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  1. Article ; Online: BmSPP

    Feng, Yu-Ting / Yang, Chun-Yan / Wu, Lin / Wang, Yuan-Cheng / Shen, Guan-Wang / Lin, Ping

    Frontiers in immunology

    2024  Volume 15, Page(s) 1377270

    Abstract: Introduction: Signal peptide peptidase (: Methods: First, we performed RT-qPCR to analyze the expression pattern of : Results: We observed a decreased in the expression of : Discussion: Collectively, this work demonstrates ... ...

    Abstract Introduction: Signal peptide peptidase (
    Methods: First, we performed RT-qPCR to analyze the expression pattern of
    Results: We observed a decreased in the expression of
    Discussion: Collectively, this work demonstrates that
    MeSH term(s) Animals ; Bombyx ; Nucleopolyhedroviruses/genetics ; Gene Editing ; Down-Regulation
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1377270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: TPA: Two-stage progressive attention segmentation framework for hepatocellular carcinoma on multi-modality MRI.

    Gao, Lei / Wang, Weilang / Meng, Xiangpan / Zhang, Shuhang / Xu, Jun / Ju, Shenghong / Wang, Yuan-Cheng

    Medical physics

    2024  

    Abstract: Background: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) plays a crucial role in the diagnosis and measurement of hepatocellular carcinoma (HCC). The multi-modality information contained in the multi-phase images of DCE-MRI is ... ...

    Abstract Background: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) plays a crucial role in the diagnosis and measurement of hepatocellular carcinoma (HCC). The multi-modality information contained in the multi-phase images of DCE-MRI is important for improving segmentation. However, this remains a challenging task due to the heterogeneity of HCC, which may cause one HCC lesion to have varied imaging appearance in each phase of DCE-MRI. In particular, some phases exhibit inconsistent sizes and boundaries will result in a lack of correlation between modalities, and it may pose inaccurate segmentation results.
    Purpose: We aim to design a multi-modality segmentation model that can learn meaningful inter-phase correlation for achieving HCC segmentation.
    Methods: In this study, we propose a two-stage progressive attention segmentation framework (TPA) for HCC based on the transformer and the decision-making process of radiologists. Specifically, the first stage aims to fuse features from multi-phase images to identify HCC and provide localization region. In the second stage, a multi-modality attention transformer module (MAT) is designed to focus on the features that can represent the actual size.
    Results: We conduct training, validation, and test in a single-center dataset (386 cases), followed by external test on a batch of multi-center datasets (83 cases). Furthermore, we analyze a subgroup of data with weak inter-phase correlation in the test set. The proposed model achieves Dice coefficient of 0.822 and 0.772 in the internal and external test sets, respectively, and 0.829, 0.791 in the subgroup. The experimental results demonstrate that our model outperforms state-of-the-art models, particularly within subgroup.
    Conclusions: The proposed TPA provides best segmentation results, and utilizing clinical prior knowledge for network design is practical and feasible.
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.16968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1210: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Differentiating tumour progression from pseudoprogression in glioblastoma patients: a monoexponential, biexponential, and stretched-exponential model-based DWI study.

    Liao, Dan / Liu, Yuan-Cheng / Liu, Jiang-Yong / Wang, Di / Liu, Xin-Feng

    BMC medical imaging

    2023  Volume 23, Issue 1, Page(s) 119

    Abstract: Background: To investigate the diagnostic performance of parameters derived from monoexponential, biexponential, and stretched-exponential diffusion-weighted imaging models in differentiating tumour progression from pseudoprogression in glioblastoma ... ...

    Abstract Background: To investigate the diagnostic performance of parameters derived from monoexponential, biexponential, and stretched-exponential diffusion-weighted imaging models in differentiating tumour progression from pseudoprogression in glioblastoma patients.
    Methods: Forty patients with pathologically confirmed glioblastoma exhibiting enhancing lesions after completion of chemoradiation therapy were enrolled in the study, which were then classified as tumour progression and pseudoprogression. All patients underwent conventional and multi-b diffusion-weighted MRI. The apparent diffusion coefficient (ADC) from a monoexponential model, the true diffusion coefficient (D), pseudodiffusion coefficient (D*) and perfusion fraction (f) from a biexponential model, and the distributed diffusion coefficient (DDC) and intravoxel heterogeneity index (α) from a stretched-exponential model were compared between tumour progression and pseudoprogression groups. Receiver operating characteristic curves (ROC) analysis was used to investigate the diagnostic performance of different DWI parameters. Interclass correlation coefficient (ICC) was used to evaluate the consistency of measurements.
    Results: The values of ADC, D, DDC, and α values were lower in tumour progression patients than that in pseudoprogression patients (p < 0.05). The values of D* and f were higher in tumour progression patients than that in pseudoprogression patients (p < 0.05). Diagnostic accuracy for differentiating tumour progression from pseudoprogression was highest for α(AUC = 0.94) than that for ADC (AUC = 0.91), D (AUC = 0.92), D* (AUC = 0.81), f (AUC = 0.75), and DDC (AUC = 0.88).
    Conclusions: Multi-b DWI is a promising method for differentiating tumour progression from pseudoprogression with high diagnostic accuracy. In addition, the α derived from stretched-exponential model is the most promising DWI parameter for the prediction of tumour progression in glioblastoma patients.
    MeSH term(s) Humans ; Glioblastoma/diagnostic imaging ; Glioblastoma/therapy ; Diffusion Magnetic Resonance Imaging ; Chemoradiotherapy ; ROC Curve
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2061975-3
    ISSN 1471-2342 ; 1471-2342
    ISSN (online) 1471-2342
    ISSN 1471-2342
    DOI 10.1186/s12880-023-01082-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Advances in medical imaging to evaluate acute respiratory distress syndrome.

    Huang, Shan / Wang, Yuan-Cheng / Ju, Shenghong

    Chinese journal of academic radiology

    2021  Volume 5, Issue 1, Page(s) 1–9

    Abstract: Acute respiratory distress syndrome is a refractory respiratory syndrome with a high prevalence in the Intensive Care Unit. Though much improvement has been achieved over the last 50 decades, the disease continues to be under-recognized and under-treated, ...

    Abstract Acute respiratory distress syndrome is a refractory respiratory syndrome with a high prevalence in the Intensive Care Unit. Though much improvement has been achieved over the last 50 decades, the disease continues to be under-recognized and under-treated, and its mortality remains high. Since the first report, the radiologic examination has been an essential part in evaluating this disease. Chest X-ray radiography and computed tomography are conventional imaging techniques in routine clinical practice. Other image modalities, including lung ultrasound, electrical impedance tomography, positron emission tomography, have demonstrated their respective advantages over recent years but have not yet been broadly applied in clinical practice. Among these modalities, computed tomography and its quantitative analysis have shown an irreplaceable power in diagnosis, intervention evaluation and prognostic prediction. In this review, we briefly introduced the basics of acute respiratory distress syndrome and summarized imaging advances. In addition, we focused on the computed tomography modality and highlighted the value of its quantitative assessment.
    Language English
    Publishing date 2021-07-17
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2967251-X
    ISSN 2520-8993 ; 2520-8985
    ISSN (online) 2520-8993
    ISSN 2520-8985
    DOI 10.1007/s42058-021-00078-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The 'body mind map' medical record.

    Wang, Cheng-Yuan

    Medical education

    2022  Volume 56, Issue 11, Page(s) 1122–1123

    MeSH term(s) Humans ; Medical Records
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 195274-2
    ISSN 1365-2923 ; 0308-0110
    ISSN (online) 1365-2923
    ISSN 0308-0110
    DOI 10.1111/medu.14924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 312: Show issues Location:
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  6. Article ; Online: An Error in Modeling and the Selection of Independent Radiomics Variables Need Caution.

    Yuan, Cheng / Huang, Runqiu / Wang, Yang

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2024  Volume 19, Issue 2, Page(s) 344–345

    MeSH term(s) Humans ; Radiomics ; Lung Neoplasms ; Retrospective Studies
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.10.015
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    Zs.A 6664: Show issues Location:
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    Zs.MO 652: Show issues

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  7. Article ; Online: Establishment and application of an indirect ELISA for Getah virus E2 antibody detection.

    You, Dong / Wang, Yu-Ling / Ge, Liang-Peng / Zhou, Yuan-Cheng / Sun, Jing / Lang, Li-Qiao / Lai, Si-Yuan / Ai, Yan-Ru / Zhu, Ling / Xu, Zhi-Wen

    Journal of virological methods

    2024  Volume 325, Page(s) 114885

    Abstract: Getah virus (GETV) is a mosquito-transmitted disease that affects animals, causing fever, aseptic meningitis, and abortion. Its prevalence in China poses risks to both animal health and public well-being. Currently, there is a scarcity of ... ...

    Abstract Getah virus (GETV) is a mosquito-transmitted disease that affects animals, causing fever, aseptic meningitis, and abortion. Its prevalence in China poses risks to both animal health and public well-being. Currently, there is a scarcity of seroepidemiological data on GETV due to the absence of commercial antibody detection kits for pigs. The aim of this study is to develop a rapid, accurate, and sensitive ELISA, providing a reliable tool for GETV seroepidemiology and laying the foundation for future commercial assay development. In this study, we removed specific hydrophobic domains and intracellular structures from E2 proteins and constructed the recombinant plasmid pCold-TF-E2. The recombinant protein was expressed using a prokaryotic expression system, and efficient purification of the rE2 protein was achieved using a nickel affinity column. The purified rE2 protein is suitable for the development of an indirect ELISA (rE2 ELISA). Following the optimization of reaction conditions for the rE2-ELISA, the cut-off value was 0.356. Additionally, the rE2-ELISA method showed a positive rate of 37.1% for IgG antibodies against GETV when testing 986 pig clinical serum samples collected from pigs in Sichuan between May 2022 and September 2022. The rE2-ELISA method displayed a 95.1% overall agreement with VNT, boasting a sensitivity of 98.2% and a specificity of 92.6%. These results indicate that IgG ELISA based on rE2 protein is an efficient and economical method for the detection of GETV antibodies in pigs, facilitating the diagnosis and prevention of GETV.
    MeSH term(s) Pregnancy ; Female ; Animals ; Swine ; Seroepidemiologic Studies ; Alphavirus ; Alphavirus Infections/diagnosis ; Antibodies, Viral ; Enzyme-Linked Immunosorbent Assay/methods ; Immunoglobulin G
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2024-01-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2024.114885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: New insight into Ca

    Wang, Wei / Cheng, Hang-Yuan / Zhou, Jian-Min

    Journal of integrative plant biology

    2024  Volume 66, Issue 3, Page(s) 623–631

    Abstract: Calcium ions ( ... ...

    Abstract Calcium ions (Ca
    MeSH term(s) Signal Transduction/physiology ; Cell Membrane/metabolism ; Cytosol/metabolism ; Endoplasmic Reticulum/metabolism ; Plant Immunity ; Calcium/metabolism ; Calcium Signaling
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2024-01-30
    Publishing country China (Republic : 1949- )
    Document type Journal Article ; Review
    ZDB-ID 2130095-1
    ISSN 1744-7909 ; 1672-9072
    ISSN (online) 1744-7909
    ISSN 1672-9072
    DOI 10.1111/jipb.13613
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  9. Article ; Online: Novel small-molecule compound VCP979 attenuates renal fibrosis in male rats with unilateral ureteral obstruction.

    Min, Shudan / Chang, Di / Wang, Yuan-Cheng / Xu, Ting-Ting / Ge, Hong / Zhang, Jilei / Wang, Binghui / Ju, Shenghong

    Experimental biology and medicine (Maywood, N.J.)

    2023  Volume 248, Issue 4, Page(s) 327–338

    Abstract: Renal fibrosis is a hallmark of chronic kidney disease, while efficient therapy against renal fibrosis is still lacking. In this study, we investigated the role of a novel small-molecule compound VCP979 on renal fibrosis and inflammation in a rat model ... ...

    Abstract Renal fibrosis is a hallmark of chronic kidney disease, while efficient therapy against renal fibrosis is still lacking. In this study, we investigated the role of a novel small-molecule compound VCP979 on renal fibrosis and inflammation in a rat model of unilateral ureteral obstruction (UUO). One week after the UUO surgery, rats were administered VCP979 by gavage for one week, and after treatment, magnetic resonance imaging of T1rho mapping and histopathological analysis were performed to evaluate renal fibrosis
    MeSH term(s) Rats ; Male ; Animals ; Ureteral Obstruction/complications ; Ureteral Obstruction/drug therapy ; Ureteral Obstruction/metabolism ; Rats, Sprague-Dawley ; Kidney Diseases/pathology ; Transforming Growth Factor beta1/metabolism ; Inflammation/pathology ; Fibrosis ; Kidney/pathology
    Chemical Substances Transforming Growth Factor beta1
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.1177/15353702221147569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.111: Show issues Location:
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  10. Article ; Online: From gut to brain: understanding the role of microbiota in inflammatory bowel disease.

    Wang, Siyu / Zhou, Shuwei / Han, Zhongyu / Yu, Bin / Xu, Yin / Lin, Yumeng / Chen, Yutong / Jin, Zi / Li, Yalong / Cao, Qinhan / Xu, Yunying / Zhang, Qiang / Wang, Yuan-Cheng

    Frontiers in immunology

    2024  Volume 15, Page(s) 1384270

    Abstract: With the proposal of the "biological-psychological-social" model, clinical decision-makers and researchers have paid more attention to the bidirectional interactive effects between psychological factors and diseases. The brain-gut-microbiota axis, as an ... ...

    Abstract With the proposal of the "biological-psychological-social" model, clinical decision-makers and researchers have paid more attention to the bidirectional interactive effects between psychological factors and diseases. The brain-gut-microbiota axis, as an important pathway for communication between the brain and the gut, plays an important role in the occurrence and development of inflammatory bowel disease. This article reviews the mechanism by which psychological disorders mediate inflammatory bowel disease by affecting the brain-gut-microbiota axis. Research progress on inflammatory bowel disease causing "comorbidities of mind and body" through the microbiota-gut-brain axis is also described. In addition, to meet the needs of individualized treatment, this article describes some nontraditional and easily overlooked treatment strategies that have led to new ideas for "psychosomatic treatment".
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Brain/metabolism ; Inflammatory Bowel Diseases/etiology ; Inflammatory Bowel Diseases/therapy ; Inflammatory Bowel Diseases/metabolism ; Microbiota ; Mental Disorders/metabolism
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1384270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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