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Article ; Online: The L

Kumar, Kamlesh / Chavarha, Mariya / Loney, Ryan W / Weiss, Thomas M / Rananavare, Shankar B / Hall, Stephen B

Langmuir : the ACS journal of surfaces and colloids

2018 Volume 34, Issue 22, Page(s) 6601–6611

Abstract: ... the essential characteristics of the L ...

Abstract	To determine how different components affect the structure of pulmonary surfactant, we measured X-ray scattering by samples derived from calf surfactant. The surfactant phospholipids demonstrated the essential characteristics of the L
MeSH term(s)	Animals ; Cattle ; Phospholipids/chemistry ; Phosphoproteins/chemistry ; Pulmonary Surfactants/chemistry ; Spectrometry, X-Ray Emission
Chemical Substances	Phospholipids ; Phosphoproteins ; Pulmonary Surfactants
Language	English
Publishing date	2018-05-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.8b00460
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Article: Application of the Sleep C.A.L.M. Tool for Assessing Nocturia in a Large Nationally Representative Cohort.

Boroda, Joseph U / De Leon, Benjamin / Khosla, Lakshay / Chobufo, Muchi D / Rahman, Syed N / Lazar, Jason M / Weiss, Jeffrey P / Monaghan, Thomas F

International neurourology journal

2024 Volume 28, Issue Suppl 1, Page(s) 55–61

Abstract: ... evaluated and treated. The "Sleep C.A.L.M." system categorizes the factors thought to collectively reflect ... of this study was to assess the association of nocturia with the Sleep C.A.L.M. categories using a nationally ... physical examination data were used to ascertain the presence of Sleep C.A.L.M. categories in adults ≥20 years of age ...

Abstract	Purpose: Nocturia significantly impacts patients' quality of life but remains insufficiently evaluated and treated. The "Sleep C.A.L.M." system categorizes the factors thought to collectively reflect most underlying causes of nocturia (Sleep disorders, Comorbidities, Actions [i.e., modifiable patient behaviors such as excess fluid intake], Lower urinary tract dysfunction, and Medications). The purpose of this study was to assess the association of nocturia with the Sleep C.A.L.M. categories using a nationally representative dataset. Methods: Retrospective analysis of the National Health and Nutrition Examination Survey from 2013/14-2017/18 cycles was conducted. Pertinent questionnaire, laboratory, dietary, and physical examination data were used to ascertain the presence of Sleep C.A.L.M. categories in adults ≥20 years of age. Nocturia was defined as ≥2 nighttime voids. Results: A total of 12,274 included subjects were included (51.6% female; median age, 49.0 years [interquartile range, 34.0-62.0 years]; 27.6% nocturia). Among subjects with nocturia, the prevalence of 0, ≥1, and ≥2 Sleep C.A.L.M. categories was 3.5% (95% confidence interval [CI], 2.8%-4.4%), 96.5% (95% CI, 95.6%-97.2%), and 81.2% (95% CI, 78.9%-83.3%), respectively. Compared to those with 0-1 Sleep C.A.L.M. categories, the adjusted odds of nocturia in subjects with 2, 3, and 4-5 Sleep C. A.L.M. categories were 1.77 (95% CI, 1.43-2.21), 2.33 (1.89-2.87), and 3.49 (2.81-4.35), respectively (P<0.001). Similar trends were observed for most age and sex subgroups. When assessed individually, each of the 5 Sleep C.A.L.M. categories were independently associated with greater odds of nocturia, which likewise persisted across multiple age and sex subgroups. Conclusion: Sleep C.A.L.M. burden is associated with increased odds of nocturia in a dose-dependent fashion, and potentially a relevant means by which to organize the underlying etiologies for nocturia among community-dwelling adults.
Language	English
Publishing date	2024-02-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2584447-7
ISSN	2093-6931 ; 2093-4777
ISSN (online)	2093-6931
ISSN	2093-4777
DOI	10.5213/inj.2346258.129
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Article ; Online: Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.

Lee, Danyel / Le Pen, Jérémie / Yatim, Ahmad / Dong, Beihua / Aquino, Yann / Ogishi, Masato / Pescarmona, Rémi / Talouarn, Estelle / Rinchai, Darawan / Zhang, Peng / Perret, Magali / Liu, Zhiyong / Jordan, Iolanda / Elmas Bozdemir, Sefika / Bayhan, Gulsum Iclal / Beaufils, Camille / Bizien, Lucy / Bisiaux, Aurelie / Lei, Weite /

Hasan, Milena / Chen, Jie / Gaughan, Christina / Asthana, Abhishek / Libri, Valentina / Luna, Joseph M / Jaffré, Fabrice / Hoffmann, H-Heinrich / Michailidis, Eleftherios / Moreews, Marion / Seeleuthner, Yoann / Bilguvar, Kaya / Mane, Shrikant / Flores, Carlos / Zhang, Yu / Arias, Andrés A / Bailey, Rasheed / Schlüter, Agatha / Milisavljevic, Baptiste / Bigio, Benedetta / Le Voyer, Tom / Materna, Marie / Gervais, Adrian / Moncada-Velez, Marcela / Pala, Francesca / Lazarov, Tomi / Levy, Romain / Neehus, Anna-Lena / Rosain, Jérémie / Peel, Jessica / Chan, Yi-Hao / Morin, Marie-Paule / Pino-Ramirez, Rosa Maria / Belkaya, Serkan / Lorenzo, Lazaro / Anton, Jordi / Delafontaine, Selket / Toubiana, Julie / Bajolle, Fanny / Fumadó, Victoria / DeDiego, Marta L / Fidouh, Nadhira / Rozenberg, Flore / Pérez-Tur, Jordi / Chen, Shuibing / Evans, Todd / Geissmann, Frédéric / Lebon, Pierre / Weiss, Susan R / Bonnet, Damien / Duval, Xavier / Pan-Hammarström, Qiang / Planas, Anna M / Meyts, Isabelle / Haerynck, Filomeen / Pujol, Aurora / Sancho-Shimizu, Vanessa / Dalgard, Clifford L / Bustamante, Jacinta / Puel, Anne / Boisson-Dupuis, Stéphanie / Boisson, Bertrand / Maniatis, Tom / Zhang, Qian / Bastard, Paul / Notarangelo, Luigi / Béziat, Vivien / Perez de Diego, Rebeca / Rodriguez-Gallego, Carlos / Su, Helen C / Lifton, Richard P / Jouanguy, Emmanuelle / Cobat, Aurélie / Alsina, Laia / Keles, Sevgi / Haddad, Elie / Abel, Laurent / Belot, Alexandre / Quintana-Murci, Lluis / Rice, Charles M / Silverman, Robert H / Zhang, Shen-Ying / Casanova, Jean-Laurent

Science (New York, N.Y.)

2023 Volume 379, Issue 6632, Page(s) eabo3627

Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies ... ...

Abstract	Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of
MeSH term(s)	Child ; Humans ; COVID-19/immunology ; Cytokines/genetics ; Cytokines/immunology ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; RNA, Double-Stranded ; SARS-CoV-2/genetics ; Systemic Inflammatory Response Syndrome/genetics
Chemical Substances	Cytokines ; Endoribonucleases (EC 3.1.-) ; RNA, Double-Stranded ; OAS1 protein, human (EC 2.7.7.-) ; OAS2 protein, human (EC 2.7.7.-) ; 2-5A-dependent ribonuclease (EC 3.1.26.-) ; MAVS protein, human
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abo3627
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Article ; Online: Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells.

Abdelaziz, Ramadan F / Hussein, Ahmed M / Kotob, Mohamed H / Weiss, Christina / Chelminski, Krzysztof / Stojanovic, Tamara / Studenik, Christian R / Aufy, Mohammed

International journal of molecular sciences

2023 Volume 24, Issue 23

Abstract: ... that cathepsin L (cath L) contributes to radiation resistance through multiple mechanisms. In this study ... we investigated the role of cath L, a member of the cysteine cathepsins (caths) in radiation sensitivity, and ... the potential reduction in radiation resistance by using the specific cath L inhibitor (Z-FY(tBu)DMK) or ...

Abstract	Cancer is one of the main causes of death globally. Radiotherapy/Radiation therapy (RT) is one of the most common and effective cancer treatments. RT utilizes high-energy radiation to damage the DNA of cancer cells, leading to their death or impairing their proliferation. However, radiation resistance remains a significant challenge in cancer treatment, limiting its efficacy. Emerging evidence suggests that cathepsin L (cath L) contributes to radiation resistance through multiple mechanisms. In this study, we investigated the role of cath L, a member of the cysteine cathepsins (caths) in radiation sensitivity, and the potential reduction in radiation resistance by using the specific cath L inhibitor (Z-FY(tBu)DMK) or by knocking out cath L with CRISPR/Cas9 in colon carcinoma cells (caco-2). Cells were treated with different doses of radiation (2, 4, 6, 8, and 10), dose rate 3 Gy/min. In addition, the study conducted protein expression analysis by western blot and immunofluorescence assay, cytotoxicity MTT, and apoptosis assays. The results demonstrated that cath L was upregulated in response to radiation treatment, compared to non-irradiated cells. In addition, inhibiting or knocking out cath L led to increased radiosensitivity in contrast to the negative control group. This may indicate a reduced ability of cancer cells to recover from radiation-induced DNA damage, resulting in enhanced cell death. These findings highlight the possibility of targeting cath L as a therapeutic strategy to enhance the effectiveness of RT. Further studies are needed to elucidate the underlying molecular mechanisms and to assess the translational implications of cath L knockout in clinical settings. Ultimately, these findings may contribute to the development of novel treatment approaches for improving outcomes of RT in cancer patients.
MeSH term(s)	Humans ; Caco-2 Cells ; Carcinoma ; Cathepsin L/genetics ; Radiation Tolerance/genetics
Chemical Substances	Cathepsin L (EC 3.4.22.15)
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242317106
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Article ; Online: Unraveling the potential of phenomic selection within and among diverse breeding material of maize (Zea mays L.).

Weiß, Thea Mi / Zhu, Xintian / Leiser, Willmar L / Li, Dongdong / Liu, Wenxin / Schipprack, Wolfgang / Melchinger, Albrecht E / Hahn, Volker / Würschum, Tobias

G3 (Bethesda, Md.)

2022 Volume 12, Issue 3

Abstract: ... Zea mays L.) comprising elite lines of the Flint and Dent heterotic pools as well as 6 Flint landraces ...

Abstract	Genomic selection is a well-investigated approach that facilitates and supports selection decisions for complex traits and has meanwhile become a standard tool in modern plant breeding. Phenomic selection has only recently been suggested and uses the same statistical procedures to predict the targeted traits but replaces marker data with near-infrared spectroscopy data. It may represent an attractive low-cost, high-throughput alternative but has not been sufficiently studied until now. Here, we used 400 genotypes of maize (Zea mays L.) comprising elite lines of the Flint and Dent heterotic pools as well as 6 Flint landraces, which were phenotyped in multienvironment trials for anthesis-silking-interval, early vigor, final plant height, grain dry matter content, grain yield, and phosphorus concentration in the maize kernels, to compare the predictive abilities of genomic as well as phenomic prediction under different scenarios. We found that both approaches generally achieved comparable predictive abilities within material groups. However, phenomic prediction was less affected by population structure and performed better than its genomic counterpart for predictions among diverse groups of breeding material. We therefore conclude that phenomic prediction is a promising tool for practical breeding, for instance when working with unknown and rather diverse germplasm. Moreover, it may make the highly monopolized sector of plant breeding more accessible also for low-tech institutions by combining well established, widely available, and cost-efficient spectral phenotyping with the statistical procedures elaborated for genomic prediction - while achieving similar or even better results than with marker data.
MeSH term(s)	Genome, Plant ; Genotype ; Hybrid Vigor ; Phenomics ; Phenotype ; Plant Breeding ; Zea mays/genetics
Language	English
Publishing date	2022-02-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1093/g3journal/jkab445
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Book ; Online: Vers une restauration collective plus respectueuse de l’environnement

Landert, Jan / Frehner, Anita / Weiner, Mareike / Thörig, Reto / Weiss, Monika

2022

Abstract: Cette fiche technique présente des mesures permettant de réduire les effets négatifs sur l ... environnement lors de l’utilisation et de la valorisation des denrées alimentaires ...

Abstract	Cette fiche technique présente des mesures permettant de réduire les effets négatifs sur l’environnement lors de l’utilisation et de la valorisation des denrées alimentaires dans la restauration collective.
Keywords	Food security ; food quality and human health ; Processing ; packaging and transportation
Language	French
Publisher	Institut de recherche de l'agriculture biologique FiBL, Bio Suisse
Publishing country	dk
Document type	Book ; Online
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Article ; Online: The chemical journey of Europium(III) through winter rye (Secale cereale L.) - Understanding through mass spectrometry and chemical microscopy.

Stadler, Julia / Vogel, Manja / Steudtner, Robin / Drobot, Björn / Kogiomtzidis, Anna L / Weiss, Martin / Walther, Clemens

Chemosphere

2022 Volume 313, Page(s) 137252

Abstract: ... the chemical journey of europium (Eu(III)) through winter rye (Secale cereale L.), providing insight ... of contaminated plants show a maximum europium concentration in Secale cereale L. after four days. Transport ...

Abstract	A combination of biochemical preparation methods with microscopic, spectroscopic, and mass spectrometric analysis techniques as contemplating state of the art application, was used for direct visualization, localization, and chemical identification of europium in plants. This works illustrates the chemical journey of europium (Eu(III)) through winter rye (Secale cereale L.), providing insight into the possibilities of speciation for Rare Earth Elements (REE) and trivalent f-elements. Kinetic experiments of contaminated plants show a maximum europium concentration in Secale cereale L. after four days. Transport of the element through the vascular bundle was confirmed with Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray analysis (EDS). For chemical speciation, plants were grown in a liquid nutrition medium, whereby Eu(III) species distribution could be measured by mass spectrometry and luminescence measurements. Both techniques confirm the occurrence of Eu malate species in the nutrition medium, and further analysis of the plant was performed. Luminescence results indicate a change in Eu(III) species distribution from root tip to plant leaves. Microscopic analysis show at least three different Eu(III) species with potential binding to organic and inorganic phosphate groups and a Eu(III) protein complex. With plant root extraction, further europium species could be identified by using Electrospray Ionization Mass Spectrometry (ESI MS). Complexation with malate, citrate, a combined malate-citrate ligand, and aspartate was confirmed mostly in a 1:1 stoichiometry (Eu:ligand). The combination of the used analytical techniques opens new possibilities in direct species analysis, especially regarding to the understanding of rare earth elements (REE) uptake in plants. This work provides a contribution in better understanding of plant mechanisms of the f-elements and their species uptake.
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.137252
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Article ; Conference proceedings: Schwangerschaftsadaptierte L-Thyroxin Substitution und Frühgeburtenrate

Torremante, E / Weiß, C

Geburtshilfe und Frauenheilkunde

2022 Volume 82, Issue 10

Event/congress	64. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e. V., München, 2022-10-12
Language	German
Publishing date	2022-10-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80111-2
ISSN	1438-8804 ; 0016-5751 ; 1615-3359
ISSN (online)	1438-8804
ISSN	0016-5751 ; 1615-3359
DOI	10.1055/s-0042-1757078
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Article ; Online: John L. Cameron, MD: Overview of His Career.

Javed, Ammar A / Weiss, Matthew J / Wolfgang, Christopher L

Annals of surgery

2017 Volume 267, Issue 2S Suppl 2, Page(s) S2

Abstract: Introduction to the John Cameron Festschrift. ...

Abstract	: Introduction to the John Cameron Festschrift.
MeSH term(s)	Baltimore ; Faculty, Medical/history ; General Surgery/education ; General Surgery/history ; History, 20th Century ; History, 21st Century ; Hospitals, Teaching/history ; Leadership ; Mentors/history ; Pancreatectomy/history ; Pancreaticoduodenectomy/history
Language	English
Publishing date	2017-10-27
Publishing country	United States
Document type	Biography ; Festschrift ; Historical Article ; Portrait
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000002588
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Article ; Online: Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms.

Apfel, Verena / Begue, Damien / Cordo', Valentina / Holzer, Laura / Martinuzzi, Laetitia / Buhles, Alexandra / Kerr, Grainne / Barbosa, Ines / Naumann, Ulrike / Piquet, Michelle / Ruddy, David / Weiss, Andreas / Ferretti, Stephane / Almeida, Reinaldo / Bonenfant, Debora / Tordella, Luca / Galli, Giorgio G

ACS pharmacology & translational science

2021 Volume 4, Issue 1, Page(s) 327–337

Abstract: Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy ...

Abstract	Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy in acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing asparagine (
Language	English
Publishing date	2021-01-13
Publishing country	United States
Document type	Journal Article
ISSN	2575-9108
ISSN (online)	2575-9108
DOI	10.1021/acsptsci.0c00196
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