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  1. Article ; Online: The valley of death: why Australia failed to develop clinically effective drugs in COVID-19.

    Martin, Jennifer H

    Internal medicine journal

    2023  Volume 53, Issue 12, Page(s) 2175–2179

    Abstract: There is a paucity of public discussion of costs spent on drug trials during coronavirus disease 2019 (COVID-19) and their value, and of large public outlay on research funding for vaccine and drug development that did not deliver medicines nor vaccines ... ...

    Abstract There is a paucity of public discussion of costs spent on drug trials during coronavirus disease 2019 (COVID-19) and their value, and of large public outlay on research funding for vaccine and drug development that did not deliver medicines nor vaccines for Australians. This oversight left us at the behest of global supply chains, politics and commercial cost-plus pricing for vaccines. It is possible that these outcomes were the result of some major cognitive biases and the failure of a clinical pharmacologist's voice in the leadership teams. Biases included unawareness of the complexities of taking interesting chemicals in vitro to development into therapeutic use that can be tolerated, show efficacy and have appropriate disposition in humans; lack of a systems approach to therapeutic development; and an understanding of the relevance and translatability of pharmacology, physiology and clinical drug development. We believe that reflecting on and addressing these biases will help Australia reposition itself better with a therapeutics and clinical trial strategy for future pandemics, built into the strategy of a Centre for Disease Control.
    MeSH term(s) Humans ; Australia/epidemiology ; COVID-19 ; Vaccines ; COVID-19 Drug Treatment ; Antiviral Agents ; Drug Development
    Chemical Substances Vaccines ; Antiviral Agents
    Language English
    Publishing date 2023-12-05
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.16260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 792: Show issues Location:
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    Zs.MO 424: Show issues

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  2. Article ; Online: Phenotype versus genotype to optimize cancer dosing in the clinical setting-focus on 5-fluorouracil and tyrosine kinase inhibitors.

    Martin, Jennifer H / Galettis, Peter / Flynn, Alex / Schneider, Jennifer

    Pharmacology research & perspectives

    2024  Volume 12, Issue 2, Page(s) e1182

    Abstract: Cancer medicines often have narrow therapeutic windows; toxicity can be severe and sometimes fatal, but inadequate dose intensity reduces efficacy and survival. Determining the optimal dose for each patient is difficult, with body-surface area used most ... ...

    Abstract Cancer medicines often have narrow therapeutic windows; toxicity can be severe and sometimes fatal, but inadequate dose intensity reduces efficacy and survival. Determining the optimal dose for each patient is difficult, with body-surface area used most commonly for chemotherapy and flat dosing for tyrosine kinase inhibitors, despite accumulating evidence of a wide range of exposures in individual patients with many receiving a suboptimal dose with these strategies. Therapeutic drug monitoring (measuring the drug concentration in a biological fluid, usually plasma) (TDM) is an accepted and well validated method to guide dose adjustments for individual patients to improve this. However, implementing TDM in routine care has been difficult outside a research context. The development of genotyping of various proteins involved in drug elimination and activity has gained prominence, with several but not all Guideline groups recommending dose reductions for particular variant genotypes. However, there is increasing concern that dosing recommendations are based on limited data sets and may lead to unnecessary underdosing and increased cancer mortality. This Review discusses the evidence surrounding genotyping and TDM to guide decisions around best practice.
    MeSH term(s) Humans ; Fluorouracil ; Tyrosine Kinase Inhibitors ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/chemically induced ; Phenotype ; Genotype
    Chemical Substances Fluorouracil (U3P01618RT) ; Tyrosine Kinase Inhibitors
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.1182
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  3. Article: Editorial: Therapeutic drug monitoring and clinical toxicology of anti-cancer drugs, volume II.

    Yan, Miao / Liu, Yao / Martin, Jennifer H

    Frontiers in oncology

    2023  Volume 13, Page(s) 1153714

    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1153714
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  4. Article ; Online: Effect of pharmaceutical regulatory policy on health impact.

    Martin, Jennifer H

    British journal of clinical pharmacology

    2020  Volume 86, Issue 12, Page(s) 2335–2337

    MeSH term(s) Drug Costs ; Drug and Narcotic Control ; Health Policy ; Humans ; Pharmaceutical Preparations ; Pharmacovigilance
    Chemical Substances Pharmaceutical Preparations
    Keywords covid19
    Language English
    Publishing date 2020-06-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.14390
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1118: Show issues Location:
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  5. Article ; Online: Critical insights to COVID-19 disease and potential treatments using a systems analysis approach that integrates physiology, pharmacology, and clinical pharmacology.

    Martin, Jennifer H / Head, Richard J

    Pharmacology research & perspectives

    2022  Volume 10, Issue 1, Page(s) e00918

    MeSH term(s) COVID-19 ; Humans ; Pharmacology, Clinical ; SARS-CoV-2 ; Systems Analysis
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.918
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  6. Article: Reporting adverse drug events to the Therapeutic Goods Administration.

    Martin, Jennifer H / Lucas, Catherine

    Australian prescriber

    2021  Volume 44, Issue 1, Page(s) 2–3

    Language English
    Publishing date 2021-02-01
    Publishing country Australia
    Document type Editorial
    ZDB-ID 1075442-8
    ISSN 0312-8008
    ISSN 0312-8008
    DOI 10.18773/austprescr.2020.077
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    Zs.A 3233: Show issues Location:
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  7. Article ; Online: Reply to: Sea-level rise may not uniformly accelerate cliff erosion rates.

    Shadrick, Jennifer R / Rood, Dylan H / Hurst, Martin D

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 8486

    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Letter
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44150-w
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  8. Article ; Online: Pharmacology Research & Perspectives: A Decade of Progress.

    Jarvis, Michael F / Davies, Emily / Martin, Jennifer H

    Pharmacology research & perspectives

    2022  Volume 11, Issue 1, Page(s) e01057

    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.1057
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  9. Article ; Online: Editorial

    Miao Yan / Yao Liu / Jennifer H. Martin

    Frontiers in Oncology, Vol

    Therapeutic drug monitoring and clinical toxicology of anti-cancer drugs, volume II

    2023  Volume 13

    Keywords therapeutic drug monitoring ; clinical toxicology ; anti-cancer drugs ; editorial ; precision medicine ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Complementary and alternative therapies in the palliative setting.

    Martin, Jennifer H / Patel, Joanne

    Internal medicine journal

    2022  Volume 52, Issue 10, Page(s) 1677–1684

    Abstract: Complementary and alternative medicine (CAM) encompasses a wide range of medication, herbal, dietary and physical therapies that are not usually considered within the realm of conventional therapeutics. Approximately two thirds of the Australian ... ...

    Abstract Complementary and alternative medicine (CAM) encompasses a wide range of medication, herbal, dietary and physical therapies that are not usually considered within the realm of conventional therapeutics. Approximately two thirds of the Australian population use CAMs and only around half of this number will discuss their use of these products with their doctor. Clinical use is commonly seen in patients with life-limiting illness, often because they experience a high burden of symptoms. However, it is also the case that many of these therapies do not have demonstrated efficacy, particularly for the often broad list of conditions and symptoms for which they are chosen to be used. Further, depending on whether they are sold as medications, sold as food supplements or imported illegally and distributed via nonstandard therapeutic channels, several products have had reports of toxicity, severe adverse effects, batch irregularities and drug interactions with other therapies. This awareness, together with lack of standardisation of products and lack of interchangeability between brands has made prescribers unwilling to put patients at risk of harm by supporting their use. In this article, we cover general pharmacological principles around use of a small selection of chemicals used in a medical setting to enable some guidance for use.
    MeSH term(s) Humans ; Australia/epidemiology ; Complementary Therapies ; Dietary Supplements ; Palliative Care
    Language English
    Publishing date 2022-09-28
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15922
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 792: Show issues Location:
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