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  1. Article ; Online: Meet the authors: Jianong Zhang and Haojie Huang.

    Zhang, Jianong / Huang, Haojie

    Molecular cell

    2023  Volume 83, Issue 15, Page(s) 2613–2615

    Abstract: Here, Molecular Cell talks to first author Jianong Zhang and co-corresponding author Haojie Huang ...

    Abstract Here, Molecular Cell talks to first author Jianong Zhang and co-corresponding author Haojie Huang about their paper, ''A lncRNA from the FTO locus acts as a suppressor of the m
    MeSH term(s) Signal Transduction
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5055: Show issues Location:
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  2. Book ; Online: Modeling the inhibition effect of straw checkerboard barriers on wind-blown sand

    Huang, Haojie

    eISSN: 2196-632X

    2023  

    Abstract: Straw checkerboard barriers (SCBs) are usually laid to prevent or delay desertification caused by eolian sand erosion in arid and semiarid regions. Understanding the impact of SCBs and their laying length on eolian sand erosion is of great significance ... ...

    Abstract Straw checkerboard barriers (SCBs) are usually laid to prevent or delay desertification caused by eolian sand erosion in arid and semiarid regions. Understanding the impact of SCBs and their laying length on eolian sand erosion is of great significance to reduce damage and laying costs. In this study, a three-dimensional wind-blown-sand model in the presence of SCBs was established by introducing the splash process and equivalent sand barriers into a large-eddy simulation airflow. From this model, the inhibition effect of SCBs on wind-blown sand was studied qualitatively, and the sensitivity of eolian sand erosion to the laying length was investigated. The results showed that the decrease in the wind speed in the SCB area oscillates along the flow direction. Moreover, the longer the laying lengths are, the lower the wind speed and the sand transport rate in the stable stage behind SCBs will be. We further found that the concentration of sand particles near the side of SCBs is higher than that in its central region, which is qualitatively consistent with previous research. Our results also indicated that whether the wind speed will decrease below the impact threshold or the fluid threshold is the key factor affecting whether sand particles can penetrate the SCBs and form stable wind-blown sand behind the SCBs under the same conditions. Although our model does not include the collision between sand particles and SCB walls, which makes the suppression of wind-blown sand by SCBs obtained from the current model conservative, our research still provides theoretical support for the minimum laying length of SCBs in anti-desertification projects.
    Subject code 551
    Language English
    Publishing date 2023-03-13
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Online: Modeling the Inhibition Effect of Straw Checkerboard Barriers on Wind-blown Sand

    Huang, Haojie

    eISSN:

    2023  

    Abstract: Straw checkerboard barriers (SCBs) are usually laid to prevent or delay desertification caused by eolian sand erosion in arid and semiarid regions. Understanding the impact of SCBs and their laying length on eolian sand erosion is of great significance ... ...

    Abstract Straw checkerboard barriers (SCBs) are usually laid to prevent or delay desertification caused by eolian sand erosion in arid and semiarid regions. Understanding the impact of SCBs and their laying length on eolian sand erosion is of great significance to reduce damage and laying costs. In this study, a three-dimensional wind-blown-sand model in the presence of SCBs was established by introducing the splash process and equivalent sand barriers into a large-eddy simulation airflow. From this model, the inhibition effect of SCBs on wind-blown sand was studied qualitatively, and the sensitivity of eolian sand erosion to the laying length was investigated. The results showed that the decrease in the wind speed in the SCB area oscillates along the flow direction. Moreover, the longer the laying lengths are, the lower the wind speed and the sand transport rate in the stable stage behind SCBs will be. We further found that the concentration of sand particles near the side of SCBs is higher than that in its central region, which is qualitatively consistent with previous research. Our results also indicated that whether the wind speed will decrease below the impact threshold or the fluid threshold is the key factor affecting whether sand particles can penetrate the SCBs and form stable wind-blown sand behind the SCBs under the same conditions. Although our model does not include the collision between sand particles and SCB walls, which makes the suppression of wind-blown sand by SCBs obtained from the current model conservative, our research still provides theoretical support for the minimum laying length of SCBs in anti-desertification projects.
    Subject code 551
    Language English
    Publishing date 2023-03-13
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Hidden tricks in MATH: Hypermorphic mutations in SPOP tumor suppressor explained by cryo-EM.

    Orme, Jacob J / Mer, Georges / Huang, Haojie

    Molecular cell

    2023  Volume 83, Issue 5, Page(s) 655–656

    Abstract: Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al. ...

    Abstract Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al.
    MeSH term(s) Humans ; Carcinogenesis ; Carcinogens ; Cryoelectron Microscopy ; Loss of Function Mutation ; Nuclear Proteins/genetics ; Repressor Proteins/genetics ; Gain of Function Mutation
    Chemical Substances Carcinogens ; SPOP protein, human ; Nuclear Proteins ; Repressor Proteins
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Zero-carbon inertization processes of hazardous mine tailings: Mineral physicochemical properties, transformation mechanism, and long-term stability.

    Huang, Xuquan / Sun, Zhenghua / Zhao, Yanhui / Wang, Haojie / Xue, Fei / Hou, Haobo

    Journal of hazardous materials

    2024  Volume 469, Page(s) 133882

    Abstract: Hazardous mine tailings (HMTs) dam failures can cause devastation to the ecology environment, people's lives and property, which require expensive and complicated remediation engineering systematacially. A cheap and sustainable inertization disposal is ... ...

    Abstract Hazardous mine tailings (HMTs) dam failures can cause devastation to the ecology environment, people's lives and property, which require expensive and complicated remediation engineering systematacially. A cheap and sustainable inertization disposal is proposed for de-risking HMTs without any carbon emissions, stabilizing hazardous heavy metal cations within safety minerals and also sequestering CO
    Language English
    Publishing date 2024-02-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.133882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Androgen receptor: Functional roles and facets of regulation in urology.

    Dehm, Scott M / Huang, Haojie

    Asian journal of urology

    2020  Volume 7, Issue 3, Page(s) 189–190

    Language English
    Publishing date 2020-05-19
    Publishing country Singapore
    Document type Editorial
    ZDB-ID 2831144-9
    ISSN 2214-3882
    ISSN 2214-3882
    DOI 10.1016/j.ajur.2020.05.002
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  7. Article ; Online: Analysis of a SARIMA-XGBoost model for hand, foot, and mouth disease in Xinjiang, China.

    Man, Haojie / Huang, Hanting / Qin, Zhuangyan / Li, Zhiming

    Epidemiology and infection

    2023  Volume 151, Page(s) e200

    Abstract: Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease. The incidence of HFMD has a pronounced seasonal tendency and is closely related to meteorological factors such as temperature, rainfall, and wind speed. In this paper, we ... ...

    Abstract Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease. The incidence of HFMD has a pronounced seasonal tendency and is closely related to meteorological factors such as temperature, rainfall, and wind speed. In this paper, we propose a combined SARIMA-XGBoost model to improve the prediction accuracy of HFMD in 15 regions of Xinjiang, China. The SARIMA model is used for seasonal trends, and the XGBoost algorithm is applied for the nonlinear effects of meteorological factors. The geographical and temporal weighted regression model is designed to analyze the influence of meteorological factors from temporal and spatial perspectives. The analysis results show that the HFMD exhibits seasonal characteristics, peaking from May to August each year, and the HFMD incidence has significant spatial heterogeneity. The meteorological factors affecting the spread of HFMD vary among regions. Temperature and daylight significantly impact the transmission of the disease in most areas. Based on the verification experiment of forecasting, the proposed SARIMA-XGBoost model is superior to other models in accuracy, especially in regions with a high incidence of HFMD.
    MeSH term(s) Humans ; Child ; Hand, Foot and Mouth Disease/epidemiology ; Temperature ; Meteorological Concepts ; Incidence ; China/epidemiology
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S0950268823001905
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    Un I Zs.271: Show issues Location:
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  8. Article: Association between testosterone levels and RigiScan parameters of patients with erectile dysfunction.

    Yuli, Fu / Qi, Zhang / Haojie, Yu / Zedong, Liao / Wenjie, Huang / Runnana, Xu / Tianhao, Shi / Yanfei, Feng / Bodong, Lv

    Sexual medicine

    2024  Volume 12, Issue 1, Page(s) qfad072

    Abstract: Background: It is difficult to diagnose hypogonadism because of the lack of objective assessments of erectile dysfunction (ED), which is caused by hypogonadism.: Aim: To provide a new approach for diagnosing hypogonadism, this study evaluated the ... ...

    Abstract Background: It is difficult to diagnose hypogonadism because of the lack of objective assessments of erectile dysfunction (ED), which is caused by hypogonadism.
    Aim: To provide a new approach for diagnosing hypogonadism, this study evaluated the efficacy of nocturnal penile tumescence and rigidity (NPTR) testing with RigiScan for patients with ED with and without hypogonadism.
    Methods: From June 2021 to February 2023, 133 patients with ED (62 with hypogonadism and 71 without) underwent NPTR testing at the Department of Andrology. A detailed history of all participants was obtained. All participants also underwent a physical examination, sex hormone testing, and ultrasound examination of the cavernous vessels of the penis.
    Outcomes: Patient characteristics, sex hormone serum levels, and RigiScan Plus data of NPTR testing of patients with ED were obtained and evaluated.
    Results: Between the groups, there were no significant differences in age, body mass index, or erectile function score or in the prevalence of smoking, drinking, diabetes, hypertension, and hyperlipidemia. RigiScan data revealed differences in erection episodes per night, average event rigidity, erection durations, and percentage of tumescence greater than baseline, which were significantly lower in the testosterone-deficient group than in the normal testosterone group. The average event rigidity of the tip displayed the largest area under the curve value, with a sensitivity of 67.6%, a specificity of 85.5%, and a cutoff value of 52.50.
    Clinical implications: Our findings may allow appropriate patients to receive testosterone replacement therapy, which has been shown to be an effective treatment for hypogonadism.
    Strengths and limitations: This is the first study of its kind to perform a comprehensive review of the association between hypogonadism and RigiScan parameters. This study was limited by its small sample size.
    Conclusion: RigiScan parameters of patients with ED and testosterone deficiency were significantly lower than those of patients with normal testosterone; therefore, RigiScan is useful for the differential diagnosis of patients with ED caused by hypogonadism.
    Language English
    Publishing date 2024-02-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2734882-9
    ISSN 2050-1161
    ISSN 2050-1161
    DOI 10.1093/sexmed/qfad072
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  9. Article ; Online: Adaptive Diffusion Pairwise Fused Lasso LMS Algorithm Over Networks.

    Huang, Wei / Shan, Haojie / Xu, Jinshan / Yao, Xinwei

    IEEE transactions on neural networks and learning systems

    2023  Volume 34, Issue 9, Page(s) 5816–5827

    Abstract: The topic of identification for sparse vector in a distributed way has triggered great interest in the area of adaptive filtering. Grouping components in the sparse vector has been validated to be an efficient way for enhancing identification performance ...

    Abstract The topic of identification for sparse vector in a distributed way has triggered great interest in the area of adaptive filtering. Grouping components in the sparse vector has been validated to be an efficient way for enhancing identification performance for sparse parameter. The technique of pairwise fused lasso, which can promote similarity between each possible pair of nonnegligible components in the sparse vector, does not require that the nonnegligible components have to be distributed in one or multiple clusters. In other words, the nonnegligible components may be randomly scattered in the unknown sparse vector. In this article, based on the technique of pairwise fused lasso, we propose the novel pairwise fused lasso diffusion least mean-square (PFL-DLMS) algorithm, to identify sparse vector. The objective function we construct consists of three terms, i.e., the mean-square error (MSE) term, the regularizing term promoting the sparsity of all components, and the regularizing term promoting the sparsity of difference between each pair of components in the unknown sparse vector. After investigating mean stability condition of mean-square behavior in theoretical analysis, we propose the strategy of variable regularizing coefficients to overcome the difficulty that the optimal regularizing coefficients are usually unknown. Finally, numerical experiments are conducted to verify the effectiveness of the PFL-DLMS algorithm in identifying and tracking sparse parameter vector.
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2021.3131335
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  10. Article ; Online: Deregulation of SPOP in Cancer.

    Zhang, Hui / Jin, Xiaofeng / Huang, Haojie

    Cancer research

    2023  Volume 83, Issue 4, Page(s) 489–499

    Abstract: Speckle-type POZ protein (SPOP) is a substrate-binding adaptor of the CULLIN3/RING-box1 E3 ubiquitin ligase complex. SPOP is frequently mutated in prostate and endometrial cancers, whereas it is overexpressed in renal cell carcinoma (RCC). SPOP can ... ...

    Abstract Speckle-type POZ protein (SPOP) is a substrate-binding adaptor of the CULLIN3/RING-box1 E3 ubiquitin ligase complex. SPOP is frequently mutated in prostate and endometrial cancers, whereas it is overexpressed in renal cell carcinoma (RCC). SPOP can mediate both degradable and nondegradable polyubiquitination of a number of substrates with diverse biological functions such as androgen receptor (AR), SRC-3, TRIM24, BRD4, PD-L1, 53BP1, GLP/G9a, c-Myc, SENP7, among others. Cancer-associated SPOP mutants often impair SPOP binding and polyubiquitination of its substrates to influence various cancer-relevant pathways, which include androgen/AR signaling, DNA repair and methylation, cellular stress surveillance, cancer metabolism, and immunity. Although SPOP is recognized as a tumor suppressor in prostate and endometrial cancers, it acts like an oncoprotein in RCC. This review provides an overview of the recent progress in understanding of the upstream regulators of SPOP and its downstream targets, highlights the significant impact of SPOP mutations and overexpression on cancer pathogenesis, and discusses the potential of targeting SPOP for cancer treatment.
    MeSH term(s) Female ; Humans ; Male ; Carcinoma, Renal Cell/genetics ; Cell Cycle Proteins/genetics ; Endometrial Neoplasms/genetics ; Kidney Neoplasms/genetics ; Mutation ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Transcription Factors/genetics
    Chemical Substances BRD4 protein, human ; Cell Cycle Proteins ; Nuclear Proteins ; SPOP protein, human ; Transcription Factors
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-22-2801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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