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  1. Article ; Online: A perspective on the Festschrift of Charles A. Czeisler, PhD MD.

    Klerman, Elizabeth B / Wright, Kenneth P / Duffy, Jeanne F / Scheer, Frank A J L / Chang, Anne-Marie / Czeisler, Charles A / Rajaratnam, Shantha Mw

    Sleep health

    2024  Volume 10, Issue 1S, Page(s) S4–S10

    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2813299-3
    ISSN 2352-7226 ; 2352-7218
    ISSN (online) 2352-7226
    ISSN 2352-7218
    DOI 10.1016/j.sleh.2024.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Update on the Status and Impact of the National Eye Institute Audacious Goals Initiative for Regenerative Medicine.

    Becker, Steven M / Wright, Charles B

    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

    2020  Volume 37, Issue 3, Page(s) 144–146

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Humans ; National Eye Institute (U.S.) ; Regenerative Medicine ; Stem Cell Transplantation ; United States
    Language English
    Publishing date 2020-09-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1237021-6
    ISSN 1557-7732 ; 1080-7683
    ISSN (online) 1557-7732
    ISSN 1080-7683
    DOI 10.1089/jop.2020.0015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2099: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Variation in the anterior talofibular ligament and the impact of sex, height, weight, and age.

    Schoonover, Charles / Wright, Barth

    Clinical anatomy (New York, N.Y.)

    2023  Volume 36, Issue 5, Page(s) 830–835

    Abstract: The anterior talofibular ligament (ATFL) is one of the lateral ankle ligaments stabilizing the ankle joint, primarily involved with restricting foot supination. There has been limited research on precise ATFL anatomy and variations, and several studies ... ...

    Abstract The anterior talofibular ligament (ATFL) is one of the lateral ankle ligaments stabilizing the ankle joint, primarily involved with restricting foot supination. There has been limited research on precise ATFL anatomy and variations, and several studies have conflicting results. The objective of this study was to determine if a correlation exists between ATFL variation and sex, height, weight, and age. In this study, 15 male ankles and 24 female ankles were dissected free of overlying structures to reveal the ATFL, which was classified based on the number of fascicles. Nine of the ligaments had one fascicle, 13 had two incompletely separated fascicles, 12 had two completely separated fascicles, and three had three fascicles. Two ankles had no ATFL. Ligament length and width were measured using the program ImageJ; average length was 19.2 mm and average width was 9.59 mm. Male ligaments were longer and wider than female ligaments. A multivariate regression model was used to assess the influence of sex, height, weight, age, ligament length, and ligament width in predicting ligament variant type; these factors were determined to have no influence. This study found a large amount of ATFL variability, but no correlation between height, weight, age, ligament length, ligament width and ATFL variation. Male ligaments were longer and wider than female ligaments.
    MeSH term(s) Male ; Humans ; Female ; Cadaver ; Lateral Ligament, Ankle/anatomy & histology ; Ankle Joint/anatomy & histology ; Ankle ; Foot ; Joint Instability
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025505-9
    ISSN 1098-2353 ; 0897-3806
    ISSN (online) 1098-2353
    ISSN 0897-3806
    DOI 10.1002/ca.24056
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2592: Show issues Location:
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  4. Article ; Online: What faculty hiring committees want.

    Wright, Charles B / Vanderford, Nathan L

    Nature biotechnology

    2017  Volume 35, Issue 9, Page(s) 885–887

    Language English
    Publishing date 2017-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/nbt.3962
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
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  5. Article ; Online: Closing Kynect and Restructuring Medicaid Threaten Kentucky's Health and Economy.

    Wright, Charles B / Vanderford, Nathan L

    Journal of health politics, policy and law

    2017  Volume 42, Issue 4, Page(s) 719–737

    Abstract: Following passage of the Patient Protection and Affordable Care Act (ACA) in the United States, the Kentucky Health Benefit Exchange, Kynect, began operating in Kentucky in October 2013. Kentucky expanded Medicaid eligibility in January 2014. Together, ... ...

    Abstract Following passage of the Patient Protection and Affordable Care Act (ACA) in the United States, the Kentucky Health Benefit Exchange, Kynect, began operating in Kentucky in October 2013. Kentucky expanded Medicaid eligibility in January 2014. Together, Kynect and Medicaid expansion provided access to affordable health care coverage to hundreds of thousands of individuals in Kentucky. However, following the Kentucky gubernatorial election in 2015, the newly inaugurated governor moved to dismantle Kynect and restructure the Medicaid expansion, jeopardizing public health gains and the state economy. As the first state to announce both the closure and restructuring of a state health insurance marketplace and Medicaid expansion, Kentucky may serve as a test case for the rest of the nation for reversal of ACA-related health policies. This article describes Kynect and the Kentucky Medicaid expansion and examines the potential short-term and long-term impacts that may occur following changes in state health policy. Furthermore, this article will offer potential strategies to ameliorate the expected negative impacts of disruption of both Kynect and the Medicaid expansion, such as the creation of a new state insurance marketplace under a new governor, the implementation of a private option, and increasing the state minimum wage for workers.
    MeSH term(s) Eligibility Determination ; Health Care Reform ; Humans ; Insurance Coverage/economics ; Kentucky ; Medicaid/economics ; Medicaid/organization & administration ; Patient Protection and Affordable Care Act/economics ; United States
    Language English
    Publishing date 2017-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752966-1
    ISSN 1527-1927 ; 0361-6878
    ISSN (online) 1527-1927
    ISSN 0361-6878
    DOI 10.1215/03616878-3856163
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1972: Show issues Location:
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  6. Article ; Online: On the (Im)Practicality of Adversarial Perturbation for Image Privacy

    Rajabi Arezoo / Bobba Rakesh B. / Rosulek Mike / Wright Charles V. / Feng Wu-chi

    Proceedings on Privacy Enhancing Technologies, Vol 2021, Iss 1, Pp 85-

    2021  Volume 106

    Abstract: Image hosting platforms are a popular way to store and share images with family members and friends. However, such platforms typically have full access to images raising privacy concerns. These concerns are further exacerbated with the advent of ... ...

    Abstract Image hosting platforms are a popular way to store and share images with family members and friends. However, such platforms typically have full access to images raising privacy concerns. These concerns are further exacerbated with the advent of Convolutional Neural Networks (CNNs) that can be trained on available images to automatically detect and recognize faces with high accuracy.
    Keywords image privacy ; convolutional neural networks (cnns) ; adversarial examples ; transferable perturbations ; transparent image overlays ; Ethics ; BJ1-1725 ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Dry Age-Related Macular Degeneration Pharmacology.

    Wright, Charles B / Ambati, Jayakrishna

    Handbook of experimental pharmacology

    2016  Volume 242, Page(s) 321–336

    Abstract: Age-related macular degeneration (AMD), the most common form of irreversible blindness in the industrially developed world, can present years before a patient begins to lose vision. For most of these patients, AMD never progresses past its early stages ... ...

    Abstract Age-related macular degeneration (AMD), the most common form of irreversible blindness in the industrially developed world, can present years before a patient begins to lose vision. For most of these patients, AMD never progresses past its early stages to the advanced forms that are principally responsible for the vast majority of vision loss. Advanced AMD can manifest as either an advanced avascular form known as geographic atrophy (GA) marked by regional retinal pigment epithelium (RPE) cell death or as an advanced form known as neovascular AMD marked by the intrusion of fragile new blood vessels into the normally avascular retina. Physicians have several therapeutic interventions available to combat neovascular AMD, but GA has no approved effective therapies as of yet. In this chapter, we will discuss the current strategies for limiting dry AMD in patients. We will also discuss previous attempts at pharmacological intervention that were tested in a clinical setting and consider reasons why these putative therapeutics did not perform successfully in large-scale trials. Despite the number of unsuccessful past trials, new pharmacological interventions may succeed. These future therapies may aid millions of AMD patients worldwide.
    MeSH term(s) Clinical Trials as Topic ; Geographic Atrophy/drug therapy ; Humans ; Macular Degeneration/drug therapy ; Retinal Pigment Epithelium/pathology
    Language English
    Publishing date 2016-11-26
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2016_36
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    In stock of ZB MED Cologne/Königswinter

    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
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  8. Article ; Online: Introducing biomarkers for invasive fungal disease in haemato-oncology patients: a single-centre experience.

    Martinelli, Anthony W / Wright, Callum B / Lopes, Marta S / Swayne, Rosemary L / Krishnamurthy, Pramila / Crawley, Charles / Uttenthal, Ben / Follows, George / Babar, Judith / Aliyu, Sani H / Enoch, David A / Sander, Clare R

    Journal of medical microbiology

    2022  Volume 71, Issue 7

    Abstract: Hypothesis/Gap Statement. ...

    Abstract Hypothesis/Gap Statement.
    MeSH term(s) Antifungal Agents/therapeutic use ; Biomarkers/analysis ; Humans ; Invasive Fungal Infections/diagnosis ; Invasive Fungal Infections/drug therapy ; Mycoses/diagnosis ; Neoplasms/complications ; Prospective Studies ; Retrospective Studies
    Chemical Substances Antifungal Agents ; Biomarkers
    Language English
    Publishing date 2022-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001564
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 634: Show issues Location:
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  9. Article: The Corticosteroid Meniscectomy Trial of Extended-Release Triamcinolone Injection After Arthroscopic Partial Meniscectomy: Protocol for a Double-Blind Randomized Controlled Trial.

    Sullivan, James K / Gottreich, Julia R / Imrey, Peter B / Winalski, Carl S / Li, Xiaojuan / Spindler, Kurt P / Tomko, Patrick M / Cox, Charles L / Wright, Rick W / Jones, Morgan H

    Orthopaedic journal of sports medicine

    2023  Volume 11, Issue 4, Page(s) 23259671231150812

    Abstract: Background: Meniscal tear in older adults often accompanies knee osteoarthritis and is commonly treated with arthroscopic partial meniscectomy (APM) when patients have persistent pain after a trial of physical therapy. Cross-sectional evidence suggests ... ...

    Abstract Background: Meniscal tear in older adults often accompanies knee osteoarthritis and is commonly treated with arthroscopic partial meniscectomy (APM) when patients have persistent pain after a trial of physical therapy. Cross-sectional evidence suggests that synovitis is associated with baseline pain in this patient population, but little is known about the relationship between synovitis and postoperative recovery or progression of knee osteoarthritis.
    Purpose/hypothesis: Intra-articular extended-release triamcinolone may reduce inflammation and thereby improve outcomes and slow disease progression. This article presents the rationale behind the Corticosteroid Meniscectomy Trial (CoMeT) and describes its study design and implementation strategies.
    Study design: Randomized controlled trial.
    Methods: CoMeT is a 2-arm, 3-center, randomized placebo-controlled trial designed to establish the clinical efficacy of extended-release triamcinolone administered via intra-articular injection immediately after APM. The primary outcome is change in Knee injury and Osteoarthritis Outcome Score Pain subscore at 3-month follow-up. Synovial biopsy, joint fluid aspirate, and urine and blood sample analyses will examine the associations between various objective measures of baseline inflammation and pre- and postoperative outcome measures and clinical responses to triamcinolone intervention. Quantitative 3-T magnetic resonance imaging will evaluate cartilage and meniscal composition and 3-dimensional bone shape to detect early joint degeneration.
    Results: We discuss methodologic innovations and challenges.
    Conclusion: To our knowledge, this is the first randomized double-blind clinical trial that will analyze the effect of extended-release triamcinolone acetonide on pain, magnetic resonance imaging measures of structural change and effusion/synovitis, soluble biomarkers, and synovial tissue transcriptomics after APM.
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706251-X
    ISSN 2325-9671
    ISSN 2325-9671
    DOI 10.1177/23259671231150812
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  10. Article: Stakeholder perceptions of a new model of care for medication supply at hospital discharge.

    Wright, Sally / Morecroft, Charles W / Mullen, Rachel / Ewing, Alison B

    European journal of hospital pharmacy : science and practice

    2018  Volume 26, Issue 5, Page(s) 268–274

    Abstract: Objectives: Problems relating to patients' medication are common during hospital discharge, often resulting in unnecessary harm to patients and even hospital readmission. To overcome these issues and improve patient discharge, an evidence-based approach ...

    Abstract Objectives: Problems relating to patients' medication are common during hospital discharge, often resulting in unnecessary harm to patients and even hospital readmission. To overcome these issues and improve patient discharge, an evidence-based approach was used to develop an innovative model of care for the supply of medication at hospital discharge. The model increases pharmacy involvement, uses community pharmacies in the supply process and encourages patient follow-up after discharge. This study aimed to determine if the proposed new model of care was considered feasible and acceptable by the target population.
    Methods: This formative evaluation involved qualitative interviews and focus groups to explore the opinions of stakeholders involved in delivery or use of the new model of care. A range of stakeholders participated, including a variety of hospital and community-based healthcare professionals as well as expert patients and carers. Thematic analysis of the data was undertaken.
    Results: The study provided a holistic overview of stakeholder perceptions of the new model of care. Overall, stakeholders were enthusiastic about the new model. Three themes emerged during analysis, providing an informative review of the new model. Themes included: impact, resources required and ensuring safety and quality of the new model of care. Potential issues were identified within each theme along with ideas for overcoming these issues.
    Conclusions: The new model of care appears to be a positive step towards improving patient discharge from hospital. Future work will involve a pilot of the new model of care using the study findings to assist with implementation.
    Language English
    Publishing date 2018-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2650179-X
    ISSN 2047-9964 ; 2047-9956
    ISSN (online) 2047-9964
    ISSN 2047-9956
    DOI 10.1136/ejhpharm-2017-001485
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