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  1. Article: Outcomes of severely ill patients with AIDS treated with efavirenz or dolutegravir: a multicenter, observational study.

    Brites, Carlos / Lacerda, Marcus / Sprinz, Eduardo / Bay, Monica / Pinto, Gustavo / Azevedo, Pollyanna / Luz, Estela / Lins-Kusterer, Liliane / Netto, Eduardo M

    Frontiers in medicine

    2024  Volume 11, Page(s) 1302710

    Abstract: Background: Currently, integrase inhibitors (INIs)-based ART regimens are the preferred initial therapy for AIDS patients. There is scarce information on the use of dolutegravir (DTG) among late-presenter people living with HIV (PLHIV).: Objectives: ... ...

    Abstract Background: Currently, integrase inhibitors (INIs)-based ART regimens are the preferred initial therapy for AIDS patients. There is scarce information on the use of dolutegravir (DTG) among late-presenter people living with HIV (PLHIV).
    Objectives: To compare the effect of DTG- or efavirenz (EFV)-based regimens on the outcomes of patients with advanced AIDS.
    Methods: We compared two cohorts of consecutive symptomatic AIDS patients (WHO stage 4, CD4 count<50 cells/mL) starting therapy with DTG-based (2018-2021, prospective cohort) or EFV-based regimens (2013-2016, retrospective cohort) from five Brazilian cities. The main endpoints were early (all-cause) mortality, viral suppression at 24 and 48 weeks, changes in CD4 count, and changes in initial therapy (for any reason).
    Results: We included all eligible patients in a consecutive way (in both groups) until we reached 92 individuals per arm. The median baseline CD4 count (20 vs. 21 cells/mL) and the median HIV plasma viral load (5.5 copies/mL log
    Conclusion: We detected a higher rate of virological suppression and greater treatment durability in patients with advanced AIDS treated with DTG than in those treated with EFV.
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1302710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 pneumonia in an HIV-positive woman on antiretroviral therapy and undetectable viral load in Porto Alegre, Brazil.

    Cipolat, Murillo Machado / Sprinz, Eduardo

    The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

    2020  Volume 24, Issue 5, Page(s) 455–457

    Abstract: COVID-19 pandemic has been a problem worldwide. It is important to identify people at risk of progressing to severe complications and to investigate if some existing antivirals could have any action against SARS-CoV-2. In this context, HIV-infected ... ...

    Abstract COVID-19 pandemic has been a problem worldwide. It is important to identify people at risk of progressing to severe complications and to investigate if some existing antivirals could have any action against SARS-CoV-2. In this context, HIV-infected individuals and antiretroviral drugs might be included, respectively. Herein we present the case of a 63-year-old HIV-infected woman with undetectable viral load, on dolutegravir, tenofovir and lamivudine, who was hospitalized due to COVID-19 pneumonia. In spite of having some clinical markers of severity on admission, the patient improved and was discharged after a week. To our knowledge, this is the first report of severe SARS-CoV-2 infection in an HIV-infected individual in Brazil.
    MeSH term(s) Betacoronavirus ; Brazil ; COVID-19 ; Coronavirus Infections/epidemiology ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Middle Aged ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Viral Load
    Keywords covid19
    Language English
    Publishing date 2020-08-26
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2041400-6
    ISSN 1678-4391 ; 1413-8670
    ISSN (online) 1678-4391
    ISSN 1413-8670
    DOI 10.1016/j.bjid.2020.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5633: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Two cases of neural tube defects with dolutegravir use at conception in south Brazil.

    Kreitchmann, Regis / Oliveira, Fernando Rocha de / Sprinz, Eduardo

    The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

    2021  Volume 25, Issue 2, Page(s) 101572

    Abstract: Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) ...

    Abstract Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two cases of NTD in women who conceived while taking DTG as part of their antiretroviral treatment in the city of Porto Alegre, Brazil.
    MeSH term(s) Africa ; Brazil ; Female ; HIV Infections/drug therapy ; Heterocyclic Compounds, 3-Ring ; Humans ; Neural Tube Defects ; Oxazines ; Piperazines ; Pyridones
    Chemical Substances Heterocyclic Compounds, 3-Ring ; Oxazines ; Piperazines ; Pyridones ; dolutegravir (DKO1W9H7M1)
    Language English
    Publishing date 2021-04-11
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2041400-6
    ISSN 1678-4391 ; 1413-8670
    ISSN (online) 1678-4391
    ISSN 1413-8670
    DOI 10.1016/j.bjid.2021.101572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5633: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Editorial: HIV and Viral Co-infections.

    Brites, Carlos / Borges, Álvaro H / Sprinz, Eduardo / Page, Kimberly

    Frontiers in microbiology

    2021  Volume 12, Page(s) 731337

    Language English
    Publishing date 2021-08-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.731337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 pneumonia in an HIV-positive woman on antiretroviral therapy and undetectable viral load in Porto Alegre, Brazil

    Murillo Machado Cipolat / Eduardo Sprinz

    Brazilian Journal of Infectious Diseases, Vol 24, Iss 5, Pp 455-

    2020  Volume 457

    Abstract: COVID-19 pandemic has been a problem worldwide. It is important to identify people at risk of progressing to severe complications and to investigate if some existing antivirals could have any action against SARS-CoV-2. In this context, HIV-infected ... ...

    Abstract COVID-19 pandemic has been a problem worldwide. It is important to identify people at risk of progressing to severe complications and to investigate if some existing antivirals could have any action against SARS-CoV-2. In this context, HIV-infected individuals and antiretroviral drugs might be included, respectively. Herein we present the case of a 63-year-old HIV-infected woman with undetectable viral load, on dolutegravir, tenofovir and lamivudine, who was hospitalized due to COVID-19 pneumonia. In spite of having some clinical markers of severity on admission, the patient improved and was discharged after a week. To our knowledge, this is the first report of severe SARS-CoV-2 infection in an HIV-infected individual in Brazil.
    Keywords SARS-CoV-2 ; COVID-19 ; HIV ; AIDS ; Infectious and parasitic diseases ; RC109-216 ; Microbiology ; QR1-502 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: COVID-19 pneumonia in an HIV-positive woman on antiretroviral therapy and undetectable viral load in Porto Alegre, Brazil

    Cipolat, Murillo Machado / Sprinz, Eduardo

    The Brazilian Journal of Infectious Diseases

    2020  Volume 24, Issue 5, Page(s) 455–457

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2041400-6
    ISSN 1678-4391 ; 1413-8670
    ISSN (online) 1678-4391
    ISSN 1413-8670
    DOI 10.1016/j.bjid.2020.07.009
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5633: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: COVID-19 pneumonia in an HIV-positive woman on antiretroviral therapy and undetectable viral load in Porto Alegre, Brazil

    Cipolat, Murillo Machado / Sprinz, Eduardo

    Braz J Infect Dis

    Abstract: COVID-19 pandemic has been a problem worldwide. It is important to identify people at risk of progressing to severe complications and to investigate if some existing antivirals could have any action against SARS-CoV-2. In this context, HIV-infected ... ...

    Abstract COVID-19 pandemic has been a problem worldwide. It is important to identify people at risk of progressing to severe complications and to investigate if some existing antivirals could have any action against SARS-CoV-2. In this context, HIV-infected individuals and antiretroviral drugs might be included, respectively. Herein we present the case of a 63-year-old HIV-infected woman with undetectable viral load, on dolutegravir, tenofovir and lamivudine, who was hospitalized due to COVID-19 pneumonia. In spite of having some clinical markers of severity on admission, the patient improved and was discharged after a week. To our knowledge, this is the first report of severe SARS-CoV-2 infection in an HIV-infected individual in Brazil.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #730218
    Database COVID19

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  8. Article ; Online: Boosting with adjuvanted SCB-2019 elicits superior Fcγ-receptor engagement driven by IgG3 to SARS-CoV-2 spike.

    Jung, Wonyeong / Yuan, Dansu / Kellman, Benjamin / Gonzalez, Isabela Garrido da Silva / Clemens, Ralf / Milan, Eveline Pipolo / Sprinz, Eduardo / Cerbino Neto, José / Smolenov, Igor / Alter, Galit / McNamara, Ryan P / Costa Clemens, Sue Ann

    NPJ vaccines

    2024  Volume 9, Issue 1, Page(s) 7

    Abstract: With the continued emergence of variants of concern, the global threat of COVID-19 persists, particularly in low- and middle-income countries with limited vaccine access. Protein-based vaccines, such as SCB-2019, can be produced on a large scale at a low ...

    Abstract With the continued emergence of variants of concern, the global threat of COVID-19 persists, particularly in low- and middle-income countries with limited vaccine access. Protein-based vaccines, such as SCB-2019, can be produced on a large scale at a low cost while antigen design and adjuvant use can modulate efficacy and safety. While effective humoral immunity against SARS-CoV-2 variants has been shown to depend on both neutralization and Fc-mediated immunity, data on the effectiveness of protein-based vaccines with enhanced Fc-mediated immunity is limited. Here, we assess the humoral profile, including antibody isotypes, subclasses, and Fc receptor binding generated by a boosting with a recombinant trimer-tag protein vaccine SCB-2019. Individuals who were primed with 2 doses of the ChAdOx1 vaccine were equally divided into 4 groups and boosted with following formulations: Group 1: 9 μg SCB-2019 and Alhydrogel; Group 2: 9 μg SCB-2019, CpG 1018, and Alhydrogel; Group 3: 30 μg SCB-2019, CpG 1018, and Alhydrogel; Group 4: ChAdOx1. Group 3 showed enhanced antibody FcγR binding against wild-type and variants compared to Groups 1 and 2, showing a dose-dependent enhancement of immunity conferred by the SCB-2019 vaccine. Moreover, from day 15 after vaccination, Group 3 exhibited higher IgG3 and FcγR binding across variants of concerns, including Omicron and its subvariants, compared to the ChAdOx1-boosted individuals. Overall, this highlights the potential of SCB-2019 as a cost-efficient boosting regimen effective across variants of concerns.
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-023-00791-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Short-term folinic acid supplementation and aerobic exercise improve vascular reactivity in HIV-infected individuals.

    Grigoletti, Shana S / Ribeiro, Jorge P / Sprinz, Eduardo / Ribeiro, Paula A B

    HIV clinical trials

    2018  Volume 19, Issue 4, Page(s) 148–151

    Abstract: The aim of this study was to determine the effect of supervised exercise and folinic acid supplementation on endothelial function in HIV-infected individuals. A randomized clinical trial, double blinded, was conducted with 16 HIV-infected individuals, ... ...

    Abstract The aim of this study was to determine the effect of supervised exercise and folinic acid supplementation on endothelial function in HIV-infected individuals. A randomized clinical trial, double blinded, was conducted with 16 HIV-infected individuals, antiretroviral therapy (at least 6 months) with undetectable viral load (<50 copies/mL), and CD4 count > 200 cells/mm
    MeSH term(s) Anti-HIV Agents/therapeutic use ; Brachial Artery/drug effects ; CD4 Lymphocyte Count ; Dietary Supplements ; Double-Blind Method ; Exercise/physiology ; Female ; HIV Infections/complications ; Humans ; Leucovorin/administration & dosage ; Male ; Middle Aged ; Regional Blood Flow ; Vasodilation ; Viral Load
    Chemical Substances Anti-HIV Agents ; Leucovorin (Q573I9DVLP)
    Language English
    Publishing date 2018-02-05
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2060516-X
    ISSN 1945-5771 ; 1528-4336
    ISSN (online) 1945-5771
    ISSN 1528-4336
    DOI 10.1080/15284336.2018.1433769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5543: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: TLR9

    Kulmann-Leal, Bruna / Ellwanger, Joel Henrique / Valverde-Villegas, Jacqueline María / Simon, Daniel / Marangon, Camila Guerra / Mattevi, Vanessa Suñé / Lazzaretti, Rosmeri Kuhmmer / Kuhmmer, Regina / Sprinz, Eduardo / Chies, José Artur Bogo

    Genetic testing and molecular biomarkers

    2022  Volume 26, Issue 5, Page(s) 263–269

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Genetic Predisposition to Disease/genetics ; Genotype ; HIV Infections/genetics ; Hepatitis C/complications ; Hepatitis C/genetics ; Humans ; Polymorphism, Single Nucleotide/genetics ; Toll-Like Receptor 9/genetics
    Chemical Substances TLR9 protein, human ; Toll-Like Receptor 9
    Language English
    Publishing date 2022-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2486664-7
    ISSN 1945-0257 ; 1945-0265
    ISSN (online) 1945-0257
    ISSN 1945-0265
    DOI 10.1089/gtmb.2021.0288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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