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Article: Verification of a cryptic t(Y;15) translocation in a male with an apparent 45,X karyotype.

Qin, Shengfang / Wang, Xueyan / Wang, Jin / Zhang, Zhuo / Chen, Ximin / Yin, Yan / Ye, Mengling / Li-Ling, Jesse

2022 Volume 15, Issue 1, Page(s) 3

Abstract: ... an apparent 45,X karyotype. STR analysis showed that he possessed a short arm of the Y chromosome, including ... A FISH assay of DXZ1 and DYZ3 probes showed a green signal of the X centromere and a red of the Y ... Background: A rare disease is that an individual with a non-chimeric karyotype of 45,X develops ...

Abstract	Background: A rare disease is that an individual with a non-chimeric karyotype of 45,X develops into a male. We explored the genetic aetiology of an infertile male with an apparent 45,X karyotype, which was subsequently verified as cryptic translocation between chromosomes Y and 15. Methods: DNA was extracted from the patient's peripheral blood. A range of genetic testing was performed, including conventional chromosomal karyotyping, short tandem repeat (STR) analysis for azoospermia factor (AZF) region, fluorescence in situ hybridization (FISH) with specific probes groups of DXZ1/DYZ3, DYZ3/D15Z1/PML and SRY/D15Z1/PML, and chromosomal microarray analysis (CMA) for genomic copy number variations (CNVs). Results: The patient was found to have an apparent 45,X karyotype. STR analysis showed that he possessed a short arm of the Y chromosome, including the SRY gene; however, he was missing the long arm of the Y chromosome, including AZFa + b + c and Yqter. A FISH assay of DXZ1 and DYZ3 probes showed a green signal of the X centromere and a red of the Y centromeric signal on a D-group-sized chromosome. By FISH assaying with D15Z1 and DYZ3 probes, chromosomes 15 and Y centromeric signals appeared closely on a single chromosome, as the PML control probe ascertained. A further FISH assay with D15Z1 and SRY probes revealed a signal of the SRY gene at the end of one arm of chromosome 15. The result of the CMA indicated a deletion with an approximate size of 45.31 Mb spanning from Yq11 to Yter. Conclusion: Our study enriched the karyotype-phenotype correlation of Y and 15 chromosomes translocation. It strengthened the critical roles of molecular genetic techniques in identifying the chromosomal breakpoints and regions involved. Genetic aetiology can guide early intervention in childhood and assisted reproduction in adulthood.
Language	English
Publishing date	2022-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2420849-8
ISSN	1755-8166
ISSN	1755-8166
DOI	10.1186/s13039-022-00581-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sexually Dimorphic Gene Expression in X and Y Sperms Instructs Sexual Dimorphism of Embryonic Genome Activation in Yellow Catfish (

Xiong, Yang / Wang, Dan-Yang / Guo, Wenjie / Gong, Gaorui / Chen, Zhen-Xia / Tang, Qin / Mei, Jie

Biology

2022 Volume 11, Issue 12

Abstract: ... genome activation, we compared X and Y sperm and different sexes of embryos before sex determination ... Through transcriptome sequencing (RNA-seq) and whole-genome bisulfite sequencing (WGBS) of X and Y sperm, we found a big ... proportion of upregulated genes in Y sperm, supported by the observation that genome-wide DNA methylation ...

Abstract	Paternal factors play an important role in embryonic morphogenesis and contribute to sexual dimorphism in development. To assess the effect of paternal DNA on sexual dimorphism of embryonic genome activation, we compared X and Y sperm and different sexes of embryos before sex determination. Through transcriptome sequencing (RNA-seq) and whole-genome bisulfite sequencing (WGBS) of X and Y sperm, we found a big proportion of upregulated genes in Y sperm, supported by the observation that genome-wide DNA methylation level is slightly lower than in X sperm. Cytokine-cytokine receptor interaction, TGF-beta, and toll-like receptor pathways play important roles in spermatogenesis. Through whole-genome re-sequencing (WGRS) of parental fish and RNA-seq of five early embryonic stages, we found the low-blastocyst time point is a key to maternal transcriptome degradation and zygotic genome activation. Generally, sexual differences emerged from the bud stage. Moreover, through integrated analysis of paternal SNPs and gene expression, we evaluated the influence of paternal inheritance on sexual dimorphism of genome activation. Besides, we screened out
Language	English
Publishing date	2022-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11121818
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Book ; Online: Building Multilingual Machine Translation Systems That Serve Arbitrary X-Y Translations

Eriguchi, Akiko / Xie, Shufang / Qin, Tao / Awadalla, Hany Hassan

2022

Abstract: ... this issue, this paper discusses how to practically build MNMT systems that serve arbitrary X-Y translation ...

Abstract	Multilingual Neural Machine Translation (MNMT) enables one system to translate sentences from multiple source languages to multiple target languages, greatly reducing deployment costs compared with conventional bilingual systems. The MNMT training benefit, however, is often limited to many-to-one directions. The model suffers from poor performance in one-to-many and many-to-many with zero-shot setup. To address this issue, this paper discusses how to practically build MNMT systems that serve arbitrary X-Y translation directions while leveraging multilinguality with a two-stage training strategy of pretraining and finetuning. Experimenting with the WMT'21 multilingual translation task, we demonstrate that our systems outperform the conventional baselines of direct bilingual models and pivot translation models for most directions, averagely giving +6.0 and +4.1 BLEU, without the need for architecture change or extra data collection. Moreover, we also examine our proposed approach in an extremely large-scale data setting to accommodate practical deployment scenarios. Comment: NAACL 2022
Keywords	Computer Science - Computation and Language ; Computer Science - Artificial Intelligence
Subject code	410
Publishing date	2022-06-29
Publishing country	us
Document type	Book ; Online
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Article ; Online: Uniform Lithium Deposition Induced by ZnF x (OH) y for High-Performance Sulfurized Polyacrylonitrile-Based Lithium-Sulfur Batteries

Wanming Teng / Yanyan Li / Ting Ma / Xiuyun Ren / Ding Nan / Jun Liu / Xiaohu Wang / Qin Yang / Jiaojiao Deng

Polymers, Vol 14, Iss 4494, p

2022 Volume 4494

Abstract: ... The Li-S battery with sulfurized polyacrylonitrile cathode and Li-ZnF x (OH) y @Cu anode (N/P ratio of 1 ... 5:1) maintains 95% capacity after 60 cycles, proving the feasibility of ZnF x (OH) y @Cu ... Coulombic efficiencies (CEs) and poor cycle life. In this research, we proposed the modification of ZnF x ...

Abstract	Lithium metal batteries are emerging as the next generation of high-density electrochemical energy storage systems because of the ultra-high specific capacity and ultra-low electrochemical potential of the Li metal anode. However, the uneven Li deposition on commercial Cu current collectors result in low Coulombic efficiencies (CEs) and poor cycle life. In this research, we proposed the modification of ZnF x (OH) y on Cu foils to expand the lifespan. As-generated ZnLi alloy and LiF could promote uniform Li nucleation and deposition, thus resulting in an improved Li plating/stripping CE and extended cycle life. The Li-S battery with sulfurized polyacrylonitrile cathode and Li-ZnF x (OH) y @Cu anode (N/P ratio of 1.5:1) maintains 95% capacity after 60 cycles, proving the feasibility of ZnF x (OH) y @Cu for practical applications.
Keywords	ZnF x (OH) y modification ; current collector ; Li-S battery ; Organic chemistry ; QD241-441
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Identification of differentially expressed proteins between bull X and Y spermatozoa.

Chen, Xiaoli / Zhu, Huabin / Wu, Chengjiang / Han, Weidong / Hao, Haisheng / Zhao, Xueming / Du, Weihua / Qin, Tong / Liu, Yan / Wang, Dong

Journal of proteomics

2012 Volume 77, Page(s) 59–67

Abstract: Differential expression of genes leads to variation in phenotypes of X and Y sperm, even ... between X and Y sperm sorted from semen of nine bulls were compared using two-dimensional electrophoresis ... detected in X sperm and Y sperm, respectively, and 42 significant protein spots were differentially ...

Abstract	Differential expression of genes leads to variation in phenotypes of X and Y sperm, even though some differential gene products are shared through an intercellular bridge. Differentially expressed proteins between X and Y sperm sorted from semen of nine bulls were compared using two-dimensional electrophoresis (2-DE) coupled with mass spectrometry (MS) analysis. Overall, 663±12 and 647±22 protein spots were detected in X sperm and Y sperm, respectively, and 42 significant protein spots were differentially expressed between them (P<0.05). Sixteen of these protein spots were successfully identified by MS and tandem MS and were found to be closely relevant to energy metabolism, stress resistance, cytoskeletal structure and the activity of serine proteases. Expression levels of two of these proteins, CAPZB and UQCRC1, were verified by Western blot. We propose that these differentially expressed proteins may affect the phenotype of X and Y sperm, binding and fusion of sperm/oocyte and development of the zygotic embryo. Our preliminary results provide an overview of differential expression in total protein levels between X and Y spermatozoa. Identification of these altered proteins may provide a theoretical basis for understanding the biological differences between the two types of sperm.
MeSH term(s)	Animals ; Cattle ; Cytoskeleton/metabolism ; Energy Metabolism/physiology ; Gene Expression Regulation/physiology ; Male ; Sperm-Ovum Interactions/physiology ; Spermatozoa/cytology ; Spermatozoa/metabolism ; Stress, Physiological/physiology ; X Chromosome ; Y Chromosome
Language	English
Publishing date	2012-12-21
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2400835-7
ISSN	1876-7737 ; 1874-3919
ISSN (online)	1876-7737
ISSN	1874-3919
DOI	10.1016/j.jprot.2012.07.004
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Article ; Online: Structural properties and superconductivity of SrFe(2)As(2 - x)P(x) (0.0 ≤ x ≤ 1.0) and CaFe(2)As(2 - y)P(y) (0.0 ≤ y ≤ 0.3).

Shi, H L / Yang, H X / Tian, H F / Lu, J B / Wang, Z W / Qin, Y B / Song, Y J / Li, J Q

Journal of physics. Condensed matter : an Institute of Physics journal

2010 Volume 22, Issue 12, Page(s) 125702

Abstract: The SrFe(2)As(2 - x)P(x) (0.0 ≤ x ≤ 1.0) and CaFe(2)As(2 - y)P(y) (0.0 ≤ y ≤ 0.3) materials were ... samples can be successfully obtained for SrFe(2)As(2 - x)P(x) (0.0 ≤ x ≤ 0.8) and CaFe(2)As(2 - y)P(y) (0 ... prepared by a solid-state reaction method. X-ray diffraction measurements indicate that the single-phase ...

Abstract	The SrFe(2)As(2 - x)P(x) (0.0 ≤ x ≤ 1.0) and CaFe(2)As(2 - y)P(y) (0.0 ≤ y ≤ 0.3) materials were prepared by a solid-state reaction method. X-ray diffraction measurements indicate that the single-phase samples can be successfully obtained for SrFe(2)As(2 - x)P(x) (0.0 ≤ x ≤ 0.8) and CaFe(2)As(2 - y)P(y) (0.0 ≤ y ≤ 0.3). Visible contraction of the lattice parameters is determined due to the relatively smaller radius of P ions in comparison with that of As. The spin-density-wave (SDW) instability associated with the tetragonal to orthorhombic phase transition is suppressed noticeably in both systems following the increase in P content. The highest superconducting transitions are observed at about 27 K in SrFe(2)As(1.3)P(0.7) and at about 13 K in CaFe(2)As(1.925)P(0.075), respectively. Structural analysis suggests that lattice contraction could notably affect the superconductivity in these materials.
Language	English
Publishing date	2010-03-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/0953-8984/22/12/125702
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Article ; Online: Sexually Dimorphic Gene Expression in X and Y Sperms Instructs Sexual Dimorphism of Embryonic Genome Activation in Yellow Catfish (Pelteobagrus fulvidraco)

Xiong, Yang / Wang, Dan-Yang / Guo, Wenjie / Gong, Gaorui / Chen, Zhen-Xia / Tang, Qin / Mei, Jie

Biology (Basel). 2022 Dec. 14, v. 11, no. 12

2022

Abstract	Paternal factors play an important role in embryonic morphogenesis and contribute to sexual dimorphism in development. To assess the effect of paternal DNA on sexual dimorphism of embryonic genome activation, we compared X and Y sperm and different sexes of embryos before sex determination. Through transcriptome sequencing (RNA-seq) and whole-genome bisulfite sequencing (WGBS) of X and Y sperm, we found a big proportion of upregulated genes in Y sperm, supported by the observation that genome-wide DNA methylation level is slightly lower than in X sperm. Cytokine–cytokine receptor interaction, TGF-beta, and toll-like receptor pathways play important roles in spermatogenesis. Through whole-genome re-sequencing (WGRS) of parental fish and RNA-seq of five early embryonic stages, we found the low-blastocyst time point is a key to maternal transcriptome degradation and zygotic genome activation. Generally, sexual differences emerged from the bud stage. Moreover, through integrated analysis of paternal SNPs and gene expression, we evaluated the influence of paternal inheritance on sexual dimorphism of genome activation. Besides, we screened out gata6 and ddx5 as potential instructors for early sex determination and gonad development in yellow catfish. This work is meaningful for revealing the molecular mechanisms of sex determination and sexual dimorphism of fish species.
Keywords	DNA ; DNA methylation ; GATA transcription factors ; Tachysurus fulvidraco ; Toll-like receptors ; bisulfites ; fish ; gene expression ; genome ; morphogenesis ; sequence analysis ; sex determination ; sexual dimorphism ; spermatogenesis ; spermatozoa ; transcriptome ; transforming growth factor beta
Language	English
Dates of publication	2022-1214
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11121818
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Article ; Online: Identification and characterization of genes differentially expressed in X and Y sperm using suppression subtractive hybridization and cDNA microarray.

Chen, Xiaoli / Yue, Yang / He, Yanan / Zhu, Huabin / Hao, Haisheng / Zhao, Xueming / Qin, Tong / Wang, Dong

Molecular reproduction and development

2014 Volume 81, Issue 10, Page(s) 908–917

Abstract: Differential expression of genes leads to variations in the phenotypes of X and Y sperm ... in bovine X and Y sperm were identified by a combination of suppression subtractive hybridization (SSH ... associated with the differences between X and Y sperm since 27 versus 4 were upregulated in X versus Y sperm ...

Abstract	Differential expression of genes leads to variations in the phenotypes of X and Y sperm, although some differentially expressed gene products are shared through intercellular bridges. Genes differentially expressed in bovine X and Y sperm were identified by a combination of suppression subtractive hybridization (SSH), cDNA microarray, and sequence-homology analysis. Microarray data and Significance Analysis of Microarrays software were used to identify 31 differentially expressed genes, only four of which were previously identified. These genes are involved in fundamental life processes of mature sperm, and may be associated with the differences between X and Y sperm since 27 versus 4 were upregulated in X versus Y sperm, respectively. The levels of expression of seven genes-including the known genes UTY, DPH3, CYTB, and ISCU, and the unknown genes X + Y contig 41, X + Y contig 18, and Y + X contig 16-were validated by quantitative real-time PCR, and some genes were clearly differentially expressed by X and Y sperm, despite the presence of intercellular bridges among spermatids. These results provide a theoretical basis for research on gene expression during sperm development, as well as on sex control at the level of sperm.
MeSH term(s)	Animals ; Cattle ; Gene Expression Regulation/physiology ; Male ; Oligonucleotide Array Sequence Analysis/methods ; Spermatozoa/cytology ; Spermatozoa/metabolism ; Subtractive Hybridization Techniques/methods ; X Chromosome/metabolism ; Y Chromosome/metabolism
Language	English
Publishing date	2014-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	20321-x
ISSN	1098-2795 ; 1040-452X
ISSN (online)	1098-2795
ISSN	1040-452X
DOI	10.1002/mrd.22386
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Article ; Online: Electronic and magnetic phase diagram in K(x)Fe(2-y)Se(2) superconductors.

Yan, Y J / Zhang, M / Wang, A F / Ying, J J / Li, Z Y / Qin, W / Luo, X G / Li, J Q / Hu, Jiangping / Chen, X H

Scientific reports

2012 Volume 2, Page(s) 212

Language	English
Publishing date	2012-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep00212
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Article: Crystallographic information of intermediate phases in binary Mg-X (X=Sn, Y, Sc, Ag) alloys.

Liu, Dongyan / Dai, Xuefeng / Wen, Xiaohong / Qin, Gaowu / Meng, Xiangying

Data in brief

2015 Volume 4, Page(s) 190–192

Abstract: ... Mg-X (X=Sn, Y, Sc, Ag) alloys are predicted using ab-initio evolutionary algorithm. The geometry ... structures, and mechanical properties of intermediate phases in binary Mg-X (X=Sn, Y, Sc, Ag ) alloys" by Liu ...

Abstract	The compositions and structures of thermodynamically stable or metastable precipitations in binary Mg-X (X=Sn, Y, Sc, Ag) alloys are predicted using ab-initio evolutionary algorithm. The geometry optimizations of the predicted intermetallic compounds are carried out in the framework of density functional theory (DFT) [1]. A complete list of the optimized crystallographic information (in cif format) of the predicted intermetallic phases is presented here. The data is related to "Predictions on the compositions, structures, and mechanical properties of intermediate phases in binary Mg-X (X=Sn, Y, Sc, Ag ) alloys" by Liu et al. [2].
Language	English
Publishing date	2015-05-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2015.05.011
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