Result 1 - 10 of total 2709
(Advances in experimental medicine and biology)
2020
| Author's details | Zheng-Hong Qin (ed.) |
|---|---|
| Series title | Advances in experimental medicine and biology |
| Language | English |
| Dates of publication | 2020-9999 |
| Size | Illustrationen |
| Publisher | Springer |
| Publishing place | Cham |
| Publishing country | China |
| Document type | Book ; Collection (display volumes) |
| HBZ-ID | HT020372344 |
| Database | Catalogue ZB MED Medicine, Health |
(Advances in experimental medicine and biology ; 1206)
2020
| Author's details | Zheng-Hong Qin (ed.) |
|---|---|
| Series title | Advances in experimental medicine and biology ; 1206 Autophagy ; Biology and diseases |
| Collection | Autophagy ; Biology and diseases |
| Language | English |
| Size | xv, 727 Seiten, Illustrationen |
| Publishing country | China |
| Document type | Book |
| HBZ-ID | HT020372356 |
| ISBN | 978-981-15-0601-7 ; 9789811506024 ; 981-15-0601-9 ; 9811506027 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| Zs A 3192 -1206- | not available for loan | Zeitschriften-Lesesaal |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
2023 Volume 40, Issue 3, Page(s) 363–382
Abstract: Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes, where proteins, lipids, and organelles are degraded and recycled. According to the way the cytoplasmic components are engulfed, autophagy can be divided into ... ...
| Abstract | Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes, where proteins, lipids, and organelles are degraded and recycled. According to the way the cytoplasmic components are engulfed, autophagy can be divided into macroautophagy, microautophagy, and chaperone-mediated autophagy. Recently, many studies have found that autophagy plays an important role in neurological diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, neuronal excitotoxicity, and cerebral ischemia. Autophagy maintains cell homeostasis in the nervous system via degradation of misfolded proteins, elimination of damaged organelles, and regulation of apoptosis and inflammation. AMPK-mTOR, Beclin 1, TP53, endoplasmic reticulum stress, and other signal pathways are involved in the regulation of autophagy and can be used as potential therapeutic targets for neurological diseases. Here, we discuss the role, functions, and signal pathways of autophagy in neurological diseases, which will shed light on the pathogenic mechanisms of neurological diseases and suggest novel targets for therapies. |
|---|---|
| MeSH term(s) | Humans ; Autophagy/physiology ; Nervous System Diseases ; Parkinson Disease/metabolism ; Alzheimer Disease ; Huntington Disease |
| Language | English |
| Publishing date | 2023-10-19 |
| Publishing country | Singapore |
| Document type | Journal Article ; Review |
| ZDB-ID | 2419741-5 |
| ISSN | 1995-8218 ; 1673-7067 |
| ISSN (online) | 1995-8218 |
| ISSN | 1673-7067 |
| DOI | 10.1007/s12264-023-01120-y |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6734: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 43, Issue 8, Page(s) 1889–1904
Abstract: The nicotinamide adenine dinucleotide ( ... ...
| Abstract | The nicotinamide adenine dinucleotide (NAD |
|---|---|
| MeSH term(s) | Energy Metabolism ; Humans ; NAD/metabolism ; NADP ; Oxidation-Reduction ; Phosphates |
| Chemical Substances | Phosphates ; NAD (0U46U6E8UK) ; NADP (53-59-8) |
| Language | English |
| Publishing date | 2022-01-11 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 1360774-1 |
| ISSN | 1745-7254 ; 0253-9756 ; 1671-4083 |
| ISSN (online) | 1745-7254 |
| ISSN | 0253-9756 ; 1671-4083 |
| DOI | 10.1038/s41401-021-00838-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1904: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Frontiers in cell and developmental biology
2022 Volume 10, Page(s) 1058861
| Language | English |
|---|---|
| Publishing date | 2022-10-24 |
| Publishing country | Switzerland |
| Document type | Editorial |
| ZDB-ID | 2737824-X |
| ISSN | 2296-634X |
| ISSN | 2296-634X |
| DOI | 10.3389/fcell.2022.1058861 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Aging and disease
2021 Volume 12, Issue 8, Page(s) 1879–1897
Abstract: Coenzyme I (nicotinamide adenine dinucleotide, ... ...
| Abstract | Coenzyme I (nicotinamide adenine dinucleotide, NAD |
|---|---|
| Language | English |
| Publishing date | 2021-12-01 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ISSN | 2152-5250 |
| ISSN | 2152-5250 |
| DOI | 10.14336/AD.2021.0523 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Antioxidants & redox signaling
2021 Volume 35, Issue 12, Page(s) 951–973
Abstract: Significance: ...
| Abstract | Significance: |
|---|---|
| MeSH term(s) | Animals ; Brain Diseases/metabolism ; Central Nervous System/metabolism ; Humans ; NADPH Oxidases/metabolism ; Reactive Oxygen Species/metabolism |
| Chemical Substances | Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-) |
| Language | English |
| Publishing date | 2021-08-04 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 1483836-9 |
| ISSN | 1557-7716 ; 1523-0864 |
| ISSN (online) | 1557-7716 |
| ISSN | 1523-0864 |
| DOI | 10.1089/ars.2021.0040 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5488: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Advances in experimental medicine and biology
2021 Volume 1208, Page(s) 265–287
Abstract: Biomarkers (short for biological markers) are biological measures of a biological state. Autophagy biomarkers play an important role as an indicator of autophagy during normal physiological processes, pathogenic processes or pharmacological responses to ... ...
| Abstract | Biomarkers (short for biological markers) are biological measures of a biological state. Autophagy biomarkers play an important role as an indicator of autophagy during normal physiological processes, pathogenic processes or pharmacological responses to drugs. In this chapter, some biomarkers of different types of autophagy, including macroautophagy, selective autophagy, chaperone-mediated autophagy, and microautophagy, as well as the lysosomal biomarkers are introduced. The described biomarkers may be used to detect the level of autophagy in cells or tissues in a dynamic, real-time, and quantitative manner. However, each biomarker has its specific significance and limitation. Therefore, the analysis of the autophagy level in cells or tissues through the detection of autophagy biomarkers should be carried out carefully. |
|---|---|
| MeSH term(s) | Autophagy ; Biomarkers ; Lysosomes ; Microautophagy |
| Chemical Substances | Biomarkers |
| Language | English |
| Publishing date | 2021-07-14 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2214-8019 ; 0065-2598 |
| ISSN (online) | 2214-8019 |
| ISSN | 0065-2598 |
| DOI | 10.1007/978-981-16-2830-6_12 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Advances in experimental medicine and biology
2019 Volume 1206, Page(s) 509–525
Abstract: Autophagy is a conserved process that degrades intracellular components through lysosomes, thereby maintaining energy homeostasis and renewal of organelles. Mounting evidence indicates that autophagy plays a key role in aging and aging-related diseases. ... ...
| Abstract | Autophagy is a conserved process that degrades intracellular components through lysosomes, thereby maintaining energy homeostasis and renewal of organelles. Mounting evidence indicates that autophagy plays a key role in aging and aging-related diseases. Enhanced autophagy can delay aging and prolong life span. The absence of autophagy leads to the accumulation of mutant and misfolded proteins in the cell, which is the basis for the emergence and development of neurodegenerative diseases and other aging-related diseases. It will be of importance to develop approaches to extend the lifespan and improve the health of elderly individuals through the modulation of autophagy. |
|---|---|
| MeSH term(s) | Aging ; Autophagy ; Homeostasis ; Humans ; Longevity ; Lysosomes ; Neurodegenerative Diseases/physiopathology |
| Language | English |
| Publishing date | 2019-11-27 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ISSN | 2214-8019 ; 0065-2598 |
| ISSN (online) | 2214-8019 |
| ISSN | 0065-2598 |
| DOI | 10.1007/978-981-15-0602-4_24 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
2022 Volume 43, Issue 10, Page(s) 2439–2447
Abstract: Both mitochondrial dysfunction and neuroinflammation are implicated in neurodegeneration and neurodegenerative diseases. Accumulating evidence shows multiple links between mitochondrial dysfunction and neuroinflammation. Mitochondrial-derived damage- ... ...
| Abstract | Both mitochondrial dysfunction and neuroinflammation are implicated in neurodegeneration and neurodegenerative diseases. Accumulating evidence shows multiple links between mitochondrial dysfunction and neuroinflammation. Mitochondrial-derived damage-associated molecular patterns (DAMPs) are recognized by immune receptors of microglia and aggravate neuroinflammation. On the other hand, inflammatory factors released by activated glial cells trigger an intracellular cascade, which regulates mitochondrial metabolism and function. The crosstalk between mitochondrial dysfunction and neuroinflammatory activation is a complex and dynamic process. There is strong evidence that mitochondrial dysfunction precedes neuroinflammation during the progression of diseases. Thus, an in-depth understanding of the specific molecular mechanisms associated with mitochondrial dysfunction and the progression of neuroinflammation in neurodegenerative diseases may contribute to the identification of new targets for the treatment of diseases. In this review, we describe in detail the DAMPs that induce or aggravate neuroinflammation in neurodegenerative diseases including mtDNA, mitochondrial unfolded protein response (mtUPR), mitochondrial reactive oxygen species (mtROS), adenosine triphosphate (ATP), transcription factor A mitochondria (TFAM), cardiolipin, cytochrome c, mitochondrial Ca |
|---|---|
| MeSH term(s) | Adenosine Triphosphate/metabolism ; Alarmins/metabolism ; Cardiolipins/metabolism ; Cytochromes c/metabolism ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Humans ; Inflammation/metabolism ; Iron/metabolism ; Mitochondria/metabolism ; Neurodegenerative Diseases/metabolism ; Neuroinflammatory Diseases/metabolism ; Reactive Oxygen Species/metabolism ; Transcription Factors/metabolism |
| Chemical Substances | Alarmins ; Cardiolipins ; DNA, Mitochondrial ; Reactive Oxygen Species ; Transcription Factors ; Adenosine Triphosphate (8L70Q75FXE) ; Cytochromes c (9007-43-6) ; Iron (E1UOL152H7) |
| Language | English |
| Publishing date | 2022-03-01 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 1360774-1 |
| ISSN | 1745-7254 ; 0253-9756 ; 1671-4083 |
| ISSN (online) | 1745-7254 |
| ISSN | 0253-9756 ; 1671-4083 |
| DOI | 10.1038/s41401-022-00879-6 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1904: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.