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Article ; Online: Dynamic Trainee Support for Residents Involved in COVID-19 Treatment and Response.

Huff, Abigail / Niedermier, Julie / Kelm, Zachary / Jara, Adam / Barnett, Laura

2020 Volume 71, Issue 7, Page(s) 753

MeSH term(s)	Betacoronavirus/isolation & purification ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Coronavirus Infections/therapy ; Health Personnel/psychology ; Help-Seeking Behavior ; Humans ; Inservice Training/methods ; Internship and Residency/methods ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Pneumonia, Viral/therapy ; Psychiatry/education ; Psychosocial Support Systems ; Stress, Psychological/etiology ; Stress, Psychological/prevention & control
Keywords	covid19
Language	English
Publishing date	2020-06-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1220173-x
ISSN	1557-9700 ; 1075-2730
ISSN (online)	1557-9700
ISSN	1075-2730
DOI	10.1176/appi.ps.71703
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Article: Dynamic Trainee Support for Residents Involved in COVID-19 Treatment and Response

Huff, Abigail / Niedermier, Julie / Kelm, Zachary / Jara, Adam / Barnett, Laura

Psychiatr Serv

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #624111
Database	COVID19

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Article ; Online: Fibroblast Activation Protein-Targeted Radioligand Therapy for Treatment of Solid Tumors.

Lindeman, Spencer D / Mukkamala, Ramesh / Horner, Autumn / Tudi, Pooja / Booth, Owen C / Huff, Roxanne / Hinsey, Joshua / Hovstadius, Anders / Martone, Peter / Zhang, Fenghua / Srinivasarao, Madduri / Cox, Abigail / Low, Philip S

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2022 Volume 64, Issue 5, Page(s) 759–766

Abstract: Fibroblast activation protein (FAP) has received increasing attention as an oncologic target because of its prominent expression in solid tumors but virtual absence from healthy tissues. Most radioligand therapies (RLTs) targeting FAP, however, suffer ... ...

Abstract	Fibroblast activation protein (FAP) has received increasing attention as an oncologic target because of its prominent expression in solid tumors but virtual absence from healthy tissues. Most radioligand therapies (RLTs) targeting FAP, however, suffer from inadequate tumor retention or clearance from healthy tissues. Herein we report a FAP-targeted RLT comprising an FAP6 ligand conjugated to DOTA and an albumin binder (4-
MeSH term(s)	Humans ; Animals ; Mice ; Tissue Distribution ; Cell Line, Tumor ; Albumins ; Fibroblasts
Chemical Substances	Albumins
Language	English
Publishing date	2022-12-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.122.264494
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Zs.MO 328: Show issues

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Article ; Online: Dietary intake of xylose impacts the transcriptome and proteome of tissues involved in xylose metabolism in swine

Nichole F. Huntley / Marcela M. de Souza / Matthew D. Schulte / Hamid Beiki / Andressa O. de Lima / Abigail E. Jantzi / Steven M. Lonergan / Elisabeth J. Huff-Lonergan / John F. Patience / James E. Koltes

Frontiers in Animal Science, Vol

2023 Volume 4

Abstract: Xylose is a primary component of arabinoxylan in swine diets. As arabinoxylan is a significant component of fiber, and fiber is generally rising in practical pig diets globally, the study of arabinoxylan and xylose is of increasing interest. However, the ...

Abstract	Xylose is a primary component of arabinoxylan in swine diets. As arabinoxylan is a significant component of fiber, and fiber is generally rising in practical pig diets globally, the study of arabinoxylan and xylose is of increasing interest. However, the mechanisms by which free xylose may be absorbed and the pathways impacted by xylose have yet to be elucidated in pigs. The objective of this study was to determine the impact of xylose supplementation on gene expression and protein abundance in jejunum, kidney, liver, and muscle tissues which have previously been identified as possible sites of xylose absorption or metabolism. This study aimed to expand the preliminary understanding of dietary xylose metabolism and utilization in pigs. One study, replicated twice with 24 crossbred gilts, was used to assess two dietary treatments: a xylose-free (0%) control and 8% D-xylose. The impact of xylose on growth was monitored by measuring initial and final body weight, serum IGF-1, and liver glycogen concentrations. The rate and efficiency of weight gain were reduced on the xylose diet but not to a level that would occur if xylose was not used at all; the detection of xylose systemically further supports this conclusion. This study confirmed that pigs can utilize dietary xylose. To determine the impact of xylose on tissue metabolism, samples were collected from all four tissues for gene expression analysis by RNA-sequencing, and kidney and liver samples were subjected to proteomic analysis using 2D-DIGE and mass spectrometry. The majority of differentially expressed (DE) genes were identified in the kidney samples (n = 157), with a few identified in the jejunum (n = 16), liver (n = 1), and muscle (n = 20) samples. The DE genes in the kidney were mainly identified as being involved in lipid biosynthesis and fatty acid metabolism. Proteomic results corroborated these findings. Although the inclusion of xylose in a diet at practical levels is shown to impact energy metabolic processes, it has been confirmed that this ...
Keywords	gene expression ; kidney ; xylose ; fiber ; pigs ; Veterinary medicine ; SF600-1100
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multiple drug resistance in hookworms infecting greyhound dogs in the USA.

Jimenez Castro, Pablo D / Venkatesan, Abhinaya / Redman, Elizabeth / Chen, Rebecca / Malatesta, Abigail / Huff, Hannah / Zuluaga Salazar, Daniel A / Avramenko, Russell / Gilleard, John S / Kaplan, Ray M

International journal for parasitology. Drugs and drug resistance

2021 Volume 17, Page(s) 107–117

Abstract: Ancylostoma caninum is the most prevalent nematode parasite of dogs. We confirmed multiple-drug resistance (MDR) in several A. caninum isolates to all anthelmintic drug classes approved for the treatment of hookworms in dogs in the USA. Cases of MDR ... ...

Abstract	Ancylostoma caninum is the most prevalent nematode parasite of dogs. We confirmed multiple-drug resistance (MDR) in several A. caninum isolates to all anthelmintic drug classes approved for the treatment of hookworms in dogs in the USA. Cases of MDR hookworms appear to be highly overrepresented in greyhounds. The aims of this study were to evaluate the drug-resistant phenotypes and genotypes of the A. caninum infecting greyhounds. Fecal samples from greyhounds of the USA were acquired from two greyhound adoption kennels, one active greyhound racing kennel, and three veterinary practices. Fecal egg counts (FECs) were performed on fecal samples from 219 greyhounds, and despite treatment with anthelmintics, the mean FEC was 822.4 eggs per gram (EPG). Resistance to benzimidazoles and macrocyclic lactones were measured using the egg hatch assay (EHA) and the larval development assay (LDA), respectively. We performed 23 EHA and 22 LDA on either individual or pooled feces, representing 54 animals. Mean and median IC
MeSH term(s)	Ancylostoma/genetics ; Ancylostomatoidea ; Animals ; Anthelmintics/pharmacology ; Anthelmintics/therapeutic use ; Dog Diseases/drug therapy ; Dog Diseases/epidemiology ; Dogs ; Drug Resistance ; Drug Resistance, Multiple ; Feces ; Parasite Egg Count ; Pyrantel/therapeutic use
Chemical Substances	Anthelmintics ; Pyrantel (4QIH0N49E7)
Language	English
Publishing date	2021-09-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2751132-7
ISSN	2211-3207 ; 2211-3207
ISSN (online)	2211-3207
ISSN	2211-3207
DOI	10.1016/j.ijpddr.2021.08.005
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Article: Journal of Open Source Software (JOSS): design and first-year review.

Smith, Arfon M / Niemeyer, Kyle E / Katz, Daniel S / Barba, Lorena A / Githinji, George / Gymrek, Melissa / Huff, Kathryn D / Madan, Christopher R / Mayes, Abigail Cabunoc / Moerman, Kevin M / Prins, Pjotr / Ram, Karthik / Rokem, Ariel / Teal, Tracy K / Guimera, Roman Valls / Vanderplas, Jacob T

PeerJ preprints

2018 Volume 4, Page(s) e147

Abstract: This article describes the motivation, design, and progress of the Journal of Open Source Software (JOSS). JOSS is a free and open-access journal that publishes articles describing research software. It has the dual goals of improving the quality of the ... ...

Abstract	This article describes the motivation, design, and progress of the Journal of Open Source Software (JOSS). JOSS is a free and open-access journal that publishes articles describing research software. It has the dual goals of improving the quality of the software submitted and providing a mechanism for research software developers to receive credit. While designed to work within the current merit system of science, JOSS addresses the dearth of rewards for key contributions to science made in the form of software. JOSS publishes articles that encapsulate scholarship contained in the software itself, and its rigorous peer review targets the software components: functionality, documentation, tests, continuous integration, and the license. A JOSS article contains an abstract describing the purpose and functionality of the software, references, and a link to the software archive. The article is the entry point of a JOSS submission, which encompasses the full set of software artifacts. Submission and review proceed in the open, on GitHub. Editors, reviewers, and authors work collaboratively and openly. Unlike other journals, JOSS does not reject articles requiring major revision; while not yet accepted, articles remain visible and under review until the authors make adequate changes (or withdraw, if unable to meet requirements). Once an article is accepted, JOSS gives it a digital object identifier (DOI), deposits its metadata in Crossref, and the article can begin collecting citations on indexers like Google Scholar and other services. Authors retain copyright of their JOSS article, releasing it under a Creative Commons Attribution 4.0 International License. In its first year, starting in May 2016, JOSS published 111 articles, with more than 40 additional articles under review. JOSS is a sponsored project of the nonprofit organization NumFOCUS and is an affiliate of the Open Source Initiative (OSI).
Language	English
Publishing date	2018-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2818058-6
ISSN	2167-9843
ISSN	2167-9843
DOI	10.7717/peerj-cs.147
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Article ; Online: Journal of Open Source Software (JOSS)

Arfon M. Smith / Kyle E. Niemeyer / Daniel S. Katz / Lorena A. Barba / George Githinji / Melissa Gymrek / Kathryn D. Huff / Christopher R. Madan / Abigail Cabunoc Mayes / Kevin M. Moerman / Pjotr Prins / Karthik Ram / Ariel Rokem / Tracy K. Teal / Roman Valls Guimera / Jacob T. Vanderplas

PeerJ Computer Science, Vol 4, p e

design and first-year review

2018 Volume 147

Abstract	This article describes the motivation, design, and progress of the Journal of Open Source Software (JOSS). JOSS is a free and open-access journal that publishes articles describing research software. It has the dual goals of improving the quality of the software submitted and providing a mechanism for research software developers to receive credit. While designed to work within the current merit system of science, JOSS addresses the dearth of rewards for key contributions to science made in the form of software. JOSS publishes articles that encapsulate scholarship contained in the software itself, and its rigorous peer review targets the software components: functionality, documentation, tests, continuous integration, and the license. A JOSS article contains an abstract describing the purpose and functionality of the software, references, and a link to the software archive. The article is the entry point of a JOSS submission, which encompasses the full set of software artifacts. Submission and review proceed in the open, on GitHub. Editors, reviewers, and authors work collaboratively and openly. Unlike other journals, JOSS does not reject articles requiring major revision; while not yet accepted, articles remain visible and under review until the authors make adequate changes (or withdraw, if unable to meet requirements). Once an article is accepted, JOSS gives it a digital object identifier (DOI), deposits its metadata in Crossref, and the article can begin collecting citations on indexers like Google Scholar and other services. Authors retain copyright of their JOSS article, releasing it under a Creative Commons Attribution 4.0 International License. In its first year, starting in May 2016, JOSS published 111 articles, with more than 40 additional articles under review. JOSS is a sponsored project of the nonprofit organization NumFOCUS and is an affiliate of the Open Source Initiative (OSI).
Keywords	Research software ; Code review ; Computational research ; Software citation ; Open-source software ; Scholarly publishing ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	070
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exome sequencing identifies the cause of a mendelian disorder.

Ng, Sarah B / Buckingham, Kati J / Lee, Choli / Bigham, Abigail W / Tabor, Holly K / Dent, Karin M / Huff, Chad D / Shannon, Paul T / Jabs, Ethylin Wang / Nickerson, Deborah A / Shendure, Jay / Bamshad, Michael J

Nature genetics

2009 Volume 42, Issue 1, Page(s) 30–35

Abstract: We demonstrate the first successful application of exome sequencing to discover the gene for a rare mendelian disorder of unknown cause, Miller syndrome (MIM%263750). For four affected individuals in three independent kindreds, we captured and sequenced ... ...

Abstract	We demonstrate the first successful application of exome sequencing to discover the gene for a rare mendelian disorder of unknown cause, Miller syndrome (MIM%263750). For four affected individuals in three independent kindreds, we captured and sequenced coding regions to a mean coverage of 40x and sufficient depth to call variants at approximately 97% of each targeted exome. Filtering against public SNP databases and eight HapMap exomes for genes with two previously unknown variants in each of the four individuals identified a single candidate gene, DHODH, which encodes a key enzyme in the pyrimidine de novo biosynthesis pathway. Sanger sequencing confirmed the presence of DHODH mutations in three additional families with Miller syndrome. Exome sequencing of a small number of unrelated affected individuals is a powerful, efficient strategy for identifying the genes underlying rare mendelian disorders and will likely transform the genetic analysis of monogenic traits.
MeSH term(s)	Abnormalities, Multiple/genetics ; Abnormalities, Multiple/pathology ; Amino Acid Sequence ; Exons/genetics ; Family Health ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Mandibulofacial Dysostosis/pathology ; Molecular Sequence Data ; Mutation ; Open Reading Frames/genetics ; Oxidoreductases Acting on CH-CH Group Donors/genetics ; Sequence Analysis, DNA/methods ; Sequence Homology, Amino Acid ; Syndrome
Chemical Substances	Oxidoreductases Acting on CH-CH Group Donors (EC 1.3.-) ; dihydroorotate dehydrogenase (EC 1.3.5.2)
Language	English
Publishing date	2009-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1108734-1
ISSN	1546-1718 ; 1061-4036
ISSN (online)	1546-1718
ISSN	1061-4036
DOI	10.1038/ng.499
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Article ; Online: Correction: Alternating Hemiplegia of Childhood: Retrospective Genetic Study and Genotype-Phenotype Correlations in 187 Subjects from the US AHCF Registry.

Viollet, Louis / Glusman, Gustavo / Murphy, Kelley J / Newcomb, Tara M / Reyna, Sandra P / Sweney, Matthew / Nelson, Benjamin / Andermann, Frederick / Andermann, Eva / Acsadi, Gyula / Barbano, Richard L / Brown, Candida / Brunkow, Mary E / Chugani, Harry T / Cheyette, Sarah R / Collins, Abigail / DeBrosse, Suzanne D / Galas, David / Friedman, Jennifer /

PloS one

2015 Volume 10, Issue 8, Page(s) e0137370

Language	English
Publishing date	2015
Publishing country	United States
Document type	Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0137370
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction

Louis Viollet / Gustavo Glusman / Kelley J Murphy / Tara M Newcomb / Sandra P Reyna / Matthew Sweney / Benjamin Nelson / Frederick Andermann / Eva Andermann / Gyula Acsadi / Richard L Barbano / Candida Brown / Mary E Brunkow / Harry T Chugani / Sarah R Cheyette / Abigail Collins / Suzanne D DeBrosse / David Galas / Jennifer Friedman /

PLoS ONE, Vol 10, Iss 8, p e

Alternating Hemiplegia of Childhood: Retrospective Genetic Study and Genotype-Phenotype Correlations in 187 Subjects from the US AHCF Registry.

2015 Volume 0137370

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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