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Article: HUA ENHANCER1

Wei, Shuai-Jie / Chai, Sen / Zhu, Rui-Min / Duan, Cun-Ying / Zhang, Yan / Li, Sha

2020 Volume 11, Page(s) 397

Abstract: Ovules are female reproductive organs of angiosperms, containing sporophytic integuments and gametophytic embryo sacs. After fertilization, embryo sacs develop into embryos and endosperm whereas integuments into seed coat. Ovule development is regulated ... ...

Abstract	Ovules are female reproductive organs of angiosperms, containing sporophytic integuments and gametophytic embryo sacs. After fertilization, embryo sacs develop into embryos and endosperm whereas integuments into seed coat. Ovule development is regulated by transcription factors (TF) whose expression is often controlled by microRNAs. Mutations of Arabidopsis DICER-LIKE 1 (DCL1), a microRNA processing protein, caused defective ovule development and reduced female fertility. However, it was not clear whether other microRNA processing proteins participate in this process and how defective ovule development influenced female fertility. We report that mutations of
Language	English
Publishing date	2020-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2020.00397
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Article: [An historical study of Hua Tuo Temples in Henan province].

Zhang, S S / Liu, X C

Zhonghua yi shi za zhi (Beijing, China : 1980)

2023 Volume 53, Issue 1, Page(s) 52–55

Abstract: Hua Tuo was a medical figure renowned for his legendary magic medical skills in the late Eastern ... on the local records and historical books in Henan Province, Hua Tuo temples and shrines in this area were ... close to the hometown of Hua Tuo. Most of them were built in the Ming and Qing Dynasties. They were ...

Abstract	Hua Tuo was a medical figure renowned for his legendary magic medical skills in the late Eastern Han Dynasty. He has been honored in history by temples or shrines built in memory of him. Based on the local records and historical books in Henan Province, Hua Tuo temples and shrines in this area were examined. A total of twelve temples or shrines were built in nine counties or cities in Henan province. They were mainly distributed in the counties of Shangqiu, Zhoukou and Xinyang along the Huai River, and were close to the hometown of Hua Tuo. Most of them were built in the Ming and Qing Dynasties. They were named as Huatuo Temple, Medical Ancestor Huatuo Temple, Medical Ancestor Hua Gong Temple, Hua Zu Temple and Divine Doctor Huatuo Ancestral Temple.
MeSH term(s)	Humans ; Books ; Physicians ; China
Language	Chinese
Publishing date	2023-03-14
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.cn112155-20220921-00130
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Zs.A 4688: Show issues

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Article ; Online: Pharmacokinetic study of multicomponent in Hong-Hua-Xiao-Yao tablet.

Li, Xiaofeng / Huang, Leyi / Xiao, Junping / Zhang, Xuemei

Biomedical chromatography : BMC

2024 , Page(s) e5830

Abstract: Hong-Hua-Xiao-Yao tablet (HHXYT) is attracting attention increasingly because of its use ...

Abstract	Hong-Hua-Xiao-Yao tablet (HHXYT) is attracting attention increasingly because of its use in treatment of mammary gland hyperplasia (MGH) and menopausal syndrome. However, its pharmacokinetics remains unclear. This study developed a sensitive and rapid method for simultaneous determination of 10 compounds of HHXYT in rat plasma by liquid chromatography-tandem mass spectrometry and to compare the pharmacokinetics of these compounds in MGH rats and sham operated rats. The linearity, accuracy, precision, stability and matrix effect were within acceptable ranges. This established method was successfully applied to a pharmacokinetics study of 10 compounds in sham operated and MGH rats. According to the results, the bioavailability of glycyrrhetinic acid was highest in MGH rats and sham operated rats. The mean residence times of glycyrrhetinic acid and glycyrrhetinic acid 3-O-glucuronide were higher than those of the other compounds while the mean residence time and half-life of liquiritin, isoliquiritin and paeoniflorin were lower. Some pharmacokinetic parameters of ormononetin, liquiritigenin, isoliquiritigenin, liquiritin, isoliquiritin, paeoniflorin, protocatechuic acid and senkyunolide I were significantly different between MGH rats and sham operated rats. This study elucidated the dynamic changes of multiple components in rats after oral administration of HHXYT systematically and comprehensively, which provided guidance for clinical application.
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5830
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Zs.A 2166: Show issues

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Article ; Online: Machine learning uncovers accumulation mechanism of flavonoid compounds in Polygonatum cyrtonema Hua.

Han, Zhigang / Gong, Qiqi / Huang, Suya / Meng, Xinyue / Xu, Yi / Li, Lige / Shi, Yan / Lin, Junhao / Chen, Xueliang / Li, Cong / Ma, Haijie / Liu, Jingjing / Zhang, Xinfeng / Chen, Donghong / Si, Jinping

Plant physiology and biochemistry : PPB

2023 Volume 201, Page(s) 107839

Abstract: The compositions and yield of flavonoid compounds of Polygonatum cyrtonema Hua (PC) are important ...

Abstract	The compositions and yield of flavonoid compounds of Polygonatum cyrtonema Hua (PC) are important indices of the quality of medicinal materials. However, the flavonoids compositions and accumulation mechanism are still unclear in PC. Here, we identified 22 flavonoids using widely-targeted metabolome analysis in 15 genotypes of PC. Then weighted gene co-expression network analysis based on 45 transcriptome samples was performed to construct 12 co-expressed modules, in which blue module highly correlated with flavonoids was identified. Furthermore, 4 feature genes including PcCHS1, PcCHI, PcCHS2 and PcCHR5 were identified from 94 hub genes in blue module via machine learning methods support vector machine-recursive feature elimination (SVM-RFE) and random forest (RF), and their functions on metabolic flux of flavonoids pathway were confirmed by tobacco transient expression system. Our findings identified representative flavonoids and key enzymes in PC that provided new insight for elite breeding rich in flavonoids, and thus will be beneficial for rapid development of great potential economic and medicinal value of PC.
MeSH term(s)	Flavonoids ; Polygonatum/genetics ; Plant Breeding ; Gene Expression Profiling ; Machine Learning
Chemical Substances	Flavonoids
Language	English
Publishing date	2023-06-18
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2023.107839
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Article: Fractional Excretion of Urate is Positively Associated with Type 2 Diabetes in HUA Patients: A Cross-Sectional Study.

Huang, Bo / Li, Xin / Zhang, Xinxin / Li, Shiwei / Liu, Yue / Zhang, Mengjuan / Cui, Jingqiu

Diabetes, metabolic syndrome and obesity : targets and therapy

2024 Volume 17, Page(s) 1701–1713

Abstract: Purpose: People with hyperuricemia (HUA) are often related to metabolic disorders such as diabetes ... diabetes (T2D).: Methods: A total of 228 HUA patients from Tianjin Medical University General Hospital ... Increased FEUA levels were significantly associated with T2D in HUA patients. Therefore, routine calculating ...

Abstract	Purpose: People with hyperuricemia (HUA) are often related to metabolic disorders such as diabetes, metabolic syndrome (MetS), and obesity. However, the correlation between excretion of uric acid and these diseases is unclear. Our study aimed to explore the relationship between uric acid excretion and type 2 diabetes (T2D). Methods: A total of 228 HUA patients from Tianjin Medical University General Hospital from 2022 to 2023 were included in this study. We collected demographic, biochemical, and anthropometric data on each subject. Urine uric acid excretion (UUAE) was calculated enzymatically from a single urine collection that lasted 24 hours. And fractional excretion of uric acid (FEUA) was calculated from serum uric acid and creatinine and uric acid and creatinine. Binary logistic regression modeling assessed the association between uric acid excretion and T2D. Results: Of the 228 subjects, 13.4% had T2D and 48.7% had obesity. The obesity group had a lower FEUA (p<0.05) and a higher UUAE compared to the control group (p<0.05). And FEUA had a stronger correlation with the risk of T2D (p<0.001). Also, there was a negative association between BMI and FEUA and a positive link between BMI and UUAE in the outpatients. Conclusion: Increased FEUA levels were significantly associated with T2D in HUA patients. Therefore, routine calculating of FEUA is essential for proper diagnosis and appropriate treatment T2D of in HUA patients.
Language	English
Publishing date	2024-04-13
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S454711
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Article ; Online: Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis.

Lv, Shuquan / Fan, Lirong / Chen, Xiaoting / Su, Xiuhai / Dong, Li / Wang, Qinghai / Wang, Yuansong / Zhang, Hui / Cui, Huantian / Zhang, Shufang / Wang, Lixin

Journal of diabetes research

2024 Volume 2024, Page(s) 9990304

Abstract: ... effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment ...

Abstract	Background: Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment of chronic kidney diseases such as DN, but the specific mechanism of action has not been fully elucidated yet. Purpose: The aim of this study is to clarify whether JPGS alleviates the progression of diabetic nephropathy by inhibiting ferroptosis. Materials and methods: We established a DN mouse model to investigate the therapeutic effect of JPGS in a DN mouse model. Subsequently, we examined the effects of JPGS on ferroptosis- and glutathione peroxidase 4 (GPX4) pathway-related indices. Finally, we validated whether JPGS inhibited ferroptosis in DN mice via the GPX4 pathway using GPX4 inhibitor and ferroptosis inhibitors. Results: The results indicate that JPGS has a therapeutic effect on DN mice by improving kidney function and reducing inflammation. Additionally, JPGS treatment decreased iron overload and oxidative stress levels while upregulating the expression of GPX4 pathway-related proteins. Moreover, JPGS demonstrated a similar therapeutic effect as Fer-1 in the context of DN treatment, and RSL3 was able to counteract the therapeutic effect of JPGS and antiferroptotic effect. Conclusion: JPGS has significant therapeutic and anti-inflammatory effects on DN mice, and its mechanism is mainly achieved by upregulating the expression of GPX4 pathway-related proteins, thereby alleviating iron overload and ultimately reducing ferroptosis.
MeSH term(s)	Animals ; Mice ; Diabetic Nephropathies/drug therapy ; Ferroptosis ; Disease Models, Animal ; Inflammation ; Iron Overload/complications ; Iron Overload/drug therapy ; Diabetes Mellitus
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2711897-6
ISSN	2314-6753 ; 2314-6753
ISSN (online)	2314-6753
ISSN	2314-6753
DOI	10.1155/2024/9990304
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Article ; Online: Comprehensive observations of carbonyls of Mt. Hua in Central China: Vertical distribution and effects on ozone formation.

Zhang, Yifan / Dai, Wenting / Li, Jianjun / Ho, Steven Sai Hang / Li, Lu / Shen, Minxia / Wang, Qiyuan / Cao, Junji

The Science of the total environment

2023 Volume 907, Page(s) 167983

Abstract: Oxygenated volatile organic compounds (OVOCs) play important roles in tropospheric chemistry, regulating the oxidation capacity and ozone ( ... ...

Abstract	Oxygenated volatile organic compounds (OVOCs) play important roles in tropospheric chemistry, regulating the oxidation capacity and ozone (O
Language	English
Publishing date	2023-10-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.167983
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Zs.A 949: Show issues

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Article ; Online: Comparison of Gas-Particle Partitioning of Glyoxal and Methylglyoxal in the Summertime Atmosphere at the Foot and Top of Mount Hua.

Qi, Weining / Zhang, Yifan / Shen, Minxia / Li, Lu / Dai, Wenting / Chen, Yukun / Liu, Yali / Guo, Xiao / Cao, Yue / Wang, Xin / Jiang, Yingkun / Li, Jianjun

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 13

Abstract: Glyoxal and methylglyoxal are important volatile organic compounds in the atmosphere. The gas-particle partitioning of these carbonyl compounds makes significant contributions to ... ...

Abstract	Glyoxal and methylglyoxal are important volatile organic compounds in the atmosphere. The gas-particle partitioning of these carbonyl compounds makes significant contributions to O
MeSH term(s)	Pyruvaldehyde ; Glyoxal ; Gases ; Organic Chemicals ; Atmosphere
Chemical Substances	Pyruvaldehyde (722KLD7415) ; Glyoxal (50NP6JJ975) ; Gases ; Organic Chemicals
Language	English
Publishing date	2023-07-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28135276
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Article ; Online: Proteomic analysis reveals that Polygonatum cyrtonema Hua polysaccharide ameliorates mice muscle atrophy in chemotherapy-induced cachexia.

Tang, Xue-Yang / Xie, Jing / Qin, You / Liu, Hao / Cheng, Fei / Zhang, Hai-Chao / He, Dan / Li, Jia-Yu / Huang, Ao / Lao, Jia / Chen, Lin / Tang, Lin / Zhou, Rong-Rong / Zeng, Hong-Liang / Zhang, Shui-Han

Journal of pharmaceutical and biomedical analysis

2023 Volume 234, Page(s) 115533

Abstract: Polygonatum cyrtonema Hua polysaccharide (PCP) is the main bioactive compound derived from the herb ...

Abstract	Polygonatum cyrtonema Hua polysaccharide (PCP) is the main bioactive compound derived from the herb Polygonati Rhizoma, known for its anti-fatigue, antioxidant, immunomodulatory, and anti-inflammatory properties. However, its effectiveness on alleviating chemotherapy-induced muscle atrophy has been unclear. In this study, we utilized proteomic analysis to investigate the effects and mechanisms of PCP on gemcitabine plus cisplatin (GC) induced muscle atrophy in mice. Quality control analysis revealed that the functional PCP, rich in glucose, is a heterogeneous polysaccharide comprised of nine monosaccharides. PCP (64 mg/kg) significantly alleviated body muscle, organ weight loss, and muscle fiber atrophy in chemotherapy-induced cachectic mice. Moreover, PCP suppressed the decrease in serum immunoglobulin levels and the increase in pro-inflammatory factor interleukin-6 (IL-6). Proteomic analysis demonstrated that PCP contributed to the homeostasis of protein metabolism in gastrocnemius muscle. Diacylglycerol kinase (DGKζ) and cathepsin L (CTSL) were identified as primary PCP targets. Furthermore, the IL-6/STAT3/CTSL and DGKζ/FoxO/Atrogin1 signaling pathways were validated. Our findings suggest that PCP exerts an anti-atrophy effect on chemotherapy-induced muscle atrophy by regulating the autophagy-lysosome and ubiquitin-proteasome systems.
MeSH term(s)	Mice ; Animals ; Cachexia/chemically induced ; Cachexia/drug therapy ; Polygonatum ; Interleukin-6 ; Proteomics ; Muscular Atrophy/chemically induced ; Muscular Atrophy/drug therapy ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Cisplatin ; Antineoplastic Agents/adverse effects
Chemical Substances	Interleukin-6 ; Polysaccharides ; Cisplatin (Q20Q21Q62J) ; Antineoplastic Agents
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115533
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Zs.A 1850: Show issues

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Article ; Online: Oligosaccharides of Polygonatum Cyrtonema Hua ameliorates dextran sulfate sodium-induced colitis and regulates the gut microbiota.

Xu, Jin / Tang, Chuankang / Din, Ahmad Ud / Lu, Yu / Ma, Xiaoyu / Zhang, Tao / Wu, Jiaqi / Zuoqin, Du / Luo, Pei / Wu, Jianbo

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 161, Page(s) 114562

Abstract: ... isolated from Polygonatum Cyrtonema Hua (PFOS) and exhibits anti-inflammatory effects. Therefore, we are ...

Abstract	Ulcerative colitis (UC) is one common chronic inflammatory bowel disease that causes severe side effects, and expensive treatment limits effective and sustained treatment of UC. Fructooligosaccharide was isolated from Polygonatum Cyrtonema Hua (PFOS) and exhibits anti-inflammatory effects. Therefore, we are curious whether PFOS could be used for the treatment of UC. PFOS was introduced via intragastric gavage to C57BL/6 J mice exposed to acute colitis induced by DSS. The results showed that doses of PFOS at 2 and 5 mg/kg/day alleviated the DSS-induced histopathological damage and improved intestinal barrier function. qPCR analysis revealed that PFOS exerted a significant downregulation of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and upregulation of antioxidant genes, including superoxide dismutase1 (SOD1), glutathion peroxidase2 (GPX2), and nuclear factor erythroid 2 related factor2 (Nrf2). Furthermore, PFOS suppressed the DSS-induced disruption of the mucosal barrier by downregulating MMP13. Moreover, using 16 S rRNA gene-based microbiota analysis, PFOS could selectively enhance the growth of probiotics, including Bifidobacterium, Alloprevofella, and Alistipes. Our findings indicated that PFOS attenuated DSS-induced colitis in mice, suggesting that PFOS might be used as an efficacious supplement for reducing inflammatory bowel disease.
MeSH term(s)	Animals ; Mice ; Dextran Sulfate/pharmacology ; Polygonatum ; Gastrointestinal Microbiome ; Mice, Inbred C57BL ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/microbiology ; Colitis, Ulcerative/drug therapy ; Inflammatory Bowel Diseases/chemically induced ; Oligosaccharides/pharmacology ; Disease Models, Animal ; Colon
Chemical Substances	Dextran Sulfate (9042-14-2) ; Oligosaccharides
Language	English
Publishing date	2023-03-17
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114562
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