LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 428

Search options

  1. Article ; Online: Rapid determination of chromium species in environmental waters using a diol-bonded polymer-stationary column under water-rich conditions coupled with ICPMS.

    Ito, Akane / Morishita, Yuhei / Morimoto, Takahiro / Tanimizu, Masaharu

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2024  Volume 40, Issue 3, Page(s) 359–366

    Abstract: ... chromatography (HILIC) coupled with ICPMS under a water-rich condition. 2,6-Pyridinedicarboxylic acid (PDCA) was ...

    Abstract Chromium speciation analysis in environmental water is of great significance for the monitoring of water pollution and assessing its influences on human health. This study proposes a rapid analytical approach for the simultaneous determination of Cr(VI) and Cr(III) in environmental waters by hydrophilic interaction chromatography (HILIC) coupled with ICPMS under a water-rich condition. 2,6-Pyridinedicarboxylic acid (PDCA) was used to unify Cr(III) species in various chemical forms into a stable Cr(III)-PDCA anion complex and then separated from Cr(VI) oxyanion on a diol-bonded polymer-based HILIC column. An aqueous mobile phase containing 50 mmol L
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 1348-2246
    ISSN (online) 1348-2246
    ISSN 1348-2246
    DOI 10.1007/s44211-023-00475-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Extracellular Microvesicles Modified with Arginine-Rich Peptides for Active Macropinocytosis Induction and Delivery of Therapeutic Molecules.

    Morimoto, Kenta / Ishitobi, Jojiro / Noguchi, Kosuke / Kira, Ryoichi / Kitayama, Yukiya / Goto, Yuto / Fujiwara, Daisuke / Michigami, Masataka / Harada, Atsushi / Takatani-Nakase, Tomoka / Fujii, Ikuo / Futaki, Shiroh / Kanada, Masamitsu / Nakase, Ikuhiko

    ACS applied materials & interfaces

    2024  Volume 16, Issue 14, Page(s) 17069–17079

    Abstract: ... uptake by modifying MV membranes with arginine-rich cell-penetrating peptides for the intracellular ...

    Abstract Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), transfer bioactive molecules from donor to recipient cells in various pathophysiological settings, thereby mediating intercellular communication. Despite their significant roles in extracellular signaling, the cellular uptake mechanisms of different EV subpopulations remain unknown. In particular, plasma membrane-derived MVs are larger vesicles (100 nm to 1 μm in diameter) and may serve as efficient molecular delivery systems due to their large capacity; however, because of size limitations, receptor-mediated endocytosis is considered an inefficient means for cellular MV uptake. This study demonstrated that macropinocytosis (lamellipodia formation and plasma membrane ruffling, causing the engulfment of large fluid volumes outside cells) can enhance cellular MV uptake. We developed experimental techniques to induce macropinocytosis-mediated MV uptake by modifying MV membranes with arginine-rich cell-penetrating peptides for the intracellular delivery of therapeutic molecules.
    MeSH term(s) Arginine ; Pinocytosis ; Cell-Derived Microparticles ; Extracellular Vesicles/metabolism ; Cell-Penetrating Peptides/chemistry
    Chemical Substances Arginine (94ZLA3W45F) ; Cell-Penetrating Peptides
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c14592
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book: Protein quality control in neurodegenerative diseases

    Morimoto, Richard I. / Christen, Yves

    (Research and perspectives in Alzheimer's disease)

    2013  

    Author's details Richard I. Morimoto ; Yves Christen (ed.)
    Series title Research and perspectives in Alzheimer's disease
    Keywords Nervendegeneration ; Proteinfaltung
    Subject Peptidfaltung ; Proteine ; Neurodegenerative Krankheit ; Neurodegenerative Erkrankung
    Language English
    Size XII, 135 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017530873
    ISBN 978-3-642-27927-0 ; 3-642-27927-9 ; 9783642279287 ; 3642279287
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 5088 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Longitudinal Measurement of Histidine-Rich Glycoprotein Levels in Bronchopulmonary Dysplasia: A Pilot Study.

    Morimoto, Daisaku / Washio, Yosuke / Tamai, Kei / Sato, Takeshi / Okamura, Tomoka / Watanabe, Hirokazu / Fukushima, Yu / Yoshimoto, Junko / Kageyama, Misao / Baba, Kenji / Tsukahara, Hirokazu

    Biomedicines

    2023  Volume 11, Issue 1

    Abstract: Histidine-rich glycoprotein (HRG) has been reported to inhibit signaling leading to the release ...

    Abstract Histidine-rich glycoprotein (HRG) has been reported to inhibit signaling leading to the release of high mobility group box 1 protein, a damage-associated molecular pattern. The present study aimed to determine the longitudinal change in HRG levels in extremely preterm infants and assess whether complications such as bronchopulmonary dysplasia (BPD) were associated with differences in HRG levels. In this multicenter, prospective, observational study, we measured serum HRG levels every 2 weeks from birth to 8 weeks of age. Serum HRG was measured using an enzyme-linked immunosorbent assay. We included 19 extremely preterm infants in the study and 74 samples were analyzed. The median gestational age was 26.0 weeks, and the median birth weight was 858 g. Serum HRG levels showed a significant upward trend after birth (p < 0.001); median HRG concentrations at birth and at 2, 4, 6, and 8 weeks of age were 1.07, 1.11, 2.86, 6.05, and 7.49 µg/mL, respectively. Onset of BPD was not associated with differences in serum HRG levels. Further, the serum HRG levels increased significantly after birth in extremely preterm infants.
    Language English
    Publishing date 2023-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11010212
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease.

    Morimoto, Richard I

    Cold Spring Harbor perspectives in biology

    2020  Volume 12, Issue 4

    Abstract: The functional health of the proteome is determined by properties of the proteostasis network (PN) that regulates protein synthesis, folding, macromolecular assembly, translocation, and degradation. In eukaryotes, the PN also integrates protein ... ...

    Abstract The functional health of the proteome is determined by properties of the proteostasis network (PN) that regulates protein synthesis, folding, macromolecular assembly, translocation, and degradation. In eukaryotes, the PN also integrates protein biogenesis across compartments within the cell and between tissues of metazoans for organismal health and longevity. Additionally, in metazoans, proteome stability and the functional health of proteins is optimized for development and yet declines throughout aging, accelerating the risk for misfolding, aggregation, and cellular dysfunction. Here, I describe the cell-nonautonomous regulation of organismal PN by tissue communication and cell stress-response pathways. These systems are robust from development through reproductive maturity and are genetically programmed to decline abruptly in early adulthood by repression of the heat shock response and other cell-protective stress responses, thus compromising the ability of cells and tissues to properly buffer against the cumulative stress of protein damage during aging. While the failure of multiple protein quality control processes during aging challenges cellular function and tissue health, genetic studies, and the identification of small-molecule proteostasis regulators suggests strategies that can be employed to reset the PN with potential benefit on cellular health and organismal longevity.
    MeSH term(s) Aging ; Animals ; Caenorhabditis elegans ; Fibroblasts/metabolism ; Gene Expression Regulation ; Heat Shock Transcription Factors/metabolism ; Heat-Shock Proteins ; Heat-Shock Response/physiology ; Humans ; Longevity ; Protein Denaturation ; Protein Folding ; Proteins/chemistry ; Proteome/metabolism ; Proteostasis ; Quality Control ; Risk ; Signal Transduction ; Stress, Physiological
    Chemical Substances HSF1 protein, human ; Heat Shock Transcription Factors ; Heat-Shock Proteins ; Proteins ; Proteome
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a034074
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Sugar-rich larval diet promotes lower adult pathogen load and higher survival after infection in a polyphagous fly.

    Dinh, Hue / Lundbäck, Ida / Kumar, Sheemal / Than, Anh The / Morimoto, Juliano / Ponton, Fleur

    The Journal of experimental biology

    2022  Volume 225, Issue 16

    Abstract: ... was lower for infected females raised on a sugar-rich larval diet than for females raised on a protein ... rich larval diet, an effect that was absent in males. Both males and females were heavier when fed ... a balanced larval diet compared with a protein- or sugar-rich diet, while body lipid reserves were higher ...

    Abstract Nutrition is a central factor influencing immunity and resistance to infection, but the extent to which nutrition during development affects adult responses to infections is poorly understood. Our study investigated how the nutritional composition of the larval diet affects the survival, pathogen load and food intake of adult fruit flies, Bactrocera tryoni, after septic bacterial infection. We found a sex-specific effect of larval diet composition on survival post-infection: survival rate was higher and bacterial load was lower for infected females raised on a sugar-rich larval diet than for females raised on a protein-rich larval diet, an effect that was absent in males. Both males and females were heavier when fed a balanced larval diet compared with a protein- or sugar-rich diet, while body lipid reserves were higher for those that had consumed the sugar-rich larval diet compared with other diets. Body protein reserves were lower for flies that had been raised on the sugar-rich larval diet compared with other diets in males, but not females. Both females and males shifted their nutrient intake to ingest a sugar-rich diet when infected compared with sham-infected flies without any effect of the larval diet, suggesting that sugar-rich diets can be beneficial to fight off bacterial infection as shown in previous literature. Overall, our findings show that nutrition during early life can shape individual fitness in adulthood.
    MeSH term(s) Animals ; Diet ; Eating ; Female ; Larva/physiology ; Male ; Sugars ; Tephritidae/physiology
    Chemical Substances Sugars
    Language English
    Publishing date 2022-08-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.243910
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2629: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Direct evaluation of the antioxidant properties of salivary proline-rich proteins.

    Komatsu, Tomoko / Kobayashi, Kyo / Morimoto, Yoshinari / Helmerhorst, Eva / Oppenheim, Frank / Chang-Il Lee, Masaichi

    Journal of clinical biochemistry and nutrition

    2020  Volume 67, Issue 2, Page(s) 131–136

    Abstract: Proline-rich proteins are associated with the formation of an acquired protein layer overlying ... However, the role of proline-rich proteins in mitigating the oxidative stress caused by reactive oxygen species ... in the oral cavity remains unclear. In this study, we investigated the antioxidant effects of proline-rich ...

    Abstract Proline-rich proteins are associated with the formation of an acquired protein layer overlying the tooth enamel surface. Previous studies have described the antioxidant activity of salivary histatin against the hydroxyl radical from Fenton's reaction, acting as the critical reactive oxygen species. However, the role of proline-rich proteins in mitigating the oxidative stress caused by reactive oxygen species in the oral cavity remains unclear. In this study, we investigated the antioxidant effects of proline-rich proteins 2 on direct reactive oxygen species using electron spin resonance spectroscopy. For the first time, we demonstrated that proline-rich proteins 2 exhibits antioxidant activity directly against the hydroxyl radical produced by hydrogen peroxide with ultraviolet. Considering that identical results were obtained when assaying 30 residues of proline-rich proteins 2, the direct antioxidant effects against the hydroxyl radical by proline-rich proteins 2 may be related to these specific 30 residues.
    Language English
    Publishing date 2020-06-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 632945-7
    ISSN 1880-5086 ; 0912-0009
    ISSN (online) 1880-5086
    ISSN 0912-0009
    DOI 10.3164/jcbn.19-75
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2981: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book: Protein homeostasis

    Morimoto, Richard I. / Selkoe, Dennis J. / Kelly, Jeffery W.

    (Cold Spring Harbor perspectives in biology)

    2012  

    Author's details ed. by Richard I. Moromoto ; Dennis Selkoe ; Jeffery W. Kelly
    Series title Cold Spring Harbor perspectives in biology
    Language English
    Size VIII, 349 S. : Ill., graph. Darst.
    Publisher Cold Spring Harbor Laboratory Press
    Publishing place Cold Spring Harbor, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016977800
    ISBN 978-1-936113-06-4 ; 1-936113-06-6
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 5360 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Protecting the future: balancing proteostasis for reproduction.

    Sala, Ambre J / Morimoto, Richard I

    Trends in cell biology

    2021  Volume 32, Issue 3, Page(s) 202–215

    Abstract: The proteostasis network (PN) regulates protein synthesis, folding, and degradation and is critical for the health and function of all cells. The PN has been extensively studied in the context of aging and age-related diseases, and loss of proteostasis ... ...

    Abstract The proteostasis network (PN) regulates protein synthesis, folding, and degradation and is critical for the health and function of all cells. The PN has been extensively studied in the context of aging and age-related diseases, and loss of proteostasis is regarded as a major contributor to many age-associated disorders. In contrast to somatic tissues, an important feature of germ cells is their ability to maintain a healthy proteome across generations. Accumulating evidence has now revealed multiple layers of PN regulation that support germ cell function, determine reproductive capacity during aging, and prioritize reproduction at the expense of somatic health. Here, we review recent insights into these different modes of regulation and their implications for reproductive and somatic aging.
    MeSH term(s) Aging/physiology ; Humans ; Protein Folding ; Proteome/metabolism ; Proteostasis ; Proteostasis Deficiencies/metabolism ; Reproduction
    Chemical Substances Proteome
    Language English
    Publishing date 2021-10-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2021.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MG 25: Show issues
    Zs.MO 113: Show issues
    Zs.A 3410: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Preparing Activated Platelet-Rich Plasma for Culturing Human Adipose-Derived Stem Cells.

    Lai, Fangyuan / Kakudo, Natsuko / Morimoto, Naoki / Ma, Yuanyuan / Kusumoto, Kenji

    Journal of visualized experiments : JoVE

    2020  , Issue 159

    Abstract: Activated platelet-rich plasma (PRP) prepared from whole blood via centrifugation demonstrated ...

    Abstract Activated platelet-rich plasma (PRP) prepared from whole blood via centrifugation demonstrated a proliferation-stimulating effect in several kinds of cultured cells, implying a possible use in regenerative medicine. Here, a double-spin method was used to prepare PRP from whole blood. PRP was further activated by autologous thrombin. The platelet count was measured in the activated PRP and the proliferation-stimulating effect in human adipose-derived stem cells (hASCs) was examined. The resulting platelet count was 11.5-times higher in PRP than in whole blood plasma. The proliferation of hASCs was markedly enhanced by incubation with 1% PRP. The described method can be used to reproducibly prepare PRP with a high concentration of platelets. PRP prepared by this method markedly promotes proliferation of hASCs.
    MeSH term(s) Adult ; Cell Proliferation ; Cells, Cultured ; Centrifugation/methods ; Humans ; Male ; Mesenchymal Stem Cells/cytology ; Platelet-Rich Plasma/chemistry ; Regenerative Medicine ; Thrombin/metabolism
    Chemical Substances Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/60480
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top