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Article: Dystonia and chorea in acquired systemic disorders.

Janavs, J L / Aminoff, M J

Journal of neurology, neurosurgery, and psychiatry

1998 Volume 65, Issue 4, Page(s) 436–445

Abstract: Dystonia and chorea are uncommon accompaniments, but sometimes the presenting features of certain acquired systemic disorders that presumably alter basal ganglia function. Hypoxia-ischaemia may injure the basal ganglia through hypoperfusion of ... ...

Abstract	Dystonia and chorea are uncommon accompaniments, but sometimes the presenting features of certain acquired systemic disorders that presumably alter basal ganglia function. Hypoxia-ischaemia may injure the basal ganglia through hypoperfusion of subcortical vascular watershed regions and by altering striatal neurotransmitter systems. Toxins interfere with striatal mitochondrial function, resulting in cellular hypoxia. Infections may affect the basal ganglia by causing vasculitic ischaemia, through the development of antibodies to basal ganglia epitopes, by direct invasion of the basal ganglia by the organism, or through cytotoxins causing neuronal injury. Autoimmune disorders alter striatal function by causing a vasculopathy, by direct reaction of antibodies with basal ganglia epitopes, or by stimulating the generation of a cytotoxic or inflammatory reaction. Endocrine and electrolyte abnormalities influence neurotransmitter balance or affect ion channel function and signalling in the basal ganglia. In general, the production of chorea involves dysfunction of the indirect pathway from the caudate and putamen to the internal globus pallidus, whereas dystonia is generated by dysfunction of the direct pathway. The time of the onset of the movement disorder relative to the primary disease process, and course vary with the age of the patient and the underlying pathology. Treatment of dystonia or chorea associated with a systemic medical disorder must initially consider the systemic disorder.
MeSH term(s)	Adolescent ; Adult ; Bacterial Infections/complications ; Brain Ischemia/complications ; Child ; Chorea/diagnosis ; Chorea/etiology ; Dystonia/complications ; Dystonia/diagnosis ; Dystonia/etiology ; Humans ; Hypoxia/complications ; Lupus Erythematosus, Systemic/complications ; Middle Aged ; Toxemia/complications
Language	English
Publishing date	1998-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp.65.4.436
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Article ; Online: Randomized, placebo-controlled trial of quetiapine XR and divalproex ER monotherapies in the treatment of the anxious bipolar patient.

Sheehan, David V / Harnett-Sheehan, Kathy / Hidalgo, Rosario B / Janavs, Juris / McElroy, Susan L / Amado, Darlene / Suppes, Trisha

Journal of affective disorders

2013 Volume 145, Issue 1, Page(s) 83–94

Abstract: Background: Anxiety disorders complicate the treatment of bipolar disorder but are seldom the focus of bipolar treatment studies.: Methods: The anxiolytic effect of quetiapine XR 50-300 mg/day compared to divalproex ER (500-3000 mg/day) was tested in ...

Abstract	Background: Anxiety disorders complicate the treatment of bipolar disorder but are seldom the focus of bipolar treatment studies. Methods: The anxiolytic effect of quetiapine XR 50-300 mg/day compared to divalproex ER (500-3000 mg/day) was tested in an 8-week, double-blind, placebo-controlled, randomized clinical trial in 149 patients with bipolar disorder and a co-occurring panic disorder or GAD. The primary efficacy measure was the Clinician Global Improvement-21 Anxiety Scale (CGI-21). Secondary measures included the Hamilton Anxiety Scale (HAM-A) and Sheehan Panic Disorder Scale (SPS). Results: Repeated measures last-observation-carried-forward (LOCF) analyses of variance demonstrated significant treatment-by-time interaction effects on 3 of the 4 anxiety measures. Quetiapine XR at a mean endpoint dose of 186 mg/day produced rapid sustained improvements relative to baseline, divalproex ER and placebo on anxiety. Mean baseline-to-endpoint improvement was significantly greater for quetiapine XR compared to divalproex ER and placebo on the HAM-A and SPS. Both active medications were well tolerated, but weight gain was higher on quetiapine XR. Limitations: The study was limited to 8 weeks and to patients with bipolar disorder and comorbid panic disorder or GAD. The results may not be applicable to quetiapine XR as an add-on treatment to mood stabilizers or to bipolar disorder comorbid with other anxiety disorders. Conclusions: Quetiapine XR in a dose range of 50-300 mg/day appears to reduce anxiety in bipolar patients with comorbid panic disorder or GAD treated for 8 weeks. The efficacy of other second-generation antipsychotics and mood stabilizers in patients with bipolar disorder and a co-occurring anxiety disorder should be investigated in double-blind, placebo-controlled studies.
MeSH term(s)	Adult ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Bipolar Disorder/complications ; Bipolar Disorder/drug therapy ; Delayed-Action Preparations/administration & dosage ; Dibenzothiazepines/administration & dosage ; Dibenzothiazepines/adverse effects ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Panic Disorder/complications ; Panic Disorder/drug therapy ; Quetiapine Fumarate ; Treatment Outcome ; Valproic Acid/administration & dosage ; Valproic Acid/adverse effects ; Weight Gain
Chemical Substances	Antipsychotic Agents ; Delayed-Action Preparations ; Dibenzothiazepines ; Quetiapine Fumarate (2S3PL1B6UJ) ; Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2013-02-15
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2012.07.016
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Article: RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells.

Janavs, J L / Pierce, M E / Takahashi, J S

Brain research. Molecular brain research

1994 Volume 23, Issue 1-2, Page(s) 47–56

Abstract: Y79 human retinoblastoma cells synthesize melatonin in cell culture thus providing a unique preparation for studying the regulation of melatonin biosynthesis in mammalian retinas. We have previously demonstrated that Y79 cells express NAT and HIOMT ... ...

Abstract	Y79 human retinoblastoma cells synthesize melatonin in cell culture thus providing a unique preparation for studying the regulation of melatonin biosynthesis in mammalian retinas. We have previously demonstrated that Y79 cells express NAT and HIOMT activity and produce melatonin in a cAMP- and protein synthesis-dependent manner by increasing NAT, and not HIOMT activity, as has been demonstrated in other retinal and pineal melatonin synthesizing systems. We have extended these studies to investigate the role of RNA synthesis in melatonin regulation, and report here that RNA synthesis inhibitors do not suppress melatonin production in Y79 retinoblastoma cells. Rather, at intermediate concentrations, the inhibitors actinomycin D and camptothecin increase melatonin levels. Camptothecin, a topoisomerase I inhibitor, also increased NAT activity and accumulated cAMP levels in a calcium-dependent manner. This effect on cAMP did not appear to occur through phosphodiesterase, and other regulators of retinal melatonin such as melatonin degradation or components of the dopamine system were unaffected. These results are in contrast with the suppression of melatonin synthesis by RNA synthesis inhibitors observed in rat and chick pineal glands and in chick retinas.
MeSH term(s)	Amidohydrolases/metabolism ; Anisomycin/pharmacology ; Arylamine N-Acetyltransferase/biosynthesis ; Arylamine N-Acetyltransferase/genetics ; Calcium/physiology ; Camptothecin/pharmacology ; Colforsin/pharmacology ; Cyclic AMP/biosynthesis ; Dactinomycin/pharmacology ; Dopamine/metabolism ; Egtazic Acid/analogs & derivatives ; Egtazic Acid/pharmacology ; Eye Neoplasms/metabolism ; Eye Neoplasms/pathology ; Humans ; Melatonin/biosynthesis ; Melatonin/genetics ; Nerve Tissue Proteins/biosynthesis ; Protein Synthesis Inhibitors/pharmacology ; Retinoblastoma/metabolism ; Retinoblastoma/pathology ; Topoisomerase I Inhibitors ; Transcription, Genetic/drug effects ; Tumor Cells, Cultured
Chemical Substances	Nerve Tissue Proteins ; Protein Synthesis Inhibitors ; Topoisomerase I Inhibitors ; Dactinomycin (1CC1JFE158) ; Colforsin (1F7A44V6OU) ; Egtazic Acid (526U7A2651) ; Anisomycin (6C74YM2NGI) ; Cyclic AMP (E0399OZS9N) ; Arylamine N-Acetyltransferase (EC 2.3.1.5) ; Amidohydrolases (EC 3.5.-) ; melatonin deacetylase (EC 3.5.1.-) ; Melatonin (JL5DK93RCL) ; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (K22DDW77C0) ; Calcium (SY7Q814VUP) ; Dopamine (VTD58H1Z2X) ; Camptothecin (XT3Z54Z28A)
Language	English
Publishing date	1994-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	632883-0
ISSN	1872-6941 ; 0169-328X
ISSN (online)	1872-6941
ISSN	0169-328X
DOI	10.1016/0169-328x(94)90210-0
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Article: N-acetyltransferase and protein synthesis modulate melatonin production by Y79 human retinoblastoma cells.

Janavs, J L / Pierce, M E / Takahashi, J S

Brain research

1991 Volume 540, Issue 1-2, Page(s) 138–144

Abstract: Melatonin is synthesized by the vertebrate pineal gland in a circadian fashion and is involved in numerous circadian and seasonal processes in the organism. The vertebrate retina also produces melatonin rhythmically to regulate rhythmic physiological ... ...

Abstract	Melatonin is synthesized by the vertebrate pineal gland in a circadian fashion and is involved in numerous circadian and seasonal processes in the organism. The vertebrate retina also produces melatonin rhythmically to regulate rhythmic physiological processes in the eye. In both organs, melatonin is synthesized from serotonin by the sequential action of the enzymes, N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), and can be stimulated by increases in cyclic AMP through a mechanism requiring protein synthesis. The regulation of ocular melatonin biosynthesis in mammals and particularly humans, has not been well studied. Recently, we have shown that Y79 human retinoblastoma cells produce melatonin and that cAMP can stimulate melatonin production. Y79 cells, therefore, provide a model system in which to study melatonin synthesis in human tissue. We report that cAMP stimulates NAT, but not HIOMT activity in Y79 cells, and that stimulation of NAT activity is linearly related to melatonin release. In addition, the stimulation of NAT and melatonin requires protein synthesis. The turnover of NAT is rather rapid, with a half-life of about 20 min. These results suggest that the regulation of melatonin in Y79 retinoblastoma cells is similar to that found in the retina and pineal of other vertebrates.
MeSH term(s)	Acetylserotonin O-Methyltransferase/metabolism ; Anisomycin/pharmacology ; Arylamine N-Acetyltransferase/metabolism ; Cell Line ; Colforsin/pharmacology ; Cycloheximide/pharmacology ; Eye Neoplasms/metabolism ; Humans ; Kinetics ; Melatonin/biosynthesis ; Neoplasm Proteins/biosynthesis ; Retinoblastoma/metabolism
Chemical Substances	Neoplasm Proteins ; Colforsin (1F7A44V6OU) ; Anisomycin (6C74YM2NGI) ; Cycloheximide (98600C0908) ; Acetylserotonin O-Methyltransferase (EC 2.1.1.4) ; Arylamine N-Acetyltransferase (EC 2.3.1.5) ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	1991-02-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/0006-8993(91)90500-u
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Zs.A 161: Show issues

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Article: Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells.

Janavs, J L / Florez, J C / Pierce, M E / Takahashi, J S

The Journal of neuroscience : the official journal of the Society for Neuroscience

1995 Volume 15, Issue 1 Pt 1, Page(s) 298–309

Abstract: The synthesis of melatonin in Xenopus retinas, chick and quail retinal cell cultures, and Y79 human retinoblastoma cells is stimulated by cAMP through a protein synthesis-dependent mechanism. In Y79 retinoblastoma cells, combined treatment with the RNA ... ...

Abstract	The synthesis of melatonin in Xenopus retinas, chick and quail retinal cell cultures, and Y79 human retinoblastoma cells is stimulated by cAMP through a protein synthesis-dependent mechanism. In Y79 retinoblastoma cells, combined treatment with the RNA synthesis inhibitor camptothecin and agents that elevate cAMP, such as forskolin, causes a synergistic elevation of melatonin. Using two-dimensional gel analysis we have identified a 30 kDa cytosolic protein (p30) whose radiolabeling was consistently increased in parallel with increases in arylalkylamine N-acetyltransferase activity and melatonin production that were induced by forskolin and/or camptothecin. Pulse-chase experiments suggest that the elevation in radiolabeling of p30 is due to increased synthesis. Three candidate proteins found in the mammalian pineal, protein 14-3-3, malate dehydrogenase, and recoverin, do not comigrate with p30.
MeSH term(s)	Camptothecin/pharmacology ; Colforsin/pharmacology ; Humans ; Immunoblotting ; Melatonin/biosynthesis ; Molecular Weight ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/metabolism ; Retinoblastoma/metabolism ; Retinoblastoma/pathology ; Time Factors ; Tumor Cells, Cultured
Chemical Substances	Neoplasm Proteins ; Colforsin (1F7A44V6OU) ; Melatonin (JL5DK93RCL) ; Camptothecin (XT3Z54Z28A)
Language	English
Publishing date	1995-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
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Article ; Online: Reliability and validity of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID).

Sheehan, David V / Sheehan, Kathy H / Shytle, R Douglas / Janavs, Juris / Bannon, Yvonne / Rogers, Jamison E / Milo, Karen M / Stock, Saundra L / Wilkinson, Berney

The Journal of clinical psychiatry

2010 Volume 71, Issue 3, Page(s) 313–326

Abstract: Objective: To investigate the concurrent validity and reliability of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID), a short structured diagnostic interview for DSM-IV and ICD-10 psychiatric disorders in ... ...

Abstract	Objective: To investigate the concurrent validity and reliability of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID), a short structured diagnostic interview for DSM-IV and ICD-10 psychiatric disorders in children and adolescents. Method: Participants were 226 children and adolescents (190 outpatients and 36 controls) aged 6 to 17 years. To assess the concurrent validity of the MINI-KID, participants were administered the MINI-KID and the Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime Version (K-SADS-PL) by blinded interviewers in a counterbalanced order on the same day. Participants also completed a self-rated measure of disability. In addition, interrater (n = 57) and test-retest (n = 83) reliability data (retest interval, 1-5 days) were collected, and agreement between the parent version of the MINI-KID and the standard MINI-KID (n = 140) was assessed. Data were collected between March 2004 and January 2008. Results: Substantial to excellent MINI-KID to K-SADS-PL concordance was found for syndromal diagnoses of any mood disorder, any anxiety disorder, any substance use disorder, any ADHD or behavioral disorder, and any eating disorder (area under curve [AUC] = 0.81-0.96, kappa = 0.56-0.87). Results were more variable for psychotic disorder (AUC = 0.94, kappa = 0.41). Sensitivity was substantial (0.61-1.00) for 15/20 individual DSM-IV disorders. Specificity was excellent (0.81-1.00) for 18 disorders and substantial (> 0.73) for the remaining 2. The MINI-KID identified a median of 3 disorders per subject compared to 2 on the K-SADS-PL and took two-thirds less time to administer (34 vs 103 minutes). Interrater and test-retest kappas were substantial to almost perfect (0.64-1.00) for all individual MINI-KID disorders except dysthymia. Concordance of the parent version (MINI-KID-P) with the standard MINI-KID was good. Conclusions: The MINI-KID generates reliable and valid psychiatric diagnoses for children and adolescents and does so in a third of the time as the K-SADS-PL.
MeSH term(s)	Adolescent ; Area Under Curve ; Child ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Humans ; International Classification of Diseases ; Male ; Mental Disorders/diagnosis ; Personality Assessment/statistics & numerical data ; Personality Inventory/statistics & numerical data ; Psychiatric Status Rating Scales/statistics & numerical data ; Psychometrics ; Reproducibility of Results ; Sensitivity and Specificity ; Severity of Illness Index ; Surveys and Questionnaires ; Time Factors
Language	English
Publishing date	2010-03
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
DOI	10.4088/JCP.09m05305whi
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Zs.B 108: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 247: Show issues

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Article: Muscle activity pattern regulates postnatal development of acetylcholinesterase molecular forms in normal mice and mice with motor endplate disease.

Yeakley, J M / Janavs, J L / Reiness, C G

The Journal of neuroscience : the official journal of the Society for Neuroscience

1987 Volume 7, Issue 12, Page(s) 4084–4094

Abstract: We have studied the relative contributions of muscle activity and nerve-supplied materials to the regulation of AChE molecular forms during postnatal development of muscles in normal mice and in mice with motor endplate disease (med mice). Onset of this ... ...

Abstract	We have studied the relative contributions of muscle activity and nerve-supplied materials to the regulation of AChE molecular forms during postnatal development of muscles in normal mice and in mice with motor endplate disease (med mice). Onset of this hereditary disease causes a progressive failure of evoked release of ACh from the motor neuron, which prevents contraction in muscles such as biceps and soleus. In these innervated but inactive muscles, one can examine the consequences of inactivity on the distribution of AChE forms. In normal mouse biceps the distribution of AChE forms, as shown by sucrose-gradient analysis, change substantially after birth; the most dramatic alteration is an increase in G4 AChE from 15 to 45% of total AChE during the third postnatal week. AChE profiles in normal or med biceps are indistinguishable until 10-12 d after birth, but the changes in distribution of AChE forms does not occur in med biceps nor in normal biceps denervated 2 weeks after birth. In contrast, the distributions of AChE forms in a predominantly slow muscle, the soleus, are similar in med and normal mice both early (10 d) and late (20 d) in the course of the disease, and the distributions are affected little by denervation. The profiles of AChE forms seen in normal soleus at all times studied resembled those seen in newborn biceps or biceps inactivated by denervation or the med disease. We conclude that neither innervation, age-dependent changes intrinsic to muscle, nor muscle activity is sufficient to induce the changes we seen in AChE forms in biceps. These results support the hypothesis that neonatal, inactive, or tonically active muscles produce an intrinsic pattern of AChE molecular forms, and that a phasic pattern of activity induces a postnatal redistribution of the AChE molecular forms expressed by the muscle.
MeSH term(s)	Acetylcholinesterase/biosynthesis ; Acetylcholinesterase/metabolism ; Animals ; Mice ; Mice, Mutant Strains ; Motor Endplate/metabolism ; Motor Endplate/physiopathology ; Muscles/innervation ; Muscles/metabolism ; Muscles/physiology ; Muscles/physiopathology ; Neuromuscular Diseases/metabolism ; Neuromuscular Diseases/physiopathology ; Neuromuscular Junction/physiopathology
Chemical Substances	Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	1987-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
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Article ; Online: Randomized, placebo-controlled trial of risperidone for acute treatment of bipolar anxiety.

Sheehan, David V / McElroy, Susan L / Harnett-Sheehan, Kathy / Keck, Paul E / Janavs, Juris / Rogers, Jamison / Gonzalez, Robert / Shivakumar, Geetha / Suppes, Trisha

Journal of affective disorders

2009 Volume 115, Issue 3, Page(s) 376–385

Abstract: Background: The treatment of bipolar disorder is often complicated by the presence of a co-occuring anxiety disorder. Although second generation antipsychotics are being used with increasing frequency in bipolar patients, their anxiolytic effects have ... ...

Abstract	Background: The treatment of bipolar disorder is often complicated by the presence of a co-occuring anxiety disorder. Although second generation antipsychotics are being used with increasing frequency in bipolar patients, their anxiolytic effects have not been well studied in this population. Methods: The anxiolytic effect of risperidone 0.5-4 mg/day was tested in an 8-week, double-blind, placebo-controlled, randomized clinical trial in 111 patients with bipolar disorder and a co-occuring panic disorder or generalized anxiety disorder (GAD). The primary outcome measure was the Clinician Global Improvement-21 Anxiety scale (CGI-21 Anxiety). Secondary measures included the Hamilton Anxiety Scale (HAM-A) and the Sheehan Panic Disorder Scale. Results: On the last-observation-carried forward analysis of repeated measures analysis of variance (ANOVA), risperidone was not more effective than placebo for the CGI-21 Anxiety score or the other anxiety outcome measures. Risperidone was well tolerated, with only two patients withdrawing because of adverse events. Limitations: The risperidone treated group had more patients with mixed states and lifetime panic disorder at randomization than the placebo group. The study was limited to 8 weeks and to individuals with bipolar and comorbid panic disorder or GAD. The results may not be applicable to risperidone as an add-on treatment to mood stabilizers, or to bipolar disorder comorbid with anxiety disorders other than panic disorder or GAD. Conclusions: Risperidone monotherapy was not an effective anxiolytic for bipolar patients with comorbid panic disorder or GAD in doses of 0.5-4 mg/day over 8 weeks of treatment. The efficacy of other second generation antipsychotics and mood stabilizers on anxiety in patients with bipolar disorder and a co-occuring anxiety disorder should be investigated in double-blind, placebo-controlled studies.
MeSH term(s)	Adolescent ; Adult ; Aged ; Analysis of Variance ; Anxiety/drug therapy ; Anxiety Disorders/drug therapy ; Anxiety Disorders/psychology ; Bipolar Disorder/drug therapy ; Bipolar Disorder/psychology ; Comorbidity ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Male ; Middle Aged ; Panic Disorder/drug therapy ; Psychiatric Status Rating Scales ; Risperidone/administration & dosage ; Risperidone/adverse effects ; Risperidone/therapeutic use ; Serotonin Antagonists/administration & dosage ; Serotonin Antagonists/adverse effects ; Serotonin Antagonists/therapeutic use ; Time Factors ; Treatment Outcome ; Young Adult
Chemical Substances	Serotonin Antagonists ; Risperidone (L6UH7ZF8HC)
Language	English
Publishing date	2009-06
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2008.10.005
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Zs.A 1485: Show issues

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Article: Two cases of atypical digital vasospasm.

Gutnik, L M / Freeman, J W / Janavs, A

South Dakota journal of medicine

1985 Volume 38, Issue 5, Page(s) 15–16

MeSH term(s)	Adult ; Age Factors ; Aged ; Diagnosis, Differential ; Fingers/blood supply ; Humans ; Ischemia/diagnosis ; Male ; Raynaud Disease/diagnosis ; Sex Factors
Language	English
Publishing date	1985-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	413910-0
ISSN	0038-3317
ISSN	0038-3317
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Zs.B 205: Show issues

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Article: Anti-thymocyte serum delays clearance of poliovirus from the mouse central nervous system.

Jubelt, B / Ropka, S L / Goldfarb, S J / Janavs, J L

Journal of neuroimmunology

1989 Volume 22, Issue 3, Page(s) 223–232

Abstract: Antibody is of primary importance for protection from poliovirus-induced paralysis (poliomyelitis) and from other enterovirus infections. However, the components of the immune response involved in the clearance of an established enterovirus infection of ... ...

Abstract	Antibody is of primary importance for protection from poliovirus-induced paralysis (poliomyelitis) and from other enterovirus infections. However, the components of the immune response involved in the clearance of an established enterovirus infection of the central nervous system (CNS) are not known. To assess the effect of thymus-dependent immune functions on a CNS poliovirus infection, adult BALB/c mice inoculated intracerebrally with the W-2 strain of human poliovirus type 2 (PV2) were treated with anti-thymocyte serum (ATS) and analyzed for clinical disease, virus persistence, antibody responses, and T-cell proliferation (Tprlf). Half (22 of 44) of the ATS-treated mice showed paralysis and death as compared to 27% (17 of 62) of control mice treated with normal rabbit serum. Virus persisted in the brain for 45 days after infection in 43% (13 of 30) of ATS-treated mice as compared to 3% (1 of 30) of controls. Tprlf to PV as well as Tprlf and antibody responses to control antigens were markedly reduced in ATS-treated mice. However, antibody responses to PV in ATS-treated mice were not suppressed, suggesting that PV may be a T-cell-independent antigen. These findings indicate that ATS-suppressible functions contribute to the clearance of PV from the mouse CNS, apparently via a sensitized T-cell mechanism.
MeSH term(s)	Animals ; Antibody Formation ; Cell Division ; Central Nervous System/immunology ; Central Nervous System/pathology ; Enzyme-Linked Immunosorbent Assay ; Immune Sera/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Poliovirus/immunology ; Poliovirus/physiology ; T-Lymphocytes/pathology ; Thymus Gland/cytology ; Thymus Gland/immunology ; Virus Replication
Chemical Substances	Immune Sera
Language	English
Publishing date	1989-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/0165-5728(89)90020-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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