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Article ; Online: La prensa carlista en el exilio

Alexandre Dupont

Pasado y Memoria, Iss 26, Pp 55-

La Voz de la Patria y la internacional blanca

2023 Volume 75

Abstract: En las dos guerras de 1833-1840 y 1872-1876, los carlistas fundaron, gracias al apoyo de exiliados instalados en el país, periódicos en Francia a través de los cuales pretendían tanto eludir la censura y la represión en su país como dirigirse a la ... ...

Abstract	En las dos guerras de 1833-1840 y 1872-1876, los carlistas fundaron, gracias al apoyo de exiliados instalados en el país, periódicos en Francia a través de los cuales pretendían tanto eludir la censura y la represión en su país como dirigirse a la opinión pública europea y más precisamente a sus partidarios contrarrevolucionarios más allá de las fronteras. La Voz de la Patria, creado en Bayona en 1874 por Carlos Benítez Caballero es buena muestra de esta prensa carlista en el exilio y de su papel fundamental en la conformación de una internacional blanca pro-carlista, tanto por las mismas condiciones de elaboración del periódico como por el ideario propagado por este título bilingüe. De hecho, los promotores de esta empresa no se limitaron en crear un periódico dirigido hacia los propios refugiados carlistas en Francia y destinado a hacer de vínculo entre ellos. Bien al contrario, hicieron de La Voz de la Patria un laboratorio y una caja de resonancia de la solidaridad pro-carlista que se organizó en Francia y en toda Europa durante la guerra de 1872-1876 y se dirigieron tanto a los carlistas como a los monárquicos y católicos de Europa –en especial franceses. La represión que padeció el periódico y el proceso que derivó en 1875 subrayan las angustias márgenes de maniobra del Estado francés para luchar contra un instrumento de subversión contrarrevolucionaria que usaba los códigos del espacio público liberal y pone de relieve la paradójica modernidad de los carlistas y de sus aliados que supieron adaptar los instrumentos de la política liberal para usarlos en su propio combate.
Keywords	prensa ; exilio ; segunda guerra carlista ; internacional blanca ; periodismo ; francia ; History (General) and history of Europe ; D
Language	Catalan
Publishing date	2023-01-01T00:00:00Z
Publisher	Universidad de Alicante
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Smooth Muscle Cell Relaxation Worsens Aortic Dilatation and Clinical Presentation in a BAPN/Angiotensin II-Induced Aortic Dissection Model in Rats.

Pellenc, Quentin / El Bitar, Sandy / Darmon, Arthur / Dupont, Sébastien / Michel, Jean-Baptiste / Jondeau, Guillaume

Journal of vascular research

2022 , Page(s) 1–12

Abstract: Introduction: Beta-aminopropionitrile (BAPN) administration is a chemically induced model for preclinical aortic pathologies research. Angiotensin II (AngII) has been widely used to promotes aortic dissections in mice. Here, we provide insight on a ... ...

Abstract	Introduction: Beta-aminopropionitrile (BAPN) administration is a chemically induced model for preclinical aortic pathologies research. Angiotensin II (AngII) has been widely used to promotes aortic dissections in mice. Here, we provide insight on a modified aortic dissection model in rats. The effect of smooth muscle cell (SMC) relaxation with vasodilators is studied in this model. Methods: Forty Sprague-Dawley rats were divided in 4 groups: control, isosorbide dinitrate (ISDN, 30 mg/kg/day) in the drinking water, BAPN (0.02%) in the food, BAPN + ISDN (same doses). Thoracic and abdominal aortic diameters were evaluated through transthoracic ultrasound echography. After 6 weeks, all rats were infused with AngII (1 mg/kg/day) subcutaneously. Survival and type of aortic events were numbered. Histological and histochemical analyses of aorta were performed. Results: Initial telesystolic ascending aorta diameters were equal in all groups and became significantly larger in the BAPN + ISDN group compared to the BAPN group (control: 3.37 ± 0.17 mm, ISDN: 3.49 ± 0.16 mm, BAPN: 3.53 ± 0.13 mm, BAPN + ISDN: 3.61 ± 0.16 mm, analysis of variance p < 0.0001). BAPN followed by AngII infusion showed a significant lower survival rate (p = 0.029) and produced a large panel of aortic events. Association of ISDN and BAPN significantly reduces survival (p = 0.001) and provides more aortic events compared to BAPN alone (p = 0.031). In both BAPN-treated groups, orcein staining revealed split and dissected elastic fibers in the media, alcian blue staining showed mucoid degeneration of the aortic wall, and Perls-diaminobenzidine staining revealed an accumulation of Fe2+. Conclusion: SMC relaxation with ISDN increases aortic dilatation, worsens aortic prognosis, and reproduces human histological findings in a low-dose BAPN/AngII-induced aortic dissection model in rats.
Language	English
Publishing date	2022-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1105259-4
ISSN	1423-0135 ; 1018-1172
ISSN (online)	1423-0135
ISSN	1018-1172
DOI	10.1159/000526417
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Article: CD123 as a Biomarker in Hematolymphoid Malignancies: Principles of Detection and Targeted Therapies.

El Achi, Hanadi / Dupont, Edouard / Paul, Shilpa / Khoury, Joseph D

Cancers

2020 Volume 12, Issue 11

Abstract: CD123, the α chain of the interleukin 3 receptor, is a cytokine receptor that is overexpressed in multiple hematolymphoid neoplasms, including acute myeloid leukemia, blastic plasmacytoid dendritic cell neoplasm, acute lymphoblastic leukemia, hairy cell ... ...

Abstract	CD123, the α chain of the interleukin 3 receptor, is a cytokine receptor that is overexpressed in multiple hematolymphoid neoplasms, including acute myeloid leukemia, blastic plasmacytoid dendritic cell neoplasm, acute lymphoblastic leukemia, hairy cell leukemia, and systemic mastocytosis. Importantly, CD123 expression is upregulated in leukemic stem cells relative to non-neoplastic hematopoietic stem cells, which makes it a useful diagnostic and therapeutic biomarker in hematologic malignancies. Varying levels of evidence have shown that CD123-targeted therapy represents a promising therapeutic approach in several cancers. Tagraxofusp, an anti-CD123 antibody conjugated to a diphtheria toxin, has been approved for use in patients with blastic plasmacytoid dendritic cell neoplasm. Multiple clinical trials are investigating the use of various CD123-targeting agents, including chimeric antigen receptor-modified T cells (expressing CD123, monoclonal antibodies, combined CD3-CD123 dual-affinity retargeting antibody therapy, recombinant fusion proteins, and CD123-engager T cells. In this review, we provide an overview of laboratory techniques used to evaluate and monitor CD123 expression, describe the strengths and limitations of detecting this biomarker in guiding therapy decisions, and provide an overview of the pharmacologic principles and strategies used in CD123-targeted therapies.
Language	English
Publishing date	2020-10-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12113087
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Article ; Online: A micro-transducer matrix design for the detection of flexural guided waves.

El Rammouz, H / Benmeddour, F / Assaad, J / Moulin, E / Smagin, N / Dupont, L / Chehami, L / Zaatar, Y / Herro, Z

Ultrasonics

2021 Volume 115, Page(s) 106430

Abstract: In this paper, a new approach is proposed for the detection of ultrasonic guided waves using a ... ...

Abstract	In this paper, a new approach is proposed for the detection of ultrasonic guided waves using a LiNbO
Language	English
Publishing date	2021-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	200839-7
ISSN	1874-9968 ; 0041-624X
ISSN (online)	1874-9968
ISSN	0041-624X
DOI	10.1016/j.ultras.2021.106430
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Article ; Online: Respiratory Exchange Ratio guided management in high-risk noncardiac surgery: The OPHIQUE multicentre randomised controlled trial.

Bar, Stéphane / Moussa, Mouhamed Djahoum / Descamps, Richard / El Amine, Younes / Bouhemad, Belaid / Fischer, Marc-Olivier / Lorne, Emmanuel / Dupont, Hervé / Diouf, Momar / Guinot, Pierre Grégoire

Anaesthesia, critical care & pain medicine

2023 Volume 42, Issue 4, Page(s) 101221

Abstract: Background: There is a need to develop non-invasive markers to identify the occurrence of anaerobic metabolism in high-risk surgery. Our objective was to demonstrate that a goal-directed therapy algorithm incorporating the respiratory exchange ratio ( ... ...

Abstract	Background: There is a need to develop non-invasive markers to identify the occurrence of anaerobic metabolism in high-risk surgery. Our objective was to demonstrate that a goal-directed therapy algorithm incorporating the respiratory exchange ratio (ratio between CO Methods: We conducted a randomized, multicenter, controlled clinical trial in four university medical centers and one non-university hospital from December 26, 2018, to September 9, 2021. 350 patients with a high risk of postoperative complications undergoing high-risk noncardiac surgery lasting 2 h or longer under general anesthesia were enrolled. The control group was treated according to current hemodynamic guidelines. The interventional group was treated according to an algorithm based on the measurement of the respiratory exchange ratio. The primary outcome was a composite of major complications or death within seven days of surgery. The secondary outcomes were the length of hospital stay, 30-day mortality, and the total intraoperative volume of fluids administered. Results: The primary outcome occurred for 78 patients (45.6%) in the interventional group and 83 patients (48.8%) in the control group (relative risk: 0.93, 95% confidence interval [CI]: 0.75-1.17; p = 0.55). There were no clinically relevant differences between the two groups for secondary outcomes. Conclusions: In high-risk surgery, a goal-directed therapy algorithm integrating the measurement of the respiratory-exchange ratio did not reduce a composite outcome of major postoperative complications or death within seven days after surgery compared to routine care. Trial registration: ClinicalTrials.gov, NCT03852147.
MeSH term(s)	Humans ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Hemodynamics ; Length of Stay
Language	English
Publishing date	2023-03-21
Publishing country	France
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ISSN	2352-5568
ISSN (online)	2352-5568
DOI	10.1016/j.accpm.2023.101221
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Article ; Online: Determinants of postoperative complications in high-risk noncardiac surgery patients optimized with hemodynamic treatment strategies: A post-hoc analysis of a randomized multicenter clinical trial.

Journal of clinical anesthesia

2023 Volume 93, Page(s) 111325

Abstract: Study objective: This post-hoc analysis of a randomized controlled trial was undertaken to establish the determinants of postoperative complications and acute kidney injury in high-risk noncardiac surgery patients supported with hemodynamic treatment ... ...

Abstract	Study objective: This post-hoc analysis of a randomized controlled trial was undertaken to establish the determinants of postoperative complications and acute kidney injury in high-risk noncardiac surgery patients supported with hemodynamic treatment strategies. Design: We conducted a post-hoc analysis of patients enrolled in the OPtimization Hemodynamic Individualized by the respiratory QUotiEnt (OPHIQUE) trial. Setting: Operating rooms in four university medical centers and one non-university hospital from December 26, 2018, to September 9, 2021. Patients: We enrolled 350 patients with a high risk of postoperative complications undergoing high-risk noncardiac surgery lasting 2 h or longer under general anesthesia. Interventions: All patients were treated according to hemodynamic treatment strategies which included cardiac output optimization by titration of fluid challenge and targeted systolic blood pressure to remain within ±10% of the reference value. Measurements: We assessed the association between pre-operative and intra-operative exposure of interest with a composite primary outcome of major complications or death within seven days following surgery using a multivariable logistic regression model. We also assessed the association between these exposures of interest and acute kidney injury. Main results: The data of 341 patients were analyzed. In multivariate analysis, the factors independently associated with the primary outcome were age (OR = 1.04 (1.01-1.06), P = 0.002), preoperative hemoglobin concentration (OR = 0.85 (0.75-0.96), P = 0.012), non-vascular surgery (OR = 0.30 (0.17-0.53), P < 0.0001), and intraoperative surgical complications (OR = 2.08 (1.02-4.24), P = 0.046). The factors independently associated with postoperative acute kidney injury were age (OR = 1.04 (1.01-1.08), P = 0.008), preoperative creatinine concentration (OR = 1.01 (1.00-1.01), P = 0.049), non-vascular surgery (OR = 0.36 (0.20-0.66), P = 0.001), and intraoperative surgical complications (OR = 3.36 (1.50-7.55), P = 0.031). Conclusions: Surgical complications, a lower preoperative hemoglobin concentration, age, and vascular surgery were associated with postoperative complications in a high-risk noncardiac surgery population supported with hemodynamic treatment strategies.
MeSH term(s)	Humans ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Risk Factors ; Hemodynamics ; Intraoperative Complications/epidemiology ; Intraoperative Complications/etiology ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Hemoglobins
Chemical Substances	Hemoglobins
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2023.111325
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Article ; Online: Assessment of the Risk of Exotic Zika Virus Strain Transmission by

Gaye, Alioune / Fall, Cheikh / Faye, Oumar / Dupont-Rouzeyrol, Myrielle / Ndiaye, El Hadji / Diallo, Diawo / de Andrade Zanotto, Paolo Marinho / Dia, Ibrahima / Weaver, Scott C / Diallo, Mawlouth

Tropical medicine and infectious disease

2023 Volume 8, Issue 2

Abstract: Zika virus (ZIKV) shows an enigmatic epidemiological profile in Africa. Despite its frequent detection in mosquitoes, few human cases have been reported. This could be due to the low infectious potential or low virulence of African ZIKV lineages. This ... ...

Abstract	Zika virus (ZIKV) shows an enigmatic epidemiological profile in Africa. Despite its frequent detection in mosquitoes, few human cases have been reported. This could be due to the low infectious potential or low virulence of African ZIKV lineages. This study sought to assess the susceptibility of
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article
ISSN	2414-6366
ISSN (online)	2414-6366
DOI	10.3390/tropicalmed8020130
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Article: Efficacy and Safety of Transcranial Electric Stimulation during the Perinatal Period: A Systematic Literature Review and Three Case Reports.

Laurin, Andrew / Nard, Noémie / Dalmont, Marine / Bulteau, Samuel / Bénard, Cloé / Bonnot, Olivier / Winer, Norbert / Dupont, Françoise / Apter, Gisèle / Terranova-Commessie, Frédérique / Guillin, Olivier / El-Hage, Wissam / Sauvaget, Anne / Rothärmel, Maud

Journal of clinical medicine

2022 Volume 11, Issue 14

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2022-07-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11144048
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Article ; Online: Gray matter volume associations in youth with ADHD features of inattention and hyperactivity/impulsivity.

Reimann, Gabrielle E / Jeong, Hee Jung / Durham, E Leighton / Archer, Camille / Moore, Tyler M / Berhe, Fanual / Dupont, Randolph M / Kaczkurkin, Antonia N

Human brain mapping

2024 Volume 45, Issue 5, Page(s) e26589

Abstract: Background: Prior research has shown smaller cortical and subcortical gray matter volumes among individuals with attention-deficit/hyperactivity disorder (ADHD). However, neuroimaging studies often do not differentiate between inattention and ... ...

Abstract	Background: Prior research has shown smaller cortical and subcortical gray matter volumes among individuals with attention-deficit/hyperactivity disorder (ADHD). However, neuroimaging studies often do not differentiate between inattention and hyperactivity/impulsivity, which are distinct core features of ADHD. The present study uses an approach to disentangle overlapping variance to examine the neurostructural heterogeneity of inattention and hyperactivity/impulsivity dimensions. Methods: We analyzed data from 10,692 9- to 10-year-old children from the Adolescent Brain Cognitive Development (ABCD) Study. Confirmatory factor analysis was used to derive factors representing inattentive and hyperactive/impulsive traits. We employed structural equation modeling to examine these factors' associations with gray matter volume while controlling for the shared variance between factors. Results: Greater endorsement of inattentive traits was associated with smaller bilateral caudal anterior cingulate and left parahippocampal volumes. Greater endorsement of hyperactivity/impulsivity traits was associated with smaller bilateral caudate and left parahippocampal volumes. The results were similar when accounting for socioeconomic status, medication, and in-scanner motion. The magnitude of these findings increased when accounting for overall volume and intracranial volume, supporting a focal effect in our results. Conclusions: Inattentive and hyperactivity/impulsivity traits show common volume deficits in regions associated with visuospatial processing and memory while at the same time showing dissociable differences, with inattention showing differences in areas associated with attention and emotion regulation and hyperactivity/impulsivity associated with volume differences in motor activity regions. Uncovering such biological underpinnings within the broader disorder of ADHD allows us to refine our understanding of ADHD presentations.
MeSH term(s)	Child ; Adolescent ; Humans ; Attention Deficit Disorder with Hyperactivity/diagnostic imaging ; Gray Matter/diagnostic imaging ; Cerebral Cortex ; Cognition ; Impulsive Behavior
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.26589
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Article: In the Arab Bedroom: The Sex Life of Arabs.

Dupont, P

Facts, views & vision in ObGyn

2016 Volume 8, Issue 4, Page(s) 237–242

Abstract: The sex life of Arabs is terra incognita for scientists and policy makers. Shereen El Feki's book ...

Abstract	The sex life of Arabs is terra incognita for scientists and policy makers. Shereen El Feki's book "Sex and the Citadel" is the first serious attempt to chart sexual intimacy in the rapidly changing Arab world.
Language	English
Publishing date	2016-12-30
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	2701574-9
ISSN	2684-4230 ; 2032-0418 ; 2032-0418
ISSN (online)	2684-4230 ; 2032-0418
ISSN	2032-0418
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