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  1. Article ; Online: Short-Term Outcomes of Apixaban Versus Warfarin in Patients With Atrial Fibrillation.

    Lip, Gregory Y H / Khan, Ahsan A / Olshansky, Brian

    Circulation

    2019  Volume 139, Issue 20, Page(s) 2301–2303

    MeSH term(s) Atrial Fibrillation ; Body Weight ; Humans ; Pyrazoles ; Pyridones ; Warfarin
    Chemical Substances Pyrazoles ; Pyridones ; apixaban (3Z9Y7UWC1J) ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2019-05-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.119.040021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Non-vitamin K antagonist oral anticoagulants beyond atrial fibrillation: what did we learn from COMPASS and COMMANDER-HF?

    Khan, Ahsan A / Lip, Gregory Y H

    European heart journal

    2019  Volume 40, Issue 46, Page(s) 3754–3756

    MeSH term(s) Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Coronary Disease/drug therapy ; Humans ; Secondary Prevention/methods ; Stroke/prevention & control ; Treatment Outcome
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2019-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehz005
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  3. Article: Non-vitamin K antagonist oral anticoagulant dosing in patients with atrial fibrillation and renal dysfunction.

    Khan, Ahsan A / Lip, Gregory Y H

    Annals of translational medicine

    2017  Volume 5, Issue 23, Page(s) 465

    Language English
    Publishing date 2017-12-22
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2017.09.19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Heart rate variability in atrial fibrillation: The balance between sympathetic and parasympathetic nervous system.

    Khan, Ahsan A / Lip, Gregory Y H / Shantsila, Alena

    European journal of clinical investigation

    2019  Volume 49, Issue 11, Page(s) e13174

    Abstract: Background: Atrial fibrillation (AF) is the commonest abnormal heart rhythm with significant related morbidity and mortality. Several pathophysiologic mechanisms have been advocated to explain the onset of AF. There has been increasing evidence that ... ...

    Abstract Background: Atrial fibrillation (AF) is the commonest abnormal heart rhythm with significant related morbidity and mortality. Several pathophysiologic mechanisms have been advocated to explain the onset of AF. There has been increasing evidence that abnormalities of the autonomic nervous system (ANS) that includes sympathetic, parasympathetic and intrinsic neural network are involved in the pathogenesis of AF. This review will consider the anatomical and pathophysiological concepts of the cardiac neuronal network and discuss how it can be investigated.
    Design: Relevant articles for this review were selected primarily from Ovid Medline and Embase databases (see appendix). We searched for key terms "atrial fibrillation," "AF," "autonomic dysfunction," "autonomic nervous system," "heart rate variability" and "HRV" to gather relevant studies. Duplicate papers were excluded.
    Results: Heart is richly innervated by autonomic nerves. Both sympathetic and parasympathetic systems interact in developing AF along with cardiac ganglionated plexi (GP). Thus autonomic dysfunction is present in AF. There are methods including selective ablation that reduce autonomic innervation and show to reduce the incidence of spontaneous or induced atrial arrhythmias. Heart rate variability (HRV) is a useful tool to assess sympathetic and parasympathetic influences on disease states. HRV can be improved following intervention and is thus a useful application in assessing autonomic dysfunction in patients with AF.
    Conclusion: ANS plays a crucial role in the development, propagation and complexity of AF. Assessment of the autonomic involvement in the propagation of AF may help in explaining why certain patients with AF do not benefit from cardioversion or ablation.
    MeSH term(s) Atrial Fibrillation/physiopathology ; Heart/innervation ; Heart Rate/physiology ; Humans ; Parasympathetic Nervous System/physiology ; Parasympathetic Nervous System/physiopathology ; Sympathetic Nervous System/physiology ; Sympathetic Nervous System/physiopathology
    Language English
    Publishing date 2019-09-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 677: Show issues Location:
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  5. Article ; Online: The prothrombotic state in atrial fibrillation: pathophysiological and management implications.

    Khan, Ahsan A / Lip, Gregory Y H

    Cardiovascular research

    2019  Volume 115, Issue 1, Page(s) 31–45

    Abstract: Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia and is associated with significant morbidity and mortality. There is plenty of evidence available to support the presence of a prothrombotic or hypercoagulable state in AF, but the ... ...

    Abstract Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia and is associated with significant morbidity and mortality. There is plenty of evidence available to support the presence of a prothrombotic or hypercoagulable state in AF, but the contributory factors are multifactorial and cannot simply be explained by blood stasis. Abnormal changes in atrial wall (anatomical and structural, as 'vessel wall abnormalities'), the presence of spontaneous echo contrast to signify abnormal changes in flow and stasis ('flow abnormalities'), and abnormal changes in coagulation, platelet, and other pathophysiologic pathways ('abnormalities of blood constituents') are well documented in AF. The presence of these components therefore fulfils Virchow's triad for thrombogenesis. In this review, we present an overview of the established and professed pathophysiological mechanisms for thrombogenesis in AF and its management implications.
    MeSH term(s) Animals ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Atrial Fibrillation/blood ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/physiopathology ; Blood Coagulation/drug effects ; Blood Coagulation Factors/metabolism ; Blood Platelets/drug effects ; Blood Platelets/metabolism ; Fibrinolysis/drug effects ; Fibrinolytic Agents/adverse effects ; Fibrinolytic Agents/therapeutic use ; Humans ; Regional Blood Flow ; Risk Factors ; Stroke/blood ; Stroke/epidemiology ; Stroke/physiopathology ; Stroke/prevention & control ; Thromboembolism/blood ; Thromboembolism/epidemiology ; Thromboembolism/physiopathology ; Thromboembolism/prevention & control ; Treatment Outcome
    Chemical Substances Anticoagulants ; Blood Coagulation Factors ; Fibrinolytic Agents
    Language English
    Publishing date 2019-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvy272
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    Zs.A 565: Show issues Location:
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  6. Article ; Online: Are atrial high rate episodes (AHREs) a precursor to atrial fibrillation?

    Khan, Ahsan A / Boriani, Giuseppe / Lip, Gregory Y H

    Clinical research in cardiology : official journal of the German Cardiac Society

    2019  Volume 109, Issue 4, Page(s) 409–416

    Abstract: Atrial high rate episodes (AHREs), also termed, subclinical atrial tachyarrhythmias or subclinical atrial fibrillation (AF) are an important cardiovascular condition. Advancement in implantable cardiac devices such as pacemakers or internal cardiac ... ...

    Abstract Atrial high rate episodes (AHREs), also termed, subclinical atrial tachyarrhythmias or subclinical atrial fibrillation (AF) are an important cardiovascular condition. Advancement in implantable cardiac devices such as pacemakers or internal cardiac defibrillators has enabled the continuous assessment of atrial tachyarrhythmias in patients with an atrial lead. Patients with device-detected AHREs are at an elevated risk of stroke and may have unmet anticoagulation needs. While the benefits of oral anticoagulation for stroke prevention in patients with clinical AF are well recognised, it is not known whether the same risk-benefit ratio exists for anticoagulation therapy in patients with AHREs. The occurrence and significance of AHRE are increasingly acknowledged but these events are still not often acted upon in patients presenting with stroke and TIA. Additionally, patients with AHRE show a significant risk for major adverse cardiovascular events (MACE) including acute heart failure, myocardial infarction, cardiovascular hospitalisation, ventricular tachycardia/fibrillation, which is dependent on AHRE burden. In this review, we present an overview of this relatively new entity, its associated thromboembolic risk and its management implications.
    MeSH term(s) Action Potentials ; Administration, Oral ; Anticoagulants/administration & dosage ; Asymptomatic Diseases ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/etiology ; Atrial Fibrillation/physiopathology ; Heart Atria/physiopathology ; Heart Rate ; Humans ; Prognosis ; Risk Assessment ; Risk Factors ; Stroke/etiology ; Stroke/physiopathology ; Stroke/prevention & control ; Tachycardia, Supraventricular/complications ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/drug therapy ; Tachycardia, Supraventricular/physiopathology ; Thromboembolism/etiology ; Thromboembolism/physiopathology ; Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2019-09-14
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2213295-8
    ISSN 1861-0692 ; 1861-0684
    ISSN (online) 1861-0692
    ISSN 1861-0684
    DOI 10.1007/s00392-019-01545-4
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  7. Article ; Online: Resumption of antiplatelet therapy in patients with primary intracranial haemorrhage: Balancing benefits and risks.

    Khan, Ahsan A / Lip, Gregory Y H

    Journal of the neurological sciences

    2017  Volume 384, Page(s) 139–140

    MeSH term(s) Brain Ischemia ; Humans ; Intracranial Hemorrhages ; Platelet Aggregation Inhibitors ; Risk Assessment
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2017-12-01
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2017.11.038
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    Zs.A 308: Show issues Location:
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  8. Article ; Online: Endothelial function in patients with atrial fibrillation.

    Khan, Ahsan A / Thomas, Graham N / Lip, Gregory Y H / Shantsila, Alena

    Annals of medicine

    2020  Volume 52, Issue 1-2, Page(s) 1–11

    Abstract: Atrial fibrillation (AF) is the most common heart arrhythmia and is associated with poor outcomes. The adverse effects of AF are mediated through multiple pathways, including endothelial dysfunction, as measured by flow-mediated dilatation. Flow-mediated ...

    Abstract Atrial fibrillation (AF) is the most common heart arrhythmia and is associated with poor outcomes. The adverse effects of AF are mediated through multiple pathways, including endothelial dysfunction, as measured by flow-mediated dilatation. Flow-mediated dilatation has demonstrated endothelial dysfunction in several conditions and is associated with poor outcomes including mortality, yet can be improved with medical therapy. It is thus a useful tool in assessing endothelial function in patients. Endothelial dysfunction is present in patients with AF and is associated with poor outcomes. These patients are generally older and have other co-morbidities such as hypertension, hypercholesterolaemia and diabetes. The precise process by which AF is affiliated with endothelial damage/dysfunction remains elusive. This review explores the endothelial structure, its physiology and how it is affected in patients with AF. It also assesses the utility of flow mediated dilatation as a technique to assess endothelial function in patients with AF. Key MessagesEndothelial function is affected in patients with atrial fibrillation as with other cardiovascular conditions.Endothelial dysfunction is associated with poor outcomes such as stroke, myocardial infarction and death, yet is a reversible condition.Flow-mediated dilatation is a reliable tool to assess endothelial function in patients with atrial fibrillation.Patients with atrial fibrillation should be considered for endothelial function assessment and attempts made to reverse this condition.
    MeSH term(s) Atrial Fibrillation/complications ; Atrial Fibrillation/physiopathology ; Endothelium/blood supply ; Endothelium/metabolism ; Endothelium/physiopathology ; Female ; Hemostasis/physiology ; Humans ; Male ; Muscle, Smooth, Vascular/blood supply ; Nitric Oxide Synthase Type III/metabolism
    Chemical Substances NOS3 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Language English
    Publishing date 2020-01-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2019.1711158
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  9. Article ; Online: Short-Term Outcomes in Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease: How Important Is Ethnicity?

    Ding, Wern Yew / Khan, Ahsan A / Gupta, Dhiraj / Lip, Gregory Y H

    Journal of the American Heart Association

    2019  Volume 8, Issue 3, Page(s) e011953

    Abstract: See Article by Goto et al . ...

    Abstract See Article by Goto et al .
    MeSH term(s) Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/ethnology ; Ethnic Groups ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Prognosis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/ethnology ; Risk Assessment ; Stroke/ethnology ; Stroke/etiology ; Survival Rate/trends ; United States/epidemiology
    Language English
    Publishing date 2019-02-03
    Publishing country England
    Document type Editorial
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.119.011953
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  10. Article ; Online: Synthesis of novel coumarin-based thiosemicarbazones and their implications in diabetic management via in-vitro and in-silico approaches.

    Zahra, Syeda Bakhtawar / Ullah, Saeed / Halim, Sobia Ahsan / Waqas, Muhammad / Huda, Noor Ul / Khan, Ajmal / Binsaleh, Ammena Y / El-Kott, Attalla F / Hussain, Javid / Al-Harrasi, Ahmed / Shafiq, Zahid

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 18014

    Abstract: Diabetes mellitus has a high prevalence rate and it has been deemed a severe chronic metabolic disorder with long-term complications. This research aimed to identify compounds that could potentially inhibit the vital metabolic enzyme α-glucosidase and ... ...

    Abstract Diabetes mellitus has a high prevalence rate and it has been deemed a severe chronic metabolic disorder with long-term complications. This research aimed to identify compounds that could potentially inhibit the vital metabolic enzyme α-glucosidase and thereby exert an anti-hyperglycemic effect. The main goal was to establish an effective approach to control diabetes. To proceed with this study, a series of novel coumarin-derived thiosemicarbazones 3a-3m was synthesized and examined using a variety of spectroscopic methods. Moreover, all the compounds were subjected to α-glucosidase inhibition bioassay to evaluate their antidiabetic potential. Fortunately, all the compounds exhibited several folds potent α-glucosidase inhibitory activities with IC
    MeSH term(s) Humans ; Glycoside Hydrolase Inhibitors/chemistry ; Molecular Docking Simulation ; alpha-Glucosidases/metabolism ; Kinetics ; Thiosemicarbazones/pharmacology ; Hypoglycemic Agents/chemistry ; Diabetes Mellitus/drug therapy ; Coumarins/chemistry ; Structure-Activity Relationship ; Molecular Structure
    Chemical Substances Glycoside Hydrolase Inhibitors ; alpha-Glucosidases (EC 3.2.1.20) ; Thiosemicarbazones ; Hypoglycemic Agents ; Coumarins
    Language English
    Publishing date 2023-10-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44837-6
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