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  1. Article ; Online: A case of pregnancy with severe polyhydramnios related to long-term use of lithium.

    Stoppa, Aldo / Roda, Ester / Garcia-Esteve, Lluïsa / Roca-Lecumberri, Alba

    Bipolar disorders

    2024  

    Abstract: Objectives: Severe polyhydramnios during pregnancy may be associated with long-term lithium use and presents considerable challenges. This complication, which has been linked to induced nephrogenic diabetes insipidus (NDI), underscores the necessity for ...

    Abstract Objectives: Severe polyhydramnios during pregnancy may be associated with long-term lithium use and presents considerable challenges. This complication, which has been linked to induced nephrogenic diabetes insipidus (NDI), underscores the necessity for cautious management of pregnant women with bipolar disorder. This case report aims to elucidate the relationship between long-term lithium use, pregnancy, and the development of severe polyhydramnios, emphasizing the importance of diagnosing NDI in order to prevent obstetric and neonatal complications.
    Methods: We present the case of a 42-year-old primigravida undergoing long-term lithium treatment for bipolar disorder type I, who developed severe polyhydramnios at 34 weeks of gestation. Clinical data including obstetric monitoring and neonatal outcomes were analyzed.
    Results: This case emphasizes the need for heightened awareness and proactive measures to mitigate the risk associated with lithium treatment during pregnancy. Close monitoring and timely interventions are essential to ensure optimal outcomes for both mother and fetus.
    Conclusions: Our article puts forth the hypothesis that there is a link between lithium use during pregnancy and the occurrence of polyhydramnios and Nephrogenic Diabetes Insipidus (NDI), which may lead to severe obstetric and neonatal complications. This case report contributes to the limited literature on the subject and gives doctors practical advice that may help them make a better risk-benefit analysis. Further research is warranted in order to refine risk assessment protocols and management strategies in this complex clinical scenario.
    Language English
    Publishing date 2024-03-26
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In honor of Professor Sylvia Daunert.

    Roda, Aldo

    Analytical and bioanalytical chemistry

    2016  Volume 408, Issue 28, Page(s) 7883–7884

    Language English
    Publishing date 2016-11
    Publishing country Germany
    Document type Editorial
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-016-9770-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In honor of Professor Larry Kricka as he retires from Luminescence.

    Roda, Aldo

    Luminescence : the journal of biological and chemical luminescence

    2015  Volume 30, Issue 1, Page(s) 1–2

    MeSH term(s) History, 20th Century ; History, 21st Century ; Luminescence ; Periodicals as Topic/history ; Retirement
    Language English
    Publishing date 2015-02
    Publishing country England
    Document type Biography ; Editorial ; Historical Article ; Portraits
    ZDB-ID 1470995-8
    ISSN 1522-7243 ; 1522-7235 ; 1099-1271
    ISSN (online) 1522-7243
    ISSN 1522-7235 ; 1099-1271
    DOI 10.1002/bio.2848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction to: Reply to Letter: Evaluation of macular blood flow after intermittent intravenous infusion of high‑dose corticosteroids (pulse therapy) in patients with thyroid‑associated orbitopathy (TAO) using angio‑OCT.

    Del Noce, Chiara / Desideri, Lorenzo Ferro / Roda, Matilde / Vagge, Aldo

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2022  Volume 260, Issue 12, Page(s) 4029

    Language English
    Publishing date 2022-09-27
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-022-05838-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply to Letter: Evaluation of macular blood flow after intermittent intravenous infusion of high-dose corticosteroids (pulse therapy) in patients with thyroid-associated orbitopathy (TAO) using angio-OCT.

    Del Noce, Chiara / Desideri, Lorenzo Ferro / Roda, Matilde / Vagge, Aldo

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2022  Volume 260, Issue 12, Page(s) 4027

    MeSH term(s) Humans ; Graves Ophthalmopathy/complications ; Graves Ophthalmopathy/diagnosis ; Graves Ophthalmopathy/drug therapy ; Infusions, Intravenous ; Tomography, Optical Coherence ; Hemodynamics ; Adrenal Cortex Hormones
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2022-06-06
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-022-05715-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Analytical science in Italy.

    Roda, Aldo

    Analytical and bioanalytical chemistry

    2013  Volume 405, Issue 2-3, Page(s) 441

    MeSH term(s) Chemistry Techniques, Analytical/methods ; Chemistry Techniques, Analytical/trends ; Italy ; Science/methods ; Science/trends
    Language English
    Publishing date 2013-01
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-012-6579-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Emerging Microfluidic Tools for Simultaneous Exosomes and Cargo Biosensing in Liquid Biopsy: New Integrated Miniaturized FFF-Assisted Approach for Colon Cancer Diagnosis.

    Marassi, Valentina / Giordani, Stefano / Placci, Anna / Punzo, Angela / Caliceti, Cristiana / Zattoni, Andrea / Reschiglian, Pierluigi / Roda, Barbara / Roda, Aldo

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 23

    Abstract: The early-stage diagnosis of cancer is a crucial clinical need. The inadequacies of surgery tissue biopsy have prompted a transition to a less invasive profiling of molecular biomarkers from biofluids, known as liquid biopsy. Exosomes are phospholipid ... ...

    Abstract The early-stage diagnosis of cancer is a crucial clinical need. The inadequacies of surgery tissue biopsy have prompted a transition to a less invasive profiling of molecular biomarkers from biofluids, known as liquid biopsy. Exosomes are phospholipid bilayer vesicles present in many biofluids with a biologically active cargo, being responsible for cell-to-cell communication in biological systems. An increase in their excretion and changes in their cargo are potential diagnostic biomarkers for an array of diseases, including cancer, and they constitute a promising analyte for liquid biopsy. The number of exosomes released, the morphological properties, the membrane composition, and their content are highly related to the physiological and pathological states. The main analytical challenge to establishing liquid biopsy in clinical practice is the development of biosensors able to detect intact exosomes concentration and simultaneously analyze specific membrane biomarkers and those contained in their cargo. Before analysis, exosomes also need to be isolated from biological fluids. Microfluidic systems can address several issues present in conventional methods (i.e., ultracentrifugation, size-exclusion chromatography, ultrafiltration, and immunoaffinity capture), which are time-consuming and require a relatively high amount of sample; in addition, they can be easily integrated with biosensing systems. A critical review of emerging microfluidic-based devices for integrated biosensing approaches and following the major analytical need for accurate diagnostics is presented here. The design of a new miniaturized biosensing system is also reported. A device based on hollow-fiber flow field-flow fractionation followed by luminescence-based immunoassay is applied to isolate intact exosomes and characterize their cargo as a proof of concept for colon cancer diagnosis.
    MeSH term(s) Humans ; Exosomes/chemistry ; Microfluidics ; Liquid Biopsy/methods ; Biomarkers/analysis ; Colonic Neoplasms/diagnosis ; Cell Communication
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23239432
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  8. Article ; Online: AAPOS Adult Strabismus Committee's Report on the Status of Adult Strabismus Telemedicine.

    Vagge, Aldo / Roda, Matilde / Valsecchi, Nicola / Capo, Hilda / Schiavi, Costantino / Velez, Federico G

    Journal of pediatric ophthalmology and strabismus

    2023  Volume 60, Issue 6, Page(s) 386–389

    Abstract: Purpose: To evaluate the utility of telemedicine in the treatment of adult patients with strabismus.: Methods: A 27-question online survey was sent to ophthalmologists of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) ... ...

    Abstract Purpose: To evaluate the utility of telemedicine in the treatment of adult patients with strabismus.
    Methods: A 27-question online survey was sent to ophthalmologists of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) Adult Strabismus Committee. The questionnaire focused on the frequency of telemedicine utilization, the benefits in the diagnosis, follow-up, and treatment of adult strabismus, and barriers of current forms of remote patient visits.
    Results: The survey was completed by 16 of 19 members of the committee. Most respondents (93.8%) reported 0 to 2 years of experience with telemedicine. Telemedicine was found to be useful for initial screening and follow-up of established patients with adult strabismus, mainly to reduce wait time for a subspecialist visit (46.7%). A successful telemedicine visit could be completed with a basic laptop (73.3%) or a camera (26.7%) or could be assisted by an orthoptist. Most participants agreed that common forms of adult strabismus (cranial nerve palsies, sagging eye syndrome, myogenic strabismus, and thyroid ophthalmopathy) could be examined via webcam. It was easier to analyze horizontal than vertical strabismus. Among the paralytic forms, sixth nerve palsy was the easiest one to assess. Latent forms of strabismus can be partially diagnosed and evaluated using telemedicine, but half of the respondents underlined the importance of in-person examinations in these cases. Sixty-nine percent believed that telemedicine could be a low-cost and time-efficient health service solution.
    Conclusions: Most members of the AAPOS Adult Strabismus Committee consider telemedicine to be a useful supplement to the current adult strabismus practice.
    MeSH term(s) Child ; Humans ; Adult ; United States/epidemiology ; Strabismus/diagnosis ; Strabismus/therapy ; Ophthalmology ; Surveys and Questionnaires ; Telemedicine ; Graves Ophthalmopathy
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800921-1
    ISSN 1938-2405 ; 0191-3913
    ISSN (online) 1938-2405
    ISSN 0191-3913
    DOI 10.3928/01913913-20221219-02
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  9. Article ; Online: Analysis of fecal bile acids and metabolites by high resolution mass spectrometry in farm animals and correlation with microbiota.

    Porru, Emanuele / Scicchitano, Daniel / Interino, Nicolò / Tavella, Teresa / Candela, Marco / Roda, Aldo / Fiori, Jessica

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 2866

    Abstract: There is a growing interest in the named "acidic sterolbiome" and in the genetic potential of the gut microbiome (GM) to modify bile acid (BA) structure. Indeed, the qualitative composition of BAs in feces correlates with the bowel microorganisms and ... ...

    Abstract There is a growing interest in the named "acidic sterolbiome" and in the genetic potential of the gut microbiome (GM) to modify bile acid (BA) structure. Indeed, the qualitative composition of BAs in feces correlates with the bowel microorganisms and their collective genetic material. GM is responsible for the production of BA metabolites, such as secondary and oxo-BAs. The specific BA profiles, as microbiome-host co-metabolic products, could be useful to investigate the GM-host interaction in animals under physiological conditions, as well as in specific diseases. In this context, we developed and validated an ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry method for the simultaneous analysis of up to 21 oxo-BAs and their 9 metabolic precursors. Chromatographic separation was achieved in 7 min with adequate analytical performance in terms of selectivity, sensitivity (LOQ from 0.05 to 0.1 µg/mL), accuracy (bias% < 5%), precision (CV% < 5%) and matrix effect (ME% < 10%). A fast solvent extraction protocol has been fine-tuned, achieving recoveries > 90%. In parallel, the gut microbiota assessment in farming animals was evaluated by 16S rRNA next-generation sequencing, and the correlation with the BA composition was performed by multivariate analysis, allowing to reconstruct species-specific associations between the BA profile and specific GM components.
    MeSH term(s) Animals ; Animals, Domestic/metabolism ; Animals, Domestic/microbiology ; Bile Acids and Salts/analysis ; Bile Acids and Salts/metabolism ; Chromatography, Liquid/methods ; Feces/chemistry ; Gastrointestinal Microbiome/genetics ; High-Throughput Nucleotide Sequencing ; Host Microbial Interactions ; Mass Spectrometry/methods ; RNA, Bacterial/genetics ; Sensitivity and Specificity ; Species Specificity
    Chemical Substances Bile Acids and Salts ; RNA, Bacterial
    Language English
    Publishing date 2022-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-06692-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Metabolic Bile Acid Profile Impairments in Dogs Affected by Chronic Inflammatory Enteropathy.

    Comito, Rossana / Porru, Emanuele / Interino, Nicolò / Conti, Matteo / Terragni, Rossella / Gotti, Roberto / Candela, Marco / Simoni, Patrizia / Roda, Aldo / Fiori, Jessica

    Metabolites

    2023  Volume 13, Issue 9

    Abstract: Bile acids (BAs), endogenous acidic steroids synthetized from cholesterol in the liver, play a key role in the gut-liver axis physiopathology, including in hepatotoxicity, intestinal inflammatory processes, and cholesterol homeostasis. Faecal Oxo-BAs, ... ...

    Abstract Bile acids (BAs), endogenous acidic steroids synthetized from cholesterol in the liver, play a key role in the gut-liver axis physiopathology, including in hepatotoxicity, intestinal inflammatory processes, and cholesterol homeostasis. Faecal Oxo-BAs, relatively stable intermediates of oxidation/epimerization reactions of the BA hydroxyls, could be relevant to investigating the crosstalk in the liver-gut axis and the relationship between diseases and alterations in microbiota composition. A paucity of information currently exists on faecal BA profiles in dogs with and without chronic inflammatory enteropathy (CIE). Comprehensive assessment of 31 molecules among faecal BAs and related microbiota metabolites was conducted with high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). Odds ratios (ORs) for associations of BAs with CIE were estimated using logistic regression. Principal component analysis was performed to find differences between the control and pathological dogs. Higher levels of primary BAs and muricholic acids, and lower levels of secondary BAs were found in pathological dogs. Higher concentrations in faecal oxo-metabolites were associated with the absence of CIE (OR < 1). This study shows a marked difference in faecal BA profiles between dogs with and without CIE. Further research will be needed to better understand the role of oxo-BAs and muricholic acids in CIE dogs.
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13090980
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