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  1. Article ; Online: Statins as a Secondary Preventive Agent for Metastatic Cancer.

    Marti, Juan Luis Gomez / Wells, Jakob Z / Wells, Alan

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Volume 18, Issue 11, Page(s) e125–e126

    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Lung Neoplasms/drug therapy ; Neoplasms, Second Primary
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Letter ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.07.027
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    Zs.A 6664: Show issues Location:
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    Zs.MO 652: Show issues

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  2. Article ; Online: Ovarian function suppression as a potential mechanism of chemotherapy.

    Gomez Marti, Juan Luis / Nasrazadani, Azadeh / Brufsky, Adam M

    EBioMedicine

    2021  Volume 70, Page(s) 103489

    MeSH term(s) Chemotherapy, Adjuvant ; Female ; Humans ; Ovary
    Language English
    Publishing date 2021-07-16
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Considerations of the effects of commonly investigated drugs for COVID-19 in the cholesterol synthesis pathway.

    Gomez Marti, Juan Luis / Brufsky, Adam M

    Expert opinion on pharmacotherapy

    2021  Volume 22, Issue 8, Page(s) 947–952

    MeSH term(s) COVID-19 ; Cholesterol ; Humans ; Pharmaceutical Preparations ; SARS-CoV-2
    Chemical Substances Pharmaceutical Preparations ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2021-03-11
    Publishing country England
    Document type Editorial
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2021.1897104
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    Zs.A 5130: Show issues Location:
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  4. Article ; Online: Preventing metastatic emergence of breast cancer.

    Wells, Alan / Beckwitt, Colin / Marti, Juan Luis Gomez

    Aging

    2021  Volume 13, Issue 19, Page(s) 22627–22628

    MeSH term(s) Aging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Neoplasm Metastasis/prevention & control ; Neoplasm Recurrence, Local/prevention & control
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2021-10-11
    Publishing country United States
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.203631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Potential interventions for SARS-CoV-2 infections: Zinc showing promise.

    Brewer, Joseph / Gomez Marti, Juan Luis / Brufsky, Adam

    Journal of medical virology

    2020  Volume 93, Issue 3, Page(s) 1201–1203

    MeSH term(s) COVID-19 ; China ; Humans ; SARS-CoV-2 ; Zinc
    Chemical Substances Zinc (J41CSQ7QDS)
    Keywords covid19
    Language English
    Publishing date 2020-10-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26523
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    Zs.A 1320: Show issues Location:
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  6. Article ; Online: Statins and endocrine resistance in breast cancer.

    Hyder, Tara / Marti, Juan Luis Gomez / Nasrazadani, Azadeh / Brufsky, Adam M

    Cancer drug resistance (Alhambra, Calif.)

    2021  Volume 4, Issue 2, Page(s) 356–364

    Abstract: Most breast cancers are hormone-receptor positive ( ... ...

    Abstract Most breast cancers are hormone-receptor positive (HR
    Language English
    Publishing date 2021-06-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2020.112
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  7. Article ; Online: Twenty-Year Follow-Up of a Phase II Trial of Taxotere/Carboplatin/Herceptin in Patients With Metastatic HER2-Positive Breast Cancer.

    Gomez Marti, Juan Luis / Nasrazadani, Azadeh / Ding, Ying / Normolle, Daniel / Brufsky, Adam M

    The oncologist

    2023  Volume 28, Issue 11, Page(s) e1123–e1126

    Abstract: Background: As the implementation of trastuzumab, several studies have investigated new agents and regimens to treat human epidermal growth factor 2-positive (HER2+) metastatic breast cancer (MBC). However, long-term survival analyses from HER2-targeted ...

    Abstract Background: As the implementation of trastuzumab, several studies have investigated new agents and regimens to treat human epidermal growth factor 2-positive (HER2+) metastatic breast cancer (MBC). However, long-term survival analyses from HER2-targeted therapies are lacking. This is a 20-year follow-up study of a phase II trial that evaluated the activity and safety of docetaxel in combination with carboplatin and trastuzumab (TCH) in patients with HER2+ MBC.
    Materials and methods: This is a follow-up of a phase II, single-arm, open-label study. The primary objective was the activity from the combination of TCH in terms of response rate (RR). Secondary objectives included the activity from TCH in terms of response duration (RD), time to progression (TTP), overall survival (OS), and percent one-year survival.
    Results: Between 11/1999 and 10/2002, 40 women were enrolled. Most patients (67.5%) had visceral metastasis on enrollment. After 2 decades and 3 months from first enrollment, there were 4 (10%) survivors (median follow-up of 3.2 years). The RR for complete response (CR) or partial response (PR) was 72.5%. The RR for CR was 42.5%. RD was 8 months. Median TTP was 10.8 months. Participants achieved a median OS of 39.8 months. Percent one-year survival was 92.5%.
    Conclusion: A subset of patients (10%) receiving trastuzumab in the metastatic setting have achieved long-term survival beyond 20 years.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Carboplatin/therapeutic use ; Docetaxel/therapeutic use ; Follow-Up Studies ; Receptor, ErbB-2/metabolism ; Antibodies, Monoclonal, Humanized/therapeutic use ; Disease-Free Survival ; Trastuzumab/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols
    Chemical Substances Carboplatin (BG3F62OND5) ; Docetaxel (15H5577CQD) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Antibodies, Monoclonal, Humanized ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Clinical Trial, Phase II ; Journal Article
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1093/oncolo/oyad258
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    Zs.A 4845: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 494: Show issues

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  8. Article: Machine Learning to Discern Interactive Clusters of Risk Factors for Late Recurrence of Metastatic Breast Cancer.

    Gomez Marti, Juan Luis / Brufsky, Adam / Wells, Alan / Jiang, Xia

    Cancers

    2022  Volume 14, Issue 1

    Abstract: Background: Risk of metastatic recurrence of breast cancer after initial diagnosis and treatment depends on the presence of a number of risk factors. Although most univariate risk factors have been identified using classical methods, machine-learning ... ...

    Abstract Background: Risk of metastatic recurrence of breast cancer after initial diagnosis and treatment depends on the presence of a number of risk factors. Although most univariate risk factors have been identified using classical methods, machine-learning methods are also being used to tease out non-obvious contributors to a patient's individual risk of developing late distant metastasis. Bayesian-network algorithms can identify not only risk factors but also interactions among these risks, which consequently may increase the risk of developing metastatic breast cancer. We proposed to apply a previously developed machine-learning method to discern risk factors of 5-, 10- and 15-year metastases.
    Methods: We applied a previously validated algorithm named the Markov Blanket and Interactive Risk Factor Learner (MBIL) to the electronic health record (EHR)-based Lynn Sage Database (LSDB) from the Lynn Sage Comprehensive Breast Center at Northwestern Memorial Hospital. This algorithm provided an output of both single and interactive risk factors of 5-, 10-, and 15-year metastases from the LSDB. We individually examined and interpreted the clinical relevance of these interactions based on years to metastasis and reliance on interactivity between risk factors.
    Results: We found that, with lower alpha values (low interactivity score), the prevalence of variables with an independent influence on long-term metastasis was higher (i.e., HER2, TNEG). As the value of alpha increased to 480, stronger interactions were needed to define clusters of factors that increased the risk of metastasis (i.e., ER, smoking, race, alcohol usage).
    Conclusion: MBIL identified single and interacting risk factors of metastatic breast cancer, many of which were supported by clinical evidence. These results strongly recommend the development of further large data studies with different databases to validate the degree to which some of these variables impact metastatic breast cancer in the long term.
    Language English
    Publishing date 2022-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14010253
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  9. Article ; Online: Poziotinib treatment in patients with HER2-positive advanced breast cancer who have received prior anti-HER2 regimens.

    Nasrazadani, Azadeh / Marti, Juan Luis Gomez / Lathrop, Kate / Restrepo, Alvaro / Leu, Szu-Yun / Bhat, Gajanan / Brufsky, Adam

    Breast cancer research and treatment

    2024  Volume 205, Issue 1, Page(s) 29–37

    Abstract: Purpose: Poziotinib is an irreversible pan-inhibitor of the human epidermal growth factor receptor (HER) that has shown acceptable tolerability and antitumor activity in phase I and II trials in patients with advanced solid tumors. In the present open- ... ...

    Abstract Purpose: Poziotinib is an irreversible pan-inhibitor of the human epidermal growth factor receptor (HER) that has shown acceptable tolerability and antitumor activity in phase I and II trials in patients with advanced solid tumors. In the present open-label, multicenter phase II study, we demonstrate safety, tolerability, and preliminary efficacy data from two different dosing schedules in patients with HER2-positive advanced breast cancer.
    Patients and methods: Patients who had received at least two prior HER2-directed therapy lines for advanced disease, received 24 mg poziotinib on an intermittent dosing schedule (cohort 1) or 16 mg poziotinib once daily on a continuous dosing schedule (cohort 2). The primary endpoint was overall response rate (ORR). Secondary endpoints were progression-free survival (PFS), disease control rate (DCR), and time to progression (TTP). Secondary endpoints additionally included safety and pharmacokinetics.
    Results: A total of 67 patients were enrolled. The ORR was 30% in both groups (p = 0.98). DCR was 60% vs 78% (p = 0.15) and median PFS and TTP were 4.1 vs 4.9 months (both p = 0.30) for cohorts 1 and 2, respectively. The most common treatment related adverse events (AEs) of any grade included diarrhea (88% vs 85%, p = 0.76), rash (88% vs 88%, p = 0.96), and stomatitis (64% vs 56%, p = 0.52), with grade 3-4 diarrhea occurring in 33% vs 32% of patients (p = 0.93) and grade 3-4 rash in 27% vs 35% of patients (p = 0.48) in cohort 1 vs cohort 2, respectively.
    Conclusion: Poziotinib demonstrated evidence of clinical activity in patients with pre-treated HER2-positive advanced breast cancer, although high levels of toxicity may preclude further studies at this time.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/mortality ; Breast Neoplasms/metabolism ; Receptor, ErbB-2/metabolism ; Middle Aged ; Aged ; Adult ; Quinazolines/therapeutic use ; Quinazolines/administration & dosage ; Treatment Outcome ; Aged, 80 and over ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/administration & dosage ; Neoplasm Staging ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1) ; Quinazolines ; HM781-36B ; ERBB2 protein, human (EC 2.7.10.1) ; Protein Kinase Inhibitors ; Antineoplastic Agents
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Journal Article ; Clinical Trial, Phase II ; Multicenter Study
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-023-07236-z
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  10. Article ; Online: Ovarian function suppression as a potential mechanism of chemotherapy

    Juan Luis Gomez Marti / Azadeh Nasrazadani / Adam M. Brufsky

    EBioMedicine, Vol 70, Iss , Pp 103489- (2021)

    2021  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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