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Article ; Online: Multidimensionality of plant defenses and herbivore niches: Implications for eco-evolutionary dynamics.

Loeuille, Nicolas / Hauzy, Céline

2018 Volume 445, Page(s) 110–119

Abstract: ... within the community (e.g., decrease in pollination or attraction of other enemies). In the present work, we model ...

Abstract	Plant defenses are very diverse and often involve contrasted costs and benefits. Quantitative defenses, whose protective effect is dependent on the dose, are effective against a wide range of herbivores, but often divert energy from growth and reproduction. Qualitative defenses often have little allocation costs. However, while deterrent to some herbivores, they often incur costs through other interactions within the community (e.g., decrease in pollination or attraction of other enemies). In the present work, we model the evolutionary dynamics of these two types of defenses, as well and the evolutionary dynamics of the herbivore niche. We assess the effects of such evolutionary dynamics for the maintenance of diversity within the plant-herbivore system, and for the functioning of such systems under various levels of resource availability. We show that the two types of defenses have different implications. Evolution of quantitative defenses often helps to maintain or even increase diversity, while evolution of qualitative defenses most often has a detrimental effect on species coexistence. From a functional point of view, increased resource availability selects for higher levels of quantitative defenses, which reduces top-down controls exerted by herbivores. Resource availability does not affect qualitative defenses, nor the evolution of the herbivore niche. The growing evidence that plant defenses are diverse in types, benefits and costs has large implications not only for the evolution of these traits, but also for their impacts on community diversity and ecosystem functioning.
MeSH term(s)	Animals ; Biological Evolution ; Ecosystem ; Herbivory ; Plants
Language	English
Publishing date	2018-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2972-5
ISSN	1095-8541 ; 0022-5193
ISSN (online)	1095-8541
ISSN	0022-5193
DOI	10.1016/j.jtbi.2018.02.006
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Article: Physicochemical stability of cefiderocol, a novel siderophore cephalosporin, in syringes at 62.5 mg/mL for continuous administration in intensive care units.

Loeuille, Guillaume / Vigneron, Jean / D'Huart, Elise / Charmillon, Alexandre / Demoré, Béatrice

European journal of hospital pharmacy : science and practice

2021 Volume 30, Issue e1, Page(s) e29–e34

Abstract: ... changes were detected.: Conclusion: In polypropylene syringes, cefiderocol 62.5 mg/mL (3 g in 48 mL ...

Abstract	Introduction: Cefiderocol is a new siderophore time-dependent antibiotic of last resort. The manufacturer reports a stability of 6 hours for the infusion solution diluted in normal saline (NS) or dextrose 5% in water (D5W) for a concentration between 7.5 and 20 mg/mL. Optimising its effectiveness by continuous infusion is crucial. The aim of this work was to study the physicochemical stability of cefiderocol diluted in NS or D5W in polypropylene syringes for 48 hours at a concentration of 62.5 mg/mL stored at room temperature, protected or not from light. Materials and methods: Three preparations for each condition were performed. At each time of the analysis, one sample for each preparation was analysed in triplicate by a validated high performance liquid chromatography method coupled to a photodiode array detector at 260 nm. Particle contamination, absorbance measurement, visual inspection and pH measurement were assessed. The limit of stability was set at 90% of the initial concentration, without physical modification. Results: The linearity was validated with an R² of 0.9999. The coefficients of variation for repeatability and intermediate precision were less than 2%. In NS and D5W, cefiderocol retained more than 90% of the initial concentration after 12 hours in syringes, exposed or not to light. Two degradation products (nos 2 and 11, observed during forced degradation) were detected during the stability study. The absorbance at 410 nm increased progressively, regardless of the storage conditions. The particulate contamination test met the specifications of the container. pH values were all between 5.22 and 5.32. No visual changes were detected. Conclusion: In polypropylene syringes, cefiderocol 62.5 mg/mL (3 g in 48 mL) diluted in NS or D5W was stable for 12 hours at room temperature. These new data allow the use of cefiderocol in continuous infusion.
MeSH term(s)	Polypropylenes/chemistry ; Siderophores ; Syringes ; Cephalosporins ; Monobactams ; Intensive Care Units ; Cefiderocol
Chemical Substances	Polypropylenes ; Siderophores ; Cephalosporins ; Monobactams
Language	English
Publishing date	2021-08-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2650179-X
ISSN	2047-9964 ; 2047-9956
ISSN (online)	2047-9964
ISSN	2047-9956
DOI	10.1136/ejhpharm-2021-002935
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Article ; Online: Plant-soil synchrony in nutrient cycles: Learning from ecosystems to design sustainable agrosystems.

Fontaine, Sébastien / Abbadie, Luc / Aubert, Michaël / Barot, Sébastien / Bloor, Juliette M G / Derrien, Delphine / Duchene, Olivier / Gross, Nicolas / Henneron, Ludovic / Le Roux, Xavier / Loeuille, Nicolas / Michel, Jennifer / Recous, Sylvie / Wipf, Daniel / Alvarez, Gaël

Global change biology

2024 Volume 30, Issue 1, Page(s) e17034

Abstract: ... that some of the practices suggested to promote synchrony (e.g., reduced tillage, rotation with perennial plant cover, crop ...

Abstract	Redesigning agrosystems to include more ecological regulations can help feed a growing human population, preserve soils for future productivity, limit dependency on synthetic fertilizers, and reduce agriculture contribution to global changes such as eutrophication and warming. However, guidelines for redesigning cropping systems from natural systems to make them more sustainable remain limited. Synthetizing the knowledge on biogeochemical cycles in natural ecosystems, we outline four ecological systems that synchronize the supply of soluble nutrients by soil biota with the fluctuating nutrient demand of plants. This synchrony limits deficiencies and excesses of soluble nutrients, which usually penalize both production and regulating services of agrosystems such as nutrient retention and soil carbon storage. In the ecological systems outlined, synchrony emerges from plant-soil and plant-plant interactions, eco-physiological processes, soil physicochemical processes, and the dynamics of various nutrient reservoirs, including soil organic matter, soil minerals, atmosphere, and a common market. We discuss the relative importance of these ecological systems in regulating nutrient cycles depending on the pedoclimatic context and on the functional diversity of plants and microbes. We offer ideas about how these systems could be stimulated within agrosystems to improve their sustainability. A review of the latest advances in agronomy shows that some of the practices suggested to promote synchrony (e.g., reduced tillage, rotation with perennial plant cover, crop diversification) have already been tested and shown to be effective in reducing nutrient losses, fertilizer use, and N
MeSH term(s)	Humans ; Soil ; Ecosystem ; Agriculture ; Plants ; Carbon
Chemical Substances	Soil ; Carbon (7440-44-0)
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.17034
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Article: Eco-evolutionary dynamics further weakens mutualistic interaction and coexistence under population decline

Weinbach, Avril / Loeuille, Nicolas / Rohr, Rudolf P.

Evolutionary ecology. 2022 June, v. 36, no. 3

2022

Abstract: ... species investment in the mutualistic interaction of a focal species (e.g. plant attractiveness via flower ...

Abstract	With current environmental changes, evolution can rescue declining populations, but what happens to their interacting species? Mutualistic interactions can help species sustain each other when their environment worsens. However, mutualism is often costly to maintain, and evolution might counter-select it when not profitable enough. We investigate how the evolution of the investment in a mutualistic interaction by a focal species affects the persistence of the system. Specifically, using eco-evolutionary dynamics, we study the evolution of the focal species investment in the mutualistic interaction of a focal species (e.g. plant attractiveness via flower or nectar production for pollinators or carbon exudate for mycorrhizal fungi), and how it is affected by the decline of the partner population with which it is interacting. We assume an allocation trade-off so that investment in the mutualistic interaction reduces the species intrinsic growth rate. First, we investigate how evolution changes species persistence, biomass production, and the intensity of the mutualistic interaction. We show that concave trade-offs allow evolutionary convergence to stable coexistence. We next assume an external disturbance that decreases the partner population by lowering its intrinsic growth rate. Such declines result in the evolution of lower investment of the focal species in the mutualistic interaction, which eventually leads to the extinction of the partner species. With asymmetric mutualism favouring the partner, the evolutionary disappearance of the mutualistic interaction is delayed. Our results suggest that evolution may account for the current collapse of some mutualistic systems like plant-pollinator ones, and that restoration attempts should be enforced early enough to prevent potential negative effects driven by evolution.
Keywords	biomass production ; carbon ; extinction ; flowers ; mutualism ; nectar secretion ; population dynamics
Language	English
Dates of publication	2022-06
Size	p. 373-387.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	15919-0
ISSN	1573-8477 ; 0269-7653
ISSN (online)	1573-8477
ISSN	0269-7653
DOI	10.1007/s10682-022-10176-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Imaging Outcomes for Axial Spondyloarthritis and Sensitivity to Change: A Five-Year Analysis of the DESIR Cohort.

Sepriano, Alexandre / Ramiro, Sofia / van der Heijde, Désirée / Dougados, Maxime / Claudepierre, Pascal / Feydy, Antoine / Reijnierse, Monique / Loeuille, Damien / Landewé, Robert

Arthritis care & research

2022 Volume 74, Issue 2, Page(s) 251–258

Abstract: ... and SI joints (e.g., Spondyloarthritis Research Consortium of Canada [SPARCC] score) and ... structural damage on MRI (e.g., ≥3 fatty lesions) and radiographs (e.g., modified New York grading) was assessed ...

Abstract	Objective: To compare the sensitivity to change of different imaging scoring methods in patients with early axial spondyloarthritis (SpA). Methods: Patients from the Devenir des Spondylarthropathies Indifferérenciées Récentes (DESIR) cohort fulfilling the Assessment of SpondyloArthritis international Society criteria for axial SpA were included. Radiographs and magnetic resonance imaging (MRI) of the sacroiliac (SI) joints and spine were obtained at baseline, 1, 2, and 5 years. Each image was scored by 2 or 3 readers in 3 separate reading waves. The rate of change of outcomes measuring inflammation of the spine and SI joints (e.g., Spondyloarthritis Research Consortium of Canada [SPARCC] score) and structural damage on MRI (e.g., ≥3 fatty lesions) and radiographs (e.g., modified New York grading) was assessed using multilevel generalized estimating equation models (taking all readers and waves into account). To allow comparisons across outcomes, rates were standardized (difference between the individual's value and the population mean divided by the SD). Results: In total, 345 patients were included. Inflammation detected on MRI of the SI joints (MRI-SI joints) (standardized rate range -0.278, -0.441) was more sensitive to change compared to spinal inflammation (range -0.030, -0.055). Structural damage in the SI joints showed a higher standardized rate of change on MRI-SI joints (range 0.015, 0.274) compared to radiography of the SI joints (range 0.043, 0.126). MRI-SI joints damage defined by ≥3 fatty lesions showed the highest sensitivity to change (0.274). Spinal structural damage slowly progressed over time with no meaningful difference between radiographic (range 0.037, 0.043) and MRI structural outcomes (range 0.008, 0.027). Conclusion: Structural damage assessed in pelvic radiographs has low sensitivity to change, while fatty lesions detected on MRI-SI joints are a promising alternative. In contrast, MRI of the spine is not better than radiography of the spine in detecting structural changes in patients with early axial SpA.
MeSH term(s)	Adult ; Axial Spondyloarthritis/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Prospective Studies ; Radiography ; Sacroiliac Joint/diagnostic imaging ; Spine/diagnostic imaging
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.24459
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Zs.A 2446: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 24: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Stem Cells and Extrusion 3D Printing for Hyaline Cartilage Engineering.

Messaoudi, Océane / Henrionnet, Christel / Bourge, Kevin / Loeuille, Damien / Gillet, Pierre / Pinzano, Astrid

Cells

2020 Volume 10, Issue 1

Abstract: ... from bone marrow, they can now be derived from many different cell sources (e.g., synovium, dental pulp ...

Abstract	Hyaline cartilage is deficient in self-healing properties. The early treatment of focal cartilage lesions is a public health challenge to prevent long-term degradation and the occurrence of osteoarthritis. Cartilage tissue engineering represents a promising alternative to the current insufficient surgical solutions. 3D printing is a thriving technology and offers new possibilities for personalized regenerative medicine. Extrusion-based processes permit the deposition of cell-seeded bioinks, in a layer-by-layer manner, allowing mimicry of the native zonal organization of hyaline cartilage. Mesenchymal stem cells (MSCs) are a promising cell source for cartilage tissue engineering. Originally isolated from bone marrow, they can now be derived from many different cell sources (e.g., synovium, dental pulp, Wharton's jelly). Their proliferation and differentiation potential are well characterized, and they possess good chondrogenic potential, making them appropriate candidates for cartilage reconstruction. This review summarizes the different sources, origins, and densities of MSCs used in extrusion-based bioprinting (EBB) processes, as alternatives to chondrocytes. The different bioink constituents and their advantages for producing substitutes mimicking healthy hyaline cartilage is also discussed.
MeSH term(s)	Alginates/therapeutic use ; Animals ; Bioprinting/methods ; Cartilage, Articular/cytology ; Humans ; Hyaline Cartilage/cytology ; Hydrogels/therapeutic use ; Mesenchymal Stem Cells/cytology ; Osteoarthritis/therapy ; Printing, Three-Dimensional ; Tissue Engineering/methods ; Tissue Scaffolds
Chemical Substances	Alginates ; Hydrogels
Language	English
Publishing date	2020-12-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10010002
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Article ; Online: Dynamics of coupled mutualistic and antagonistic interactions, and their implications for ecosystem management.

Georgelin, E / Loeuille, N

Journal of theoretical biology

2014 Volume 346, Page(s) 67–74

Abstract: ... We develop a model that describes the dynamics of a plant species interacting with one antagonistic (e.g ... an herbivore) and one mutualistic (e.g. a pollinator) species confronted to a perturbation to assess how ...

Abstract	Understanding the interplay of antagonistic and mutualistic interactions is an important challenge for predicting the fate of ecological communities. So far, studies of propagation of disturbances have focused on a single interaction type (antagonistic or mutualistic), leaving out part of the natural diversity. We develop a model that describes the dynamics of a plant species interacting with one antagonistic (e.g. an herbivore) and one mutualistic (e.g. a pollinator) species confronted to a perturbation to assess how each interaction type will affect the other. We analyze the effect of additional mortality as a press perturbation acting on the plant's partners. We study how the intensity of the disturbance and the relative sensitivities of partner species determine community structure, as well as extinction orders. We show that due to indirect effects between the two types of interactions, additional mortality on both pollinators and herbivores can either decrease or increase their densities. The presence of pollinators can stabilize the antagonistic interaction by preventing cyclic dynamics in the plant-herbivore system. We propose explanatory mechanisms based on indirect effects and discuss the implications of our results for the conservation of interactions and communities. Our results suggest that, in agricultural landscapes, direct effects of insecticides on herbivore densities can be fully offset by indirect effects mediated through pollinators. The loss of pollinators, due to insecticide use, can also destabilize the dynamics of insect herbivores.
MeSH term(s)	Animals ; Ecosystem ; Extinction, Biological ; Herbivory/physiology ; Pollination/physiology ; Symbiosis
Language	English
Publishing date	2014-04-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2972-5
ISSN	1095-8541 ; 0022-5193
ISSN (online)	1095-8541
ISSN	0022-5193
DOI	10.1016/j.jtbi.2013.12.012
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Article: Stability Studies of 16 Antibiotics for Continuous Infusion in Intensive Care Units and for Performing Outpatient Parenteral Antimicrobial Therapy.

Loeuille, Guillaume / D'Huart, Elise / Vigneron, Jean / Nisse, Yann-Eric / Beiler, Benoit / Polo, Caroline / Ayari, Gillian / Sacrez, Matthieu / Demoré, Béatrice / Charmillon, Alexandre

Antibiotics (Basel, Switzerland)

2022 Volume 11, Issue 4

Abstract: The use of continuous infusion to improve the therapeutic efficacy of time-dependent antibiotics has been demonstrated. There is still a lack of data to safely perform these continuous infusions. The objectives in this study were to evaluate the ... ...

Abstract	The use of continuous infusion to improve the therapeutic efficacy of time-dependent antibiotics has been demonstrated. There is still a lack of data to safely perform these continuous infusions. The objectives in this study were to evaluate the stability by using stability-indicating methods (High-Performance Liquid Chromatography) of 16 antibiotics in concentrated solutions, especially for administration in intensive care units and solutions in elastomeric diffusers at 37 °C for outpatient parenteral antimicrobial therapy. The solutions were considered stable if the percentage of the drug was ≥90%, and the colour and clearness remained unchanged. In syringes, the stability data vary from 4 to 8 h (h) for meropenem in Dextrose 5% (D5W) and Normal Saline (NS), respectively, 6 h for cefotaxime, 12 h for cefoxitin, and 24 h for aztreonam, cefazolin, cefepime, cefiderocol, ceftazidime/avibactam, ceftolozane/tazobactam in NS and D5W, and in water for injection for cloxacillin. A stability period of 48 h has been validated for vancomycin (D5W), aztreonam, and piperacillin/tazobactam. Cefoxitin, cefazolin, cefepime, cefotaxime, cloxacillin, and piperacillin are unstable for diffuser administration. In diffusers, stability times vary from 6 h for cefiderocol, 8 h for ceftazidime, 12 h for ceftazidime/avibactam and ceftolozane/tazobactam (NS), 24 h for temocillin (NS) and piperacillin/tazobactam (D5W), up to 48 h for aztreonam and vancomycin. Solutions stored at 37 °C are less stable and allow the administration of seven antibiotics using diffusers.
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11040458
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Article ; Online: Meeting Yield and Conservation Objectives by Harvesting Both Juveniles and Adults.

Lundström, Niklas L P / Loeuille, Nicolas / Meng, Xinzhu / Bodin, Mats / Brännström, Åke

The American naturalist

2019 Volume 193, Issue 3, Page(s) 373–390

Abstract: ... to assess in the field (e.g., basic reproduction ratio and resilience) are systematically negatively ...

Abstract	Sustainable yields that are at least 80% of the maximum sustainable yield are sometimes referred to as "pretty good yields" (PGY). The range of PGY harvesting strategies is generally broad and thus leaves room to account for additional objectives besides high yield. Here, we analyze stage-dependent harvesting strategies that realize PGY with conservation as a second objective. We show that (1) PGY harvesting strategies can give large conservation benefits and (2) equal harvesting rates of juveniles and adults is often a good strategy. These conclusions are based on trade-off curves between yield and four measures of conservation that form in two established population models, one age-structured model and one stage-structured model, when considering different harvesting rates of juveniles and adults. These conclusions hold for a broad range of parameter settings, although our investigation of robustness also reveals that (3) predictions of the age-structured model are more sensitive to variations in parameter values than those of the stage-structured model. Finally, we find that (4) measures of stability that are often quite difficult to assess in the field (e.g., basic reproduction ratio and resilience) are systematically negatively correlated with impacts on biomass and size structure, so that these later quantities can provide integrative signals to detect possible collapses.
MeSH term(s)	Age Factors ; Biomass ; Conservation of Natural Resources ; Fisheries ; Models, Theoretical
Language	English
Publishing date	2019-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	207092-3
ISSN	1537-5323 ; 0003-0147
ISSN (online)	1537-5323
ISSN	0003-0147
DOI	10.1086/701631
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Article ; Online: Stem Cells and Extrusion 3D Printing for Hyaline Cartilage Engineering

Océane Messaoudi / Christel Henrionnet / Kevin Bourge / Damien Loeuille / Pierre Gillet / Astrid Pinzano

Cells, Vol 10, Iss 2, p

2021 Volume 2

Abstract: ... from bone marrow, they can now be derived from many different cell sources (e.g., synovium, dental pulp ...

Abstract	Hyaline cartilage is deficient in self-healing properties. The early treatment of focal cartilage lesions is a public health challenge to prevent long-term degradation and the occurrence of osteoarthritis. Cartilage tissue engineering represents a promising alternative to the current insufficient surgical solutions. 3D printing is a thriving technology and offers new possibilities for personalized regenerative medicine. Extrusion-based processes permit the deposition of cell-seeded bioinks, in a layer-by-layer manner, allowing mimicry of the native zonal organization of hyaline cartilage. Mesenchymal stem cells (MSCs) are a promising cell source for cartilage tissue engineering. Originally isolated from bone marrow, they can now be derived from many different cell sources (e.g., synovium, dental pulp, Wharton’s jelly). Their proliferation and differentiation potential are well characterized, and they possess good chondrogenic potential, making them appropriate candidates for cartilage reconstruction. This review summarizes the different sources, origins, and densities of MSCs used in extrusion-based bioprinting (EBB) processes, as alternatives to chondrocytes. The different bioink constituents and their advantages for producing substitutes mimicking healthy hyaline cartilage is also discussed.
Keywords	stem cells ; 3D printing ; cartilage engineering ; bio-ink ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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