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  1. Article ; Online: Kai-xin-san improves cognitive impairment in D-gal and Aβ

    Wang, Huijuan / Zhou, Lifen / Zheng, Qin / Song, Yonggui / Huang, Weihua / Yang, Lin / Xiong, Yongchang / Cai, Zhinan / Chen, Ying / Yuan, Jinbin

    Journal of ethnopharmacology

    2024  Volume 329, Page(s) 118161

    Abstract: Ethnopharmacological relevance: Kai-Xin-San (KXS) is a classic herbal formula for the treatment ...

    Abstract Ethnopharmacological relevance: Kai-Xin-San (KXS) is a classic herbal formula for the treatment and prevention of AD (Alzheimer's disease) with definite curative effect, but its mechanism, which involves multiple components, pathways, and targets, is not yet fully understood.
    Aim of the study: To verify the effect of KXS on gut microbiota and explore its anti-AD mechanism related with gut microbiota.
    Materials and methods: AD rat model was established and evaluated by intraperitoneal injection of D-gal and bilateral hippocampal CA1 injections of Aβ
    Results: KXS could significantly improve cognitive impairment, reduce neuronal damage and attenuate neuroinflammation and colonic inflammation in vivo in AD model rats. Nine differential intestinal bacteria associated with AD were screened, in which four bacteria (Lactobacillus murinus, Ligilactobacillus, Alloprevotella, Prevotellaceae_NK3B31_group) were very significant.
    Conclusion: KXS can maintain the ecological balance of intestinal microbiota and exert its anti-AD effect by regulating the composition and proportion of gut microbiota in AD rats through the microbiota-gut-brain axis.
    Language English
    Publishing date 2024-04-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cardiac Overexpression of XIN Prevents Dilated Cardiomyopathy Caused by

    Li, Bin / Guo, Yifan / Zhan, Yongkun / Zhou, Xinyan / Li, Yongbo / Zhao, Chao / Sun, Ning / Xu, Chen / Liang, Qianqian

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 691749

    Abstract: ... ...

    Abstract TNNT2
    Language English
    Publishing date 2021-06-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.691749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bu-Shen-Ning-Xin decoction alleviates premature ovarian insufficiency (POI) by regulating autophagy of granule cells through activating PI3K/AKT/mTOR pathway.

    Dou, Xiaoqing / Jin, Xin / Chen, Xingbei / Zhou, Qun / Chen, Hanyu / Wen, Mingxiao / Chen, Wenjun

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2022  Volume 38, Issue 9, Page(s) 754–764

    Abstract: Purpose: To explore the therapeutic effects of Bu-Shen-Ning-Xin decoction (BSNXD) on POI and ...

    Abstract Purpose: To explore the therapeutic effects of Bu-Shen-Ning-Xin decoction (BSNXD) on POI and the underlying mechanism.
    Methods: VCD was used to induce the
    Results: Decreased primary follicles in the ovarian tissues, elevated concentration of FSH, and LH, suppressed concentration of E2 and AMH in the serum, reduced number of oocytes, and mitochondrial dysfunction in oocytes induced by VCD were significantly reversed by BSNXD. Activated autophagy state and inhibited PI3K/AKT/mTOR pathway stimulated by VCD in both ovarian tissues and GCs were dramatically reversed by BSNXD. The protective effect of BSNXD on VCD-treated GCs was abolished by LY294002, an inhibitor of the PI3K/AKT/mTOR pathway.
    Conclusion: Our data revealed that BSNXD alleviated POI by regulating autophagy of granule cells through activating PI3K/AKT/mTOR pathway.
    MeSH term(s) Animals ; Apoptosis ; Autophagy ; Beclin-1/pharmacology ; Drugs, Chinese Herbal ; Female ; Follicle Stimulating Hormone/therapeutic use ; Humans ; Menopause, Premature ; Phosphatidylinositol 3-Kinases/metabolism ; Primary Ovarian Insufficiency/chemically induced ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Beclin-1 ; Drugs, Chinese Herbal ; Proto-Oncogene Proteins c-bcl-2 ; bu-shen-ning-xin ; Follicle Stimulating Hormone (9002-68-0) ; MTOR protein, human (EC 2.7.1.1) ; mTOR protein, rat (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-08-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2022.2112941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 608: Show issues

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  4. Article ; Online: Bu-Shen-Ning-Xin decoction inhibits macrophage activation to ameliorate premature ovarian insufficiency-related osteoimmune disorder via FSH/FSHR pathway.

    Sun, Hongmei / Qi, Qing / Pan, Xinyao / Zhou, Jing / Wang, Jing / Li, Lisha / Li, Dajing / Wang, Ling

    Drug discoveries & therapeutics

    2024  

    Abstract: ... osteoimmune disorder currently. Bu-Shen-Ning-Xin decoction (BSNXD) displayed a favorable role in treating ...

    Abstract Limited studies are associated with premature ovarian insufficiency (POI)-related osteoimmune disorder currently. Bu-Shen-Ning-Xin decoction (BSNXD) displayed a favorable role in treating postmenopausal osteoporosis. However, its impact on the POI-related osteoimmune disorder remains unclear. The study primarily utilized animal experiments and network pharmacology to investigate the effects and underlying mechanisms of BSNXD on the POI-related osteoimmune disorder. First, a 4-vinylcyclohexene dioxide (VCD)-induced POI murine model was conducted to explore the therapeutical action of BSNXD. Second, we analyzed the active compounds of BSNXD and predicted their potential mechanisms for POI-related osteoimmune disorder via network pharmacology, further confirmed by molecular biology experiments. The results demonstrated that VCD exposure led to elevated follicle-stimulating hormone (FSH) levels, a 50% reduction in the primordial follicles, bone microstructure changes, and macrophage activation, indicating an osteoimmune disorder. BSNXD inhibited macrophage activation and osteoclast differentiation but did not affect serum FSH and estradiol levels in the VCD-induced POI model. Network pharmacology predicted the potential mechanisms of BSNXD against the POI-related osteoimmune disorder involving tumor necrosis factor α and MAPK signaling pathways, highlighting BSNXD regulated inflammation, hormone, and osteoclast differentiation. Further experiments identified BSNXD treatment suppressed macrophage activation via downregulating FSH receptor (FSHR) expression and inhibiting the phosphorylation of ERK and CCAAT enhancer binding proteins β. In conclusion, BSNXD regulated POI-related osteoimmune disorder by suppressing the FSH/FSHR pathway to reduce macrophage activation and further inhibiting osteoclastogenesis.
    Language English
    Publishing date 2024-04-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2568828-5
    ISSN 1881-784X ; 1881-784X
    ISSN (online) 1881-784X
    ISSN 1881-784X
    DOI 10.5582/ddt.2024.01006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Kai-Xin-San ameliorates Alzheimer's disease-related neuropathology and cognitive impairment in APP/PS1 mice via the mitochondrial autophagy-NLRP3 inflammasome pathway.

    Shan, Xiaoxiao / Tao, Wenwen / Li, Junying / Tao, Wenkang / Li, Dawei / Zhou, Lele / Yang, Xuan / Dong, Chong / Huang, Shunwang / Chu, Xiaoqin / Zhang, Caiyun

    Journal of ethnopharmacology

    2024  Volume 329, Page(s) 118145

    Abstract: Ethnopharmacological relevance: Kai-Xin-San (KXS) is a classic famous prescription that has been ...

    Abstract Ethnopharmacological relevance: Kai-Xin-San (KXS) is a classic famous prescription that has been utilized for centuries to address dementia. New investigations have shown that the anti-dementia effect of KXS is connected with improved neuroinflammation. Nevertheless, the underlying mechanism is not well elucidated.
    Aim of the study: We propose to discover the ameliorative impact of KXS on Alzheimer's disease (AD) and its regulatory role on the mitochondrial autophagy-nod-like receptor protein 3 (NLRP3) inflammasome pathway.
    Materials and methods: The Y maze, Morris water maze, and new objection recognition tests were applied to ascertain the spatial learning and memory capacities of amyloid precursor protein/presenilin 1 (APP/PS1) mice after KXS-treatment. Meanwhile, the biochemical indexes of the hippocampus were detected by reagent kits. The pathological alterations and mitochondrial autophagy in the mice' hippocampus were detected utilizing hematoxylin and eosin (H&E), immunohistochemistry, immunofluorescence staining, and transmission electron microscopy. Besides, the PTEN-induced putative kinase 1 (PINK1)/Parkin and NLRP3 inflammasome pathways protein expressions were determined employing the immunoblot analysis.
    Results: The results of behavioral tests showed that KXS significantly enhanced the AD mice' spatial learning and memory capacities. Furthermore, KXS reversed the biochemical index levels and reduced amyloid-β protein deposition in AD mice brains. Besides, H&E staining showed that KXS remarkably ameliorated the neuronal damage in AD mice. Concurrently, the results of transmission electron microscopy suggest that KXS ameliorated the mitochondrial damage in microglia and promoted mitochondrial autophagy. Moreover, the immunofluorescence outcomes exhibited that KXS promoted the expression of protein 1 light chain 3B (LC3B) associated with microtubule and the generation of autophagic flux. Notably, the immunofluorescence co-localization results confirmed the presence of mitochondrial autophagy in microglia. Finally, KXS promoted the protein expressions of the PINK1/Parkin pathway and reduced the activation of NLRP3 inflammasome. Most importantly, these beneficial effects of KXS were attenuated by the mitochondrial autophagy inhibitor chloroquine.
    Conclusion: KXS ameliorates AD-related neuropathology and cognitive impairment in APP/PS1 mice by enhancing the mitochondrial autophagy and suppressing the NLRP3 inflammasome pathway.
    Language English
    Publishing date 2024-04-04
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
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  6. Article ; Online: Xin-Ji-Er-Kang protects myocardial and renal injury in hypertensive heart failure in mice.

    Ling, Xin-Xin / Chen, Hua / Fu, Bei-Bei / Ruan, Cheng-Shao / Pana, Ming / Zhou, Kai / Fang, Zhi-Rui / Shao, Jun-Tang / Zhu, Feng-Qin / Gao, Shan

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2021  Volume 91, Page(s) 153675

    Abstract: Background: Xin-Ji-Er-Kang (XJEK) as a herbal formula of traditional Chinese medicine (TCM) has ...

    Abstract Background: Xin-Ji-Er-Kang (XJEK) as a herbal formula of traditional Chinese medicine (TCM) has shown the protective effects on myocardial function as well as renal function in mouse models of myocardial infarction.
    Hypothesis/purpose: We investigated the effects of XJEK on cardiovascular- and renal-function in a heart failure mouse model induced by high salt (HS) and the associated mechanisms.
    Study design: For the purpose of assessing the effects of XJEK on a hypertensive heart failure model, mice were fed with 8% high salt diet. XJEK was administered by oral gavage for 8 weeks. Cardiovascular function parameters, renal function associated biomarkers and XJEK's impact on renin-angiotensin-aldosterone system (RAAS) activation were assessed. To determine the underlying mechanism, the calpain1/junctophilin-2 (JP2)/sarcoplasmic reticulum Ca
    Results: Mice on HS-diet exhibited hypertensive heart failure along with progressive kidney injury. Similar to fosinopril, XJEK ameliorated hypertension, cardiovascular-and renal- dysfunction in mice of HS-diet group. XJEK inhibited HS-induced activation of RAAS and reversed the abnormal expression pattern of calpain1and JP2 protein in heart tissues. XJEK significantly improved cell viability of angiotensin II-challenged AC16 cells. Moreover, XJEK's impact on calpain1/JP2 pathway was partly diminished in AC16 cells transfected with calpastatin siRNA.
    Conclusion: XJEK was found to exert cardiovascular- and renal protection in HS-diet induced heart failure mouse model. XJEK inhibited HS-diet induced RAAS activation by inhibiting the activity and expression of calpain1 and protected the junctional membrane complex (JMC) in cardiomyocytes.
    MeSH term(s) Animals ; Blood Pressure ; Calpain ; Drugs, Chinese Herbal/pharmacology ; Heart Failure/drug therapy ; Hypertension/drug therapy ; Kidney/drug effects ; Kidney/physiology ; Membrane Proteins ; Mice ; Muscle Proteins ; Oxidative Stress ; Sarcoplasmic Reticulum Calcium-Transporting ATPases ; Signal Transduction
    Chemical Substances Drugs, Chinese Herbal ; Membrane Proteins ; Muscle Proteins ; junctophilin-2 protein, mouse ; xin-ji-er-kang ; Calpain (EC 3.4.22.-) ; Capn1 protein, mouse (EC 3.4.22.52) ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8) ; Atp2a2 protein, mouse (EC 7.2.2.10)
    Language English
    Publishing date 2021-07-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2021.153675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4115: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Research on the quality markers of antioxidant activity of Kai-Xin-San based on the spectrum-effect relationship.

    Shan, Xiaoxiao / Yang, Xuan / Li, Dawei / Zhou, Lele / Qin, Shaogang / Li, Junying / Tao, Wenkang / Peng, Can / Wei, Jinming / Chu, Xiaoqin / Wang, Haixuan / Zhang, Caiyun

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1270836

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-12-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1270836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1.

    Chen, Chao / Xu, Yuan-Jie / Zhang, Shang-Rong / Wang, Xiao-Hui / Hu, Yuan / Guo, Dai-Hong / Zhou, Xiao-Jiang / Zhu, Wei-Yu / Wen, Ai-Dong / Tan, Qing-Rong / Dong, Xian-Zhe / Liu, Ping

    Heliyon

    2023  Volume 9, Issue 3, Page(s) e14265

    Abstract: Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression ...

    Abstract Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. Recent studies indicated that miRNAs were involved in the pathophysiology of depression. However, there have been few studies on the mechanism underlying the miRNAs directly mediating antidepressant at clinical level, especially in nature drugs and TCM compound. In this study, we identified circulating miRNAs defferentially expressed among the depression patients (DPs), DPs who underwent 8weeks of KXS treatment and health controls (HCs). A total of 45 miRNAs (17 were up-regulated and 28 were down-regulated) were significantly differentially expressed among three groups. Subsequently, qRT-PCR was used to verify 10 differentially expressed candidate miRNAs in more serum samples, and the results showed that 6 miRNAs (miR-1281, miR-365a-3p, miR-2861, miR-16-5p, miR-1202 and miR-451a) were consistent with the results of microarray. Among them, miR-1281, was the novel dynamically altered and appeared to be specifically related to depression and antidepressant effects of KXS. MicroRNA-gene-pathway-net analysis showed that miR-1281-regulated genes are mostly key nodes in the classical signaling pathway related to depression. Additionally, our data suggest that ADCY1 and DVL1 were the targets of miR-1281. Thus, based on the discovery of miRNA expression profiles in vivo, our findings suggest a new role for miR-1281 related to depression and demonstrated in vitro that KXS may activate cAMP/PKA/ERK/CREB and Wnt/β-catenin signal transduction pathways by down-regulating miR-1281 that targets ADCY1 and DVL1 to achieve its role in neuronal cell protection.
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro.

    Yan, Chenchen / Yang, Song / Shao, Simai / Zu, Runru / Lu, Hao / Chen, Yuanzhao / Zhou, Yangang / Ying, Xiran / Xiang, Shixie / Zhang, Peixu / Li, Zhonghua / Yuan, Ye / Zhang, Zhenqiang / Wang, Pan / Xie, Zhishen / Wang, Wang / Ma, Huifen / Sun, Yiran

    Journal of ethnopharmacology

    2024  Volume 326, Page(s) 117915

    Abstract: Ethnopharmacological relevance: Kai Xin San (KXS), first proposed by Sun Simiao during the Tang ...

    Abstract Ethnopharmacological relevance: Kai Xin San (KXS), first proposed by Sun Simiao during the Tang Dynasty, has been utilized to treat dementia by tonifying qi and dispersing phlegm.
    Aim of the study: This study aimed to elucidate the mechanism by which KXS exerts its therapeutic effects on Alzheimer's disease (AD) by targeting ferroptosis, using a combination of network pharmacology, bioinformatics, and experimental validation strategies.
    Materials and methods: The active target sites and the further potential mechanisms of KXS in protecting against AD were investigated through molecular docking, molecular dynamics simulation, and network pharmacology, and combined with the validation of animal experiments.
    Results: Computational and experimental findings provide the first indication that KXS significantly improves learning and memory defects and inhibits neuronal ferroptosis by repairing mitochondria damage and upregulating the protein expression of ferroptosis suppressor protein 1 (FSP1) in vivo APP/PS1 mice AD model. According to bioinformatics analysis, the mechanism by which KXS inhibits ferroptosis may involve SIRT1. KXS notably upregulated the mRNA and protein expression of SIRT1 in both vivo APP/PS1 mice and in vitro APP-overexpressed HT22 cells. Additionally, KXS inhibited ferroptosis induced by APP-overexpression in HT22 cells through activating the SIRT1-FSP1 signal pathway.
    Conclusions: Collectively, our findings suggest that KXS may inhibit neuronal ferroptosis through activating the SIRT1/FSP1 signaling pathway. This study reveals the scientific basis and underlying modern theory of replenishing qi and eliminating phlegm, which involves the inhibition of ferroptosis. Moreover, it highlights the potential application of SIRT1 or FSP1 activators in the treatment of AD and other ferroptosis-related diseases.
    MeSH term(s) Mice ; Animals ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Sirtuin 1/genetics ; Ferroptosis ; Molecular Docking Simulation ; Network Pharmacology ; Computational Biology ; Drugs, Chinese Herbal
    Chemical Substances Kai-Xin-San ; Sirtuin 1 (EC 3.5.1.-) ; Drugs, Chinese Herbal
    Language English
    Publishing date 2024-02-13
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A Comparative Study of Serum Pharmacochemistry of Kai-Xin-San in Normal and AD Rats Using UPLC-LTQ-Orbitrap-MS.

    Yang, Lin / Liang, Jian / Zheng, Qin / Zhou, Lifen / Xiong, Yongchang / Wang, Huijuan / Yuan, Jinbin

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 16, Issue 1

    Abstract: Kai-Xin-San (KXS) is a classic formula for the treatment of Alzheimer's disease (AD). KXS has been ...

    Abstract Kai-Xin-San (KXS) is a classic formula for the treatment of Alzheimer's disease (AD). KXS has been widely used to treat emotional diseases; however, its active components remain unknown. There have been some reports about the efficacy and metabolic analysis of KXS, which are mainly based on studying normal animals. The current work first established an AD rat model by injecting D-galactose into the abdominal cavity and injecting Aβ
    Language English
    Publishing date 2022-12-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16010030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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