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  1. Article ; Online: Evolution in treatment of acute promyelocytic leukemia: a major victory.

    Tallman, Martin S

    Haematologica

    2024  Volume 109, Issue 2, Page(s) 367–368

    MeSH term(s) Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/genetics ; Tretinoin
    Chemical Substances Tretinoin (5688UTC01R)
    Language English
    Publishing date 2024-02-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.284421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Acute leukemia

    Tallman, Martin S.

    (Hematology oncology clincis of North America ; 25,6)

    2011  

    Author's details guest ed. Martin S. Tallman
    Series title Hematology oncology clincis of North America ; 25,6
    Hematology, oncology clinics of North America
    Collection Hematology, oncology clinics of North America
    Language English
    Size XII S., S. 1119 - 1350 : Ill., graph. Darst.
    Publisher Saunders an imprint of Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT017100735
    ISBN 978-1-4557-1197-0 ; 1-4557-1197-7
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: How to avoid early mortality in acute promyelocytic leukemia.

    Odetola, Oluwatobi / Tallman, Martin S

    Hematology. American Society of Hematology. Education Program

    2023  Volume 2023, Issue 1, Page(s) 248–253

    Abstract: Acute promyelocytic leukemia (APL), a phenotypically and genotypically unique subtype of acute myeloid leukemia, has seen unprecedented advances in its management since the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide. However, the ...

    Abstract Acute promyelocytic leukemia (APL), a phenotypically and genotypically unique subtype of acute myeloid leukemia, has seen unprecedented advances in its management since the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide. However, the phenomenal pharmacologic conversion of this once highly fatal disease to one with a long-term survival exceeding 90% among patients who survive induction remains impaired by the significant incidence of early death (ED) reaching 30% in some real-world studies. The key driver for ED in APL is catastrophic hemorrhage with a proclivity for cranial sites. Most EDs in APL are currently considered preventable. Here, we discuss the concept of early death in APL and its characteristics. Importantly, we outline implementable strategies to reduce the incidence of ED. Early recognition of APL underpins these preventive measures as significant delays in the diagnosis increase the likelihood of ED. While early administration of ATRA is often taught to all hematology trainees, this lifesaving intervention is only possible if providers, including those in emergency departments and urgent/immediate care settings, are trained to have a high index of suspicion and competence to recognize the morphologic and clinical characteristics of the disease. Other proposed strategies tackle the complications that can be present at diagnosis or arise during induction therapy and address the issues of expert consultation and protocol adherence in the management of these patients. While some of these measures appear intuitive and others aspirational, widespread adoption could bring about an era of cure for almost every patient with APL.
    MeSH term(s) Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/complications ; Arsenic Trioxide/therapeutic use ; Tretinoin/therapeutic use ; Hemorrhage/complications ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances Arsenic Trioxide (S7V92P67HO) ; Tretinoin (5688UTC01R)
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2023000477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Evolution of targeted and multifunctional agents for leukemias and lymphomas

    Tallman, Martin S.

    (Seminars in hematology ; 45,3, Suppl. 2)

    2008  

    Author's details Martin S. Tallman, guest ed
    Series title Seminars in hematology ; 45,3, Suppl. 2
    Collection
    Language English
    Size S29 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT015699224
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Exciting Times in Acute Myeloid Leukemia.

    Tallman, Martin S

    Seminars in hematology

    2018  Volume 56, Issue 2, Page(s) 83

    Language English
    Publishing date 2018-09-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 206923-4
    ISSN 1532-8686 ; 0037-1963
    ISSN (online) 1532-8686
    ISSN 0037-1963
    DOI 10.1053/j.seminhematol.2019.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Acute promyelocytic leukaemia

    Tallman, Martin S.

    (Best practice & research : Clinical haematology ; 16,3)

    2003  

    Author's details guest ed. Martin S. Tallman
    Series title Best practice & research : Clinical haematology ; 16,3
    Best practice & research
    Best practice & research ; Clinical haematology
    Collection Best practice & research
    Best practice & research ; Clinical haematology
    Language English
    Size S. 347 - 543 : Ill., graph. Darst.
    Publisher Baillière Tindall
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013793523
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Incorporation of Novel therapies for the treatment of acute myeloid leukemia: a perspective.

    Waksal, Julian A / Tallman, Martin S

    Leukemia & lymphoma

    2021  Volume 62, Issue 4, Page(s) 779–790

    Abstract: Acute myeloid leukemia (AML) is a heterogeneous group of diseases that poses an array of therapeutic challenges. For decades two chemotherapeutic agents, cytarabine and daunorubicin, remained the backbone of AML therapy protocols. However, since 2017 ... ...

    Abstract Acute myeloid leukemia (AML) is a heterogeneous group of diseases that poses an array of therapeutic challenges. For decades two chemotherapeutic agents, cytarabine and daunorubicin, remained the backbone of AML therapy protocols. However, since 2017 nine novel therapies have been approved for the management of AML. With the rapid expansion of therapeutic options, hematologists must adapt their practice to optimize the benefits of these novel therapy options and minimize treatment toxicity. Here, we discuss the novel therapies that have changed the standard of care in management of patients with AML. We summarize the pivotal clinical trials that lead to the approval of these agents, and ongoing trials evaluating additional potential indications. We discuss several promising therapy candidates and their corresponding clinical trials. We discuss therapeutic strategies to incorporate these therapies into practice and pose unanswered questions that have arisen along with the expansion of treatment options.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Cytarabine/therapeutic use ; Daunorubicin/therapeutic use ; Humans ; Leukemia, Myeloid, Acute/drug therapy
    Chemical Substances Antineoplastic Agents ; Cytarabine (04079A1RDZ) ; Daunorubicin (ZS7284E0ZP)
    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2020.1842403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Arsenic trioxide as a selective anticancer agent

    Tallman, Martin S.

    rationale and clinical utility

    (Seminars in hematology ; 39,2, Suppl. 1)

    2002  

    Author's details Martin S. Tallman, guest ed
    Series title Seminars in hematology ; 39,2, Suppl. 1
    Collection
    Language English
    Size 26 S. : graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT013359231
    Database Catalogue ZB MED Medicine, Health

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  9. Book: Antibody based strategies for treatment of acute myeloid leukemia

    Tallman, Martin S.

    (Clinical lymphoma ; 2, Suppl. 1)

    2002  

    Title variant Antibody-based strategies for treatment of acute myeloid leukemia
    Author's details guest ed.: Martin S. Tallman
    Series title Clinical lymphoma ; 2, Suppl. 1
    Collection
    Language English
    Size S39 S. : graph. Darst.
    Publisher Cancer Information Group
    Publishing place Dallas, Tex
    Publishing country United States
    Document type Book
    HBZ-ID HT014198455
    Database Catalogue ZB MED Medicine, Health

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  10. Book: Advancing the treatment of hematologic malignancies through the development of targeted interventions

    Tallman, Martin S.

    (Seminars in hematology ; 39,4, Suppl. 3)

    2002  

    Author's details Martin S. Tallman, guest ed
    Series title Seminars in hematology ; 39,4, Suppl. 3
    Collection
    Keywords Leukämie ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Blutkrebs
    Language English
    Size 37 S. : graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT013527006
    Database Catalogue ZB MED Medicine, Health

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