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  1. Article ; Online: In vitro diagnostic testing for drug allergy in children.

    Saretta, Francesca / Tomei, Leonardo / Mori, Francesca / Mayorga, Cristobalina

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 4, Page(s) e13955

    Abstract: Diagnosing Drug Hypersensitivity Reactions (DHRs) could be a complicated process especially in children, since allergic-like manifestation at this age is more often the expression of concomitant infections rather than a actual DHRs. In vivo tests are ... ...

    Abstract Diagnosing Drug Hypersensitivity Reactions (DHRs) could be a complicated process especially in children, since allergic-like manifestation at this age is more often the expression of concomitant infections rather than a actual DHRs. In vivo tests are usually suggested as a first step; however, prick and intradermal tests could be painful and have shown different sensitivity and specificity among published studies. In some cases, in vivo tests such as Drug Provocation test (DPT) could be even contraindicated. Therefore, the need for in vitro testing is compelling, to add useful information along the diagnostic pathway and to limit the need of DPT. In this review, we analyze the different types of in vitro tests, focusing on those used more widely such as specific IgE and on those that are still for research settings, such as basophil activation test and lymphocyte transformation test, but that have shown some useful diagnostic potential.
    MeSH term(s) Humans ; Child ; Drug Hypersensitivity/diagnosis ; Hypersensitivity/diagnosis ; Basophil Degranulation Test ; Sensitivity and Specificity ; In Vitro Techniques ; Skin Tests
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3096: Show issues Location:
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  2. Article ; Online: Drug provocation tests in children: All that glitters is not gold.

    Moral, Luis / Mori, Francesca

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 8, Page(s) e14002

    Abstract: A proper allergy work-up, based on the gold standard drug provocation test (DPT), usually rules out suspected drug hypersensitivity in children. These tests are generally open, given their high efficiency compared with double-blind placebo-controlled ... ...

    Abstract A proper allergy work-up, based on the gold standard drug provocation test (DPT), usually rules out suspected drug hypersensitivity in children. These tests are generally open, given their high efficiency compared with double-blind placebo-controlled DPTs. Although their negative predictive value is excellent, no studies have calculated their positive predictive value, highly dependent on the prevalence of the disease. Most studies have found a rate of <5%-10% of true beta-lactam hypersensitivity in children. Given this low prevalence (pre-test probability), a few false-positive results can significantly reduce the estimated positive predictive value. False positives may arise from the nocebo effect during the test, including nocebo by proxy, or from observer bias, which depends on professional expertise and organizational circumstances. Some studies have found a high rate of tolerance on a second DPT in children who failed the first, but these results may be affected by the interval between the two tests, of a year or more in most cases, reflecting a loss of hypersensitivity over time. Taking into account the low rate of positive DPTs, with commonly mild reactions, we suggest confirming nonsevere positive DPTs with a second provocation performed soon after the first, especially in the case of beta-lactam antibiotics, in order to improve the diagnostic accuracy, de-label more patients, and achieve a better estimation of true drug hypersensitivity prevalence. In case of mild immediate reactions, the potential benefits of a second DPT should be carefully weighed against the risk of anaphylaxis.
    MeSH term(s) Child ; Humans ; Anaphylaxis/diagnosis ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Immune Tolerance ; Monobactams ; Double-Blind Method
    Chemical Substances diphenylthiosulfinate (1208-20-4) ; Monobactams
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.14002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: A survey-based study on diagnosis and management of vernal keratoconjunctivitis.

    Leonardi, Andrea / Mori, Francesca / Ghiglioni, Daniele Giovanni

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 5, Page(s) e13962

    MeSH term(s) Humans ; Conjunctivitis, Allergic/diagnosis ; Conjunctivitis, Allergic/therapy ; Surveys and Questionnaires
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13962
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Molecules Inducing Dental Stem Cells Differentiation and Bone Regeneration: State of the Art.

    Ariano, Anastasia / Posa, Francesca / Storlino, Giuseppina / Mori, Giorgio

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Teeth include mesenchymal stem cells (MSCs), which are multipotent cells that promote tooth growth and repair. Dental tissues, specifically the dental pulp and the dental bud, constitute a relevant source of multipotent stem cells, known as dental- ... ...

    Abstract Teeth include mesenchymal stem cells (MSCs), which are multipotent cells that promote tooth growth and repair. Dental tissues, specifically the dental pulp and the dental bud, constitute a relevant source of multipotent stem cells, known as dental-derived stem cells (d-DSCs): dental pulp stem cells (DPSCs) and dental bud stem cells (DBSCs). Cell treatment with bone-associated factors and stimulation with small molecule compounds are, among the available methods, the ones who show excellent advantages promoting stem cell differentiation and osteogenesis. Recently, attention has been paid to studies on natural and non-natural compounds. Many fruits, vegetables, and some drugs contain molecules that can enhance MSC osteogenic differentiation and therefore bone formation. The purpose of this review is to examine research work over the past 10 years that has investigated two different types of MSCs from dental tissues that are attractive targets for bone tissue engineering: DPSCs and DBSCs. The reconstruction of bone defects, in fact, is still a challenge and therefore more research is needed; the articles reviewed are meant to identify compounds useful to stimulate d-DSC proliferation and osteogenic differentiation. We only consider the results of the research which is encouraging, assuming that the mentioned compounds are of some importance for bone regeneration.
    MeSH term(s) Osteogenesis ; Bone Regeneration ; Cell Differentiation ; Mesenchymal Stem Cells/metabolism ; Stem Cells/metabolism ; Dental Pulp ; Cells, Cultured ; Cell Proliferation
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129897
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  5. Article ; Online: Molecules Inducing Dental Stem Cells Differentiation and Bone Regeneration

    Anastasia Ariano / Francesca Posa / Giuseppina Storlino / Giorgio Mori

    International Journal of Molecular Sciences, Vol 24, Iss 9897, p

    State of the Art

    2023  Volume 9897

    Abstract: Teeth include mesenchymal stem cells (MSCs), which are multipotent cells that promote tooth growth and repair. Dental tissues, specifically the dental pulp and the dental bud, constitute a relevant source of multipotent stem cells, known as dental- ... ...

    Abstract Teeth include mesenchymal stem cells (MSCs), which are multipotent cells that promote tooth growth and repair. Dental tissues, specifically the dental pulp and the dental bud, constitute a relevant source of multipotent stem cells, known as dental-derived stem cells (d-DSCs): dental pulp stem cells (DPSCs) and dental bud stem cells (DBSCs). Cell treatment with bone-associated factors and stimulation with small molecule compounds are, among the available methods, the ones who show excellent advantages promoting stem cell differentiation and osteogenesis. Recently, attention has been paid to studies on natural and non-natural compounds. Many fruits, vegetables, and some drugs contain molecules that can enhance MSC osteogenic differentiation and therefore bone formation. The purpose of this review is to examine research work over the past 10 years that has investigated two different types of MSCs from dental tissues that are attractive targets for bone tissue engineering: DPSCs and DBSCs. The reconstruction of bone defects, in fact, is still a challenge and therefore more research is needed; the articles reviewed are meant to identify compounds useful to stimulate d-DSC proliferation and osteogenic differentiation. We only consider the results of the research which is encouraging, assuming that the mentioned compounds are of some importance for bone regeneration.
    Keywords dental stem cells ; mesenchymal stem cells ; dental pulp stem cells ; dental bud stem cells ; bone regeneration ; osteogenic differentiation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Exosomes: Potential Next-Generation Nanocarriers for the Therapy of Inflammatory Diseases.

    Mori, Tosca / Giovannelli, Lisa / Bilia, Anna Rita / Margheri, Francesca

    Pharmaceutics

    2023  Volume 15, Issue 9

    Abstract: Inflammatory diseases are common pathological processes caused by various acute and chronic factors, and some of them are autoimmune diseases. Exosomes are fundamental extracellular vesicles secreted by almost all cells, which contain a series of ... ...

    Abstract Inflammatory diseases are common pathological processes caused by various acute and chronic factors, and some of them are autoimmune diseases. Exosomes are fundamental extracellular vesicles secreted by almost all cells, which contain a series of constituents, i.e., cytoskeletal and cytosolic proteins (actin, tubulin, and histones), nucleic acids (mRNA, miRNA, and DNA), lipids (diacylglycerophosphates, cholesterol, sphingomyelin, and ceramide), and other bioactive components (cytokines, signal transduction proteins, enzymes, antigen presentation and membrane transport/fusion molecules, and adhesion molecules). This review will be a synopsis of the knowledge on the contribution of exosomes from different cell sources as possible therapeutic agents against inflammation, focusing on several inflammatory diseases, neurological diseases, rheumatoid arthritis and osteoarthritis, intestinal bowel disease, asthma, and liver and kidney injuries. Current knowledge indicates that the role of exosomes in the therapy of inflammation and in inflammatory diseases could be distinctive. The main limitations to their clinical translation are still production, isolation, and storage. Additionally, there is an urgent need to personalize the treatments in terms of the selection of exosomes; their dosages and routes of administration; and a deeper knowledge about their biodistribution, type and incidence of adverse events, and long-term effects of exosomes. In conclusion, exosomes can be a very promising next-generation therapeutic option, superior to synthetic nanocarriers and cell therapy, and can represent a new strategy of effective, safe, versatile, and selective delivery systems in the future.
    Language English
    Publishing date 2023-09-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15092276
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  7. Article: Ovine Mesenchymal Stem Cell Chondrogenesis on a Novel 3D-Printed Hybrid Scaffold In Vitro.

    De Mori, Arianna / Heyraud, Agathe / Tallia, Francesca / Blunn, Gordon / Jones, Julian R / Roncada, Tosca / Cobb, Justin / Al-Jabri, Talal

    Bioengineering (Basel, Switzerland)

    2024  Volume 11, Issue 2

    Abstract: This study evaluated the use of silica/poly(tetrahydrofuran)/poly(ε-caprolactone) ( ... ...

    Abstract This study evaluated the use of silica/poly(tetrahydrofuran)/poly(ε-caprolactone) (SiO
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering11020112
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  8. Article ; Online: Rapid response of generalized pustular psoriasis to treatment with risankizumab. A therapeutic option for a difficult-to-treat disease.

    May Lee, Marco / Fantini, Carolina / Mori, Emma / Feliciani, Claudio / Satolli, Francesca

    Italian journal of dermatology and venereology

    2023  Volume 158, Issue 4, Page(s) 377–378

    MeSH term(s) Humans ; Psoriasis/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Exanthema/drug therapy
    Chemical Substances risankizumab (90ZX3Q3FR7) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-05-17
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.23.07600-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Acute FPIES and DIES: is a G lacking?

    Novembre, Elio / Giovannini, Mattia / Catamerò, Francesco / Liccioli, Giulia / Sarti, Lucrezia / Barni, Simona / Mori, Francesca

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1185196

    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1185196
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  10. Article ; Online: From the Global Initiative for Asthma report and asthma guidelines to real-life asthma control: is there room for improvement?

    Novembre, Elio / Giovannini, Mattia / Barni, Simona / Mori, Francesca

    Italian journal of pediatrics

    2022  Volume 48, Issue 1, Page(s) 110

    Abstract: Available guidelines for asthma management represent an important and suitable tool to make the entire medical process evidence-based, effective, and safe for patients. Their purpose is to help doctors and patients formulate the best decisions in regard ... ...

    Abstract Available guidelines for asthma management represent an important and suitable tool to make the entire medical process evidence-based, effective, and safe for patients. Their purpose is to help doctors and patients formulate the best decisions in regard to asthma management by choosing the most appropriate strategies in each specific clinical situation.The Global Initiative for Asthma (GINA) document, together with other national and international recommendations, is one of the main documents used for asthma prevention and management in Italy, but several studies reported that these recommendations are often not applied in real-life clinical practice, which consequently results in inadequate asthma control.In this context, a substantial simplification of the GINA document and asthma guidelines may represent a feasible strategy to be pursued to ameliorate the knowledge among GPs, primary care pediatricians, and specialists taking care of children and adults with asthma.On the other hand, another critical factor that may explain unsatisfactory control of asthma is the limited importance that all recommendations place on asthma heterogeneity. In the era of personalized medicine and target therapies, phenotype-driven asthma management may become a desirable approach for optimizing the management of asthmatic patients. In addition, digital health strategies have been investigated in the literature to improve asthma monitoring and may represent a promising tool in the future from this point of view.Relevant stakeholders should continue to investigate how to optimize real-life asthma control to propose novel solutions to translate into clinical practice.
    MeSH term(s) Asthma/drug therapy ; Asthma/prevention & control ; Humans ; Italy ; Precision Medicine
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Letter
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-022-01304-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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