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  1. Article: Investigation of two-pore K

    Kaur, Amandeep / Madhu / Sharma, Alok / Singh, Kashmir / Upadhyay, Santosh Kumar

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27814

    Abstract: Two-pore K ...

    Abstract Two-pore K
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27814
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  2. Article ; Online: Correction to: The biotechnological importance of the plant-specific NAC transcription factor family in crop improvement.

    Singh, Sadhana / Koyama, Hiroyuki / Bhati, Kaushal K / Alok, Anshu

    Journal of plant research

    2021  Volume 134, Issue 3, Page(s) 643

    Language English
    Publishing date 2021-04-09
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 2077362-6
    ISSN 1618-0860 ; 0918-9440
    ISSN (online) 1618-0860
    ISSN 0918-9440
    DOI 10.1007/s10265-021-01281-9
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  3. Article: Virulence and pathogenicity determinants in whole genome sequence of

    Srivastava, Alok K / Srivastava, Ruchi / Yadav, Jagriti / Singh, Alok K / Tiwari, Praveen K / Srivastava, Anchal K / Sahu, Pramod K / Singh, Shiv M / Kashyap, Prem Lal

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1066096

    Abstract: The present study deals with whole genome analysis ... ...

    Abstract The present study deals with whole genome analysis of
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1066096
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  4. Article: Severe Acute Liver Injury: First Manifestation of Systemic Lupus Erythematosus.

    Singh, Alok K / Vaithiyam, Venkatesh / Sonika, Ujjwal / Goyal, Surbhi

    Journal of clinical and experimental hepatology

    2023  Volume 14, Issue 3, Page(s) 101339

    Abstract: Systemic lupus erythematosus (SLE) is a common multisystem disease characterised by a wide variety of presentation patterns and complex manifestations. As a lymphoid organ, the liver plays an important role in the immune response and is a target of ... ...

    Abstract Systemic lupus erythematosus (SLE) is a common multisystem disease characterised by a wide variety of presentation patterns and complex manifestations. As a lymphoid organ, the liver plays an important role in the immune response and is a target of autoimmune responses.
    Language English
    Publishing date 2023-12-21
    Publishing country India
    Document type Case Reports
    ISSN 0973-6883
    ISSN 0973-6883
    DOI 10.1016/j.jceh.2023.101339
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  5. Article: Epigenetic Silencing of

    Singh, Satya P / Tewari, Mallika / Singh, Alok K / Mishra, Raghvendra R / Shukla, Hari S

    Indian journal of surgical oncology

    2023  Volume 14, Issue 4, Page(s) 822–828

    Abstract: Epigenetic alterations of tumor suppressor genes (TSG) involved in the onset and progression of Breast Cancer (BC) may serve as biomarkers for early detection and prediction of disease prognosis. We have herein tried to determine the methylation status ... ...

    Abstract Epigenetic alterations of tumor suppressor genes (TSG) involved in the onset and progression of Breast Cancer (BC) may serve as biomarkers for early detection and prediction of disease prognosis. We have herein tried to determine the methylation status of TSG,
    Language English
    Publishing date 2023-06-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 2568289-1
    ISSN 0976-6952 ; 0975-7651
    ISSN (online) 0976-6952
    ISSN 0975-7651
    DOI 10.1007/s13193-023-01780-2
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  6. Article ; Online: Potential of engineering the myo-inositol oxidation pathway to increase stress resilience in plants.

    Alok, Anshu / Singh, Sadhana / Kumar, Pankaj / Bhati, Kaushal K

    Molecular biology reports

    2022  Volume 49, Issue 8, Page(s) 8025–8035

    Abstract: Myo-inositol is one of the most abundant form of inositol. The myo-inositol (MI) serves as substrate to diverse biosynthesis pathways and hence it is conserved across life forms. The biosynthesis of MI is well studied in animals. Beyond biosynthesis ... ...

    Abstract Myo-inositol is one of the most abundant form of inositol. The myo-inositol (MI) serves as substrate to diverse biosynthesis pathways and hence it is conserved across life forms. The biosynthesis of MI is well studied in animals. Beyond biosynthesis pathway, implications of MI pathway and enzymes hold potential implications in plant physiology and crop improvement. Myo-inositol oxygenase (MIOX) enzyme catabolize MI into D-glucuronic acid (D-GlcUA). The MIOX enzyme family is well studied across few plants. More recently, the MI associated pathway's crosstalk with other important biosynthesis and stress responsive pathways in plants has drawn attention. The overall outcome from different plant species studied so far are very suggestive that MI derivatives and associated pathways could open new directions to explore stress responsive novel metabolic networks. There are evidences for upregulation of MI metabolic pathway genes, specially MIOX under different stress condition. We also found MIOX genes getting differentially expressed according to developmental and stress signals in Arabidopsis and wheat. In this review we try to highlight the missing links and put forward a tailored view over myo-inositol oxidation pathway and MIOX proteins.
    MeSH term(s) Animals ; Arabidopsis/metabolism ; Biosynthetic Pathways ; Inositol/metabolism ; Inositol Oxygenase/genetics ; Inositol Oxygenase/metabolism ; Oxidation-Reduction
    Chemical Substances Inositol (4L6452S749) ; Inositol Oxygenase (EC 1.13.99.1)
    Language English
    Publishing date 2022-03-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07333-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
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  7. Article ; Online: Point-of-Care Ultrasonography for Evaluation of Blunt Tracheal Injury.

    Dubey, Prakash K / Singh, Kunal / Bharti, Alok K

    Journal of cardiothoracic and vascular anesthesia

    2021  Volume 35, Issue 8, Page(s) 2545–2546

    MeSH term(s) Humans ; Point-of-Care Systems ; Trachea/diagnostic imaging ; Trachea/injuries ; Ultrasonography ; Wounds, Nonpenetrating/diagnostic imaging
    Language English
    Publishing date 2021-01-15
    Publishing country United States
    Document type Letter
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2021.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2203: Show issues Location:
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    Zs.MO 31: Show issues

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  8. Article ; Online: Low-Molecular-Weight Heparin Salvage in Pedicled Flap Reconstruction in Head and Neck: A Prospective Cohort Study.

    Panda, Smriti / Gautam, Vimmi / Mitra, Sandipta / Singh, Chirom Amit / M, Suresh / Palreddy, Akshara / K, Yuvanesh / Konkimalla, Abhilash / K, Dheeraj / Bagchi, Debadeep / Raveendran, Sarath / Sikka, Kapil / Kumar, Rajeev / Singh, Anup / Thakar, Alok

    The Journal of laryngology and otology

    2024  , Page(s) 1–24

    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215124000562
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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.64: Show issues Location:
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  9. Article ; Online: Use of 'Low approach' femoral central venous cannulation during COVID 19 pandemic.

    Singh, Kunal / Bharti, Alok Kumar / Dubey, Prakash K

    The American journal of emergency medicine

    2021  Volume 49, Page(s) 406–407

    MeSH term(s) Adult ; COVID-19/prevention & control ; Catheterization, Central Venous/methods ; Female ; Femoral Artery/diagnostic imaging ; Humans ; Personal Protective Equipment ; Pulmonary Edema/therapy ; Rheumatic Heart Disease/complications ; Ultrasonography
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2021.02.010
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    Zs.A 2005: Show issues Location:
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  10. Article ; Online: Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain.

    Kurmi, Alka / Singh, Akash Pratap / Gautam, Yashveer / Singh, Nandan / Tripathi, Alok / Negi, Arvind Singh / Gautam, Hemant K / Pal, Anirban / Saikia, Dharmendra

    Current topics in medicinal chemistry

    2024  

    Abstract: Background: In recent decades, Candida albicans has become a serious issue for public health. The worldwide rapid rise in drug resistance to conventional therapies is the main contributing reason. Moreover, because of their potent activity at low ... ...

    Abstract Background: In recent decades, Candida albicans has become a serious issue for public health. The worldwide rapid rise in drug resistance to conventional therapies is the main contributing reason. Moreover, because of their potent activity at low concentrations and apparent lack of toxicity, compounds originating from plants are used in therapeutic treatments because of their potent activity at low concentrations and apparent lack of toxicity. Particularly in immunocompromised people, Candida species can result in a wide range of ailments.
    Objectives: Present manuscript describes antifungal activity of an indole derivative 1-(4-((5- methoxy-2-(3,4,5-trimethoxyphenyl)-1H-indol-1-yl) methyl) phenoxy)-N,N-dimethylethan-1- amine (7, 100DL-6) by using an in-silico and in-vitro anti-candidal activity against two Candida strains; Candida kefyr-DS-02 (ATCC-204093) and Candida albicans (AI-clinical isolate, AIIMS- Delhi).
    Methods: The synthetic strategy for the preparation of indole derivatives was modified through Fischer indole reaction. Antifungal activity of an indole derivative 1-(4-((5-methoxy-2-(3,4,5- trimethoxyphenyl)-1H-indol-1-yl) methyl) phenoxy)-N,N-dimethylethan-1-amine (7, 100DL-6) was done by using an in-silico and in-vitro anti-candidal activity against two Candida strains; Candida kefyr-DS-02 (ATCC-204093) and Candida albicans (AI-clinical isolate, AIIMS-Delhi). Compound 100DL-6 efficacy was determined by Combination synergy study, ergosterol binding assay, MTT toxicity study and Mutagenicity.
    Results: Compound 100DL-6 was obtained in 65% yield on desired motifs. Docking scores found were 100DL-6 (-8.7 kcal/mol) and Fluconazole (-7.6 kcal/mol). Further, RMSD were shown for 100DL6 (0.26 ± 0.23 nm) and fluconazole (1.2 ± 0.62 nm). Indole derivative 100DL-6 was active against the tested fungal pathogens and the total zone of inhibition was measured between 13-14 mm in diameter and MIC values between 31.25 μg/mL to 250 μg/mL and MFC values between 62.5 μg/mL to 500 μg/mL. In checkerboard assay synergistic mode of interaction of 100DL-6 with known antifungal drugs was observed. In the presence of ergosterol 100DL-6 and standard drug (s) increased their MIC values, demonstrating a considerable affinity for ergosterol. Compound 100DL-6 was considered to be less-cytotoxic to the cells as determined by MTT assay. Lead compound 100DL-6 was found to be non-mutagenic.
    Conclusion: In the present study, 100DL6 (indole derivatives) significantly abrupted the ergosterol biosynthetic pathway and showed moderate anti-candidal effects. These studies suggest that 100DL6 significantly enhances antifungal effect of clinical drug fluconazole synergistically and may be considered as in clinical trial prior to some extensive in-vivo validations.
    Language English
    Publishing date 2024-02-15
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/0115680266278892240102045630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5572: Show issues Location:
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