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  1. Article ; Online: Exploring Atherosclerosis Imaging With FDG-PET in Motion.

    Fayad, Zahi A / Calcagno, Claudia

    JACC. Cardiovascular imaging

    2022  Volume 15, Issue 12, Page(s) 2109–2111

    MeSH term(s) Humans ; Predictive Value of Tests ; Positron-Emission Tomography ; Atherosclerosis/diagnostic imaging
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2022.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6846: Show issues Location:
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  2. Article ; Online: USPIO-Enhanced CMR of Myocardial Inflammation: What Are We Imaging?

    Fayad, Zahi A / Calcagno, Claudia

    JACC. Cardiovascular imaging

    2021  Volume 14, Issue 2, Page(s) 377–378

    MeSH term(s) Dextrans ; Heart Failure ; Humans ; Inflammation/diagnostic imaging ; Magnetite Nanoparticles ; Predictive Value of Tests
    Chemical Substances Dextrans ; Magnetite Nanoparticles ; ferumoxtran-10
    Language English
    Publishing date 2021-04-07
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2020.12.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical imaging of cardiovascular inflammation.

    Calcagno, Claudia / Fayad, Zahi A

    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...

    2020  Volume 64, Issue 1, Page(s) 74–84

    Abstract: Cardiovascular disease due to atherosclerosis is the number one cause of morbidity and mortality worldwide. In the past twenty years, compelling preclinical and clinical data have indicated that a maladaptive inflammatory response plays a crucial role in ...

    Abstract Cardiovascular disease due to atherosclerosis is the number one cause of morbidity and mortality worldwide. In the past twenty years, compelling preclinical and clinical data have indicated that a maladaptive inflammatory response plays a crucial role in the development of atherosclerosis initiation and progression in the vasculature, all the way to the onset of life-threatening cardiovascular events. Furthermore, inflammation is key to heart and brain damage and healing after myocardial infarction or stroke. Recent evidence indicates that this interplay between the vasculature, organs target of ischemia and the immune system is mediated by the activation of hematopoietic organs (bone marrow and spleen). In this evolving landscape, non-invasive imaging is becoming more and more essential to support either mechanistic preclinical studies to investigate the role of inflammation in cardiovascular disease (CVD), or as a translational tool to quantify inflammation in the cardiovascular system and hematopoietic organs in patients. In this review paper, we will describe the clinical applications of non-invasive imaging to quantify inflammation in the vasculature, infarcted heart and brain, and hematopoietic organs in patients with cardiovascular disease, with specific focus on [18F]FDG PET and other novel inflammation-specific radiotracers. Furthermore, we will briefly describe the most recent clinical applications of other imaging techniques such as MRI, SPECT, CT, CEUS and OCT in this arena.
    MeSH term(s) Animals ; Cardiovascular Diseases/diagnostic imaging ; Cardiovascular Diseases/metabolism ; Diagnostic Imaging/methods ; Humans ; Inflammation/diagnostic imaging ; Inflammation/metabolism ; Translational Medical Research
    Language English
    Publishing date 2020-02-18
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 1281687-5
    ISSN 1827-1936 ; 0392-0208 ; 1125-0135 ; 1824-4661 ; 1824-4785
    ISSN (online) 1827-1936
    ISSN 0392-0208 ; 1125-0135 ; 1824-4661 ; 1824-4785
    DOI 10.23736/S1824-4785.20.03228-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sodium Fluoride PET and Aortic Bioprosthetic Valve Degeneration: Implications for Patient Diagnosis, Management, and Treatment.

    Fayad, Zahi A / Calcagno, Claudia

    Journal of the American College of Cardiology

    2019  Volume 73, Issue 10, Page(s) 1120–1122

    MeSH term(s) Aortic Valve ; Aortic Valve Stenosis ; Bioprosthesis ; Humans ; Positron-Emission Tomography ; Sodium Fluoride
    Chemical Substances Sodium Fluoride (8ZYQ1474W7)
    Language English
    Publishing date 2019-03-15
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2018.12.057
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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  5. Article ; Online: Imaging-guided nanomedicine development.

    Bernal, Aurora / Calcagno, Claudia / Mulder, Willem J M / Pérez-Medina, Carlos

    Current opinion in chemical biology

    2021  Volume 63, Page(s) 78–85

    Abstract: Nanomedicine research is an active field that produces thousands of studies every year. However, translation of nanotherapeutics to the clinic has yet to catch up with such a vast output. In recent years, the need to better understand nanomedicines' in ... ...

    Abstract Nanomedicine research is an active field that produces thousands of studies every year. However, translation of nanotherapeutics to the clinic has yet to catch up with such a vast output. In recent years, the need to better understand nanomedicines' in vivo behavior has been identified as one of the major challenges for efficient clinical translation. In this context, noninvasive imaging offers attractive solutions to provide valuable information about nanomedicine biodistribution, pharmacokinetics, stability, or therapeutic efficacy. Here, we review the latest imaging approaches used in the development of therapeutic nanomedicines, discuss why these strategies bring added value along the translational pipeline, and give a perspective on future advances in the field.
    MeSH term(s) Animals ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Humans ; Indicators and Reagents/chemistry ; Magnetic Resonance Imaging ; Molecular Targeted Therapy ; Nanomedicine ; Nanoparticles/chemistry ; Optical Imaging ; Tissue Distribution ; Tomography, Emission-Computed
    Chemical Substances Drug Carriers ; Indicators and Reagents
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2021.01.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4986: Show issues Location:
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  6. Article ; Online: PET/MR imaging of inflammation in atherosclerosis.

    Senders, Max L / Calcagno, Claudia / Tawakol, Ahmed / Nahrendorf, Matthias / Mulder, Willem J M / Fayad, Zahi A

    Nature biomedical engineering

    2022  Volume 7, Issue 3, Page(s) 202–220

    Abstract: Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact the haematopoietic system, which through immunity and inflammation may aggravate pre-existing ... ...

    Abstract Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact the haematopoietic system, which through immunity and inflammation may aggravate pre-existing atherosclerosis. The interplay between the haematopoietic system and its modulation of atherosclerosis has been studied by imaging the cardiovascular system and the activation of haematopoietic organs via scanners integrating positron emission tomography and resonance imaging (PET/MRI). In this Perspective, we review the applicability of integrated whole-body PET/MRI for the study of immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease, and discuss the translational opportunities and challenges of the technology.
    MeSH term(s) Humans ; Multimodal Imaging/methods ; Atherosclerosis/diagnostic imaging ; Positron-Emission Tomography/methods ; Inflammation/diagnostic imaging ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2022-12-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-022-00970-7
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  7. Article ; Online: Intraplaque and Cellular Distribution of Dextran-Coated Iron Oxide Fluorescently Labeled Nanoparticles: Insights Into Atherothrombosis and Plaque Rupture.

    Calcagno, Claudia / Fayad, Zahi A

    Circulation. Cardiovascular imaging

    2017  Volume 10, Issue 5

    MeSH term(s) Carotid Stenosis ; Dextrans ; Ferric Compounds ; Humans ; Molecular Imaging ; Nanoparticles ; Permeability ; Plaque, Atherosclerotic ; Thrombosis
    Chemical Substances Dextrans ; Ferric Compounds ; ferric oxide (1K09F3G675)
    Language English
    Publishing date 2017-05-09
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.117.006533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6743: Show issues Location:
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  8. Article ; Online: Imaging the Permeable Endothelium: Predicting Plaque Rupture in Atherosclerotic Rabbits.

    Calcagno, Claudia / Fayad, Zahi A

    Circulation. Cardiovascular imaging

    2016  Volume 9, Issue 12

    MeSH term(s) Animals ; Atherosclerosis ; Contrast Media ; Endothelium ; Humans ; Magnetic Resonance Imaging ; Plaque, Atherosclerotic ; Rabbits
    Chemical Substances Contrast Media
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.116.005955
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    Zs.A 6743: Show issues Location:
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  9. Article: Outcomes of Drug Interactions Between Antiretrovirals and Co-Medications, Including Over-the-Counter Drugs: A Real-World Study.

    Ambrosioni, Juan / Díaz, Natalia Anahí / Marzolini, Catia / Dragovic, Gordana / Imaz, Arkaitz / Calcagno, Andrea / Luque, Sonia / Curran, Adrian / Troya, Jesus / Tuset, Montse / Khoo, Saye / Burger, David / Cortés, Claudia P / Naous, Nadia / Molto, Jose

    Infectious diseases and therapy

    2024  Volume 13, Issue 3, Page(s) 609–617

    Abstract: Introduction: The objective was to characterize real-world outcomes of drug-drug interactions (DDIs) between antiretrovirals (ARVs) and other drugs, including over-the-counter medications (OTC), and treatment outcomes in clinical practice.: Methods: ... ...

    Abstract Introduction: The objective was to characterize real-world outcomes of drug-drug interactions (DDIs) between antiretrovirals (ARVs) and other drugs, including over-the-counter medications (OTC), and treatment outcomes in clinical practice.
    Methods: www.clinicalcasesDDIs.com is an open-access website for healthcare providers to consult and briefly describe real-world clinical cases on DDI with ARVs. We reviewed all the clinical cases reported to the website between March 2019 and May 2023.
    Results: A total of 139 cases were reported, mostly involving ritonavir or cobicistat (boosters; 74 cases), unboosted integrase inhibitors (InSTI; 29 cases), and non-nucleoside reverse transcriptase inhibitors (NNRTI; 23 cases). Central nervous system drugs (29 cases) and cardiovascular drugs (19 cases) were the most frequently described co-medications. Notably, OTC medications were implicated in 27 cases, including mineral supplements (11 cases), herbals (8 cases), weight loss drugs (4 cases), anabolic steroids (3 cases), and recreational drugs (1 case). OTC acted as the perpetrator drug in 21 cases, leading to loss of ARV efficacy in 17 instances (mineral supplements in 10 cases, weight loss drugs in 4 cases, herbals in 3 cases). Additionally, toxicity was reported in 4 out of 6 cases where OTC was considered the victim drug of the DDI (anabolic steroids in 3 cases, MDMA in 1 case).
    Conclusions: Frequent unwanted outcomes resulting from DDIs between ARVs and OTC medications underscore the importance of integrating non-prescription drugs into medication reconciliation. The real-world data available through www.clinicalcasesDDIs.com serves as a valuable resource for assessing the clinical relevance of DDIs.
    Language English
    Publishing date 2024-02-19
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-024-00935-0
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  10. Article ; Online: Plaque microvascularization and permeability: Key players in atherogenesis and plaque rupture.

    Calcagno, Claudia / Fayad, Zahi A / Raggi, Paolo

    Atherosclerosis

    2017  Volume 263, Page(s) 320–321

    MeSH term(s) Atherosclerosis ; Humans ; Magnetic Resonance Imaging ; Permeability ; Plaque, Atherosclerotic ; Vasa Vasorum
    Language English
    Publishing date 2017-06-21
    Publishing country Ireland
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2017.06.915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 226: Show issues Location:
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