LIVIVO - Search results -

Search results

Result 1 - 10 of total 53

Search options

Article ; Online: Cytokines as predictors of COVID-19 severity: evidence from a meta-analysis. Authors' reply.

Kosmaczewska, Agata / Frydecka, Irena

2021 Volume 131, Issue 1, Page(s) 99–100

MeSH term(s)	COVID-19 ; Cytokines ; Humans ; SARS-CoV-2
Chemical Substances	Cytokines
Language	English
Publishing date	2021-01-29
Publishing country	Poland
Document type	Letter ; Comment
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.15793
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 360: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Are patients with lung cystic fibrosis at increased risk of severe and fatal COVID-19? Interleukin 6 as a predictor of COVID-19 outcomes. Authors' reply.

Kosmaczewska, Agata / Frydecka, Irena

Polish archives of internal medicine

2020 Volume 130, Issue 10, Page(s) 920–921

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Cystic Fibrosis ; Humans ; Immune System ; Interleukin-6 ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Chemical Substances	Interleukin-6
Keywords	covid19
Language	English
Publishing date	2020-10-29
Publishing country	Poland
Document type	Letter ; Comment
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.15660
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 360: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dysregulation of the immune system as a driver of the critical course of novel coronavirus disease 2019.

Kosmaczewska, Agata / Frydecka, Irena

Polish archives of internal medicine

2020 Volume 130, Issue 9, Page(s) 779–788

Abstract: Novel coronavirus disease 2019 (COVID‑19) is a highly contagious, respiratory disease caused by the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). Given that inflammatory immune cells may induce severe lung injury, the ... ...

Abstract	Novel coronavirus disease 2019 (COVID‑19) is a highly contagious, respiratory disease caused by the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). Given that inflammatory immune cells may induce severe lung injury, the involvement of immunological factors in the pathogenesis of the disease cannot be overestimated. It has been demonstrated that coronaviruses have developed mechanisms of immune evasion, making themselves invisible to the immune system at an early stage of infection. The mechanism relies on inhibiting the antiviral response of type I interferons, which enhances uncontrolled viral replication in epithelial cells. There has been a growing body of evidence showing that fatal hyperinflammation (cytokine storm) responsible for the severe course of COVID‑19 is a consequence of massive SARS‑CoV‑2 replication rather than inappropriate hyperresponsiveness of the immune system. Therefore, the suppressed antiviral innate immune response seems to be the primary cause of the delayed critical cascade of uncontrolled immune events leading to fulminant systemic inflammation. The occurrence of virus transmission even in asymptomatic individuals infected with SARS‑CoV‑2 clearly strengthens the evidence for the key role played by the sufficient immune control of viral replication in a subset of cases (eg, in children, a population with a highly effective innate immune response). Although administration of immunomodulatory drugs is recommended under certain conditions by the guidelines for COVID‑19 management, controversies regarding treatment protocols in immunocompromised patients infected with SARS‑CoV‑2 still exist. Extending clinicians' knowledge on the dysregulated immune response, which is a driver of the COVID‑19 outcome, may improve both therapeutic strategies and the prognosis of patients infected with SARS‑CoV‑2.
MeSH term(s)	COVID-19 ; Coronavirus Infections/immunology ; Cytokines/immunology ; Female ; Humans ; Immune System/immunology ; Immunity, Innate ; Inflammation ; Male ; Pandemics ; Pneumonia, Viral/immunology
Chemical Substances	Cytokines
Keywords	covid19
Language	English
Publishing date	2020-07-06
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.15482
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 360: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Low-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunity.

Kosmaczewska, Agata

International journal of molecular sciences

2014 Volume 15, Issue 10, Page(s) 18574–18592

Abstract: For many years, the role of interleukin-2 (IL-2) in autoimmune responses was established as a cytokine possessing strong pro-inflammatory activity. Studies of the past few years have changed our knowledge on IL-2 in autoimmune chronic inflammation, ... ...

Abstract	For many years, the role of interleukin-2 (IL-2) in autoimmune responses was established as a cytokine possessing strong pro-inflammatory activity. Studies of the past few years have changed our knowledge on IL-2 in autoimmune chronic inflammation, suggesting its protective role, when administered at low-doses. The disrupted balance between regulatory and effector T cells (Tregs and Teffs, respectively) is a characteristic of autoimmune diseases, and is dependent on homeostatic cytokines, including IL-2. Actually, inherent defects in the IL-2 signaling pathway and/or levels leading to Treg compromised function and numbers as well as Th17 expansion have been attributed to autoimmune disorders. In this review, we discuss the role of IL-2 in the pathogenesis of autoimmune diseases. In particular, we highlight the impact of the dysregulated IL-2 pathway on disruption of the Treg/Th17 balance, reversal of which appears to be a possible mechanism of the low-dose IL-2 treatment. The negative effects of IL-2 on the differentiation of follicular helper T cells (Tfh) and pathogenic Th17 cells, both of which contribute to autoimmunity, is emphasized in the paper as well. We also compare the current IL-2-based therapies of animal and human subjects with immune-mediated diseases aimed at boosting the Treg population, which is the most IL-2-dependent cell subset desirable for sufficient control of autoimmunity. New perspectives of therapeutic approaches focused on selective delivery of IL-2 to inflamed tissues, thus allowing local activity of IL-2 to be combined with its reduced systemic and pleiotropic toxicity, are also proposed in this paper.
MeSH term(s)	Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmune Diseases/therapy ; Autoimmunity ; Humans ; Immune Tolerance ; Immunotherapy/methods ; Interleukin-2/administration & dosage ; Interleukin-2/immunology ; Interleukin-2/therapeutic use ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/pathology ; Th17 Cells/immunology ; Th17 Cells/pathology
Chemical Substances	Interleukin-2
Language	English
Publishing date	2014-10-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms151018574
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Are patients with lung cystic fibrosis at increased risk of severe and fatal COVID-19? Interleukin 6 as a predictor of COVID-19 outcomes. Authors' reply

Kosmaczewska, Agata / Frydecka, Irena

Pol Arch Intern Med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #895813
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Low-Dose Interleukin-2 Therapy

Agata Kosmaczewska

International Journal of Molecular Sciences, Vol 15, Iss 10, Pp 18574-

A Driver of an Imbalance between Immune Tolerance and Autoimmunity

2014 Volume 18592

Abstract	For many years, the role of interleukin-2 (IL-2) in autoimmune responses was established as a cytokine possessing strong pro-inflammatory activity. Studies of the past few years have changed our knowledge on IL-2 in autoimmune chronic inflammation, suggesting its protective role, when administered at low-doses. The disrupted balance between regulatory and effector T cells (Tregs and Teffs, respectively) is a characteristic of autoimmune diseases, and is dependent on homeostatic cytokines, including IL-2. Actually, inherent defects in the IL-2 signaling pathway and/or levels leading to Treg compromised function and numbers as well as Th17 expansion have been attributed to autoimmune disorders. In this review, we discuss the role of IL-2 in the pathogenesis of autoimmune diseases. In particular, we highlight the impact of the dysregulated IL-2 pathway on disruption of the Treg/Th17 balance, reversal of which appears to be a possible mechanism of the low-dose IL-2 treatment. The negative effects of IL-2 on the differentiation of follicular helper T cells (Tfh) and pathogenic Th17 cells, both of which contribute to autoimmunity, is emphasized in the paper as well. We also compare the current IL-2-based therapies of animal and human subjects with immune-mediated diseases aimed at boosting the Treg population, which is the most IL-2-dependent cell subset desirable for sufficient control of autoimmunity. New perspectives of therapeutic approaches focused on selective delivery of IL-2 to inflamed tissues, thus allowing local activity of IL-2 to be combined with its reduced systemic and pleiotropic toxicity, are also proposed in this paper.
Keywords	interleukin-2 ; immunotherapy ; immune-mediated disease ; autoimmunity ; immune tolerance ; clinical trial ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2014-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Dysregulation of the immune system as a driver of the critical course of novel coronavirus disease 2019

Kosmaczewska, Agata / Frydecka, Irena

Pol Arch Intern Med

Abstract: Novel coronavirus disease 2019 (COVID19) is a highly contagious, respiratory disease caused by the newly emerged severe acute respiratory syndrome coronavirus 2 (SARSCoV2). Given that inflammatory immune cells may induce severe lung injury, the ... ...

Abstract	Novel coronavirus disease 2019 (COVID19) is a highly contagious, respiratory disease caused by the newly emerged severe acute respiratory syndrome coronavirus 2 (SARSCoV2). Given that inflammatory immune cells may induce severe lung injury, the involvement of immunological factors in the pathogenesis of the disease cannot be overestimated. It has been demonstrated that coronaviruses have developed mechanisms of immune evasion, making themselves invisible to the immune system at an early stage of infection. The mechanism relies on inhibiting the antiviral response of type I interferons, which enhances uncontrolled viral replication in epithelial cells. There has been a growing body of evidence showing that fatal hyperinflammation (cytokine storm) responsible for the severe course of COVID19 is a consequence of massive SARSCoV2 replication rather than inappropriate hyperresponsiveness of the immune system. Therefore, the suppressed antiviral innate immune response seems to be the primary cause of the delayed critical cascade of uncontrolled immune events leading to fulminant systemic inflammation. The occurrence of virus transmission even in asymptomatic individuals infected with SARSCoV2 clearly strengthens the evidence for the key role played by the sufficient immune control of viral replication in a subset of cases (eg, in children, a population with a highly effective innate immune response). Although administration of immunomodulatory drugs is recommended under certain conditions by the guidelines for COVID19 management, controversies regarding treatment protocols in immunocompromised patients infected with SARSCoV2 still exist. Extending clinicians' knowledge on the dysregulated immune response, which is a driver of the COVID19 outcome, may improve both therapeutic strategies and the prognosis of patients infected with SARSCoV2.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #634302
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Inappropriate Expression of PD-1 and CTLA-4 Checkpoints in Myeloma Patients Is More Pronounced at Diagnosis: Implications for Time to Progression and Response to Therapeutic Checkpoint Inhibitors.

Kulikowska de Nałęcz, Anna / Ciszak, Lidia / Usnarska-Zubkiewicz, Lidia / Pawlak, Edyta / Frydecka, Irena / Szmyrka, Magdalena / Kosmaczewska, Agata

International journal of molecular sciences

2023 Volume 24, Issue 6

Abstract: Multiple myeloma (MM) is a hematologic malignancy characterized by severely profound immune dysfunction. Therefore, the efficacy of drugs targeting the immune environments, such as immune checkpoint inhibitors (ICIs), is of high clinical importance. ... ...

Abstract	Multiple myeloma (MM) is a hematologic malignancy characterized by severely profound immune dysfunction. Therefore, the efficacy of drugs targeting the immune environments, such as immune checkpoint inhibitors (ICIs), is of high clinical importance. However, several clinical trials evaluating ICIs in MM in different therapeutic combinations revealed underwhelming results showing a lack of clinical efficacy and excessive side effects. The underlying mechanisms of resistance to ICIs observed in the majority of MM patients are still under investigation. Recently, we demonstrated that inappropriate expression of PD-1 and CTLA-4 on CD4 T cells in active MM is associated with adverse clinical outcomes and treatment status. The aim of the current study was to determine the usefulness of immune checkpoint expression assessment as a predictive biomarker of the response to therapeutic inhibitors. For this purpose, along with checkpoint expression estimated by flow cytometry, we evaluated the time to progression (TTP) of MM patients at different clinical stages (disease diagnosis and relapse) depending on the checkpoint expression level; the cut-off point (dividing patients into low and high expressors) was selected based on the median value. Herein, we confirmed the defective levels of regulatory PD-1, CTLA-4 receptors, and the CD69 marker activation in newly diagnosed (ND) patients, whereas relapsed/refractory patients (RR) exhibited their recovered values and reactivity. Additionally, substantially higher populations of senescent CD4
MeSH term(s)	Humans ; CTLA-4 Antigen ; Multiple Myeloma/diagnosis ; Multiple Myeloma/drug therapy ; Multiple Myeloma/genetics ; Programmed Cell Death 1 Receptor ; Neoplasm Recurrence, Local/etiology ; Immunotherapy/methods
Chemical Substances	CTLA-4 Antigen ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24065730
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Archaeobotanical evidence and ethnobotanical interpretation of plants used as coffin pillow fillings in burials in Poland (17th-18/19th centuries)

Badura, Monika / Jarosińska, Marta / Noryśkiewicz, Agnieszka M. / Kosmaczewska, Agata / Sady-Bugajska, Agata / Święta-Musznicka, Joanna / Pińska, Katarzyna / Latałowa, Małgorzata

Veget Hist Archaeobot. 2023 Jan., v. 32, no. 1 p.85-103

2023

Abstract: The aim of this article is the study of the botanical material in the fillings of 54 coffin pillows from Catholic and Protestant burials dated to the 17th-18/19th centuries, collected during the investigation of 15 church crypts in different regions of ... ...

Abstract	The aim of this article is the study of the botanical material in the fillings of 54 coffin pillows from Catholic and Protestant burials dated to the 17th-18/19th centuries, collected during the investigation of 15 church crypts in different regions of Poland, and consideration of the role of the plants used for this purpose. In a large part of the dataset, a comprehensive picture of the botanical composition of the pillow fills has been obtained through the parallel studies of plant macroremains and pollen. Advantages and pitfalls in the use of pollen analysis on these specific remains are discussed. The results show that a large number of taxa were used in pillow fillings. The choice of plants was mostly dictated by their aromatic, insect repellent and preservative properties as well as their symbolic meanings, but the morphology and other physical properties of plants used in the fillings was also of importance. In some cases, the use of plants from bouquets which had been blessed in specific Catholic church ceremonies is suggested. The possible season of burial according to the botanical composition of the pillows is discussed.
Keywords	archaeobotany ; botanical composition ; data collection ; insect repellents ; pollen ; pollen analysis ; Poland
Language	English
Dates of publication	2023-01
Size	p. 85-103.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1481434-1
ISSN	1617-6278 ; 0939-6314
ISSN (online)	1617-6278
ISSN	0939-6314
DOI	10.1007/s00334-022-00884-z
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Inappropriate Expression of PD-1 and CTLA-4 Checkpoints in Myeloma Patients Is More Pronounced at Diagnosis

Anna Kulikowska de Nałęcz / Lidia Ciszak / Lidia Usnarska-Zubkiewicz / Edyta Pawlak / Irena Frydecka / Magdalena Szmyrka / Agata Kosmaczewska

International Journal of Molecular Sciences, Vol 24, Iss 5730, p

Implications for Time to Progression and Response to Therapeutic Checkpoint Inhibitors

2023 Volume 5730

Abstract	Multiple myeloma (MM) is a hematologic malignancy characterized by severely profound immune dysfunction. Therefore, the efficacy of drugs targeting the immune environments, such as immune checkpoint inhibitors (ICIs), is of high clinical importance. However, several clinical trials evaluating ICIs in MM in different therapeutic combinations revealed underwhelming results showing a lack of clinical efficacy and excessive side effects. The underlying mechanisms of resistance to ICIs observed in the majority of MM patients are still under investigation. Recently, we demonstrated that inappropriate expression of PD-1 and CTLA-4 on CD4 T cells in active MM is associated with adverse clinical outcomes and treatment status. The aim of the current study was to determine the usefulness of immune checkpoint expression assessment as a predictive biomarker of the response to therapeutic inhibitors. For this purpose, along with checkpoint expression estimated by flow cytometry, we evaluated the time to progression (TTP) of MM patients at different clinical stages (disease diagnosis and relapse) depending on the checkpoint expression level; the cut-off point (dividing patients into low and high expressors) was selected based on the median value. Herein, we confirmed the defective levels of regulatory PD-1, CTLA-4 receptors, and the CD69 marker activation in newly diagnosed (ND) patients, whereas relapsed/refractory patients (RR) exhibited their recovered values and reactivity. Additionally, substantially higher populations of senescent CD4 + CD28 − T cells were found in MM, primarily in NDMM subjects. These observations suggest the existence of two dysfunctional states in MM CD4 T cells with the predominance of immunosenescence at disease diagnosis and exhaustion at relapse, thus implying different responsiveness to the external receptor blockade depending on the disease stage. Furthermore, we found that lower CTLA-4 levels in NDMM patients or higher PD-1 expression in RRMM patients may predict early relapse. In conclusion, ...
Keywords	multiple myeloma ; PD-1 ; CTLA-4 ; immune checkpoint inhibitors ; time to progression ; clinical response ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED