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  1. Article ; Online: A Method for the Tensile Strength Prediction of Tablets with Differing Powder Plasticities.

    Yano, Takeru / Oshiro, Atsushi / Ohsaki, Shuji / Nakamura, Hideya / Watano, Satoru

    Chemical & pharmaceutical bulletin

    2024  Volume 72, Issue 4, Page(s) 374–380

    Abstract: Tablets are the most commonly used dosage form in the pharmaceutical industry, and their properties such as disintegration, dissolution, and portability are influenced by their strength. However, in industry, the mixing fraction of powders to obtain a ... ...

    Abstract Tablets are the most commonly used dosage form in the pharmaceutical industry, and their properties such as disintegration, dissolution, and portability are influenced by their strength. However, in industry, the mixing fraction of powders to obtain a tablet compact with sufficient strength is determined based on empirical rules. Therefore, a method for predicting tablet strength based on the properties of a single material is required. The objective of this study was to quantitatively evaluate the relationship between the compression properties and tablet strength of powder mixtures. The compression properties of the powder mixtures with different plasticities were evaluated based on the force-displacement curves obtained from the powder compression tests. Heckel and compression energy analyses were performed to evaluate compression properties. During the compression energy analysis, the ratio of plastic deformation energy to elastic deformation energy (E
    MeSH term(s) Chemistry, Pharmaceutical/methods ; Powders ; Tensile Strength ; Tablets ; Pressure ; Drug Compounding
    Chemical Substances Powders ; Tablets
    Language English
    Publishing date 2024-04-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c24-00090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antiobesity Effect of

    Kaburagi, Tomoko / Otsuka, Yuko / Oshiro, Satoru

    Journal of medicinal food

    2023  Volume 26, Issue 8, Page(s) 550–559

    Abstract: The sialic ... ...

    Abstract The sialic acid
    MeSH term(s) Mice ; Male ; Animals ; N-Acetylneuraminic Acid/pharmacology ; Antioxidants/pharmacology ; Anti-Obesity Agents/pharmacology ; Diet, High-Fat/adverse effects ; Adipogenesis ; Plant Extracts/pharmacology ; Mice, Inbred C57BL ; Obesity/metabolism ; 3T3-L1 Cells
    Chemical Substances N-Acetylneuraminic Acid (GZP2782OP0) ; Antioxidants ; Anti-Obesity Agents ; Plant Extracts
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2023.K.0016
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  3. Article: [Successful second allogeneic hematopoietic stem cell transplantation with azacitidine as bridging therapy for relapsed juvenile myelomonocytic leukemia].

    Oshiro, Tokiko / Hyakuna, Nobuyuki / Abe, Hitomi / Hamada, Satoru / Nakanishi, Koichi

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2023  Volume 64, Issue 3, Page(s) 187–192

    Abstract: Hematopoietic cell transplantation (HCT) is the only curative therapy for juvenile myelomonocytic leukemia (JMML). Meanwhile, an established conventional chemotherapy before HCT remains unavailable. Studies have shown that azacitidine (AZA), which is a ... ...

    Abstract Hematopoietic cell transplantation (HCT) is the only curative therapy for juvenile myelomonocytic leukemia (JMML). Meanwhile, an established conventional chemotherapy before HCT remains unavailable. Studies have shown that azacitidine (AZA), which is a DNA methyltransferase inhibitor, is clinically effective for JMML as a bridging therapy for HCT; a prospective clinical trial in Japan is ongoing. Herein, we present a case of a patient with JMML who was administered AZA as bridging therapy for both first and second HCT. A 3-year-old boy with neurofibromatosis type 1 was administered with intravenous AZA (75 mg/m
    MeSH term(s) Male ; Humans ; Child, Preschool ; Azacitidine/therapeutic use ; Leukemia, Myelomonocytic, Juvenile/therapy ; Prospective Studies ; Hematopoietic Stem Cell Transplantation/adverse effects ; Recurrence
    Chemical Substances Azacitidine (M801H13NRU)
    Language Japanese
    Publishing date 2023-03-14
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.64.187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pediatric erythroblastic transformation of JAK2-mutated prefibrotic primary myelofibrosis with concurrent PHF6 mutations.

    Oshiro, Tokiko / Hamada, Satoru / Kiyuna, Sinobu / Sakiyama, Hideki / Hyakuna, Nobuyuki / Tamaki, Tomoko / Muramatsu, Hideki / Nakanishi, Koichi

    Pediatric blood & cancer

    2023  Volume 70, Issue 10, Page(s) e30508

    MeSH term(s) Humans ; Bone Marrow ; Calreticulin/genetics ; Janus Kinase 2/genetics ; Mutation ; Primary Myelofibrosis/genetics ; Repressor Proteins/genetics ; Male ; Adolescent
    Chemical Substances Calreticulin ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; PHF6 protein, human ; Repressor Proteins
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30508
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  5. Article ; Online: High serum cystatin C levels in juvenile myelomonocytic leukemia patients without abnormal kidney function.

    Shimabukuro, Wataru / Hamada, Satoru / Oshiro, Tokiko / Nakada, Shougo / Hyakuna, Nobuyuki / Nakanishi, Koichi

    Pediatric nephrology (Berlin, Germany)

    2022  Volume 37, Issue 7, Page(s) 1687–1691

    Abstract: Background: In pediatric cancer patients, the estimated glomerular filtration rate based on serum cystatin C (CysC) was reported to be suitable for estimating kidney function because of low serum creatinine (Cr) and high serum β: Case reports: We ... ...

    Abstract Background: In pediatric cancer patients, the estimated glomerular filtration rate based on serum cystatin C (CysC) was reported to be suitable for estimating kidney function because of low serum creatinine (Cr) and high serum β
    Case reports: We describe two pediatric cases of JMML with an elevated serum CysC level. Urinalysis tests showed no abnormalities and no evidence of nephritis or nephropathy, and there were no findings indicating abnormal kidney function, such as Cr clearance in one case or the estimated glomerular filtration rate based on serum Cr in both cases, except for the serum CysC levels. There were no other causes of a high serum CysC level, including hyperthyroidism and steroid administration. The patients were treated with a conventional dosage of drugs, and their serum CysC levels decreased to the normal range when they were in complete remission after treatment.
    Conclusion: An elevated serum CysC level may reflect tumor burden independent of kidney function in JMML patients. Therefore, creatinine or inulin clearance should be determined to more accurately estimate kidney function for administering an optimal dose of anticancer drugs. In addition, a high serum CysC level may be a potential biomarker of cancer progression.
    MeSH term(s) Biomarkers ; Child ; Creatinine ; Cystatin C ; Glomerular Filtration Rate ; Humans ; Kidney ; Leukemia, Myelomonocytic, Juvenile/complications ; Leukemia, Myelomonocytic, Juvenile/diagnosis ; Neoplasms
    Chemical Substances Biomarkers ; Cystatin C ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-01-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05418-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2196: Show issues Location:
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  6. Article ; Online: Myeloid sarcoma concurrent with de novo KMT2A gene-rearranged infantile acute lymphoblastic leukemia.

    Abe, Hitomi / Hamada, Satoru / Sakiyama, Hideki / Oshiro, Tokiko / Kato, Miho / Yagi, Takeshi / Matsuda, Takehiro / Higa, Takeshi / Hyakuna, Nobuyuki / Nakanishi, Koichi

    Pediatric blood & cancer

    2022  Volume 69, Issue 4, Page(s) e29573

    MeSH term(s) Gene Rearrangement ; Humans ; Infant ; Leukemia, Myeloid, Acute/genetics ; Myeloid-Lymphoid Leukemia Protein/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Sarcoma, Myeloid
    Chemical Substances Myeloid-Lymphoid Leukemia Protein (149025-06-9)
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29573
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  7. Article ; Online: Domino donor lymphocyte infusion for secondary poor graft function after HLA-mismatched allogeneic stem cell transplantation between HLA-identical sibling pairs with congenital immunodeficiency.

    Hamada, Satoru / Uehara, Taichi / Miyamoto, Jiro / Kiyuna, Shinobu / Oshiro, Tokiko / Yagi, Takeshi / Kurokawa, Shingo / Hyakuna, Nobuyuki / Nakanishi, Koichi

    Pediatric blood & cancer

    2021  Volume 68, Issue 5, Page(s) e28851

    MeSH term(s) Child, Preschool ; Graft vs Host Disease/therapy ; HLA Antigens ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Hyper-IgM Immunodeficiency Syndrome/therapy ; Lymphocyte Transfusion/methods ; Male ; Siblings
    Chemical Substances HLA Antigens
    Language English
    Publishing date 2021-01-15
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.28851
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  8. Article ; Online: Juxtaglomerular cell tumor with pulmonary metastases: A case report and review of the literature.

    Sakiyama, Hideki / Hamada, Satoru / Oshiro, Tokiko / Hyakuna, Nobuyuki / Kuda, Masaaki / Hishiki, Tomoro / Aoyama, Hajime / Kuroda, Naoto / Yorita, Kenji / Wada, Naoki / Yoshioka, Takako / Koga, Yuhki / Nakanishi, Koichi

    Pediatric blood & cancer

    2022  Volume 70, Issue 4, Page(s) e30068

    MeSH term(s) Humans ; Kidney Neoplasms/pathology ; Lung Neoplasms
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Review ; Case Reports ; Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30068
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  9. Article ; Online: Decreased incidence of acute immune thrombocytopenia in children during the COVID-19 pandemic.

    Harama, Daisuke / Goi, Kumiko / Saito, Kinuko / Sato, Hiroki / Somazu, Shinpei / Furuichi, Yoshiyuki / Takahashi, Kazuya / Oshiro, Hiroko / Nakamura, Makoto / Sawanobori, Emi / Sato, Kazumasa / Tsuruta, Makoto / Murakami, Yasushi / Shinohara, Tamao / Nemoto, Atsushi / Kasai, Shin / Tamai, Minori / Watanabe, Atsushi / Akahane, Koshi /
    Kojika, Satoru / Sugita, Kanji / Inukai, Takeshi

    International journal of hematology

    2023  Volume 117, Issue 2, Page(s) 307–308

    MeSH term(s) Child ; Humans ; COVID-19 ; Japan ; Lymphohistiocytosis, Hemophagocytic ; Incidence ; Pandemics ; Purpura, Thrombocytopenic, Idiopathic/complications ; Purpura, Thrombocytopenic, Idiopathic/epidemiology ; Blood Platelet Disorders
    Language English
    Publishing date 2023-01-12
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-022-03521-7
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    Zs.A 269: Show issues Location:
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  10. Article ; Online: RNA-seq analysis, targeted long-read sequencing and in silico prediction to unravel pathogenic intronic events and complicated splicing abnormalities in dystrophinopathy

    Okubo, Mariko / Noguchi, Satoru / Awaya, Tomonari / Hosokawa, Motoyasu / Tsukui, Nobue / Ogawa, Megumu / Hayashi, Shinichiro / Komaki, Hirofumi / Mori-Yoshimura, Madoka / Oya, Yasushi / Takahashi, Yūji / Fukuyama, Tetsuhiro / Funato, Michinori / Hosokawa, Yousuke / Kinoshita, Satoru / Matsumura, Tsuyoshi / Nakamura, Sadao / Oshiro, Azusa / Terashima, Hiroshi /
    Nagasawa, Tetsuro / Sato, Tatsuharu / Shimada, Yumi / Tokita, Yasuko / Hagiwara, Masatoshi / Ogata, Katsuhisa / Nishino, Ichizo

    Hum Genet. 2023 Jan., v. 142, no. 1, p. 59-71

    2023  , Page(s) 59–71

    Abstract: Dystrophinopathy is caused by alterations in DMD. Approximately 1% of patients remain genetically undiagnosed, because intronic variations are not detected by standard methods. Here, we combined laboratory and in silico analyses to identify disease- ... ...

    Abstract Dystrophinopathy is caused by alterations in DMD. Approximately 1% of patients remain genetically undiagnosed, because intronic variations are not detected by standard methods. Here, we combined laboratory and in silico analyses to identify disease-causing genomic variants in genetically undiagnosed patients and determine the regulatory mechanisms underlying abnormal DMD transcript generation. DMD transcripts from 20 genetically undiagnosed dystrophinopathy patients in whom no exon variants were identified, despite dystrophin deficiency on muscle biopsy, were analyzed by transcriptome sequencing. Genome sequencing captured intronic variants and their effects were interpreted using in silico tools. Targeted long-read sequencing was applied in cases with suspected structural genomic abnormalities. Abnormal DMD transcripts were detected in 19 of 20 cases; Exonization of intronic sequences in 15 cases, exon skipping in one case, aberrantly spliced and polyadenylated transcripts in two cases and transcription termination in one case. Intronic single nucleotide variants, chromosomal rearrangements and nucleotide repeat expansion were identified in DMD gene as pathogenic causes of transcript alteration. Our combined analysis approach successfully identified pathogenic events. Detection of diseasing-causing mechanisms in DMD transcripts could inform the therapeutic options for patients with dystrophinopathy.
    Keywords biopsy ; computer simulation ; dystrophin ; exons ; muscles ; prediction ; sequence analysis ; structural genomics ; transcription termination ; transcriptome
    Language English
    Dates of publication 2023-01
    Size p. 59-71
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 223009-4
    ISSN 1432-1203 ; 0340-6717
    ISSN (online) 1432-1203
    ISSN 0340-6717
    DOI 10.1007/s00439-022-02485-2
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