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  1. Article ; Online: Denitrification regulates spatiotemporal pattern of N

    Wang, Chunlin / Xv, Yuhan / Wu, Zefeng / Li, Xing / Li, Siyue

    Water research

    2024  Volume 251, Page(s) 121144

    Abstract: Urban rivers are hotspots of ... ...

    Abstract Urban rivers are hotspots of N
    MeSH term(s) Humans ; Denitrification ; Rivers ; Lakes ; Nitrous Oxide ; Nitrification ; Hypoxia
    Chemical Substances Nitrous Oxide (K50XQU1029)
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2024.121144
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  2. Article: Environmental Influences and Allergic Diseases in the Asia-Pacific Region: What Will Happen in Next 30 Years?

    Xing, Yuhan / Wong, Gary Wing-Kin

    Allergy, asthma & immunology research

    2022  Volume 14, Issue 1, Page(s) 21–39

    Abstract: Asia-Pacific is a populous region with remarkable variations in socioeconomic development and environmental exposure among countries. The prevalence rates of asthma and allergic rhinitis appear to have recently reached a plateau in Western countries, ... ...

    Abstract Asia-Pacific is a populous region with remarkable variations in socioeconomic development and environmental exposure among countries. The prevalence rates of asthma and allergic rhinitis appear to have recently reached a plateau in Western countries, whereas they are still increasing in many Asian countries. Given the large population in Asia, even a slight increase in the prevalence rate will translate into an overwhelming number of patients. To reduce the magnitude of the increase in allergic diseases in next few decades in Asia, we must understand the potential factors leading to the occurrence of these disorders and the development of potential preventive strategies. The etiology of allergic disorders is likely due to complex interactions among genetic, epigenetic, and environmental factors for the manifestations of inappropriate immune responses. As urbanization and industrialization inevitably progress in Asia, there is an urgent need to curtail the upcoming waves of the allergy epidemic. Potentially modifiable risk exposure, such as air pollution, should be minimized through timely implementation of effective legislations. Meanwhile, re-introduction of protective factors that were once part of the traditional farming lifestyle might give new insight into primary prevention of allergy.
    Language English
    Publishing date 2022-01-04
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2545725-1
    ISSN 2092-7363 ; 2092-7355
    ISSN (online) 2092-7363
    ISSN 2092-7355
    DOI 10.4168/aair.2022.14.1.21
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  3. Article ; Online: HUH Endonuclease: A Sequence-specific Fusion Protein Tag for Precise DNA-Protein Conjugation.

    Du, Jiajun / Kong, Yuhan / Wen, Yujian / Shen, Enxi / Xing, Hang

    Bioorganic chemistry

    2024  Volume 144, Page(s) 107118

    Abstract: Synthetic DNA-protein conjugates have found widespread applications in diagnostics and therapeutics, prompting a growing interest in developing chemical biology methodologies for the precise and site-specific preparation of covalent DNA-protein ... ...

    Abstract Synthetic DNA-protein conjugates have found widespread applications in diagnostics and therapeutics, prompting a growing interest in developing chemical biology methodologies for the precise and site-specific preparation of covalent DNA-protein conjugates. In this review article, we concentrate on techniques to achieve precise control over the structural and site-specific aspects of DNA-protein conjugates. We summarize conventional methods involving unnatural amino acids and self-labeling proteins, accompanied by a discussion of their potential limitations. Our primary focus is on introducing HUH endonuclease as a novel generation of fusion protein tags for DNA-protein conjugate preparation. The detailed conjugation mechanisms and structures of representative endonucleases are surveyed, showcasing their advantages as fusion protein tag in sequence selectivity, biological orthogonality, and no requirement for DNA modification. Additionally, we present the burgeoning applications of HUH-tag-based DNA-protein conjugates in protein assembly, biosensing, and gene editing. Furthermore, we delve into the future research directions of the HUH-tag, highlighting its significant potential for applications in the biomedical and DNA nanotechnology fields.
    MeSH term(s) Endonucleases ; Proteins/chemistry ; DNA/chemistry ; Amino Acids ; Nanotechnology
    Chemical Substances Endonucleases (EC 3.1.-) ; Proteins ; DNA (9007-49-2) ; Amino Acids
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2024.107118
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
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  4. Article ; Online: Gestational diabetes mellitus in the era of COVID-19: Challenges and opportunities.

    Xing, Yuhan / Wang, Hong / Chao, Cong / Ding, Xueteng / Li, Guoju

    Diabetes & metabolic syndrome

    2024  Volume 18, Issue 3, Page(s) 102991

    Abstract: Background and aims: The impact of the coronavirus disease 2019 (COVID-19) pandemic on pregnant women, especially those with gestational diabetes mellitus (GDM), has yet to be fully understood. This review aims to examine the interaction between GDM and ...

    Abstract Background and aims: The impact of the coronavirus disease 2019 (COVID-19) pandemic on pregnant women, especially those with gestational diabetes mellitus (GDM), has yet to be fully understood. This review aims to examine the interaction between GDM and COVID-19 and to elucidate the pathophysiological mechanisms underlying the comorbidity of these two conditions.
    Methods: We performed a systematic literature search using the databases of PubMed, Embase, and Web of Science with appropriate keywords and MeSH terms. Our analysis included studies published up to January 26, 2023.
    Results: Despite distinct clinical manifestations, GDM and COVID-19 share common pathophysiological characteristics, which involve complex interactions across multiple organs and systems. On the one hand, infection with severe acute respiratory syndrome coronavirus 2 may target the pancreas and placenta, resulting in β-cell dysfunction and insulin resistance in pregnant women. On the other hand, the hormonal and inflammatory changes that occur during pregnancy could also increase the risk of severe COVID-19 in mothers with GDM. Personalized management and close monitoring are crucial for treating pregnant women with both GDM and COVID-19.
    Conclusions: A comprehensive understanding of the interactive mechanisms of GDM and COVID-19 would facilitate the initiation of more targeted preventive and therapeutic strategies. There is an urgent need to develop novel biomarkers and functional indicators for early identification and intervention of these conditions.
    Language English
    Publishing date 2024-03-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2024.102991
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  5. Article ; Online: From preschool wheezing to asthma: Environmental determinants.

    Xing, Yuhan / Leung, Agnes Sze-Yin / Wong, Gary Wing-Kin

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 11, Page(s) e14049

    Abstract: Wheezing is common among preschool children, representing a group of highly heterogeneous conditions with varying natural history. Several phenotypes of wheezing have been proposed to facilitate the identification of young children who are at risk of ... ...

    Abstract Wheezing is common among preschool children, representing a group of highly heterogeneous conditions with varying natural history. Several phenotypes of wheezing have been proposed to facilitate the identification of young children who are at risk of subsequent development of asthma. Epidemiological and immunological studies across different populations have revealed the key role of environmental factors in influencing the progression from preschool wheezing to childhood asthma. Significant risk factors include severe respiratory infections, allergic sensitization, and exposure to tobacco smoke. In contrast, a farming/rural environment has been linked to asthma protection in both human and animal studies. Early and intense exposures to microorganisms and microbial metabolites have been demonstrated to alter host immune responses to allergens and viruses, thereby driving the trajectory away from wheezing illness and asthma. Ongoing clinical trials of candidate microbes and microbial products have shown promise in shaping the immune function to reduce episodes of viral-induced wheezing. Moreover, restoring immune training may be especially important for young children who had reduced microbial exposure due to pandemic restrictions. A comprehensive understanding of the role of modifiable environmental factors will pave the way for developing targeted prevention strategies for preschool wheezing and asthma.
    MeSH term(s) Animals ; Humans ; Child, Preschool ; Infant ; Child ; Respiratory Sounds/etiology ; Asthma/epidemiology ; Asthma/etiology ; Asthma/prevention & control ; Risk Factors ; Allergens ; Respiratory Tract Infections
    Chemical Substances Allergens
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.14049
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3096: Show issues Location:
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  6. Article ; Online: Allergic rhinitis as a predictor of moderate-to-severe paediatric obstructive sleep apnoea.

    Yang, Bo / Zou, Qiyuan / Wang, Fan / Pang, Ying / Wei, Ping / Xing, Yuhan

    Sleep & breathing = Schlaf & Atmung

    2024  

    Abstract: Purpose: Obstructive sleep apnoea (OSA) is a common sleep-related breathing disorder affecting children. This study aims to characterize factors associated with the development and progression of severe forms of paediatric OSA.: Methods: This study ... ...

    Abstract Purpose: Obstructive sleep apnoea (OSA) is a common sleep-related breathing disorder affecting children. This study aims to characterize factors associated with the development and progression of severe forms of paediatric OSA.
    Methods: This study included children admitted to Children's Hospital of Chongqing Medical University, a tertiary children's hospital in southwest China between January 2020 and December 2020 with a discharge diagnosis of OSA. Each patient underwent polysomnography examination, following assessments of apnoea-hypopnea index (AHI) and lowest oxygen saturation (LSaO
    Results: A total of 263 children were identified during the study period. Among patients presenting with OSA, 51.3% had mild and 48.7% had moderate to severe symptoms according to standardized guidelines. The incidence of mild and moderate to severe hypoxemia in our population was 39.2% and 60.8%, respectively. Allergic rhinitis (AR; adjusted odds ratio (aOR) = 1.75, 95% CI 1.03-2.96) and male gender (aOR = 1.77, 95% CI 1.03-3.06) were significantly associated with moderate-to-severe OSA (all P-values < 0.05) after adjustment for covariates. AR was also the only significant predictor of hypoxemia (P < 0.05).
    Conclusion: Our results suggest that male gender and presence of AR may be associated with an increased likelihood of moderate-to-severe OSA in children. These findings underscore the importance of timely intervention and individualized management for at-risk individuals.
    Language English
    Publishing date 2024-02-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1500381-4
    ISSN 1522-1709 ; 1520-9512
    ISSN (online) 1522-1709
    ISSN 1520-9512
    DOI 10.1007/s11325-024-03011-6
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    Zs.A 5658: Show issues Location:
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  7. Article: Individual and combined associations of alanine aminotransferase and hemoglobin with metabolic syndrome in the elderly in Qingdao, China.

    Liu, Li / Shao, Yuhan / Feng, Enqiang / Shao, Zhugang / Xing, Dongming

    Frontiers in medicine

    2023  Volume 10, Page(s) 1152747

    Abstract: Background and aims: Combined associations of alanine aminotransferase (ALT) and hemoglobin (Hb) with metabolic syndrome (MetS) have not been assessed yet. The current study investigated the independent and combined relationships between ALT, Hb, and ... ...

    Abstract Background and aims: Combined associations of alanine aminotransferase (ALT) and hemoglobin (Hb) with metabolic syndrome (MetS) have not been assessed yet. The current study investigated the independent and combined relationships between ALT, Hb, and MetS in the elderly.
    Methods: The 37,966 elderly participants aged 65 years and older were recruited from community centers in Qingdao, China. The sampled elderly population visited the health centers once a year where they were offered a free health checkup. Based on a combination of ALT and Hb levels categorized by tertile, participants were grouped into nine groups (Group 1-9). Logistic regression models were used to analyze the individual and combined associations of ALT and Hb with MetS.
    Results: ALT and Hb were both independently related to MetS in both genders. With the elevation of ALT or Hb levels, risks for MetS and its components increased. Compared to the reference group (the 1st tertiles of both ALT and Hb levels), respective odds ratio of combined ALT and Hb for MetS in Group 2-9 ranged from 1.32-3.38 and 1.14-2.31 in men and women after adjusting for age, sex, education, married status, current smoking, current drinking, physical activity, and diet habit.
    Conclusion: ALT and Hb were both independently related to MetS and its components. Combined ALT and Hb levels could increase risks of MetS and its components than an elevation in ALT or Hb alone.
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1152747
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  8. Article ; Online: Inhibitory mechanism of chrysin and diosmetin to α-glucosidase: insights from kinetics, multispectroscopy and molecular docking investigations.

    Zhang, Yuqing / Li, Yaping / Zhai, Yuhan / Zhao, Xing / Lv, Mingxing / Yu, Shaoxuan / Xiao, Haifang / Song, Yuanda

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–13

    Abstract: Inhibition of α-glucosidase activity is a promising method to prevent postprandial hyperglycemia. The inhibitory effect and interaction of chrysin and diosmetin on α-glucosidase were studied in this study. The results of inhibition kinetics showed that ... ...

    Abstract Inhibition of α-glucosidase activity is a promising method to prevent postprandial hyperglycemia. The inhibitory effect and interaction of chrysin and diosmetin on α-glucosidase were studied in this study. The results of inhibition kinetics showed that chrysin and diosmetin reversibly inhibited α-glucosidase activity with IC
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2310207
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    Zs.A 2093: Show issues Location:
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  9. Article ; Online: Engineering bacterial surface interactions using DNA as a programmable material.

    Kong, Yuhan / Du, Qi / Li, Juan / Xing, Hang

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 19, Page(s) 3086–3100

    Abstract: The diverse surface interactions and functions of a bacterium play an important role in cell signaling, host infection, and colony formation. To understand and synthetically control the biological functions of individual cells as well as the whole ... ...

    Abstract The diverse surface interactions and functions of a bacterium play an important role in cell signaling, host infection, and colony formation. To understand and synthetically control the biological functions of individual cells as well as the whole community, there is growing attention on the development of chemical and biological tools that can integrate artificial functional motifs onto the bacterial surface to replace the native interactions, enabling a variety of applications in biosynthesis, environmental protection, and human health. Among all these functional motifs, DNA emerges as a powerful tool that can precisely control bacterial interactions at the bio-interface due to its programmability and biorecognition properties. Compared with conventional chemical and genetic approaches, the sequence-specific Watson-Crick interaction enables almost unlimited programmability in DNA nanostructures, realizing one base-pair spatial control and bio-responsive properties. This highlight aims to provide an overview on this emerging research topic of DNA-engineered bacterial interactions from the aspect of synthetic chemists. We start with the introduction of native bacterial surface ligands and established synthetic approaches to install artificial ligands, including direct modification, metabolic engineering, and genetic engineering. A brief overview of DNA nanotechnology, reported DNA-bacteria conjugation chemistries, and several examples of DNA-engineered bacteria are included in this highlight. The future perspectives and challenges in this field are also discussed, including the development of dynamic bacterial surface chemistry, assembly of programmable multicellular community, and realization of bacteria-based theranostic agents and synthetic microbiota as long-term goals.
    MeSH term(s) Bacteria/chemistry ; Bacteria/metabolism ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; DNA, Bacterial/metabolism ; Genetic Engineering ; Ligands ; Metabolic Engineering
    Chemical Substances DNA, Bacterial ; Ligands
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc06138k
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  10. Article ; Online: Windows of sensitivity for risk of adverse birth outcomes related to gestational PM

    Ni, Wei / Xing, Yuhan / Li, Guoju / Du, Zhanhui / Yang, Ping / Wang, Qinzheng / Yang, Xinmeng / Lyu, Bei / Fa, Hongge / Shi, Qiuling / Xing, Quansheng

    Environmental pollution (Barking, Essex : 1987)

    2024  Volume 347, Page(s) 123759

    Abstract: While numerous studies have associated maternal exposure to ... ...

    Abstract While numerous studies have associated maternal exposure to PM
    MeSH term(s) Infant, Newborn ; Pregnancy ; Humans ; Female ; Air Pollutants/analysis ; Particulate Matter/analysis ; Infant, Low Birth Weight ; Premature Birth ; Maternal Exposure/adverse effects ; COVID-19/epidemiology ; Air Pollution/adverse effects ; Air Pollution/analysis
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.123759
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