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Article ; Online: N

Paskal, Wiktor / Paskal, Adriana M / Pietruski, Piotr / Stachura, Albert / Pełka, Kacper / Woessner, Alan E / Quinn, Kyle P / Kopka, Michał / Galus, Ryszard / Wejman, Jarosław / Włodarski, Paweł

International journal of molecular sciences

2021 Volume 22, Issue 14

Abstract: The aim of the study was to evaluate if a pre- ... ...

Abstract	The aim of the study was to evaluate if a pre-incisional
MeSH term(s)	Acetylcysteine/pharmacology ; Anesthesia, Local/methods ; Anesthetics, Local/pharmacology ; Animals ; Cicatrix/drug therapy ; Cicatrix/pathology ; Disease Models, Animal ; Drug Therapy, Combination ; Free Radical Scavengers/pharmacology ; Male ; Rats ; Rats, Sprague-Dawley ; Wound Healing/drug effects
Chemical Substances	Anesthetics, Local ; Free Radical Scavengers ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2021-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22147549
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Statistical (n,

Lewis, R / Couture, A / Liddick, S N / Spyrou, A / Bleuel, D L / Campo, L Crespo / Crider, B P / Dombos, A C / Guttormsen, M / Kawano, T / Larsen, A C / Lewis, A M / Mosby, S / Perdikakis, G / Prokop, C J / Quinn, S J / Renstrøm, T / Siem, S

The European physical journal. A, Hadrons and nuclei

2023 Volume 59, Issue 3, Page(s) 42

Abstract: Neutron-capture cross sections of neutron-rich nuclei are calculated using a Hauser-Feshbach model when direct experimental cross sections cannot be obtained. A number of codes to perform these calculations exist, and each makes different assumptions ... ...

Abstract	Neutron-capture cross sections of neutron-rich nuclei are calculated using a Hauser-Feshbach model when direct experimental cross sections cannot be obtained. A number of codes to perform these calculations exist, and each makes different assumptions about the underlying nuclear physics. We investigated the systematic uncertainty associated with the choice of Hauser-Feshbach code used to calculate the neutron-capture cross section of a short-lived nucleus. The neutron-capture cross section for Supplementary information: The online version contains supplementary material available at 10.1140/epja/s10050-023-00920-0.
Language	English
Publishing date	2023-03-09
Publishing country	France
Document type	Journal Article
ZDB-ID	1459066-9
ISSN	1434-601X ; 1434-6001
ISSN (online)	1434-601X
ISSN	1434-6001
DOI	10.1140/epja/s10050-023-00920-0
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Article: Utilizing multimodal mass spectrometry imaging for profiling immune cell composition and N-glycosylation across colorectal carcinoma disease progression.

Young, Lyndsay E A / Nietert, Paul J / Stubler, Rachel / Kittrell, Caroline G / Grimsley, Grace / Lewin, David N / Mehta, Anand S / Hajar, Chadi / Wang, Katherine / O'Quinn, Elizabeth C / Angel, Peggi M / Wallace, Kristin / Drake, Richard R

Frontiers in pharmacology

2024 Volume 14, Page(s) 1337319

Abstract: ... we conducted N-glycomic profiling using matrix-assisted laser desorption-ionization mass spectrometry imaging ... MALDI-MSI). We detected nearly 100 N-glycan species across all samples, revealing a shift in N-glycome ... profiles from normal to cancerous tissues, marked by a decrease in high mannose N-glycans. Further analysis ...

Abstract	Colorectal cancer (CRC) stands as a leading cause of death worldwide, often arising from specific genetic mutations, progressing from pre-cancerous adenomas to adenocarcinomas. Early detection through regular screening can result in a 90% 5-year survival rate for patients. However, unfortunately, only a fraction of CRC cases are identified at pre-invasive stages, allowing progression to occur silently over 10-15 years. The intricate interplay between the immune system and tumor cells within the tumor microenvironment plays a pivotal role in the progression of CRC. Immune cell clusters can either inhibit or facilitate tumor initiation, growth, and metastasis. To gain a better understanding of this relationship, we conducted N-glycomic profiling using matrix-assisted laser desorption-ionization mass spectrometry imaging (MALDI-MSI). We detected nearly 100 N-glycan species across all samples, revealing a shift in N-glycome profiles from normal to cancerous tissues, marked by a decrease in high mannose N-glycans. Further analysis of precancerous to invasive carcinomas showed an increase in pauci-mannose biantennary, and tetraantennary N-glycans with disease progression. Moreover, a distinct stratification in the N-glycome profile was observed between non-mucinous and mucinous CRC tissues, driven by pauci-mannose, high mannose, and bisecting N-glycans. Notably, we identified immune clusters of CD20
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1337319
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Article: Cardioprotective Effects of a Selective c-Jun N-terminal Kinase Inhibitor in a Rat Model of Myocardial Infarction.

Plotnikov, Mark B / Chernysheva, Galina A / Smol'yakova, Vera I / Aliev, Oleg I / Fomina, Tatyana I / Sandrikina, Lyubov A / Sukhodolo, Irina V / Ivanova, Vera V / Osipenko, Anton N / Anfinogenova, Nina D / Khlebnikov, Andrei I / Atochin, Dmitriy N / Schepetkin, Igor A / Quinn, Mark T

Biomedicines

2023 Volume 11, Issue 3

Abstract: Activation of c-Jun N-terminal kinases (JNKs) is involved in myocardial injury ...

Abstract	Activation of c-Jun N-terminal kinases (JNKs) is involved in myocardial injury, left ventricular remodeling (LV), and heart failure (HF) after myocardial infarction (MI). The aim of this research was to evaluate the effects of a selective JNK inhibitor, 11
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11030714
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Article ; Online: Novel c-Jun N-Terminal Kinase (JNK) Inhibitors with an 11

Liakhov, Serhii A / Schepetkin, Igor A / Karpenko, Olexander S / Duma, Hanna I / Haidarzhy, Nadiia M / Kirpotina, Liliya N / Kovrizhina, Anastasia R / Khlebnikov, Andrei I / Bagryanskaya, Irina Y / Quinn, Mark T

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 18

Abstract: c-Jun N-terminal kinase (JNK) plays a central role in stress signaling pathways implicated ...

Abstract	c-Jun N-terminal kinase (JNK) plays a central role in stress signaling pathways implicated in important pathological processes, including rheumatoid arthritis and ischemia-reperfusion injury. Therefore, inhibition of JNK is of interest for molecular targeted therapy to treat various diseases. We synthesized 13 derivatives of our reported JNK inhibitor 11
MeSH term(s)	Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Biological Availability ; Cell Line ; Humans ; Interleukin-6/metabolism ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; JNK Mitogen-Activated Protein Kinases/metabolism ; Lipopolysaccharides/toxicity ; Monocytes/drug effects ; Oximes/chemistry ; Oximes/pharmacology ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Quinoxalines/chemistry ; Quinoxalines/pharmacology
Chemical Substances	Anti-Inflammatory Agents ; IL6 protein, human ; Interleukin-6 ; Lipopolysaccharides ; Oximes ; Protein Isoforms ; Protein Kinase Inhibitors ; Quinoxalines ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2021-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26185688
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Article ; Online: Reactions of N

Shaloski, Michael A / Gord, Joseph R / Staudt, Sean / Quinn, Sarah L / Bertram, Timothy H / Nathanson, Gilbert M

The journal of physical chemistry. A

2017 Volume 121, Issue 19, Page(s) 3708–3719

Abstract: Gas-liquid scattering and product-yield experiments are used to investigate reactions of N ...

Abstract	Gas-liquid scattering and product-yield experiments are used to investigate reactions of N
Language	English
Publishing date	2017-05-18
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.7b02040
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Article ; Online: Blood oxidative stress biomarkers in women: influence of oral contraception, exercise, and N-acetylcysteine.

Quinn, Karlee M / Roberts, Llion / Cox, Amanda J / Borg, David N / Pennell, Evan N / McKeating, Daniel R / Fisher, Joshua J / Perkins, Anthony V / Minahan, Clare

European journal of applied physiology

2022 Volume 122, Issue 8, Page(s) 1949–1964

Abstract: ... whether N-acetylcysteine (NAC) supplementation mediates these responses.: Methods: Twenty recreationally ...

Abstract	Purpose: To compare physiological responses to submaximal cycling and sprint cycling performance in women using oral contraceptives (WomenOC) and naturally cycling women (WomenNC) and to determine whether N-acetylcysteine (NAC) supplementation mediates these responses. Methods: Twenty recreationally trained women completed five exercise trials (i.e., an incremental cycling test, a familiarisation trial, a baseline performance trial and two double-blind crossover intervention trials). During the intervention trials participants supplemented with NAC or a placebo 1 h before exercise. Cardiopulmonary parameters and blood biochemistry were assessed during 40 min of fixed-intensity cycling at 105% of gas-exchange threshold and after 1-km cycling time-trial. Results: WomenOC had higher ventilation (β [95% CI] = 0.07 L·min Conclusions: Blood biomarkers relating to oxidative stress and inflammation are elevated in WomenOC during exercise. There may be an increased strain on the endogenous antioxidant system during exercise, since NAC supplementation in WomenOC did not dampen the exercise-induced increase in malondialdehyde. Future investigations should explore the impact of elevated oxidative stress on exercise adaptations or recovery from exercise in WomenOC.
MeSH term(s)	Acetylcysteine/pharmacology ; Biomarkers ; Contraception ; Contraceptives, Oral/pharmacology ; Cross-Over Studies ; Double-Blind Method ; Female ; Humans ; Malondialdehyde ; Oxidative Stress
Chemical Substances	Biomarkers ; Contraceptives, Oral ; Malondialdehyde (4Y8F71G49Q) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2022-06-08
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-022-04964-w
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Article ; Online: Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation.

Anfinogenova, Nina D / Quinn, Mark T / Schepetkin, Igor A / Atochin, Dmitriy N

Cells

2020 Volume 9, Issue 11

Abstract: ... the release from the cellular components of the infarct core and penumbra. Increased c-Jun N-terminal kinase ...

Abstract	Neuroinflammation is involved in the progression or secondary injury of multiple brain conditions, including stroke and neurodegenerative diseases. Alarmins, also known as damage-associated molecular patterns, are released in the presence of neuroinflammation and in the acute phase of ischemia. Defensins, cathelicidin, high-mobility group box protein 1, S100 proteins, heat shock proteins, nucleic acids, histones, nucleosomes, and monosodium urate microcrystals are thought to be alarmins. They are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors. Being principal sterile inflammation triggering agents, alarmins are considered biomarkers and therapeutic targets. They are recognized by host cells and prime the innate immune system toward cell death and distress. In stroke, alarmins act as mediators initiating the inflammatory response after the release from the cellular components of the infarct core and penumbra. Increased c-Jun N-terminal kinase (JNK) phosphorylation may be involved in the mechanism of stress-induced release of alarmins. Putative crosstalk between the alarmin-associated pathways and JNK signaling seems to be inherently interwoven. This review outlines the role of alarmins/JNK-signaling in cerebral neurovascular inflammation and summarizes the complex response of cells to alarmins. Emerging anti-JNK and anti-alarmin drug treatment strategies are discussed.
MeSH term(s)	Alarmins/metabolism ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Biomarkers ; Disease Susceptibility ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Molecular Targeted Therapy ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurogenic Inflammation/etiology ; Neurogenic Inflammation/metabolism ; Neurogenic Inflammation/pathology ; Neurogenic Inflammation/therapy ; Signal Transduction/drug effects
Chemical Substances	Alarmins ; Anti-Inflammatory Agents ; Biomarkers ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2020-10-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9112350
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Article ; Online: Utilizing multimodal mass spectrometry imaging for profiling immune cell composition and N-glycosylation across colorectal carcinoma disease progression

Lyndsay E. A. Young / Paul J. Nietert / Rachel Stubler / Caroline G. Kittrell / Grace Grimsley / David N. Lewin / Anand S. Mehta / Chadi Hajar / Katherine Wang / Elizabeth C. O’Quinn / Peggi M. Angel / Kristin Wallace / Richard R. Drake

Frontiers in Pharmacology, Vol

2024 Volume 14

Abstract	Colorectal cancer (CRC) stands as a leading cause of death worldwide, often arising from specific genetic mutations, progressing from pre-cancerous adenomas to adenocarcinomas. Early detection through regular screening can result in a 90% 5-year survival rate for patients. However, unfortunately, only a fraction of CRC cases are identified at pre-invasive stages, allowing progression to occur silently over 10–15 years. The intricate interplay between the immune system and tumor cells within the tumor microenvironment plays a pivotal role in the progression of CRC. Immune cell clusters can either inhibit or facilitate tumor initiation, growth, and metastasis. To gain a better understanding of this relationship, we conducted N-glycomic profiling using matrix-assisted laser desorption-ionization mass spectrometry imaging (MALDI-MSI). We detected nearly 100 N-glycan species across all samples, revealing a shift in N-glycome profiles from normal to cancerous tissues, marked by a decrease in high mannose N-glycans. Further analysis of precancerous to invasive carcinomas showed an increase in pauci-mannose biantennary, and tetraantennary N-glycans with disease progression. Moreover, a distinct stratification in the N-glycome profile was observed between non-mucinous and mucinous CRC tissues, driven by pauci-mannose, high mannose, and bisecting N-glycans. Notably, we identified immune clusters of CD20+ B cells and CD3/CD44+ T cells distinctive and predictive with signature profiles of bisecting and branched N-glycans. These spatial N-glycan profiles offer potential biomarkers and therapeutic targets throughout the progression of CRC.
Keywords	colorectal carcinoma ; adenoma ; N-glycosylation ; imaging mass spectrometry ; spatial biology ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Novel Tryptanthrin Derivatives with Selectivity as c –Jun N–Terminal Kinase (JNK) 3 Inhibitors

Igor A. Schepetkin / Oleksander S. Karpenko / Anastasia R. Kovrizhina / Liliya N. Kirpotina / Andrei I. Khlebnikov / Stepan I. Chekal / Alevtyna V. Radudik / Maryna O. Shybinska / Mark T. Quinn

Molecules, Vol 28, Iss 4806, p

2023 Volume 4806

Abstract: The c -Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate ...

Abstract	The c -Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including cell proliferation and differentiation, cell survival, and inflammation. Because of emerging data suggesting that JNK3 may play an important role in neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease, as well as cancer pathogenesis, we sought to identify JNK inhibitors with increased selectivity for JNK3. A panel of 26 novel tryptanthrin-6-oxime analogs was synthesized and evaluated for JNK1-3 binding (K d ) and inhibition of cellular inflammatory responses. Compounds 4d (8-methoxyindolo[2,1- b ]quinazolin-6,12-dione oxime) and 4e (8-phenylindolo[2,1- b ]quinazolin-6,12-dione oxime) had high selectivity for JNK3 versus JNK1 and JNK2 and inhibited lipopolysaccharide (LPS)-induced nuclear factor-κB/activating protein 1 (NF-κB/AP-1) transcriptional activity in THP-1Blue cells and interleukin-6 (IL-6) production by MonoMac-6 monocytic cells in the low micromolar range. Likewise, compounds 4d , 4e , and pan-JNK inhibitor 4h (9-methylindolo[2,1- b ]quinazolin-6,12-dione oxime) decreased LPS-induced c -Jun phosphorylation in MonoMac-6 cells, directly confirming JNK inhibition. Molecular modeling suggested modes of binding interaction of these compounds in the JNK3 catalytic site that were in agreement with the experimental data on JNK3 binding. Our results demonstrate the potential for developing anti-inflammatory drugs based on these nitrogen-containing heterocyclic systems with selectivity for JNK3.
Keywords	anti-inflammatory ; c -Jun N-terminal kinase ; molecular docking ; nuclear factor-κB ; oxime ; selective kinase inhibitor ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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