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Article ; Online: Utilizing 4D Printing to Design Smart Gastroretentive, Esophageal, and Intravesical Drug Delivery Systems.

Mahmoud, Dina B / Schulz-Siegmund, Michaela

2023 Volume 12, Issue 10, Page(s) e2202631

Abstract: The breakthrough of 3D printing in biomedical research has paved the way for the next evolutionary step referred to as four dimensional (4D) printing. This new concept utilizes the time as the fourth dimension in addition to the x, y, and z axes with the ...

Abstract	The breakthrough of 3D printing in biomedical research has paved the way for the next evolutionary step referred to as four dimensional (4D) printing. This new concept utilizes the time as the fourth dimension in addition to the x, y, and z axes with the idea to change the configuration of a printed construct with time usually in response to an external stimulus. This can be attained through the incorporation of smart materials or through a preset smart design. The 4D printed constructs may be designed to exhibit expandability, flexibility, self-folding, self-repair or deformability. This review focuses on 4D printed devices for gastroretentive, esophageal, and intravesical delivery. The currently unmet needs and challenges for these application sites are tried to be defined and reported on published solution concepts involving 4D printing. In addition, other promising application sites that may similarly benefit from 4D printing approaches such as tracheal and intrauterine drug delivery are proposed.
MeSH term(s)	Drug Delivery Systems/instrumentation ; Drug Delivery Systems/methods ; Printing, Three-Dimensional ; Time Factors
Language	English
Publishing date	2023-01-18
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202202631
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Article ; Online: Fabrication of 3D Printed, Core-and-Shell Implants as Controlled Release Systems for Local siRNA Delivery.

Mahmoud, Dina B / Wölk, Christian / Schulz-Siegmund, Michaela

Advanced healthcare materials

2023 Volume 12, Issue 31, Page(s) e2301643

Abstract: The development and clinical translation of small interfering RNA (siRNA) therapies remains challenging owing to their poor pharmacokinetics. 3D printing technology presents a great opportunity to fabricate personalized implants for local and sustained ... ...

Abstract	The development and clinical translation of small interfering RNA (siRNA) therapies remains challenging owing to their poor pharmacokinetics. 3D printing technology presents a great opportunity to fabricate personalized implants for local and sustained delivery of siRNA. Hydrogels can mimic the mechanical properties of tissues, avoiding the problems associated with rigid implants. Herein, a thermoresponsive composite hydrogel suitable for extrusion 3D-printing is formulated to fabricate controlled-release implants loaded with siRNA-Lipofectamine RNAiMAX complexes. A hydrogel matrix mainly composed of uncharged agarose to protect siRNA from decomplexation is selected. Additionally, pluronic F127 and gelatin are added to improve the printability, degradation, and cell adhesion to the implants. To avoid exposing siRNA to thermal stress during the printing process, a core-and-shell design is set up for the implants in which a core of siRNA-complexes loaded-pluronic F127 is printed without heat and enclosed with a shell comprising the thermoresponsive composite hydrogel. The release profile of siRNA-complexes is envisioned to be controlled by varying the printing patterns. The results reveal that the implants sustain siRNA release for one month. The intactness of the released siRNA-complexes is proven until the eighth day. Furthermore, by changing the printing patterns, the release profiles can be tailored.
MeSH term(s)	RNA, Small Interfering ; Delayed-Action Preparations ; Poloxamer ; Printing, Three-Dimensional ; Hydrogels
Chemical Substances	RNA, Small Interfering ; Delayed-Action Preparations ; Poloxamer (106392-12-5) ; Hydrogels
Language	English
Publishing date	2023-09-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202301643
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Article ; Online: Photodynamic therapy fortified with topical oleyl alcohol-based transethosomal 8-methoxypsoralen for ameliorating vitiligo: Optimization and clinical study.

Mahmoud, Dina B / ElMeshad, Aliaa N / Fadel, Maha / Tawfik, Abeer / Ramez, Shahenda A

International journal of pharmaceutics

2022 Volume 614, Page(s) 121459

Abstract: Vitiligo is a common autoimmune skin disorder that is characterized by patchy depigmentation of the skin due to melanocytes and melanin loss. Herein, photodynamic therapy mediated 8-methoxypsoralen (8-MOP), has been used fortified with topical oleyl ... ...

Abstract	Vitiligo is a common autoimmune skin disorder that is characterized by patchy depigmentation of the skin due to melanocytes and melanin loss. Herein, photodynamic therapy mediated 8-methoxypsoralen (8-MOP), has been used fortified with topical oleyl alcohol-based transethosomes; to overcome the poor solubility and adverse effects associated with 8-MOP oral delivery. A 2
MeSH term(s)	Administration, Cutaneous ; Drug Delivery Systems ; Fatty Alcohols ; Humans ; Methoxsalen ; Photochemotherapy ; Skin ; Vitiligo/drug therapy
Chemical Substances	Fatty Alcohols ; oleyl alcohol (172F2WN8DV) ; Methoxsalen (U4VJ29L7BQ)
Language	English
Publishing date	2022-01-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2022.121459
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Article ; Online: Drug repurposing of nitazoxanide: can it be an effective therapy for COVID-19?

Mahmoud, Dina B / Shitu, Zayyanu / Mostafa, Ahmed

Journal, genetic engineering & biotechnology

2020 Volume 18, Issue 1, Page(s) 35

Abstract: ... such as coronaviruses, influenza, hepatitis C virus (HCV), hepatitis B virus (HBV), and other viruses signifying ...

Abstract	Background: The current outbreak of pandemic coronavirus disease 2019 (COVID-19) aggravates serious need for effective therapeutics. Over recent years, drug repurposing has been accomplished as an important opportunity in drug development as it shortens the time consumed for development, besides sparing the cost and the efforts exerted in the research and development process. The FDA-approved antiparasitic drug, nitazoxanide (NTZ), has been found to have antiviral activity against different viral infections such as coronaviruses, influenza, hepatitis C virus (HCV), hepatitis B virus (HBV), and other viruses signifying its potential as a broad spectrum antiviral drug. Moreover, it has been recently reported that NTZ exhibited in vitro inhibition of SARS-CoV-2 at a small micromolar concentration. Additionally, NTZ suppresses the production of cytokines emphasizing its potential to manage COVID-19-induced cytokine storm. Furthermore, the reported efficacy of NTZ to bronchodilate the extremely contracted airways can be beneficial in alleviating COVID-19-associated symptoms. Short conclusion: All these findings, along with the high safety record of the drug, have gained our interest to urge conductance of clinical trials to assess the potential benefits of using it in COVID-19 patients. Thus, in this summarized article, we review the antiviral activities of NTZ and highlight its promising therapeutic actions that make the drug worth clinical trials.
Keywords	covid19
Language	English
Publishing date	2020-07-28
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2637420-1
ISSN	2090-5920 ; 1687-157X ; 2090-5920
ISSN (online)	2090-5920
ISSN	1687-157X ; 2090-5920
DOI	10.1186/s43141-020-00055-5
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Article ; Online: Drug repurposing of nitazoxanide

Dina B. Mahmoud / Zayyanu Shitu / Ahmed Mostafa

Journal of Genetic Engineering and Biotechnology, Vol 18, Iss 1, Pp 1-

can it be an effective therapy for COVID-19?

2020 Volume 10

Abstract: ... different viral infections such as coronaviruses, influenza, hepatitis C virus (HCV), hepatitis B virus (HBV ...

Abstract	Abstract Background The current outbreak of pandemic coronavirus disease 2019 (COVID-19) aggravates serious need for effective therapeutics. Over recent years, drug repurposing has been accomplished as an important opportunity in drug development as it shortens the time consumed for development, besides sparing the cost and the efforts exerted in the research and development process. Main body of the abstract The FDA-approved antiparasitic drug, nitazoxanide (NTZ), has been found to have antiviral activity against different viral infections such as coronaviruses, influenza, hepatitis C virus (HCV), hepatitis B virus (HBV), and other viruses signifying its potential as a broad spectrum antiviral drug. Moreover, it has been recently reported that NTZ exhibited in vitro inhibition of SARS-CoV-2 at a small micromolar concentration. Additionally, NTZ suppresses the production of cytokines emphasizing its potential to manage COVID-19-induced cytokine storm. Furthermore, the reported efficacy of NTZ to bronchodilate the extremely contracted airways can be beneficial in alleviating COVID-19-associated symptoms. Short conclusion All these findings, along with the high safety record of the drug, have gained our interest to urge conductance of clinical trials to assess the potential benefits of using it in COVID-19 patients. Thus, in this summarized article, we review the antiviral activities of NTZ and highlight its promising therapeutic actions that make the drug worth clinical trials.
Keywords	Broad spectrum antiviral ; Bronchodilation ; COVID-19 ; Cytokines ; Repurposed nitazoxanide ; Biotechnology ; TP248.13-248.65 ; Genetics ; QH426-470 ; covid19
Subject code	610
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Drug repurposing of nitazoxanide

Mahmoud, Dina B. / Shitu, Zayyanu / Mostafa, Ahmed

Journal of Genetic Engineering and Biotechnology

can it be an effective therapy for COVID-19?

2020 Volume 18, Issue 1

Keywords	Biotechnology ; Genetics ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ISSN	2090-5920
DOI	10.1186/s43141-020-00055-5
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers.

Mahmoud, Dina B / Afifi, Samar A / El Sayed, Nesrine S

Molecular pharmaceutics

2020 Volume 17, Issue 10, Page(s) 3952–3965

Abstract: Drug repositioning is an important drug development strategy as it saves the time and efforts exerted in drug discovery. Since reepithelization of the cornea is a critical problem, we envisioned that the anticonvulsant phenytoin sodium can promote ... ...

Abstract	Drug repositioning is an important drug development strategy as it saves the time and efforts exerted in drug discovery. Since reepithelization of the cornea is a critical problem, we envisioned that the anticonvulsant phenytoin sodium can promote reepithelization of corneal ulcers as it was repurposed for skin wound healing. Herein, our aim is to develop novel crown ether-based nanovesicles "Crownsomes" of phenytoin sodium for ocular delivery with minimal drug-induced irritation and enhanced efficacy owing to "host-guest" properties of crown ethers. Crownsomes were successfully fabricated using span-60 and 18-crown-6 and their size, morphology, polydispersity index, ζ potential, drug loading efficiency, conductivity, and drug release were characterized. Crownsomes exhibited favorable properties such as formation of spherical nanovesicles of 280 ± 18 nm and -26.10 ± 1.21 mV surface charges. Crownsomes depicted a high entrapment efficiency (77 ± 5%) with enhanced and controlled-release pattern of phenytoin sodium. The optimum crownsomes formulation ameliorated
MeSH term(s)	Administration, Ophthalmic ; Animals ; Cornea/drug effects ; Cornea/pathology ; Corneal Ulcer/chemically induced ; Corneal Ulcer/drug therapy ; Corneal Ulcer/pathology ; Crown Ethers/chemistry ; Disease Models, Animal ; Drug Carriers/chemistry ; Drug Liberation ; Drug Repositioning ; Humans ; Nanoparticles/chemistry ; Ophthalmic Solutions ; Particle Size ; Permeability ; Phenytoin/administration & dosage ; Phenytoin/adverse effects ; Phenytoin/pharmacokinetics ; Procaine/administration & dosage ; Procaine/analogs & derivatives ; Procaine/toxicity ; Rabbits ; Wound Healing/drug effects
Chemical Substances	Crown Ethers ; Drug Carriers ; Ophthalmic Solutions ; Procaine (4Z8Y51M438) ; Phenytoin (6158TKW0C5) ; 18-crown-6 (63J177NC5B) ; benoxinate (AXQ0JYM303)
Language	English
Publishing date	2020-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.0c00742
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Article ; Online: Essential Oil of Cestrum diurnum L.: GC/MS Analysis, in Vitro and in Silico Anti-HCoV-229E Effects and Inhibitory Activity against LPS-Induced Inflammation.

Bahgat, Dina M / Gad, Haidy A / Al-Sayed, Eman / Mahmoud, Sara H / Mostafa, Ahmed / Mahfouz, Nadia M / Eldahshan, Omayma A / Nasser B Singab, Abdel

Chemistry & biodiversity

2023 Volume 20, Issue 4, Page(s) e202201045

Abstract: Cestrum diurnum L. (Solanaceae) is a fragrant ornamental tree cultivated in different parts around the world. In this study, the essential oil (EO) of the aerial parts was extracted by hydrodistillation (HD), steam distillation (SD) and microwave- ... ...

Abstract	Cestrum diurnum L. (Solanaceae) is a fragrant ornamental tree cultivated in different parts around the world. In this study, the essential oil (EO) of the aerial parts was extracted by hydrodistillation (HD), steam distillation (SD) and microwave-assisted hydro-distillation (MAHD). GC/MS analysis of the three EOs revealed that phytol represents the major component in SD-EO and MAHD-EO (40.84 and 40.04 %, respectively); while in HD-EO it only represented 15.36 %. The SD-EO showed a strong antiviral activity against HCoV-229E with IC
MeSH term(s)	Cestrum/chemistry ; Coronavirus 229E, Human ; Inflammation/chemically induced ; Inflammation/drug therapy ; Interleukin-6 ; Lipopolysaccharides/pharmacology ; Molecular Docking Simulation ; Oils, Volatile/chemistry ; Plant Extracts/chemistry ; Tumor Necrosis Factor-alpha ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology
Chemical Substances	Interleukin-6 ; Lipopolysaccharides ; Oils, Volatile ; Plant Extracts ; Tumor Necrosis Factor-alpha ; Antiviral Agents
Language	English
Publishing date	2023-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202201045
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Article ; Online: Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19.

Mahmoud, Dina B / Bakr, Mohamed Mofreh / Al-Karmalawy, Ahmed A / Moatasim, Yassmin / El Taweel, Ahmed / Mostafa, Ahmed

AAPS PharmSciTech

2021 Volume 23, Issue 1, Page(s) 44

Abstract: Investigating bicelles as an oral drug delivery system and exploiting their structural benefits can pave the way to formulate hydrophobic drugs and potentiate their activity. Herein, the ability of non-ionic surfactants ( ... ...

Abstract	Investigating bicelles as an oral drug delivery system and exploiting their structural benefits can pave the way to formulate hydrophobic drugs and potentiate their activity. Herein, the ability of non-ionic surfactants (labrasol
MeSH term(s)	Antiviral Agents ; COVID-19 ; Curcumin ; Feasibility Studies ; Humans ; Micelles ; Molecular Docking Simulation ; SARS-CoV-2 ; Surface-Active Agents
Chemical Substances	Antiviral Agents ; Micelles ; Surface-Active Agents ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2021-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-021-02197-2
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Article ; Online: Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents.

Al-Sanea, Mohammad M / Hamdi, Abdelrahman / Brogi, Simone / S Tawfik, Samar / Othman, Dina I A / Elshal, Mahmoud / Ur Rahman, Hidayat / Parambi, Della G T / M Elbargisy, Rehab / Selim, Samy / Mostafa, Ehab M / Mohamed, Ahmed A B

Journal of enzyme inhibition and medicinal chemistry

2023 Volume 38, Issue 1, Page(s) 2162511

Abstract: A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles ( ...

Abstract	A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (
MeSH term(s)	Humans ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Antipyrine/pharmacology ; Celecoxib/pharmacology ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/pharmacology ; Drug Design ; Edema/drug therapy ; Molecular Docking Simulation ; Structure-Activity Relationship
Chemical Substances	Anti-Inflammatory Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Antipyrine (T3CHA1B51H) ; Celecoxib (JCX84Q7J1L) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Cyclooxygenase 2 Inhibitors
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2082578-X
ISSN	1475-6374 ; 1475-6366
ISSN (online)	1475-6374
ISSN	1475-6366
DOI	10.1080/14756366.2022.2162511
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