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  1. Article: [Analysis on water-soluble inorganic ions in the atmospheric aerosol of Xinglong].

    Li, Xing-Ru / Song, Ai-Li / Wang, Ying-Feng / Sun, Ying / Liu, Zi-Rui / Wang, Yue-Si

    Huan jing ke xue= Huanjing kexue

    2013  Volume 34, Issue 1, Page(s) 15–20

    Abstract: ... 2010 in Xinglong, a regional atmospheric background station. The water-soluble inorganic ions were ...

    Abstract Size-segregated aerosol samples were collected using Andersen cascade sampler from Sep. 2009 to Aug. 2010 in Xinglong, a regional atmospheric background station. The water-soluble inorganic ions were analyzed by IC. The result showed that the annual concentrations of the total water-soluble inorganic ions were (89.66 +/- 47.66), (54.44 +/- 34.08) and (44.39 +/- 29.95) microg x m(-3) in TSP, PM2.1 and PM1.1 respectively. SO4(2-), NO3(-), Ca(2) and NH4(+) were the dominant contributors of water-soluble inorganic ions. The total water-soluble inorganic ions in PM2.1 accounted for 61% of TSP. The total water-soluble inorganic ions in PM1.1 accounted for 50% and 82% in TSP and PM2.1, respectively. The seasonal variations of the total water-soluble inorganic ion concentration in TSP, PM2.1 and PM1.1 were the same, following the order of summer > autumn > springs > winter. The mean molar ratio of NH4(+) to SO4(2-) was larger than 2, indicating that NH4(+) was not completely neutralized by SO4(2-). NH4(+) -SO4(2-) and NH4(+) -NO3(-) concentrations were strongly correlated (R2 0.96 and 0.87), indicating that NH4(+) was mainly present as (NH4) 2SO4 and NH4NO3.
    MeSH term(s) Aerosols/analysis ; Air Pollutants/analysis ; Atmosphere/analysis ; China ; Environmental Monitoring ; Inorganic Chemicals/analysis ; Ions/analysis ; Particle Size ; Particulate Matter/analysis ; Solubility
    Chemical Substances Aerosols ; Air Pollutants ; Inorganic Chemicals ; Ions ; Particulate Matter
    Language Chinese
    Publishing date 2013-01
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0250-3301
    ISSN 0250-3301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Effect of xinglong pingchuan recipe on interleukin-5 and the inflammagen related to oxygen free radical in asthmatic mice].

    Feng, Jun-tao / Luo, Bai-ling / Hu, Cheng-ping / Pan, Pin-hua

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2005  Volume 30, Issue 4, Page(s) 437–440

    Abstract: Objective: To observe the effect of Xinglong Pingchuan recipe (XLPCR) on interleukin-5 (IL-5 ...

    Abstract Objective: To observe the effect of Xinglong Pingchuan recipe (XLPCR) on interleukin-5 (IL-5), superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA) in mouse asthma models, and to explore its mechanism in treating asthma.
    Methods: The mouse asthma models were established by sensitization and challenge with ovalbumin (OVA). The asthma model was treated with XLPCR. At last, the number of white blood cells and eosinophil was counted, and the concentrations of inflammation factors such as IL-5, SOD, GPx, and MDA in the serum or the lung tissue of each mouse were detected.
    Results: Compared with the asthmatic group, the number of eosinophil in the XLPCR group decreased significantly (P < 0.01); the concentration of IL-5 in the XLPCR group significantly decreased in the serum or the lung tissue (all P < 0.01); and the concentrations of SOD and GPx in the XLPCR group increased (P < 0.01 and P > 0.05, respectively). On the other hand, the concentration of MDA in the XLPCR group was significantly lower than that of the asthmatic group (P < 0.05).
    Conclusion: XLPCR might inhibit the airway inflammation by decreasing the IL-5 level and adjusting the balance of oxidants/antioxidants.
    MeSH term(s) Animals ; Asthma/chemically induced ; Asthma/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Glutathione Peroxidase/metabolism ; Interleukin-5/metabolism ; Lung/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Phytotherapy ; Superoxide Dismutase/metabolism
    Chemical Substances Drugs, Chinese Herbal ; Interleukin-5 ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1)
    Language Chinese
    Publishing date 2005-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Implementation of Underwater Electric Field Communication Based on Direct Sequence Spread Spectrum (DSSS) and Binary Phase Shift Keying (BPSK) Modulation.

    Zhang, Yuzhong / Zhao, Zhenyi / Feng, Xinglong / Zhao, Tianyi / Hu, Qiao

    Biomimetics (Basel, Switzerland)

    2024  Volume 9, Issue 2

    Abstract: Stable communication technologies in complex waters are a prerequisite for underwater operations. Underwater acoustic communication is susceptible to multipath interference, while underwater optical communication is susceptible to environmental impact. ... ...

    Abstract Stable communication technologies in complex waters are a prerequisite for underwater operations. Underwater acoustic communication is susceptible to multipath interference, while underwater optical communication is susceptible to environmental impact. The underwater electric field communication established based on the weak electric fish perception mechanism is not susceptible to environmental interference, and the communication is stable. It is a new type of underwater communication technology. To address issues like short communication distances and high bit error rates in existing underwater electric field communication systems, this study focuses on underwater electric field communication systems based on direct sequence spread spectrum (DSSS) and binary phase shift keying (BPSK) modulation techniques. To verify the feasibility of the established spread spectrum electric field communication system, static communication experiments were carried out in a swimming pool using the DSSS-based system. The experimental results show that in fresh water with a conductivity of 739 μS/cm, the system can achieve underwater current electric field communication within a 11.2 m range with 10
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics9020103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Effects of Hand Tremors on the Shooting Performance of Air Pistol Shooters with Different Skill Levels.

    Liu, Yu / Hu, Nijia / Sun, Mengzi / Qu, Feng / Zhou, Xinglong

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 8

    Abstract: Physiologic hand tremors are a critical factor affecting the aim of air pistol shooters. However, the extent of the effect of hand tremors on shooting performance is unclear. In this study, we aim to explore the relationship between hand tremors and ... ...

    Abstract Physiologic hand tremors are a critical factor affecting the aim of air pistol shooters. However, the extent of the effect of hand tremors on shooting performance is unclear. In this study, we aim to explore the relationship between hand tremors and shooting performance scores as well as investigate potential links between muscle activation and hand tremors. In this study, 17 male air pistol shooters from China's national team and the Air Pistol Sports Center were divided into two groups: the elite group and the sub-elite group. Each participant completed 40 shots during the experiment, with shooters' hand tremors recorded using three-axis digital accelerometers affixed to their right hands. Muscle activation was recorded using surface electromyography on the right anterior deltoid, posterior deltoid, biceps brachii (short head), triceps brachii (long head), flexor carpi radialis, and extensor carpi radialis. Our analysis revealed weak correlations between shooting scores and hand tremor amplitude in multiple directions (middle-lateral, ML: r
    MeSH term(s) Humans ; Tremor/physiopathology ; Male ; Electromyography ; Hand/physiology ; Hand/physiopathology ; Adult ; Firearms ; Young Adult ; Athletic Performance/physiology ; Muscle, Skeletal/physiopathology ; Muscle, Skeletal/physiology
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24082438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus.

    Huang, Yan / Xiao, Yong / Li, Linji / Feng, Xinglong / Ding, Weixing / Cai, Feng

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1327293

    Abstract: Propofol is the most widely used intravenous general anesthetic; however, the neuronal circuits that mediate its anesthetic effects are still poorly understood. Glutamatergic neurons in the lateral hypothalamus have been reported to be involved in ... ...

    Abstract Propofol is the most widely used intravenous general anesthetic; however, the neuronal circuits that mediate its anesthetic effects are still poorly understood. Glutamatergic neurons in the lateral hypothalamus have been reported to be involved in maintenance of arousal and consciousness. Using Vglut2-Cre transgenic mice, we recorded this group of cells specifically and found that propofol can directly inhibit the glutamatergic neurons, and enhance inhibitory synaptic inputs on these cells, thereby reducing neuronal excitability. Through chemogenetic interventions, we found that inhibition of these neurons increased the duration of propofol-induced anesthesia and reduced movement in the animals after the recovery of right reflex. In contrast, activating this group of cells reduced the duration of propofol anesthesia and increased the animals' locomotor activity after the recovery of right reflex. These results suggest that propofol-induced anesthesia involves the inhibition of glutamatergic neurons in the lateral hypothalamus.
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1327293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Tumor Necrosis Factor-α-Induced Protein-8-like 2 Transfected Adipose-Derived Stem Cells Regulated the Dysfunction of Monocrotaline Pyrrole-Induced Pulmonary Arterial Smooth Muscle Cells and Pulmonary Arterial Endothelial Cells.

    Li, Jing / He, Xin / Liu, Feng / Zheng, Xinglong / Jiang, Jing

    Journal of cardiovascular pharmacology

    2024  Volume 83, Issue 1, Page(s) 73–85

    Abstract: Abstract: Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial cell (PAEC) dysfunction and pulmonary arterial smooth muscle cell (PASMC) activation. For decades, the therapies for PAH based on stem cells have been ... ...

    Abstract Abstract: Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial cell (PAEC) dysfunction and pulmonary arterial smooth muscle cell (PASMC) activation. For decades, the therapies for PAH based on stem cells have been shown to be effective. Meanwhile, tumor necrosis factor-α-induced protein-8-like 2 (TIPE2) promote the viability of human amniotic mesenchymal stem cells. Therefore, we aimed to explore the role of TIPE2 in adipose-derived stem cells (ADSCs) and the function of TIPE2-transfected ADSCs in the regulation of PAH. We first explored the role and underlying molecular mechanism of TIPE2 in viability and migration of ADSCs. Moreover, the ADSCs transfected with TIPE2 were cocultured with monocrotaline pyrrole (MCTP)-stimulated PASMCs or PAECs. The effects and mechanisms of TIPE2-transfected ADSCs on MCTP-induced PASMCs and PAECs were further investigated. The results showed that TIPE2 overexpression promoted viability and migration of ADSCs by activating the TLR4-ERK1/2 pathway. In addition, TIPE2-transfected ADSCs inhibited the abnormal proliferation and the impaired apoptosis of PASMCs via NF-κB signaling and promoted the conversion of PASMCs from synthetic to contractile. Meanwhile, TIPE2-transfected ADSCs reduced the apoptosis, endothelial-to-mesenchymal transition, and migration of PAECs via PI3K/AKT signaling after MCTP treatment. MCTP-induced oxidative stress and inflammation of PAECs were significantly decreased by TIPE2-transfected ADSCs. In rat model, TIPE2-ADSCs administration further decreased the monocrotaline-induced increase in the right ventricular systolic pressure and ratio of right ventricle weight/left ventricle and septa weight (L + S) and right ventricle weight/body weight compared with the ADSCs group. In conclusion, TIPE2-transfected ADSCs dramatically attenuated the PAH via inhibiting the dysfunction of PASMCs and PAECs.
    MeSH term(s) Animals ; Humans ; Rats ; Endothelial Cells ; Hypertension, Pulmonary/chemically induced ; Hypertension, Pulmonary/therapy ; Monocrotaline/toxicity ; Phosphatidylinositol 3-Kinases ; Pulmonary Arterial Hypertension ; Pulmonary Artery ; Intracellular Signaling Peptides and Proteins/metabolism
    Chemical Substances Monocrotaline (73077K8HYV) ; monocrotaline pyrrole (23291-96-5) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; TNFAIP8L2 protein, human ; Intracellular Signaling Peptides and Proteins
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation

    Jing Cui / Yongwei Feng / Ting Yang / Xinglong Wang / Heng Tang

    Molecules, Vol 28, Iss 5933, p

    2023  Volume 5933

    Abstract: Human hematopoietic prostaglandin D2 synthase (HPGDS) is involved in the production of prostaglandin D2, which participates in various physiological processes, including inflammation, allergic reactions, and sleep regulation. Inhibitors of HPGDS have ... ...

    Abstract Human hematopoietic prostaglandin D2 synthase (HPGDS) is involved in the production of prostaglandin D2, which participates in various physiological processes, including inflammation, allergic reactions, and sleep regulation. Inhibitors of HPGDS have been investigated as potential anti-inflammatory agents. For the investigation of potent HPGDS inhibitors, we carried out a computational modeling study combining molecular docking and molecular dynamics simulation for selecting and virtual confirming the designed binders. We selected the structure of HPGDS (PDB ID: 2CVD) carrying its native inhibitor compound HQL as our research target. The random 5-mer peptide library was created by building the 3-D structure of random peptides using Rosetta Buildpeptide and performing conformational optimization. Molecular docking was carried out by accommodating the peptides into the location of their native binder and then conducting docking using FlexPepDock. The two peptides RMYYY and VMYMI, which display the lowest binding energy against HPGDS, were selected to perform a comparative study. The interaction of RMYYY and VMYMI against HPGDS was further confirmed using molecular dynamics simulation and aligned with its native binder, HQL. We show the selected binders to have stronger binding energy and more frequent interactions against HPGDS than HQL. In addition, we analyzed the solubility, hydrophobicity, charge, and bioactivity of the generated peptides, and we show that the selected strong binder may be further used as therapeutic drugs.
    Keywords inhibitor ; hematopoietic prostaglandin D2 synthase ; molecular docking ; molecular dynamics simulation ; Rosetta script ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation.

    Cui, Jing / Feng, Yongwei / Yang, Ting / Wang, Xinglong / Tang, Heng

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 15

    Abstract: Human hematopoietic prostaglandin D2 synthase (HPGDS) is involved in the production of prostaglandin D2, which participates in various physiological processes, including inflammation, allergic reactions, and sleep regulation. Inhibitors of HPGDS have ... ...

    Abstract Human hematopoietic prostaglandin D2 synthase (HPGDS) is involved in the production of prostaglandin D2, which participates in various physiological processes, including inflammation, allergic reactions, and sleep regulation. Inhibitors of HPGDS have been investigated as potential anti-inflammatory agents. For the investigation of potent HPGDS inhibitors, we carried out a computational modeling study combining molecular docking and molecular dynamics simulation for selecting and virtual confirming the designed binders. We selected the structure of HPGDS (PDB ID: 2CVD) carrying its native inhibitor compound HQL as our research target. The random 5-mer peptide library was created by building the 3-D structure of random peptides using Rosetta Buildpeptide and performing conformational optimization. Molecular docking was carried out by accommodating the peptides into the location of their native binder and then conducting docking using FlexPepDock. The two peptides RMYYY and VMYMI, which display the lowest binding energy against HPGDS, were selected to perform a comparative study. The interaction of RMYYY and VMYMI against HPGDS was further confirmed using molecular dynamics simulation and aligned with its native binder, HQL. We show the selected binders to have stronger binding energy and more frequent interactions against HPGDS than HQL. In addition, we analyzed the solubility, hydrophobicity, charge, and bioactivity of the generated peptides, and we show that the selected strong binder may be further used as therapeutic drugs.
    MeSH term(s) Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Computer-Aided Design ; Peptides/pharmacology ; Computers
    Chemical Substances prostaglandin R2 D-isomerase (EC 5.3.99.2) ; Peptides
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28155933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Preparation of 5-hydroxymethylfurfural using magnetic Fe

    Li, Xinglong / Li, Mingming / Liu, Yuxin / Feng, Yisi / Pan, Pan

    RSC advances

    2022  Volume 12, Issue 21, Page(s) 13251–13260

    Abstract: 5-Hydroxymethylfurfural (HMF) is one of the most important platform molecules and could be transformed into a variety of fuel additives and high value-added chemicals. Multiple catalyst systems have been developed for the conversion of carbohydrates to ... ...

    Abstract 5-Hydroxymethylfurfural (HMF) is one of the most important platform molecules and could be transformed into a variety of fuel additives and high value-added chemicals. Multiple catalyst systems have been developed for the conversion of carbohydrates to HMF, but there are still unavoidable problems, including high temperature and pressure, difficult recovery of solvent, corrosion of equipment, poor catalyst circulation,
    Language English
    Publishing date 2022-05-03
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra02182j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Complete genome sequence and characterization of Clostridium perfringens type D carrying optrA-plasmid and Tn6218-like transposon.

    Wu, Ke / Wang, Juan / Feng, Hang / Li, Ruichao / Wang, Xinglong / Yang, Zengqi

    The Journal of antimicrobial chemotherapy

    2022  Volume 78, Issue 1, Page(s) 311–313

    MeSH term(s) Humans ; Clostridium perfringens/genetics ; Plasmids/genetics ; Clostridium Infections
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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