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  1. Article ; Online: Can antigenic drift of SARS-CoV-2 spike protein jeopardize current vaccine development?

    Senanayake, Suranga L

    2020  

    Abstract: peer-reviewed ... An effective vaccine against COVID-19 is widely considered the most promising exit strategy from the gravest pandemic in over a century. There were over 70 candidates employing diverse technology platforms as reported by the WHO in April ... ...

    Abstract peer-reviewed

    An effective vaccine against COVID-19 is widely considered the most promising exit strategy from the gravest pandemic in over a century. There were over 70 candidates employing diverse technology platforms as reported by the WHO in April 2020, most targeting the spike (S) protein/subunits of SARS-CoV-21
    Keywords Avian Influenza ; Steinerization ; covid19
    Language English
    Publisher ONMY Publishing Group
    Publishing country ie
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Drug repurposing strategies for COVID-19

    Senanayake, Suranga L

    2020  

    Abstract: peer-reviewed ... COVID-19 has now been declared a pandemic and new treatments are urgently needed as we enter a phase beyond containment. Developing new drugs from scratch is a lengthy process, thus impractical to face the immediate global challenge. Drug ...

    Abstract peer-reviewed

    COVID-19 has now been declared a pandemic and new treatments are urgently needed as we enter a phase beyond containment. Developing new drugs from scratch is a lengthy process, thus impractical to face the immediate global challenge. Drug repurposing is an emerging strategy where existing medicines, having already been tested safe in humans, are redeployed to combat difficult-to-treat diseases. While using such repurposed drugs individually may ultimately not yield a significant clinical benefit, carefully combined cocktails could be very effective, as was for HIV in the 1990s; the urgent question now being which combination.
    Keywords broad spectrum ; antiviral agents ; COVID-19 ; drug repurposing ; covid19
    Language English
    Publisher future science group
    Publishing country ie
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Drug repurposing strategies for COVID-19

    Senanayake, Suranga L.

    Future Drug Discovery

    Abstract: COVID-19 has now been declared a pandemic and new treatments are urgently needed as we enter a phase beyond containment Developing new drugs from scratch is a lengthy process, thus impractical to face the immediate global challenge Drug repurposing is an ...

    Abstract COVID-19 has now been declared a pandemic and new treatments are urgently needed as we enter a phase beyond containment Developing new drugs from scratch is a lengthy process, thus impractical to face the immediate global challenge Drug repurposing is an emerging strategy where existing medicines, having already been tested safe in humans, are redeployed to combat difficult-to-treat diseases While using such repurposed drugs individually may ultimately not yield a significant clinical benefit, carefully combined cocktails could be very effective, as was for HIV in the 1990s;the urgent question now being which combination
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #831227
    Database COVID19

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  4. Article ; Online: Overcoming nonstructural protein 15-nidoviral uridylate-specific endoribonuclease (nsp15/NendoU) activity of SARS-CoV-2

    Senanayake, Suranga L

    Abstract: COVID-19 has become the gravest global public health crisis since the Spanish Flu of 1918. Combination antiviral therapy with repurposed broad-spectrum antiviral agents holds a highly promising immediate treatment strategy, especially given uncertainties ...

    Abstract COVID-19 has become the gravest global public health crisis since the Spanish Flu of 1918. Combination antiviral therapy with repurposed broad-spectrum antiviral agents holds a highly promising immediate treatment strategy, especially given uncertainties of vaccine efficacy and developmental timeline. Here, we describe a novel hypothetical approach: combining available broad-spectrum antiviral agents such as nucleoside analogs with potential inhibitors of NendoU, for example nsp15 RNA substrate mimetics. While only hypothesis-generating, this approach may constitute a ‘double-hit’ whereby two CoV-unique protein elements of the replicase–transcriptase complex are inhibited simultaneously; this may be an Achilles' heel and precipitate lethal mutagenesis in a coronavirus. It remains to be seen whether structurally optimized RNA substrate mimetics in combination with clinically approved and repurposed backbone antivirals can synergistically inhibit this endonuclease in vitro, thus fulfilling the ‘double-hit hypothesis’.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.4155/fdd-2020-0012
    Database COVID19

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  5. Article ; Online: Overcoming nonstructural protein 15-nidoviral uridylate-specific endoribonuclease (nsp15/NendoU) activity of SARS-CoV-2

    Senanayake, Suranga L

    2020  

    Abstract: peer-reviewed ... COVID-19 has become the gravest global public health crisis since the Spanish Flu of 1918. Combination antiviral therapy with repurposed broad-spectrum antiviral agents holds a highly promising immediate treatment strategy, especially ... ...

    Abstract peer-reviewed

    COVID-19 has become the gravest global public health crisis since the Spanish Flu of 1918. Combination antiviral therapy with repurposed broad-spectrum antiviral agents holds a highly promising immediate treatment strategy, especially given uncertainties of vaccine efficacy and developmental timeline. Here, we describe a novel hypothetical approach: combining available broad-spectrum antiviral agents such as nucleoside analogs with potential inhibitors of NendoU, for example nsp15 RNA substrate mimetics. While only hypothesis-generating, this approach may constitute a ‘double-hit’ whereby two CoV-unique protein elements of the replicase–transcriptase complex are inhibited simultaneously; this may be an Achilles’ heel and precipitate lethal mutagenesis in a coronavirus. It remains to be seen whether structurally optimized RNA substrate mimetics in combination with clinically approved and repurposed backbone antivirals can synergistically inhibit this endonuclease in vitro, thus fulfilling the ‘double-hit hypothesis’.
    Keywords combination antiviral therapy ; COVID-19 ; double-hit hypothesis ; substrate mimetics ; covid19
    Language English
    Publisher future science group
    Publishing country ie
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Perception on the abortion laws in Sri Lanka: A community based study in the city of Colombo

    Suranga, M S / Silva, K T / Senanayake, L

    The Ceylon medical journal

    2016  Volume 61, Issue 4, Page(s) 171–175

    Abstract: Introduction: Abortion is legally permitted in Sri Lanka, only if it is performed to save the mother’s life. However, it is estimated that a large number of induced abortions take place in Sri Lanka. Knowledge and attitudes towards induced abortion in ... ...

    Abstract Introduction: Abortion is legally permitted in Sri Lanka, only if it is performed to save the mother’s life. However, it is estimated that a large number of induced abortions take place in Sri Lanka. Knowledge and attitudes towards induced abortion in the society are key issues influencing the policy response towards changes in the law. This study aimed to assess the knowledge and attitudes of adults towards induced abortion in Sri Lanka.
    Methods: Six Grama Niladhari Divisions (GNDs) and five to eight housing clusters from each GND were selected from Thimbirigasyaya Divisional Secretariat Division using multi stage stratified random sampling. Fifty households were systematically selected from each GND. An interview was scheduled among 743 residents aged between 19 to 49 years of age after receiving written informed consent.
    Results: Only 11% of the respondents knew the situations in which abortion was legal in Sri Lanka. Approximately one tenth of the respondents (11%) did not agree with the current law which allows an induced abortion only to save the life of the mother. However, a majority agreed to legalization of abortion for rape (65%), incest (55%) and pregnancies with lethal fetal abnormalities (53%). Less than one tenth of respondents agreed with legalisation of induced abortion for other reasons such as con-traceptive failure (6%), poor economic conditions (7%) and, on request (4%).
    Conclusions: Although the society rejects abortion on request majority are in favour of allowing abortions for rape, incest and fetuses with lethal abnormalities.
    Language English
    Publishing date 2016--30
    Publishing country Sri Lanka
    Document type Journal Article
    ZDB-ID 419365-9
    ISSN 0009-0875
    ISSN 0009-0875
    DOI 10.4038/cmj.v61i4.8384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: MicroRNA and Other Non-Coding RNAs in Epstein-Barr Virus-Associated Cancers.

    Notarte, Kin Israel / Senanayake, Suranga / Macaranas, Imee / Albano, Pia Marie / Mundo, Lucia / Fennell, Eanna / Leoncini, Lorenzo / Murray, Paul

    Cancers

    2021  Volume 13, Issue 15

    Abstract: EBV is a direct causative agent in around 1.5% of all cancers. The oncogenic properties of EBV are related to its ability to activate processes needed for cellular proliferation, survival, migration, and immune evasion. The EBV latency program is ... ...

    Abstract EBV is a direct causative agent in around 1.5% of all cancers. The oncogenic properties of EBV are related to its ability to activate processes needed for cellular proliferation, survival, migration, and immune evasion. The EBV latency program is required for the immortalization of infected B cells and involves the expression of non-coding RNAs (ncRNAs), including viral microRNAs. These ncRNAs have different functions that contribute to virus persistence in the asymptomatic host and to the development of EBV-associated cancers. In this review, we discuss the function and potential clinical utility of EBV microRNAs and other ncRNAs in EBV-associated malignancies. This review is not intended to be comprehensive, but rather to provide examples of the importance of ncRNAs.
    Language English
    Publishing date 2021-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13153909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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