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  1. Article ; Online: Proteolysis of Orai1 controls cellular Ca

    Derler, Isabella

    Cell calcium

    2022  Volume 102, Page(s) 102535

    MeSH term(s) Calcium/metabolism ; Calcium Signaling ; ORAI1 Protein/metabolism ; Proteolysis ; Stromal Interaction Molecule 1/metabolism
    Chemical Substances ORAI1 Protein ; Stromal Interaction Molecule 1 ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-01-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2022.102535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
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  2. Article ; Online: Genetic code expansion, an emerging tool in the Ca

    Söllner, Julia / Derler, Isabella

    The Journal of physiology

    2024  

    Abstract: Various methods for characterizing binding forces as well as for monitoring and remote control of ion channels are still emerging. A recent innovation is the direct incorporation of unnatural amino acids (UAAs) with corresponding biophysical or ... ...

    Abstract Various methods for characterizing binding forces as well as for monitoring and remote control of ion channels are still emerging. A recent innovation is the direct incorporation of unnatural amino acids (UAAs) with corresponding biophysical or biochemical properties, which are integrated using genetic code expansion technology. Minimal changes to natural amino acids, which are achieved by chemical synthesis of corresponding UAAs, are valuable tools to provide insight into the contributions of physicochemical properties of side chains in binding events. To gain unique control over the conformational changes or function of ion channels, a series of light-sensitive, chemically reactive and posttranslationally modified UAAs have been developed and utilized. Here, we present the existing UAA tools, their mode of action, their potential and limitations as well as their previous applications to Ca
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP285840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tubular aggregate myopathy mutant unveils novel activation and inactivation mechanisms of Orai1.

    Derler, Isabella / Romanin, Christoph

    Cell calcium

    2023  Volume 112, Page(s) 102739

    MeSH term(s) Humans ; Mutation/genetics ; Miosis ; Myopathies, Structural, Congenital/genetics ; ORAI1 Protein/genetics ; Stromal Interaction Molecule 1/genetics ; Calcium/metabolism
    Chemical Substances ORAI1 Protein ; Stromal Interaction Molecule 1 ; Calcium (SY7Q814VUP) ; ORAI1 protein, human
    Language English
    Publishing date 2023-04-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2023.102739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Synthetic Biology Meets Ca

    Bacsa, Bernadett / Hopl, Valentina / Derler, Isabella

    Cells

    2024  Volume 13, Issue 6

    Abstract: Many essential biological processes are triggered by the proximity of molecules. Meanwhile, diverse approaches in synthetic biology, such as new biological parts or engineered cells, have opened up avenues to precisely control the proximity of molecules ... ...

    Abstract Many essential biological processes are triggered by the proximity of molecules. Meanwhile, diverse approaches in synthetic biology, such as new biological parts or engineered cells, have opened up avenues to precisely control the proximity of molecules and eventually downstream signaling processes. This also applies to a main Ca
    MeSH term(s) Calcium Signaling/physiology ; Synthetic Biology ; Stromal Interaction Molecule 1/metabolism ; Calcium Release Activated Calcium Channels/metabolism ; Immunity
    Chemical Substances Stromal Interaction Molecule 1 ; Calcium Release Activated Calcium Channels
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13060468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Insights into the dynamics of the Ca2+ release-activated Ca2+ channel pore-forming complex Orai1.

    Fröhlich, Maximilian / Söllner, Julia / Derler, Isabella

    Biochemical Society transactions

    2024  Volume 52, Issue 2, Page(s) 747–760

    Abstract: An important calcium (Ca2+) entry pathway into the cell is the Ca2+ release-activated Ca2+ (CRAC) channel, which controls a series of downstream signaling events such as gene transcription, secretion and proliferation. It is composed of a Ca2+ sensor in ... ...

    Abstract An important calcium (Ca2+) entry pathway into the cell is the Ca2+ release-activated Ca2+ (CRAC) channel, which controls a series of downstream signaling events such as gene transcription, secretion and proliferation. It is composed of a Ca2+ sensor in the endoplasmic reticulum (ER), the stromal interaction molecule (STIM), and the Ca2+ ion channel Orai in the plasma membrane (PM). Their activation is initiated by receptor-ligand binding at the PM, which triggers a signaling cascade within the cell that ultimately causes store depletion. The decrease in ER-luminal Ca2+ is sensed by STIM1, which undergoes structural rearrangements that lead to coupling with Orai1 and its activation. In this review, we highlight the current understanding of the Orai1 pore opening mechanism. In this context, we also point out the questions that remain unanswered and how these can be addressed by the currently emerging genetic code expansion (GCE) technology. GCE enables the incorporation of non-canonical amino acids with novel properties, such as light-sensitivity, and has the potential to provide novel insights into the structure/function relationship of CRAC channels at a single amino acid level in the living cell.
    MeSH term(s) Humans ; ORAI1 Protein/metabolism ; Calcium/metabolism ; Calcium Release Activated Calcium Channels/metabolism ; Endoplasmic Reticulum/metabolism ; Stromal Interaction Molecule 1/metabolism ; Calcium Signaling ; Animals ; Cell Membrane/metabolism
    Chemical Substances ORAI1 Protein ; Calcium (SY7Q814VUP) ; Calcium Release Activated Calcium Channels ; Stromal Interaction Molecule 1 ; ORAI1 protein, human
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20230815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 944: Show issues Location:
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  6. Article: Molecular Choreography and Structure of Ca

    Tiffner, Adéla / Derler, Isabella

    Membranes

    2020  Volume 10, Issue 12

    Abstract: ... ...

    Abstract Ca
    Language English
    Publishing date 2020-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes10120425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology.

    Tiffner, Adéla / Derler, Isabella

    International journal of molecular sciences

    2021  Volume 22, Issue 15

    Abstract: ... ...

    Abstract Ca
    MeSH term(s) Animals ; Calcium/chemistry ; Calcium/metabolism ; Calcium Release Activated Calcium Channels/chemistry ; Calcium Release Activated Calcium Channels/genetics ; Calcium Release Activated Calcium Channels/metabolism ; Calcium Signaling ; Endoplasmic Reticulum/chemistry ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Humans ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Stromal Interaction Molecule 1/chemistry ; Stromal Interaction Molecule 1/genetics ; Stromal Interaction Molecule 1/metabolism ; Structure-Activity Relationship
    Chemical Substances Calcium Release Activated Calcium Channels ; Neoplasm Proteins ; Protein Isoforms ; STIM1 protein, human ; Stromal Interaction Molecule 1 ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22158020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.

    Tiffner, Adéla / Hopl, Valentina / Derler, Isabella

    Cancers

    2022  Volume 15, Issue 1

    Abstract: Cancer represents a major health burden worldwide. Several molecular targets have been discovered alongside treatments with positive clinical outcomes. However, the reoccurrence of cancer due to therapy resistance remains the primary cause of mortality. ... ...

    Abstract Cancer represents a major health burden worldwide. Several molecular targets have been discovered alongside treatments with positive clinical outcomes. However, the reoccurrence of cancer due to therapy resistance remains the primary cause of mortality. Endeavors in pinpointing new markers as molecular targets in cancer therapy are highly desired. The significance of the co-regulation of Ca
    Language English
    Publishing date 2022-12-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15010101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Role of Lipids in CRAC Channel Function.

    Maltan, Lena / Andova, Ana-Marija / Derler, Isabella

    Biomolecules

    2022  Volume 12, Issue 3

    Abstract: The composition and dynamics of the lipid membrane define the physical properties of the bilayer and consequently affect the function of the incorporated membrane transporters, which also applies for the prominent ... ...

    Abstract The composition and dynamics of the lipid membrane define the physical properties of the bilayer and consequently affect the function of the incorporated membrane transporters, which also applies for the prominent Ca
    MeSH term(s) Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Release Activated Calcium Channels/metabolism ; Cell Membrane/metabolism ; Endoplasmic Reticulum/metabolism ; Lipids ; Membrane Proteins/metabolism
    Chemical Substances Calcium Channels ; Calcium Release Activated Calcium Channels ; Lipids ; Membrane Proteins ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12030352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Natural photoswitches expose STIM1 activation steps.

    Derler, Isabella / Romanin, Christoph

    Cell calcium

    2020  Volume 90, Page(s) 102240

    Abstract: STIM1, an ER-located Ca2+ sensor, activates Orai1 channels upon Ca2+-storedepletion. Prior to this, STIM1 undergoes a sequence of conformational changes, which cannot be controlled individually with high spatiotemporal resolution. Ma et al. [1] used the ... ...

    Abstract STIM1, an ER-located Ca2+ sensor, activates Orai1 channels upon Ca2+-storedepletion. Prior to this, STIM1 undergoes a sequence of conformational changes, which cannot be controlled individually with high spatiotemporal resolution. Ma et al. [1] used the power of optogenetic engineering to transfer light-sensitivity to STIM1 and precisely characterize individual STIM1 activation steps.
    MeSH term(s) Animals ; Humans ; Light ; Models, Biological ; Optogenetics ; Protein Domains ; Stromal Interaction Molecule 1/chemistry ; Stromal Interaction Molecule 1/metabolism
    Chemical Substances Stromal Interaction Molecule 1
    Language English
    Publishing date 2020-06-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2020.102240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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