacoronavirus ; COVID-19 ; Chronic Disease/drug therapy ; Chronic Disease/epidemiology ; Comorbidity ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Drug Interactions ; Humans ; Inappropriate Prescribing/prevention & control ; Medication Therapy Management/standards ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Potentially Inappropriate Medication List ; SARS-CoV-2
Chemical Substances	Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2020-07-21
Publishing country	Japan
Document type	Letter
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.13970
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Article ; Online: Cumulative Effect of Visual Impairment, Multimorbidity, and Frailty on Intrinsic Capacity in Community-Dwelling Older Adults.

Ho, Vanda W T / Chen, Cynthia / Merchant, Reshma Aziz

Journal of aging and health

2019 Volume 32, Issue 7-8, Page(s) 670–676

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Activities of Daily Living ; Aged ; Aged, 80 and over ; Cognition/physiology ; Female ; Frailty/diagnosis ; Frailty/psychology ; Geriatric Assessment/methods ; Humans ; Independent Living/psychology ; Male ; Mental Status and Dementia Tests ; Multimorbidity ; Prevalence ; Quality of Life ; Vision Disorders/diagnosis ; Vision Disorders/psychology
Language	English
Publishing date	2019-05-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1045392-1
ISSN	1552-6887 ; 0898-2643
ISSN (online)	1552-6887
ISSN	0898-2643
DOI	10.1177/0898264319847818
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Article: Drug interactions with potential antivirals used for COVID‐19 in older persons

Ho, Vanda / Tee, Caroline / Kay Choong, See

Geriatrics and Gerontology International

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #656085
Database	COVID19

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