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Article ; Online: Antibody-mediated immunity against lung cancer goes retro.

Langel, Stephanie N / Martinez, David R

Science immunology

2023 Volume 8, Issue 84, Page(s) eadi8769

Abstract: Endogenous retrovirus antibody responses contribute to survival after immune checkpoint blockade therapy against lung adenocarcinoma. ...

Abstract	Endogenous retrovirus antibody responses contribute to survival after immune checkpoint blockade therapy against lung adenocarcinoma.
MeSH term(s)	Humans ; Programmed Cell Death 1 Receptor ; Lung Neoplasms ; Antibodies
Chemical Substances	Programmed Cell Death 1 Receptor ; Antibodies
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article ; Comment
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.adi8769
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Maternal immune protection against infectious diseases.

Langel, Stephanie N / Blasi, Maria / Permar, Sallie R

Cell host & microbe

2022 Volume 30, Issue 5, Page(s) 660–674

Abstract: The maternal immune system protects developing offspring against pathogens before birth via transplacental transfer and after birth through secreted milk. This transferred maternal immunity influences each generation's susceptibility to infections and ... ...

Abstract	The maternal immune system protects developing offspring against pathogens before birth via transplacental transfer and after birth through secreted milk. This transferred maternal immunity influences each generation's susceptibility to infections and responsiveness to immunization. Thus, boosting immunity in the maternal-neonatal dyad is a potentially valuable public health strategy. Additionally, at critical times during fetal and postnatal development, environmental factors and immune stimuli influence immune development. These "windows of opportunity" offer a chance to identify both risk and protective factors that promote long-term health and limit disease. Here, we review pre- and postpartum maternal immune factors that protect against infectious agents in offspring and how they may shape the infant's immune landscape over time. Additionally, we discuss the influence of maternal immunity on the responsiveness to immunization in early life. Lastly, when maternal factors are insufficient to prevent neonatal infectious diseases, we discuss pre- and postnatal therapeutic strategies for the maternal-neonatal dyad.
MeSH term(s)	Animals ; Communicable Diseases ; Female ; Humans ; Immunity, Maternally-Acquired ; Immunization ; Immunologic Factors ; Infant ; Infant, Newborn ; Milk ; Vaccination
Chemical Substances	Immunologic Factors
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2022.04.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Design and validation of an exposure system for efficient inter-animal SARS-CoV-2 airborne transmission in Syrian hamsters.

Kuehl, Philip J / Dearing, Justin / Werts, Adam / Cox, Jason / Irshad, Hammad / Barrett, Edward G / Tucker, Sean N / Langel, Stephanie N

Microbiology spectrum

2023 Volume 11, Issue 6, Page(s) e0471722

Abstract: Importance: The main route of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is airborne. However, there are few experimental systems that can assess the airborne transmission dynamics of SARS-CoV- ... ...

Abstract	Importance: The main route of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is airborne. However, there are few experimental systems that can assess the airborne transmission dynamics of SARS-CoV-2
MeSH term(s)	Cricetinae ; Animals ; SARS-CoV-2 ; Mesocricetus ; COVID-19 ; Respiratory Aerosols and Droplets ; Disease Models, Animal
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.04717-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Maternal gatekeepers: How maternal antibody Fc characteristics influence passive transfer and infant protection.

Langel, Stephanie N / Otero, Claire E / Martinez, David R / Permar, Sallie R

PLoS pathogens

2020 Volume 16, Issue 3, Page(s) e1008303

MeSH term(s)	Female ; Humans ; Immunity, Maternally-Acquired ; Immunization, Passive ; Immunoglobulin Fc Fragments/chemistry ; Immunoglobulin Fc Fragments/immunology ; Infant ; Male ; Receptors, Fc/immunology
Chemical Substances	Immunoglobulin Fc Fragments ; Receptors, Fc
Language	English
Publishing date	2020-03-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1008303
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Host Factors Affecting Generation of Immunity Against Porcine Epidemic Diarrhea Virus in Pregnant and Lactating Swine and Passive Protection of Neonates.

Langel, Stephanie N / Wang, Qiuhong / Vlasova, Anastasia N / Saif, Linda J

Pathogens (Basel, Switzerland)

2020 Volume 9, Issue 2

Abstract: Porcine epidemic diarrhea virus (PEDV) is a highly virulent re-emerging enteric coronavirus that causes acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets. Despite this, a safe and effective PEDV vaccine against highly ... ...

Abstract	Porcine epidemic diarrhea virus (PEDV) is a highly virulent re-emerging enteric coronavirus that causes acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets. Despite this, a safe and effective PEDV vaccine against highly virulent strains is unavailable, making PEDV prevention and control challenging. Lactogenic immunity induced via the gut-mammary gland-secretory IgA (sIgA) axis, remains the most promising and effective way to protect suckling piglets from PEDV. Therefore, a successful PEDV vaccine must induce protective maternal IgA antibodies that passively transfer into colostrum and milk. Identifying variables that influence lymphocyte migration and IgA secretion during gestation and lactation is imperative for designing maternal immunization strategies that generate the highest amount of lactogenic immune protection against PEDV in suckling piglets. Because pregnancy-associated immune alterations influence viral pathogenesis and adaptive immune responses in many different species, a better understanding of host immune responses to PEDV in pregnant swine may translate into improved maternal immunization strategies against enteric pathogens for multiple species. In this review, we discuss the role of host factors during pregnancy on antiviral immunity and their implications for generating protective lactogenic immunity in suckling neonates.
Keywords	covid19
Language	English
Publishing date	2020-02-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9020130
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Article ; Online: Maternal antibody interference contributes to reduced rotavirus vaccine efficacy in developing countries.

Otero, Claire E / Langel, Stephanie N / Blasi, Maria / Permar, Sallie R

PLoS pathogens

2020 Volume 16, Issue 11, Page(s) e1009010

Abstract: Rotavirus (RV) vaccine efficacy is significantly reduced in lower- and middle-income countries (LMICs) compared to high-income countries. This review summarizes current research into the mechanisms behind this phenomenon, with a particular focus on the ... ...

Abstract	Rotavirus (RV) vaccine efficacy is significantly reduced in lower- and middle-income countries (LMICs) compared to high-income countries. This review summarizes current research into the mechanisms behind this phenomenon, with a particular focus on the evidence that maternal antibody (matAb) interference is a contributing factor to this disparity. All RV vaccines currently in use are orally administered, live-attenuated virus vaccines that replicate in the infant gut, which leaves their efficacy potentially impacted by both placentally transferred immunoglobulin G (IgG) and mucosal IgA Abs conferred via breast milk. Observational studies of cohorts in LMICs demonstrated an inverse correlation between matAb titers, both in serum and breast milk, and infant responses to RV vaccination. However, a causal link between maternal humoral immunity and reduced RV vaccine efficacy in infants has yet to be definitively established, partially due to limitations in current animal models of RV disease. The characteristics of Abs mediating interference and the mechanism(s) involved have yet to be determined, and these may differ from mechanisms of matAb interference for parenterally administered vaccines due to the contribution of mucosal immunity conferred via breast milk. Increased vaccine doses and later age of vaccine administration have been strategies applied to overcome matAb interference, but these approaches are difficult to safely implement in the setting of RV vaccination in LMICs. Ultimately, the development of relevant animal models of matAb interference is needed to determine what alternative approaches or vaccine designs can safely and effectively overcome matAb interference of infant RV vaccination.
MeSH term(s)	Antibodies, Viral/immunology ; Developing Countries ; Female ; Humans ; Immunity, Mucosal ; Immunoglobulin A/immunology ; Immunoglobulin G/immunology ; Infant ; Milk, Human/immunology ; Rotavirus/immunology ; Rotavirus Infections/immunology ; Rotavirus Infections/prevention & control ; Rotavirus Infections/virology ; Rotavirus Vaccines/immunology ; Vaccination ; Vaccines, Attenuated/immunology
Chemical Substances	Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G ; Rotavirus Vaccines ; Vaccines, Attenuated
Language	English
Publishing date	2020-11-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1009010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Host Factors Affecting Generation of Immunity Against Porcine Epidemic Diarrhea Virus in Pregnant and Lactating Swine and Passive Protection of Neonates

Langel, Stephanie N / Wang, Qiuhong / Vlasova, Anastasia N / Saif, Linda J

Pathogens. 2020 Feb. 18, v. 9, no. 2

2020

Abstract	Porcine epidemic diarrhea virus (PEDV) is a highly virulent re-emerging enteric coronavirus that causes acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets. Despite this, a safe and effective PEDV vaccine against highly virulent strains is unavailable, making PEDV prevention and control challenging. Lactogenic immunity induced via the gut-mammary gland-secretory IgA (sIgA) axis, remains the most promising and effective way to protect suckling piglets from PEDV. Therefore, a successful PEDV vaccine must induce protective maternal IgA antibodies that passively transfer into colostrum and milk. Identifying variables that influence lymphocyte migration and IgA secretion during gestation and lactation is imperative for designing maternal immunization strategies that generate the highest amount of lactogenic immune protection against PEDV in suckling piglets. Because pregnancy-associated immune alterations influence viral pathogenesis and adaptive immune responses in many different species, a better understanding of host immune responses to PEDV in pregnant swine may translate into improved maternal immunization strategies against enteric pathogens for multiple species. In this review, we discuss the role of host factors during pregnancy on antiviral immunity and their implications for generating protective lactogenic immunity in suckling neonates.
Keywords	Porcine epidemic diarrhea virus ; adaptive immunity ; antibodies ; colostrum ; diarrhea ; enteropathogens ; immune response ; immunization ; lactation ; milk ; mortality ; neonates ; pathogenesis ; piglets ; pregnancy ; secretion ; suckling ; vaccines ; virulence ; virulent strains
Language	English
Dates of publication	2020-0218
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9020130
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Accuracy of Speech and Linguistic Analysis in Early Diagnostics of Neurocognitive Disorders in a Memory Clinic Setting.

Ter Huurne, Daphne / Ramakers, Inez / Possemis, Nina / Banning, Leonie / Gruters, Angelique / Van Asbroeck, Stephanie / König, Alexandra / Linz, Nicklas / Tröger, Johannes / Langel, Kai / Verhey, Frans / de Vugt, Marjolein

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

2023 Volume 38, Issue 5, Page(s) 667–676

Abstract: ... of the Maastricht University Medical Center+ (with Subjective Cognitive Decline [SCD; N = 69] and ... Mild Cognitive Impairment [MCI]/dementia [N = 66]). The SVF task (one minute, category animals) was recorded and processed ...

Abstract	Objective: To investigate whether automatic analysis of the Semantic Verbal Fluency test (SVF) is reliable and can extract additional information that is of value for identifying neurocognitive disorders. In addition, the associations between the automatically derived speech and linguistic features and other cognitive domains were explored. Method: We included 135 participants from the memory clinic of the Maastricht University Medical Center+ (with Subjective Cognitive Decline [SCD; N = 69] and Mild Cognitive Impairment [MCI]/dementia [N = 66]). The SVF task (one minute, category animals) was recorded and processed via a mobile application, and speech and linguistic features were automatically extracted. The diagnostic performance of the automatically derived features was investigated by training machine learning classifiers to differentiate SCD and MCI/dementia participants. Results: The intraclass correlation for interrater reliability between the clinical total score (golden standard) and automatically derived total word count was 0.84. The full model including the total word count and the automatically derived speech and linguistic features had an Area Under the Curve (AUC) of 0.85 for differentiating between people with SCD and MCI/dementia. The model with total word count only and the model with total word count corrected for age showed an AUC of 0.75 and 0.81, respectively. Semantic switching correlated moderately with memory as well as executive functioning. Conclusion: The one-minute SVF task with automatically derived speech and linguistic features was as reliable as the manual scoring and differentiated well between SCD and MCI/dementia. This can be considered as a valuable addition in the screening of neurocognitive disorders and in clinical practice.
MeSH term(s)	Humans ; Speech ; Reproducibility of Results ; Neuropsychological Tests ; Linguistics ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Dementia/diagnosis ; Alzheimer Disease/psychology
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	632972-x
ISSN	1873-5843 ; 0887-6177
ISSN (online)	1873-5843
ISSN	0887-6177
DOI	10.1093/arclin/acac105
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Article: Escherichia coli

Michael, Husheem / Miyazaki, Ayako / Langel, Stephanie N / Amimo, Joshua O / Kick, Maryssa K / Chepngeno, Juliet / Paim, Francine C / Fischer, David D / Rajashekara, Gireesh / Saif, Linda J / Vlasova, Anastasia N

Vaccines

2022 Volume 10, Issue 1

Abstract: Human rotavirus (HRV) infection is a major cause of viral gastroenteritis in young children worldwide. Current oral vaccines perform poorly in developing countries where efficacious vaccines are needed the most. Therefore, an alternative affordable ... ...

Abstract	Human rotavirus (HRV) infection is a major cause of viral gastroenteritis in young children worldwide. Current oral vaccines perform poorly in developing countries where efficacious vaccines are needed the most. Therefore, an alternative affordable strategy to enhance efficacy of the current RV vaccines is necessary. This study evaluated the effects of colonization of neonatal gnotobiotic (Gn) pigs with
Language	English
Publishing date	2022-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10010083
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Article ; Online: Maternal gatekeepers

Stephanie N Langel / Claire E Otero / David R Martinez / Sallie R Permar

PLoS Pathogens, Vol 16, Iss 3, p e

How maternal antibody Fc characteristics influence passive transfer and infant protection.

2020 Volume 1008303

Keywords	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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