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Article ; Online: Response to Letter to the Editor: "Zidovudine/azidothymidine (AZT) unexpressed clinical potential against multidrug-resistant Gram negatives".

Foletto, Vitória S / da Rosa, Taciéli F / Serafin, Marissa B / Bottega, Angelita / Hörner, Rosmari

International journal of antimicrobial agents

2021 Volume 59, Issue 1, Page(s) 106501

MeSH term(s)	Anti-HIV Agents ; Zidovudine
Chemical Substances	Anti-HIV Agents ; Zidovudine (4B9XT59T7S)
Language	English
Publishing date	2021-12-18
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2021.106501
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: In-vitro antibacterial activity of omeprazole and esomeprazole in combination with ciprofloxacin as an alternative to repositioning against ESKAPE pathogens and evaluation of the cleavage capacity of plasmid DNA.

da Rosa, Taciéli F / Foletto, Vitória S / Serafin, Marissa B / de Paula, Bruno R / Franco, Laísa N / Marion, Sara de L / da Mota, Augusto D / Hörner, Rosmari

International journal of antimicrobial agents

2023 Volume 61, Issue 5, Page(s) 106753

MeSH term(s)	Omeprazole/pharmacology ; Esomeprazole/pharmacology ; Ciprofloxacin/pharmacology ; Proton Pump Inhibitors/pharmacology ; Anti-Bacterial Agents/pharmacology ; DNA ; Plasmids
Chemical Substances	Omeprazole (KG60484QX9) ; Esomeprazole (N3PA6559FT) ; Ciprofloxacin (5E8K9I0O4U) ; Proton Pump Inhibitors ; Anti-Bacterial Agents ; DNA (9007-49-2)
Language	English
Publishing date	2023-02-10
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.106753
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Repositioning of non-antibiotic drugs as an alternative to microbial resistance: a systematic review.

Foletto, Vitória S / da Rosa, Taciéli F / Serafin, Marissa B / Bottega, Angelita / Hörner, Rosmari

International journal of antimicrobial agents

2021 Volume 58, Issue 3, Page(s) 106380

Abstract: The global spread of microbial resistance coupled with high costs and slow pace in the discovery of a new antibiotic have made drug repositioning an attractive and promising alternative in the treatment of infections caused by multidrug resistant (MDR) ... ...

Abstract	The global spread of microbial resistance coupled with high costs and slow pace in the discovery of a new antibiotic have made drug repositioning an attractive and promising alternative in the treatment of infections caused by multidrug resistant (MDR) microorganisms. The reuse involves the production of compounds with lower costs and development time, using diversified production technologies. The present systematic review aimed to present a selection of studies published in the last 20 years, which report the antimicrobial activity of non-antibiotic drugs that are candidates for repositioning, which could be used against the current microbial multidrug resistance. A search was performed in the PubMed, SciELO and Google Scholar databases using the following search strategies: [(drug repurposing) OR (drug repositioning) OR (repositioning) AND (non-antibiotic) AND (antibacterial activity) AND (antimicrobial activity)]. Overall, 112 articles were included, which explored the antimicrobial activity in antidepressants, antihypertensives, anti-inflammatories, antineoplastics, hypoglycemic agents, among other drugs. It was concluded that they have significant antimicrobial activity in vitro and in vivo, against standard strain and clinical isolates (Gram-negative and Gram-positive) and fungi. When associated with antibacterials, most of these drugs had their antibacterial activity enhanced. It was also a consensus of the studies included in this review that the presence of aromatic rings in the molecular structure contributes to antimicrobial activity. This review highlights the potential repositioning of several classes of non-antibiotic drugs as promising candidates for repositioning in the treatment of severe bacterial infections of MDR bacteria, extensively resistant (XDR) and pan-resistant (PDR) to drugs.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Bacterial Infections/drug therapy ; Drug Repositioning ; Drug Resistance, Multiple, Bacterial/drug effects ; Humans ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2021-06-22
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2021.106380
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Repositioning of Benzodiazepine Drugs and Synergistic Effect with Ciprofloxacin Against ESKAPE Pathogens.

da Rosa, Taciéli F / Serafin, Marissa B / Foletto, Vitória S / Franco, Laísa N / de Paula, Bruno R / Fuchs, Luana B / Calegari, Luciano / Hörner, Rosmari

Current microbiology

2023 Volume 80, Issue 5, Page(s) 160

Abstract: Infectious diseases are among the leading causes of morbidity and mortality worldwide. Combating them becomes more complex when caused by the pathogens of the ESKAPE group, which are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, ... ...

Abstract	Infectious diseases are among the leading causes of morbidity and mortality worldwide. Combating them becomes more complex when caused by the pathogens of the ESKAPE group, which are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. The purpose of this study was to investigate the repositioning potential of the benzodiazepines clonazepam and diazepam individually and in combination with the antibacterial ciprofloxacin against ESKAPE. The minimum inhibitory concentration and minimum bactericidal concentration against seven American Type Culture Collection (ATCC) reference standard strains and 64 ESKAPE clinical isolates were determined. In addition, the interaction with ciprofloxacin was determined by the checkerboard method and fractional inhibitory concentration index (FICI) of clonazepam against 11 ESKAPE and diazepam against five ESKAPE. We also list the results found and their clinical significance. Benzodiazepines showed similar antibacterial activity against Gram-positive and Gram-negative. The checkerboard and FICI results showed a synergistic effect of these drugs when associated with ciprofloxacin against almost all tested isolates. Viewing the clinical cases studied, benzodiazepines have potential as treatment alternatives. The results allow us to conclude that clonazepam and diazepam, when in combination with ciprofloxacin, have promising activity against ESKAPE, therefore, assuming the position of candidates for repositioning.
MeSH term(s)	Ciprofloxacin/pharmacology ; Benzodiazepines/pharmacology ; Clonazepam ; Drug Repositioning ; Anti-Bacterial Agents/pharmacology ; Diazepam
Chemical Substances	Ciprofloxacin (5E8K9I0O4U) ; Benzodiazepines (12794-10-4) ; Clonazepam (5PE9FDE8GB) ; Anti-Bacterial Agents ; Diazepam (Q3JTX2Q7TU)
Language	English
Publishing date	2023-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-023-03242-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1446: Show issues

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Article ; Online: Repositioning of Benzodiazepine Drugs and Synergistic Effect with Ciprofloxacin Against ESKAPE Pathogens

da Rosa, Taciéli F. / Serafin, Marissa B. / Foletto, Vitória S. / Franco, Laísa N. / de Paula, Bruno R. / Fuchs, Luana B. / Calegari, Luciano / Hörner, Rosmari

Curr Microbiol. 2023 May, v. 80, no. 5 p.160-160

2023

Abstract	Infectious diseases are among the leading causes of morbidity and mortality worldwide. Combating them becomes more complex when caused by the pathogens of the ESKAPE group, which are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. The purpose of this study was to investigate the repositioning potential of the benzodiazepines clonazepam and diazepam individually and in combination with the antibacterial ciprofloxacin against ESKAPE. The minimum inhibitory concentration and minimum bactericidal concentration against seven American Type Culture Collection (ATCC) reference standard strains and 64 ESKAPE clinical isolates were determined. In addition, the interaction with ciprofloxacin was determined by the checkerboard method and fractional inhibitory concentration index (FICI) of clonazepam against 11 ESKAPE and diazepam against five ESKAPE. We also list the results found and their clinical significance. Benzodiazepines showed similar antibacterial activity against Gram-positive and Gram-negative. The checkerboard and FICI results showed a synergistic effect of these drugs when associated with ciprofloxacin against almost all tested isolates. Viewing the clinical cases studied, benzodiazepines have potential as treatment alternatives. The results allow us to conclude that clonazepam and diazepam, when in combination with ciprofloxacin, have promising activity against ESKAPE, therefore, assuming the position of candidates for repositioning.
Keywords	Acinetobacter baumannii ; Enterobacter ; Enterococcus faecium ; Klebsiella pneumoniae ; Pseudomonas aeruginosa ; Staphylococcus aureus ; antibacterial properties ; ciprofloxacin ; diazepam ; minimum inhibitory concentration ; mortality ; reference standards ; synergism
Language	English
Dates of publication	2023-05
Size	p. 160.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-023-03242-y
Database	NAL-Catalogue (AGRICOLA)

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Article: Repositioning of non-antibiotic drugs as an alternative to microbial resistance: a systematic review

Foletto, Vitória S. / da Rosa, Taciéli F. / Serafin, Marissa B. / Bottega, Angelita / Hörner, Rosmari

International journal of antimicrobial agents. 2021 Sept., v. 58, no. 3

2021

Abstract	The global spread of microbial resistance coupled with high costs and slow pace in the discovery of a new antibiotic have made drug repositioning an attractive and promising alternative in the treatment of infections caused by multidrug resistant (MDR) microorganisms. The reuse involves the production of compounds with lower costs and development time, using diversified production technologies. The present systematic review aimed to present a selection of studies published in the last 20 years, which report the antimicrobial activity of non-antibiotic drugs that are candidates for repositioning, which could be used against the current microbial multidrug resistance. A search was performed in the PubMed, SciELO and Google Scholar databases using the following search strategies: [(drug repurposing) OR (drug repositioning) OR (repositioning) AND (non-antibiotic) AND (antibacterial activity) AND (antimicrobial activity)]. Overall, 112 articles were included, which explored the antimicrobial activity in antidepressants, antihypertensives, anti-inflammatories, antineoplastics, hypoglycemic agents, among other drugs. It was concluded that they have significant antimicrobial activity in vitro and in vivo, against standard strain and clinical isolates (Gram-negative and Gram-positive) and fungi. When associated with antibacterials, most of these drugs had their antibacterial activity enhanced. It was also a consensus of the studies included in this review that the presence of aromatic rings in the molecular structure contributes to antimicrobial activity. This review highlights the potential repositioning of several classes of non-antibiotic drugs as promising candidates for repositioning in the treatment of severe bacterial infections of MDR bacteria, extensively resistant (XDR) and pan-resistant (PDR) to drugs.
Keywords	antibacterial properties ; antibiotics ; antihypertensive agents ; chemical structure ; multiple drug resistance ; systematic review
Language	English
Dates of publication	2021-09
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2021.106380
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Repositioning of antidepressant drugs and synergistic effect with ciprofloxacin against multidrug-resistant bacteria.

Foletto, Vitória S / da Rosa, Taciéli F / Serafin, Marissa B / Bottega, Angelita / Franco, Laísa N / de Paula, Bruno R / Hörner, Rosmari

World journal of microbiology & biotechnology

2021 Volume 37, Issue 3, Page(s) 53

Abstract: The repositioning of drugs has been shown to be an advantageous alternative for treating diseases caused by multidrug-resistant (MDR) microorganisms. The study aimed to investigate the in vitro antibacterial activity of the antidepressants fluoxetine and ...

Abstract	The repositioning of drugs has been shown to be an advantageous alternative for treating diseases caused by multidrug-resistant (MDR) microorganisms. The study aimed to investigate the in vitro antibacterial activity of the antidepressants fluoxetine and paroxetine alone and in combination with the antibacterial ciprofloxacin against standard strains and clinical isolates to explore the repositioning of these drugs in severe bacterial infections. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), tolerance level, fractional inhibitory concentration index (FICI) and interaction of antidepressants with the ciprofloxacin antibiotic were determined using the Checkerboard method against six American Type Culture Collection (ATCC) standard strains and seventy MDR clinical isolates. Both antidepressants showed better antibacterial activity than ciprofloxacin, in addition to being separately bactericidal against all tested Gram-negative and Gram-positive strains. When associated with ciprofloxacin, fluoxetine and paroxetine exhibited significant synergism compared to seventy ciprofloxacin-resistant clinical isolates, demonstrating that these antidepressants were able to increase the antibacterial activity of the antibiotic by eight times. The combination of antidepressants with ciprofloxacin showed relatively better activity against Acinetobacter baumannii, Enterococcus faecium and Klebsiella pneumoniae, strains in which the FICI value obtained was 0.008. The MDR isolates tested in this study ratify the antibacterial properties of the non-antibiotic fluoxetine and paroxetine. In addition, synergism when associated with ciprofloxacin is an alternative for treating serious infections in hospitalized patients. However, additional in vivo studies must be conducted to elucidate the mechanisms of action of these drugs.
MeSH term(s)	Acinetobacter Infections ; Acinetobacter baumannii/drug effects ; Anti-Bacterial Agents/pharmacology ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Bacterial Infections ; Ciprofloxacin/pharmacology ; Drug Repositioning/methods ; Drug Resistance, Multiple, Bacterial/drug effects ; Humans ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Antidepressive Agents ; Ciprofloxacin (5E8K9I0O4U)
Language	English
Publishing date	2021-02-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1499109-3
ISSN	1573-0972 ; 0959-3993
ISSN (online)	1573-0972
ISSN	0959-3993
DOI	10.1007/s11274-021-03016-3
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Article: Drug repositioning is an alternative for the treatment of coronavirus COVID-19

Serafin, Marissa B / Bottega, Angelita / Foletto, Vitória S / da Rosa, Taciéli F / Hörner, Andreas / Hörner, Rosmari

International journal of antimicrobial agents. 2020,

2020

Abstract: Given the extreme importance of the current pandemic caused by COVID-19, and as scientists agree there is no identified pharmacological treatment, where possible, therapeutic alternatives are raised through drug repositioning. This paper presents a ... ...

Abstract	Given the extreme importance of the current pandemic caused by COVID-19, and as scientists agree there is no identified pharmacological treatment, where possible, therapeutic alternatives are raised through drug repositioning. This paper presents a selection of studies involving drugs from different pharmaceutical classes with activity against SARS-CoV-2 and SARS-CoV, with the potential for use in the treatment of COVID-19 disease.
Keywords	Coronavirus infections ; Severe acute respiratory syndrome coronavirus ; anti-infective agents ; drugs ; pandemic ; therapeutics ; covid19
Language	English
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2020.105969
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Amlodipine Repositioning: Scientific Studies and Synergistic Effects.

Coelho, Silvana S / da Rosa, Taciéli F / Rampelotto, Roberta F / Serafin, Marissa B / Bottega, Angelita / Foletto, Vitória S / Machado, Catrine S / Hörner, Rosmari

American journal of therapeutics

2019 Volume 28, Issue 6, Page(s) e772–e776

Language	English
Publishing date	2019-12-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1280786-2
ISSN	1536-3686 ; 1075-2765
ISSN (online)	1536-3686
ISSN	1075-2765
DOI	10.1097/MJT.0000000000001122
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Article ; Online: Drug repositioning is an alternative for the treatment of coronavirus COVID-19.

Serafin, Marissa B / Bottega, Angelita / Foletto, Vitória S / da Rosa, Taciéli F / Hörner, Andreas / Hörner, Rosmari

International journal of antimicrobial agents

2020 Volume 55, Issue 6, Page(s) 105969

Abstract	Given the extreme importance of the current pandemic caused by COVID-19, and as scientists agree there is no identified pharmacological treatment, where possible, therapeutic alternatives are raised through drug repositioning. This paper presents a selection of studies involving drugs from different pharmaceutical classes with activity against SARS-CoV-2 and SARS-CoV, with the potential for use in the treatment of COVID-19 disease.
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; COVID-19 ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Drug Repositioning/methods ; Humans ; Hydroxychloroquine/therapeutic use ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Teicoplanin/therapeutic use ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Hydroxychloroquine (4QWG6N8QKH) ; Teicoplanin (61036-62-2) ; Chloroquine (886U3H6UFF) ; Alanine (OF5P57N2ZX)
Keywords	covid19
Language	English
Publishing date	2020-04-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2020.105969
Database	MEDical Literature Analysis and Retrieval System OnLINE

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