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  1. Article: Treatment of unexplained facial numbness with stellate ganglion blockade: A case report.

    Imaizumi, Uno / Beppu, Satoshi / Sanuki, Takuro

    Clinical case reports

    2023  Volume 11, Issue 1, Page(s) e6871

    Abstract: To date, there is no established treatment for facial numbness or dysesthesia of unspecified causes. Herein, we report a case of unexplained facial numbness and confirmed hypesthesia that achieved clinical response to stellate ganglion blockade (SGB). ... ...

    Abstract To date, there is no established treatment for facial numbness or dysesthesia of unspecified causes. Herein, we report a case of unexplained facial numbness and confirmed hypesthesia that achieved clinical response to stellate ganglion blockade (SGB). SGB might be an effective treatment of psychological stress-related facial numbness of unknown origin.
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6871
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  2. Article ; Online: Treatment of unexplained facial numbness with stellate ganglion blockade

    Uno Imaizumi / Satoshi Beppu / Takuro Sanuki

    Clinical Case Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)

    A case report

    2023  

    Abstract: Abstract To date, there is no established treatment for facial numbness or dysesthesia of unspecified causes. Herein, we report a case of unexplained facial numbness and confirmed hypesthesia that achieved clinical response to stellate ganglion blockade ( ...

    Abstract Abstract To date, there is no established treatment for facial numbness or dysesthesia of unspecified causes. Herein, we report a case of unexplained facial numbness and confirmed hypesthesia that achieved clinical response to stellate ganglion blockade (SGB). SGB might be an effective treatment of psychological stress‐related facial numbness of unknown origin.
    Keywords dysesthesia ; hypesthesia ; numbness ; stellate ganglion blockade ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: HDL Mimetics Enhances Mitochondrial Function via Stimulation of PGC1-α.

    Zhang, Hang / Komatsu, Tomohiro / Nakashima, Shihoko / Abe, Satomi / Kawachi, Emi / Imaizumi, Satoshi / Saku, Keijiro / Uehara, Yoshinari

    European cardiology

    2023  Volume 18, Page(s) e27

    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1758-3764
    ISSN (online) 1758-3764
    DOI 10.15420/ecr.2023.18.PO10
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  4. Article ; Online: Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato.

    Imaizumi, Riki / Matsuura, Hiroaki / Yanai, Taro / Takeshita, Kohei / Misawa, Shuto / Yamaguchi, Haruhiko / Sakai, Naoki / Miyagi-Inoue, Yukino / Suenaga-Hiromori, Miki / Waki, Toshiyuki / Kataoka, Kunishige / Nakayama, Toru / Yamamoto, Masaki / Takahashi, Seiji / Yamashita, Satoshi

    Chembiochem : a European journal of chemical biology

    2024  Volume 25, Issue 7, Page(s) e202300796

    Abstract: Neryl diphosphate ( ... ...

    Abstract Neryl diphosphate (C
    MeSH term(s) Solanum lycopersicum/genetics ; Transferases/metabolism ; Protein Domains ; Mutagenesis, Site-Directed
    Chemical Substances cis-prenyl transferase (EC 2.5.1.-) ; Transferases (EC 2.-)
    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202300796
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  5. Article: Pressure-Induced Superconductivity in Iron-Based Spin-Ladder Compound BaFe

    Takahashi, Hiroki / Kikuchi, Ryosuke / Kawashima, Chizuru / Imaizumi, Satoshi / Aoyama, Takuya / Ohgushi, Kenya

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 4

    Abstract: The iron-based superconductors had a significant impact on condensed matter physics. They have a common structural motif of a two-dimensional square iron lattice and exhibit fruitful physical properties as a strongly correlated electron system. During ... ...

    Abstract The iron-based superconductors had a significant impact on condensed matter physics. They have a common structural motif of a two-dimensional square iron lattice and exhibit fruitful physical properties as a strongly correlated electron system. During the extensive investigations, quasi-one-dimensional iron-based spin-ladder compounds attracted much attention as a platform for studying the interplay between magnetic and orbital ordering. In these compounds, BaFe
    Language English
    Publishing date 2022-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15041401
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  6. Article ; Online: Associations of High-Density Lipoprotein Functionality with Coronary Plaque Characteristics in Diabetic Patients with Coronary Artery Disease: Integrated Backscatter Intravascular Ultrasound Analysis.

    Takata, Kohei / Imaizumi, Satoshi / Iwata, Atsushi / Zhang, Bo / Kawachi, Emi / Miura, Shin-Ichiro / Ogawa, Masahiro

    Biomolecules

    2023  Volume 13, Issue 9

    Abstract: High-density lipoprotein (HDL) functionality has been reported to be associated with coronary artery disease (CAD). However, little is known about the impact of HDL functionality on coronary atherosclerosis. Thirty-eight type 2 diabetic patients with CAD ...

    Abstract High-density lipoprotein (HDL) functionality has been reported to be associated with coronary artery disease (CAD). However, little is known about the impact of HDL functionality on coronary atherosclerosis. Thirty-eight type 2 diabetic patients with CAD who underwent percutaneous coronary intervention were examined. Coronary atheroma burden and plaque composition of the culprit lesions were assessed using conventional gray-scale and integrated backscatter intravascular ultrasound. HDL-mediated cholesterol efflux capacity (HDL-CEC) and HDL antioxidant capacity, estimated as HDL inflammatory index (HII), were examined. The associations between HDL functionality and coronary plaques were analyzed using multivariate data analysis, including principal components analysis and orthogonal partial least squares (OPLS) models. Percent atheroma volume was correlated with HDL-CEC (r = 0.34,
    Language English
    Publishing date 2023-08-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13091278
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  7. Article ; Online: Clinical Significance of Controlling Nutritional Status (CONUT) Score in Patients With Colorectal Liver Metastases After Hepatectomy.

    Okamoto, Atsuko / Furukawa, Kenei / Ohkuma, Masahisa / Nakano, Takafumi / Yoshioka, Satoshi / Imaizumi, Yuta / Sugano, Hiroshi / Takeda, Yasuhiro / Kosuge, Makoto / Eto, Ken

    In vivo (Athens, Greece)

    2023  Volume 37, Issue 6, Page(s) 2678–2686

    Abstract: Background/aim: The prognostic outcome of the controlling nutritional status (CONUT) score in patients with colorectal liver metastases (CRLM) who underwent hepatectomy has not been investigated. The aim of this study was to investigate the prognostic ... ...

    Abstract Background/aim: The prognostic outcome of the controlling nutritional status (CONUT) score in patients with colorectal liver metastases (CRLM) who underwent hepatectomy has not been investigated. The aim of this study was to investigate the prognostic value of preoperative CONUT score and other systemic inflammation-related biomarkers in patients who underwent hepatectomy for CRLM.
    Patients and methods: The subjects included 145 patients with CRLM who underwent hepatectomy and retrospectively investigated the association of preoperative CONUT score with disease-free survival (DFS), surgical failure-free survival (SFS), and overall survival (OS) using univariate and multivariate analyses.
    Results: In this study, the cut-off of the CONUT score was 4. In the univariate analysis, the high CONUT score was associated with worse SFS and OS (p=0.01, 0.01). The multivariate analysis showed significant and independent predictors of OS were lymph node metastases (p=0.03) and a high CONUT score (p=0.04). In patients with a high CONUT score, postoperative complications due to infections were significantly more than in those with a low CONUT score (27% vs. 9%, p=0.04).
    Conclusion: The CONUT score can be useful for predicting not only short-term but also long-term outcomes in patients with CRLM after hepatectomy.
    MeSH term(s) Humans ; Nutritional Status ; Hepatectomy/adverse effects ; Retrospective Studies ; Clinical Relevance ; Liver Neoplasms/pathology ; Prognosis ; Colorectal Neoplasms/surgery
    Language English
    Publishing date 2023-10-30
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13377
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  8. Article ; Online: Comparison of Dasatinib- and Imatinib-Related Cardiotoxic Adverse Events in Japanese Patients With Chronic Myeloid Leukemia and Gastrointestinal Stromal Tumor.

    Motokawa, Tetsufumi / Ikeda, Satoshi / Ueno, Yuki / Eguchi, Masamichi / Minami, Takako / Kawano, Hiroaki / Kobayashi, Kazuma / Imaizumi, Yoshitaka / Maemura, Koji

    Circulation reports

    2021  Volume 4, Issue 1, Page(s) 1–8

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-16
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-21-0140
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  9. Article ; Online: Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5.

    Kajikawa, Mizuho / Hata, Mizuki / Ishimura, Maho / Imaizumi, Nanae / Kimura, Minako / Miyano, Kei / Ose, Toyoyuki / Asai, Daisuke / Ishido, Satoshi / Kanamoto, Taisei

    The Biochemical journal

    2022  Volume 479, Issue 20, Page(s) 2261–2278

    Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) is a carcinogenic virus that latently infects B cells and causes malignant tumors in immunocompromised patients. KSHV utilizes two viral E3 ubiquitin ligases, K3 and K5, in KSHV-infected cells to mediate the ...

    Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) is a carcinogenic virus that latently infects B cells and causes malignant tumors in immunocompromised patients. KSHV utilizes two viral E3 ubiquitin ligases, K3 and K5, in KSHV-infected cells to mediate the polyubiquitination-dependent down-regulation of several host membrane proteins involved in the immune system. Although K3 and K5 are members of the same family and have similar structural topologies, K3 and K5 have different substrate specificities. Hence, K5 may have a different substrate recognition mode than K3; however, the molecular basis of substrate recognition remains unclear. Here, we investigated the reason why human CD8α, which is known not to be a substrate for both K3 and K5, is not recognized by them, to obtain an understanding for molecular basis of substrate specificity. CD8α forms a disulfide-linked homodimer under experimental conditions to evaluate the viral ligase-mediated down-regulation. It is known that two interchain disulfide linkages in the stalk region between each CD8α monomer (Cys164-Cys164 and Cys181-Cys181) mediate homodimerization. When the interchain disulfide linkage of Cys181-Cys181 was eliminated, CD8α was down-regulated by K5 with a functional RING variant (RINGv) domain via polyubiquitination at the cytoplasmic tail. Aspartic acid, located at the stalk/transmembrane interface of CD8α, was essential for K5-mediated down-regulation of the CD8α mutant without a Cys181-Cys181 linkage. These results suggest that disulfide linkage near the stalk/transmembrane interface critically inhibits substrate targeting by K5. Accessibility to the extracellular juxtamembrane stalk region of membrane proteins may be important for substrate recognition by the viral ubiquitin ligase K5.
    MeSH term(s) Humans ; Ubiquitin/metabolism ; Immediate-Early Proteins/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Membrane Proteins/metabolism ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Disulfides/metabolism
    Chemical Substances Ubiquitin ; Immediate-Early Proteins ; Viral Proteins ; Membrane Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Disulfides
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20220288
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  10. Article ; Online: Structural insights into a bacterial β-glucosidase capable of degrading sesaminol triglucoside to produce sesaminol: toward the understanding of the aglycone recognition mechanism by the C-terminal lid domain.

    Yanai, Taro / Takahashi, Yukino / Katsumura, Eri / Sakai, Naoki / Takeshita, Kohei / Imaizumi, Riki / Matsuura, Hiroaki / Hongo, Shuntaro / Waki, Toshiyuki / Takahashi, Seiji / Yamamoto, Masaki / Kataoka, Kunishige / Nakayama, Toru / Yamashita, Satoshi

    Journal of biochemistry

    2023  Volume 174, Issue 4, Page(s) 335–344

    Abstract: The sesaminol triglucoside (STG)-hydrolyzing β-glucosidase from Paenibacillus sp. (PSTG1), which belongs to glycoside hydrolase family 3 (GH3), is a promising catalyst for the industrial production of sesaminol. We determined the X-ray crystal structure ... ...

    Abstract The sesaminol triglucoside (STG)-hydrolyzing β-glucosidase from Paenibacillus sp. (PSTG1), which belongs to glycoside hydrolase family 3 (GH3), is a promising catalyst for the industrial production of sesaminol. We determined the X-ray crystal structure of PSTG1 with bound glycerol molecule in the putative active site. PSTG1 monomer contained typical three domains of GH3 with the active site in domain 1 (TIM barrel). In addition, PSTG1 contained an additional domain (domain 4) at the C-terminus that interacts with the active site of the other protomer as a lid in the dimer unit. Interestingly, the interface of domain 4 and the active site forms a hydrophobic cavity probably for recognizing the hydrophobic aglycone moiety of substrate. The short flexible loop region of TIM barrel was found to be approaching the interface of domain 4 and the active site. We found that n-heptyl-β-D-thioglucopyranoside detergent acts as an inhibitor for PSTG1. Thus, we propose that the recognition of hydrophobic aglycone moiety is important for PSTG1-catalyzed reactions. Domain 4 might be a potential target for elucidating the aglycone recognition mechanism of PSTG1 as well as for engineering PSTG1 to create a further excellent enzyme to degrade STG more efficiently to produce sesaminol.
    MeSH term(s) beta-Glucosidase/chemistry ; beta-Glucosidase/metabolism ; Glycoside Hydrolases/chemistry ; Glycoside Hydrolases/metabolism ; Furans/metabolism ; Crystallography, X-Ray ; Substrate Specificity
    Chemical Substances sesaminol (74061-79-3) ; sesaminol triglucoside ; beta-Glucosidase (EC 3.2.1.21) ; Glycoside Hydrolases (EC 3.2.1.-) ; Furans
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvad048
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