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Article ; Online: Jia-Wei-Kai-Xin-San Treatment Alleviated Mild Cognitive Impairment through Anti-Inflammatory and Antiapoptotic Mechanisms in SAMP8 Mice.

Zhang, Xiaolu / Sun, Yingxin / Yu, Qun / Zeng, Wenyun / Zhang, Yue / Zeng, Miao / Pang, Kexin / Yu, Yifei / Gan, Jiali / Li, Huhu / Yang, Lin / Jiang, Xijuan

Mediators of inflammation

2023 Volume 2023, Page(s) 7807302

Abstract: ... of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism ...

Abstract	Background: Alleviating mild cognitive impairment (MCI) is crucial to delay the progression of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism of JWKXS in the treatment of MCI is unclear. Thus, this study aimed to investigate the effect and mechanism of JWKXS in SAMP8 mice models of MCI. Methods: MCI models were established to examine learning and memory ability and explore the pathomechanisms in brain of SAMP8 mice at 4, 6, and 8 months. The mice were treated for 8 weeks and the effects of JWKXS on MCI were characterized through Morris water maze and HE/Nissl's/immunohistochemical staining. Its mechanism was predicted by the combination of UPLC-Q-TOF/MS and system pharmacology analysis, further verified with SAMP8 mice, BV2 microglial cells, and PC12 cells. Results: It was found that 4-month-old SAMP8 mice exhibited MCI. Two months of JWKXS treatment improved the learning and memory ability, alleviated the hippocampal tissue and neuron damage. Through network pharmacology, four key signaling pathways were found to be involved in treatment of MCI by JWKXS, including TLR4/NF- Conclusion: JWKXS treatment improved the learning and memory ability and conferred neuroprotective effects against MCI by inducing anti-inflammation and antiapoptosis.
MeSH term(s)	Rats ; Mice ; Animals ; Inflammasomes/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Toll-Like Receptor 4/metabolism ; Cognitive Dysfunction/drug therapy ; Alzheimer Disease/drug therapy ; Anti-Inflammatory Agents/therapeutic use
Chemical Substances	Kai-Xin-San ; Inflammasomes ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Toll-Like Receptor 4 ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2023/7807302
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Si-Wei-Qing-Gan-Tang Improves Non-Alcoholic Steatohepatitis by Modulating the Nuclear Factor-κB Signal Pathway and Autophagy in Methionine and Choline Deficient Diet-Fed Rats.

Xiao, Lingyun / Liang, Shu / Ge, Lanlan / Qiu, Shuling / Wan, Haoqiang / Wu, Shipin / Fei, Jia / Peng, Shusong / Zeng, Xiaobin

Frontiers in pharmacology

2020 Volume 11, Page(s) 530

Abstract: Si-Wei-Qing-Gan-Tang (SWQGT) is a Chinese medicine formula that is widely used as a folk remedy ...

Abstract	Si-Wei-Qing-Gan-Tang (SWQGT) is a Chinese medicine formula that is widely used as a folk remedy of herbal tea for the treatment of chronic hepatitis, like non-alcoholic steatohepatitis (NASH), around Ganzhou City (Jiangxi province, China). However, the underlying mechanisms of this formula against NASH are still unknown. This study aimed to explore the effect and mechanisms of SWQGT against NASH. A network pharmacology approach was used to predict the potential mechanisms of SWQGT against NASH. Then a rat model of NASH established by feeding the methionine and choline deficient (MCD) diet was used to verify the effect and mechanisms of SWQGT on NASH
Language	English
Publishing date	2020-05-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.00530
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Article ; Online: Combined pressure-thermal inactivation effect on spores in lu-wei beef--a traditional Chinese meat product.

Wang, B-S / Li, B-S / Du, J-Z / Zeng, Q-X

Journal of applied microbiology

2015 Volume 119, Issue 2, Page(s) 446–454

Abstract: ... Geobacillus stearothermophilus spores suspended in lu-wei beef by combining high pressure (500 and 600 MPa) and moderate heat (70 ... than that in lu-wei beef. Among the bacteria evaluated, G. stearothermophilus spores had a higher resistance ...

Abstract	Aims: This study investigated the inactivation effect and kinetics of Bacillus coagulans and Geobacillus stearothermophilus spores suspended in lu-wei beef by combining high pressure (500 and 600 MPa) and moderate heat (70 and 80 °C or 80 and 90 °C). Methods and results: During pressurization, the temperature of pressure-transmitting fluid was tested with a K-type thermocouple, and the number of surviving cells was determined by a plate count method. The pressure come-up time and corresponding inactivation of Bacillus coagulans and G. stearothermophilus spores were considered during the pressure-thermal treatment. For the two types of spores, the results showed a higher inactivation effect in phosphate buffer solution than that in lu-wei beef. Among the bacteria evaluated, G. stearothermophilus spores had a higher resistance than B. coagulans spores during the pressure-thermal processing. One linear model and two nonlinear models (i.e. the Weibull and log-logistic models) were fitted to the survivor data to obtain relevant kinetic parameters, and the performance of these models was compared. The results suggested that the survival curve of the spores could be accurately described utilizing the log-logistic model, which produced the best fit for all inactivation data. Conclusions: The compression heating characteristics of different pressure-transmitting fluids should be considered when using high pressure to sterilize spores, particularly while the pressure is increasing. Spores can be inactivated by combining high pressure and moderate heat. Significance and impact of the study: The study demonstrates the synergistic inactivation effect of moderate heat in combination with high pressure in real-life food. The use of mathematical models to predict the inactivation for spores could help the food industry further to develop optimum process conditions.
MeSH term(s)	Animals ; Bacillus/growth & development ; Cattle ; Geobacillus stearothermophilus/growth & development ; Hot Temperature ; Hydrostatic Pressure ; Kinetics ; Meat Products/microbiology ; Pressure ; Red Meat ; Spores, Bacterial/growth & development ; Sterilization/methods
Language	English
Publishing date	2015-08
Publishing country	England
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/jam.12841
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Article: [Metabonomics Study on Urine 1H-NMR in Chronic Superficial Gastritis Patients with Pi-qi Deficiency Syndrome/Pi-Wei Dampness-heat Syndrome].

Shi, Xu-guang / Zou, Zhong-jie / Wu, Mei-yin / Zeng, Yuan-gui / Lian, Zhi-cheng / Huang, Man-ting / Gong, Meng-juan

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

2015 Volume 35, Issue 12, Page(s) 1427–1432

Abstract: ... with Pi-qi deficiency syndrome (PQDS) or Pi-Wei dampness-heat syndrome (PWDHS), thereby providing ...

Abstract	Objective: To observe metabolomic changes in urine of chronic superficial gastritis (CSG) patients with Pi-qi deficiency syndrome (PQDS) or Pi-Wei dampness-heat syndrome (PWDHS), thereby providing scientific evidence for syndrome typing of them. Methods: Urine samples were collected from CSG patients with PQDS/PWDHS and healthy volunteers, 10 in each group. Proton nuclear magnetic resonance spectroscopy (1H-NMR) based metabonomic analysis was performed on urine samples. Contents of related biomarkers were analyzed by principal component analysis (PCA), partial least square discriminant analysis (PLS-DA), and urivariate statistical analysis. Results: PLS-DA analysis showed that metabolites among CSG patients with PQDS/PWDHS and healthy volunteers could be mutually distinguished. Seven differentially identified metabolites were screened from urines of CSG patients with PQDS and healthy volunteers included glutamate, methionine, α-oxoglutarate, dimethylglycine, creatinine, taurine, and glucose. Four differentially identified metabolites were screened from urines of CSG patients with PWDHS and healthy volunteers included 2-hydroxybutyric acid, trimethylamine oxide, taurine, and hippuric acid. Eleven differentially identified metabolites were screened from urines of CSG patients with PQDS and PWDHS included fucose, β-hydroxybutyric acid, alanine, glutamate, methionine, succinic acid, citric acid, creatinine, glucose, hippuric acid, and lactic acid. Conclusion: The metabolic differences of CSG patients PQDS and PWDHS mainly manifested in glycometabolism, lipid metabolism, and amino acids catabolism, and 1H-NMR based metabonomics may be used in classified study of Chinese medical syndrome typing.
MeSH term(s)	Biomarkers/urine ; Discriminant Analysis ; Gastritis/urine ; Hot Temperature ; Humans ; Hydroxybutyrates ; Ketoglutaric Acids ; Least-Squares Analysis ; Medicine, Chinese Traditional ; Metabolome/physiology ; Metabolomics ; Principal Component Analysis ; Proton Magnetic Resonance Spectroscopy ; Qi ; Syndrome
Chemical Substances	Biomarkers ; Hydroxybutyrates ; Ketoglutaric Acids ; alpha-ketoglutaric acid (8ID597Z82X) ; 2-hydroxybutyric acid (O0ADR0I4H5)
Language	Chinese
Publishing date	2015-12
Publishing country	China
Document type	Journal Article
ZDB-ID	1195456-5
ISSN	1003-5370
ISSN	1003-5370
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 2863: Show issues

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Article: Combined pressure‐thermal inactivation effect on spores in lu‐wei beef – a traditional Chinese meat product

Wang, B.‐S / Li, B.‐S / Du, J.‐Z / Zeng, Q.‐X

Journal of applied microbiology. 2015 Aug., v. 119, no. 2

2015

Abstract: ... Geobacillus stearothermophilus spores suspended in lu‐wei beef by combining high pressure (500 and 600 MPa) and moderate heat (70 ... the results showed a higher inactivation effect in phosphate buffer solution than that in lu‐wei beef ...

Abstract	AIMS: This study investigated the inactivation effect and kinetics of Bacillus coagulans and Geobacillus stearothermophilus spores suspended in lu‐wei beef by combining high pressure (500 and 600 MPa) and moderate heat (70 and 80°C or 80 and 90°C). METHODS AND RESULTS: During pressurization, the temperature of pressure‐transmitting fluid was tested with a K‐type thermocouple, and the number of surviving cells was determined by a plate count method. The pressure come‐up time and corresponding inactivation of Bacillus coagulans and G. stearothermophilus spores were considered during the pressure‐thermal treatment. For the two types of spores, the results showed a higher inactivation effect in phosphate buffer solution than that in lu‐wei beef. Among the bacteria evaluated, G. stearothermophilus spores had a higher resistance than B. coagulans spores during the pressure‐thermal processing. One linear model and two nonlinear models (i.e. the Weibull and log‐logistic models) were fitted to the survivor data to obtain relevant kinetic parameters, and the performance of these models was compared. The results suggested that the survival curve of the spores could be accurately described utilizing the log‐logistic model, which produced the best fit for all inactivation data. CONCLUSIONS: The compression heating characteristics of different pressure‐transmitting fluids should be considered when using high pressure to sterilize spores, particularly while the pressure is increasing. Spores can be inactivated by combining high pressure and moderate heat. SIGNIFICANCE AND IMPACT OF THE STUDY: The study demonstrates the synergistic inactivation effect of moderate heat in combination with high pressure in real‐life food. The use of mathematical models to predict the inactivation for spores could help the food industry further to develop optimum process conditions.
Keywords	Bacillus coagulans ; Geobacillus stearothermophilus ; bacteria ; beef ; food industry ; heat ; linear models ; nonlinear models ; plate count ; spores ; sterilizing ; temperature
Language	English
Dates of publication	2015-08
Size	p. 446-454.
Publishing place	Published for the Society for Applied Bacteriology by Blackwell Science
Document type	Article
ZDB-ID	1358023-1
ISSN	1364-5072
ISSN	1364-5072
DOI	10.1111/jam.12841
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 259: Show issues

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Article: [Proteomic analysis of gastric mucosa in chronic gastritis rats of Pi-Wei damp-heat syndrome treated by sanren decoction: an experimental study].

Liao, Sheng-Yin / Zeng, Jun / Wang, Ai-Yao / Chen, Jian-Yong

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

2013 Volume 33, Issue 1, Page(s) 76–80

Abstract: ... of Pi-Wei damp-heat syndrome (PWDHS), to investigate the pathogenesis correlated to CG rats of PWDHS ...

Abstract	Objective: To study the expressions of gastric mucosal proteins in chronic gastritis (CG) rats of Pi-Wei damp-heat syndrome (PWDHS), to investigate the pathogenesis correlated to CG rats of PWDHS, to observe the differential expressions of gastric mucosal proteins in CG rats of PWDHS, and to investigate the mechanisms of Sanren Decoction (SD) for treating CG rats of PWDHS. Methods: Totally 36 male SD rats were adaptable fed for 3 days and randomly divided into 3 groups, i.e., the normal control group, the CG of PWDHS rat model group (abbreviated as the model group), and the SD treatment group, 12 in each group. The CG of PWDHS rat model was prepared by composite factors. The gastric mucosal protein was separated using two-dimensional gel electrophoresis technique, and stained by Coomassie brilliant blue. The protein spots expressed differently were analyzed by PDquest 8.0 software. The protein spots expressed differently was identified by MALDI-TOF/TOF-MS. Results: The protein spots were 1 025 +/- 3 9, 994 +/- 51, 1 087 +/- 33 in the normal control group, the model group, and the SD treatment group respectively detected from two-dimensional gel electrophoresis profiles. Compared with the normal control group, there were 74 protein spots differentially expressed in the model group, 30 spots up-regulated and 44 spots down-regulated. Compared with the model group, there were 75 protein spots differentially expressed in the SD treatment group, 49 spots up-regulated and 26 spots down-regulated. Five protein spots differentially expressed were successfully identified, i.e., heat shock protein 72 (HSP72), heat shock protein 60 (HSP60), protein disulfide-isomerase (PDI), malate dehydrogenase (MDH), and unnamed protein. Conclusions: The pathogenesis of CG of PWDHS may be correlated to energy metabolism disturbance and stress. The mechanisms of SD for treating it may possibly adjust differential expressions of gastric mucosal proteins.
MeSH term(s)	Animals ; Drugs, Chinese Herbal/therapeutic use ; Gastric Mucosa/metabolism ; Gastritis/diagnosis ; Gastritis/drug therapy ; Gastritis/metabolism ; Male ; Medicine, Chinese Traditional ; Phytotherapy ; Proteome/metabolism ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Drugs, Chinese Herbal ; Proteome
Language	Chinese
Publishing date	2013-01
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1195456-5
ISSN	1003-5370
ISSN	1003-5370
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Zhongguo gong gong wei sheng yu jian kang xin si wei

Zeng, Guang

(Zi zheng wen ku)

2006

Title translation	Chinese public health and new thoughts in health.
Author's details	Zeng Guang zhu bian
Series title	Zi zheng wen ku
MeSH term(s)	Public Health Administration ; Delivery of Health Care ; Health Status
Keywords	China
Language	Chinese
Size	8, 6, 754 p. :, ill.
Publisher	Ren min chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787010054940 ; 7010054940
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: [Study on the best concentration of combination of the effects of the four original constituents of liu-wei di-huang pill on the proliferation and differentiation of rat preadipocyte].

Dai, Bing / Li, Xing-Feng / Xiao, Zi-Zeng / Shen, Ke-Jia / Zhao, Jing / Peng, Liu

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

2010 Volume 33, Issue 12, Page(s) 1904–1908

Abstract: ... Peoniflorin, Paeonol) of Liu-wei Di-huang pills on the proliferation and differentiation of rat preadipocyte ... The combination of four original constituents of Liu-wei Di-huang pills could stimulate rat preadipocyte ... of the four original constituents of Liu-wei Di-huang pills on the proliferation and differentiation of rat ...

Abstract	Objective: To investigate the effects of four original constituents (Loganin, Morroniside, Peoniflorin, Paeonol) of Liu-wei Di-huang pills on the proliferation and differentiation of rat preadipocyte, and optimize the best concentration by the orthogonal test. Methods: The rat preadipocytes were cultured, then above four original constituents according to 4 factors and 3 levels to make L9 (3(4)) orthogonal test, and the control was performed at the same time. The proliferation of preadipocytes was determined by MTT method, and the accumulation of cellular lipid was determined by Oil Red O staining, the differences between factors and variances were compared by the value of absorbance. Results: The combination of four original constituents of Liu-wei Di-huang pills could stimulate rat preadipocyte proliferation and inhibited its lipid accumulation. Both the effects were highly significant (P < 0.01) with the combination of A3 B1 C3 D2; Compared with the monosomic group, the effects of the A3 B1 C3 D2 was highly significant (P < 0.01). Conclusion: Compared with the monosomic group, the effects of the combination of the four original constituents of Liu-wei Di-huang pills on the proliferation and differentiation of rat preadipocyte were highly significant. This combination consists of Loganin, morroniside with high doses, Paeonol, Peoniflorin with mid-dose and low-dose, respectively. Regnesent the overall regulatory role of synergy and officiencg.
MeSH term(s)	Acetophenones/administration & dosage ; Acetophenones/pharmacology ; Adipocytes/cytology ; Adipocytes/drug effects ; Animals ; Benzoates/administration & dosage ; Benzoates/pharmacology ; Bridged-Ring Compounds/administration & dosage ; Bridged-Ring Compounds/pharmacology ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Drug Combinations ; Drug Synergism ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Fats/metabolism ; Glucosides/administration & dosage ; Glucosides/pharmacology ; Glycosides/administration & dosage ; Glycosides/pharmacology ; Iridoids/administration & dosage ; Iridoids/pharmacology ; Male ; Monoterpenes ; Plants, Medicinal/chemistry ; Rats ; Rats, Wistar
Chemical Substances	Acetophenones ; Benzoates ; Bridged-Ring Compounds ; Drug Combinations ; Drugs, Chinese Herbal ; Fats ; Glucosides ; Glycosides ; Iridoids ; Liuwei Dihuang Decoction ; Monoterpenes ; morroniside ; peoniflorin (21AIQ4EV64) ; paeonol (3R834EPI82) ; loganin (H7WJ16Q93C)
Language	Chinese
Publishing date	2010-12
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1001-4454
ISSN	1001-4454
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pharmacological effects of ba-wei-xi-lei powder on ulcerative colitis in rats with enema application.

Liu, Duan-Yong / Zhao, Hai-Mei / Zhao, Ning / Xin, Zeng-Ping / Lu, Ai-Ping

The American journal of Chinese medicine

2006 Volume 34, Issue 3, Page(s) 461–469

Abstract: Ba-wei-xi-lei powder is a classical herbal mixture, and is widely used for the treatment ... of oral ulcer and ulcerative colitis. This study aimed to explore the effect of Ba-wei-xi-lei powder with enema ... alpha expression area increased in colonic mucosa, while CD4 lymphocyte decreased. Ba-wei-xi-lei powder ...

Abstract	Ba-wei-xi-lei powder is a classical herbal mixture, and is widely used for the treatment of oral ulcer and ulcerative colitis. This study aimed to explore the effect of Ba-wei-xi-lei powder with enema application on ulcerative colitis in rats. Ulcerative colitis was induced by immunization with rabbit's colonic mucosal protein emulsified with Completely Freund's Adjuvant. The mucosal inflammatory reaction and ulcer have been observed in the model rats. Characteristic changes of ulceractive colitis include that CD4 lymphocyte increased in peripheral blood while CD8 lymphocyte decreased; CD8 lymphocyte and TNF-alpha expression area increased in colonic mucosa, while CD4 lymphocyte decreased. Ba-wei-xi-lei powder and sulfasalazine with enema application could alleviate the pathological changes in the model rats. The results suggest that the pharmacological effects of Ba-wei-xi-lei powder on ulcerative colitis in rats are similar to the effect of sulfasalazine.
MeSH term(s)	Animals ; CD4-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/cytology ; Colitis, Ulcerative/drug therapy ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/therapeutic use ; Enema ; Herbal Medicine ; Immunohistochemistry ; Powders ; Rabbits ; Rats
Chemical Substances	Drugs, Chinese Herbal ; Powders ; ba-wei-xi-lei
Language	English
Publishing date	2006
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	193085-0
ISSN	0192-415X ; 0090-2942
ISSN	0192-415X ; 0090-2942
DOI	10.1142/S0192415X06003990
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Microwave Remote Sensing of Soil Moisture

Zeng, Jiangyuan / Peng, Jian / Zhao, Wei / Ma, Chunfeng / Ma, Hongliang / Zhao, Wei

2023

Keywords	Research & information: general ; Geography ; Soil moisture ; Remote sensing ; Active microwave ; Passive microwave ; Hydrology
Language	English
Size	1 electronic resource (242 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030645943
ISBN	9783036590950 ; 3036590951
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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