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  1. Article ; Online: Cocaine-Induced Microvascular Dysfunction and its Reversal by Administration of Intracoronary Calcium-Channel Blocker.

    Chokkalingam Mani, Bhalaghuru / Fischman, David L / Savage, Michael P

    The Journal of invasive cardiology

    2016  Volume 28, Issue 10, Page(s) E120–E121

    Abstract: A 47-year-old male smoker with recent cocaine use presented with 6 hours of chest pain unrelieved by sublingual and intravenous nitroglycerin. To our knowledge, this is the first reported case demonstrating the efficacy of an intracoronary calcium- ... ...

    Abstract A 47-year-old male smoker with recent cocaine use presented with 6 hours of chest pain unrelieved by sublingual and intravenous nitroglycerin. To our knowledge, this is the first reported case demonstrating the efficacy of an intracoronary calcium-channel blocker to ameliorate cocaine-induced microvascular spasm.
    MeSH term(s) Chest Pain/diagnosis ; Chest Pain/etiology ; Chest Pain/physiopathology ; Chest Pain/therapy ; Cocaine-Related Disorders/complications ; Coronary Angiography/methods ; Coronary Vasospasm/chemically induced ; Coronary Vasospasm/drug therapy ; Coronary Vasospasm/physiopathology ; Electrocardiography/methods ; Humans ; Injections, Intra-Arterial ; Male ; Middle Aged ; Nicardipine/administration & dosage ; Treatment Outcome ; Vasodilator Agents/administration & dosage
    Chemical Substances Vasodilator Agents ; Nicardipine (CZ5312222S)
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3701: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 272: Show issues
    Zs.MG 31: Show issues

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  2. Article: Dual atrioventricular nodal pathways physiology: a review of relevant anatomy, electrophysiology, and electrocardiographic manifestations.

    Mani, Bhalaghuru Chokkalingam / Pavri, Behzad B

    Indian pacing and electrophysiology journal

    2014  Volume 14, Issue 1, Page(s) 12–25

    Abstract: More than half a century has passed since the concept of dual atrioventricular (AV) nodal pathways physiology was conceived. Dual AV nodal pathways have been shown to be responsible for many clinical arrhythmia syndromes, most notably AV nodal reentrant ... ...

    Abstract More than half a century has passed since the concept of dual atrioventricular (AV) nodal pathways physiology was conceived. Dual AV nodal pathways have been shown to be responsible for many clinical arrhythmia syndromes, most notably AV nodal reentrant tachycardia. Although there has been a considerable amount of research on this topic, the subject of dual AV nodal pathways physiology remains heavily debated and discussed. Despite advances in understanding arrhythmia mechanisms and the widespread use of invasive electrophysiologic studies, there is still disagreement on the anatomy and physiology of the AV node that is the basis of discontinuous antegrade AV conduction. The purpose of this paper is to review the concept of dual AV nodal pathways physiology and its varied electrocardiographic manifestations.
    Language English
    Publishing date 2014-01-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2123606-9
    ISSN 0972-6292
    ISSN 0972-6292
    DOI 10.1016/s0972-6292(16)30711-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sepsis-induced cardiomyopathy: a review of pathophysiologic mechanisms.

    Flynn, Anthony / Chokkalingam Mani, Bhalaghuru / Mather, Paul J

    Heart failure reviews

    2010  Volume 15, Issue 6, Page(s) 605–611

    Abstract: Cardiac dysfunction is a well-recognized complication of severe sepsis and septic shock. Cardiac dysfunction in sepsis is characterized by ventricular dilatation, reduction in ejection fraction and reduced contractility. Initially, cardiac dysfunction ... ...

    Abstract Cardiac dysfunction is a well-recognized complication of severe sepsis and septic shock. Cardiac dysfunction in sepsis is characterized by ventricular dilatation, reduction in ejection fraction and reduced contractility. Initially, cardiac dysfunction was considered to occur only during the "hypodynamic" phase of shock. But we now know that it occurs very early in sepsis even during the "hyperdynamic" phase of septic shock. Circulating blood-borne factors were suspected to be involved in the evolution of sepsis induced cardiomyopathy, but it is not until recently that the cellular and molecular events are being targeted by researchers in a quest to understand this enigmatic process. Septic cardiomyopathy has been the subject of investigation for nearly half a century now and yet controversies exist in understanding it's pathophysiology. Here, we discuss our understanding of the pathogenesis of septic cardiomyopathy and the complex roles played by nitric oxide, mitochondrial dysfunction, complements and cytokines.
    MeSH term(s) Animals ; Cardiomyopathies/immunology ; Cardiomyopathies/physiopathology ; Cytokines/blood ; Humans ; Mitochondria, Heart/immunology ; Nitric Oxide/blood ; Sepsis/complications ; Sepsis/immunology ; Sepsis/physiopathology ; Shock, Septic/complications ; Shock, Septic/physiopathology
    Chemical Substances Cytokines ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2010-06-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1336499-6
    ISSN 1573-7322 ; 1382-4147
    ISSN (online) 1573-7322
    ISSN 1382-4147
    DOI 10.1007/s10741-010-9176-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: Strongyloides stercoralis and Organ Transplantation.

    Chokkalingam Mani, Bhalaghuru / Mathur, Moses / Clauss, Heather / Alvarez, Rene / Hamad, Eman / Toyoda, Yoshiya / Birkenbach, Mark / Ahmed, Mustafa

    Case reports in transplantation

    2013  Volume 2013, Page(s) 549038

    Abstract: Strongyloides is a parasite that is common in tropical regions. Infection in the immunocompetent host is usually associated with mild gastrointestinal symptoms. However, in immunosuppressed individuals it has been known to cause a "hyperinfection ... ...

    Abstract Strongyloides is a parasite that is common in tropical regions. Infection in the immunocompetent host is usually associated with mild gastrointestinal symptoms. However, in immunosuppressed individuals it has been known to cause a "hyperinfection syndrome" with fatal complications. Reactivation of latent infection and rarely transmission from donor organs in transplanted patients have been suggested as possible causes. Our case highlights the importance suspecting Strongyloides in transplant recipients with atypical presentations and demonstrates an incidence of donor derived infection. We also review the challenges associated with making this diagnosis.
    Language English
    Publishing date 2013-05-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627657-4
    ISSN 2090-6951 ; 2090-6943
    ISSN (online) 2090-6951
    ISSN 2090-6943
    DOI 10.1155/2013/549038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Strongyloides stercoralis and Organ Transplantation

    Bhalaghuru Chokkalingam Mani / Moses Mathur / Heather Clauss / Rene Alvarez / Eman Hamad / Yoshiya Toyoda / Mark Birkenbach / Mustafa Ahmed

    Case Reports in Transplantation, Vol

    2013  Volume 2013

    Keywords Surgery ; RD1-811 ; Medicine ; R ; DOAJ:Surgery ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Cardiovascular disease in patients with chronic human immunodeficiency virus infection.

    Escárcega, Ricardo O / Franco, Joseph J / Mani, Bhalaghuru Chokkalingam / Vyas, Apurva / Tedaldi, Ellen M / Bove, Alfred A

    International journal of cardiology

    2014  Volume 175, Issue 1, Page(s) 1–7

    Abstract: In 2012, the United Nations estimated that globally, 34 million people were living with human immunodeficiency virus (HIV) infection at the end of 2011. About 6.5% of AIDS-related mortality is attributable to cardiovascular disease. HIV related ... ...

    Abstract In 2012, the United Nations estimated that globally, 34 million people were living with human immunodeficiency virus (HIV) infection at the end of 2011. About 6.5% of AIDS-related mortality is attributable to cardiovascular disease. HIV related cardiovascular disease is diverse. In this review we explore the different disease states associated with HIV such as cardiomyopathy, coronary artery disease, dyslipidemia, electrocardiographic abnormalities, prolonged QT interval and sudden death. The pathophysiology of these numerous diseases is complex and multifactorial. Current management of these patients is challenging due to multiple drug-drug interactions and side effects. However, the approach to prevention is quite familiar, taking on the same rules that apply for any patient to minimize cardiovascular disease risk. The challenges are many, therefore for HIV patients who present after a cardiovascular event, or for prevention of cardiovascular disease, the concept of a heart team is essential, where cardiovascular specialists and the HIV care team work side by side to ensure safety of medications (avoid drug interactions) and to institute a goal directed prevention plan of care.
    MeSH term(s) Anti-Retroviral Agents/metabolism ; Anti-Retroviral Agents/therapeutic use ; Cardiovascular Agents/metabolism ; Cardiovascular Agents/therapeutic use ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/therapy ; Chronic Disease ; Drug Interactions/physiology ; HIV Infections/epidemiology ; HIV Infections/metabolism ; HIV Infections/therapy ; Humans
    Chemical Substances Anti-Retroviral Agents ; Cardiovascular Agents
    Language English
    Publishing date 2014-07-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2014.04.155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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