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  1. AU=Basta Giuseppina
  2. AU="Karppinen, Maarit"
  3. AU="Rounis, Konstantinos"
  4. AU="Perrier, Prunelle"
  5. AU=Chisari Emanuele AU=Chisari Emanuele
  6. AU="Sibiya, Maureen Nokuthula"
  7. AU="Gokce, Emine"
  8. AU="Muth, Christiane"
  9. AU="Cüneyt Orhan Kara"
  10. AU="Arnberg, Fabian"
  11. AU="Rana, Shubham"
  12. AU="Hugen, Cory M"
  13. AU="Andres M. Rubiano"
  14. AU="Nicole Matejka"
  15. AU="Nunes, Pedro M. Sales"
  16. AU="Sánchez-Montero, María Teresa"
  17. AU="Jiexin Zhang"
  18. AU=Mladinic M
  19. AU="Canfarotta, Michael W"
  20. AU="Merani, Shaheed"
  21. AU="Tarver, James E"
  22. AU=Wirestam Lina
  23. AU="Karen Martz"
  24. AU="Yadav, Kanhaiya L."
  25. AU="Girmay, Tigisty"
  26. AU="Hain, Sofia"
  27. AU="de Kler, R C F"
  28. AU="Veness, R."

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Treffer 1 - 10 von insgesamt 108

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  1. Artikel ; Online: Direct or indirect endothelial damage? An unresolved question

    Giuseppina Basta

    EBioMedicine, Vol 64, Iss , Pp 103215- (2021)

    2021  

    Schlagwörter Medicine ; R ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Direct or indirect endothelial damage? An unresolved question.

    Basta, Giuseppina

    EBioMedicine

    2021  Band 64, Seite(n) 103215

    Mesh-Begriff(e) Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Biomarkers ; COVID-19/complications ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/virology ; Endothelium/metabolism ; Endothelium/pathology ; Gene Expression ; Humans ; Immunohistochemistry ; Organ Specificity/genetics ; SARS-CoV-2/physiology
    Chemische Substanzen Biomarkers ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Sprache Englisch
    Erscheinungsdatum 2021-01-22
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103215
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Extracellular Vesicles and Intercellular Communication: Challenges for In Vivo Molecular Imaging and Tracking.

    Petroni, Debora / Fabbri, Costanza / Babboni, Serena / Menichetti, Luca / Basta, Giuseppina / Del Turco, Serena

    Pharmaceutics

    2023  Band 15, Heft 6

    Abstract: Extracellular vesicles (EVs) are a heterogeneous class of cell-derived membrane vesicles released by various cell types that serve as mediators of intercellular signaling. When released into circulation, EVs may convey their cargo and serve as ... ...

    Abstract Extracellular vesicles (EVs) are a heterogeneous class of cell-derived membrane vesicles released by various cell types that serve as mediators of intercellular signaling. When released into circulation, EVs may convey their cargo and serve as intermediaries for intracellular communication, reaching nearby cells and possibly also distant organs. In cardiovascular biology, EVs released by activated or apoptotic endothelial cells (EC-EVs) disseminate biological information at short and long distances, contributing to the development and progression of cardiovascular disease and related disorders. The significance of EC-EVs as mediators of cell-cell communication has advanced, but a thorough knowledge of the role that intercommunication plays in healthy and vascular disease is still lacking. Most data on EVs derive from in vitro studies, but there are still little reliable data available on biodistribution and specific homing EVs in vivo tissues. Molecular imaging techniques for EVs are crucial to monitoring in vivo biodistribution and the homing of EVs and their communication networks both in basal and pathological circumstances. This narrative review provides an overview of EC-EVs, trying to highlight their role as messengers of cell-cell interaction in vascular homeostasis and disease, and describes emerging applications of various imaging modalities for EVs visualization in vivo.
    Sprache Englisch
    Erscheinungsdatum 2023-06-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15061639
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Different inflammatory profile in young and elderly STEMI patients undergoing primary percutaneous coronary intervention (PPCI): Its influence on no-reflow and mortality.

    Del Turco, Serena / Basta, Giuseppina / Mazzone, Annamaria

    International journal of cardiology

    2020  Band 298, Seite(n) 17

    Mesh-Begriff(e) Aged ; Humans ; No-Reflow Phenomenon ; Percutaneous Coronary Intervention ; ST Elevation Myocardial Infarction
    Sprache Englisch
    Erscheinungsdatum 2020-01-04
    Erscheinungsland Netherlands
    Dokumenttyp Letter ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2019.08.052
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Cholangiocyte Organoids: The New Frontier in Regenerative Medicine for the Study and Treatment of Cholangiopathies.

    Babboni, Serena / Vacca, Pier Giuseppe / Simonini, Ludovica / Pezzati, Daniele / Martinelli, Caterina / Frongillo, Francesco / Bianco, Giuseppe / Marciano, Emanuele / Basta, Giuseppina / Ghinolfi, Davide / Del Turco, Serena

    Journal of clinical medicine

    2024  Band 13, Heft 6

    Abstract: Cholangiopathies include a group of chronic progressive disorders, affecting the cholangiocytes, the epithelial cells that line the biliary tree, leading to liver parenchymal fibrosis and eventually end-stage liver disease necessitating transplantation. ... ...

    Abstract Cholangiopathies include a group of chronic progressive disorders, affecting the cholangiocytes, the epithelial cells that line the biliary tree, leading to liver parenchymal fibrosis and eventually end-stage liver disease necessitating transplantation. Experimental modeling of these multifactorial cholestatic diseases faces challenges due to the lack of adequate experimental in vitro and in vivo models. A novel approach employs three-dimensional organoid systems that offer several advantages for modeling disease and testing drug response in vitro. Organoids mimic intercellular communication, replicate the architecture of organs, and maintain the cell's original phenotype. Cholangiocyte organoids provide an in vitro model to study the pathogenesis and pharmacotherapeutic treatment of cholangiopathies and show great promise for regenerative therapies. In particular, patient-derived organoids allow personalized medicine approaches and the study of individual disease characteristics. This review highlights the significance of cholangiocyte organoid models in advancing our understanding of cholangiopathies and driving advancements in regenerative medicine strategies.
    Sprache Englisch
    Erscheinungsdatum 2024-03-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061804
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: A possible role for ST2 as prognostic biomarker for COVID-19.

    Ragusa, Rosetta / Basta, Giuseppina / Del Turco, Serena / Caselli, Chiara

    Vascular pharmacology

    2021  Band 138, Seite(n) 106857

    Abstract: COVID-19 is a pandemic illness caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2). It has been estimated that 80% of subject infected are asymptomatic or have mild to moderate symptoms. Differently, in severe cases of COVID-19, ... ...

    Abstract COVID-19 is a pandemic illness caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2). It has been estimated that 80% of subject infected are asymptomatic or have mild to moderate symptoms. Differently, in severe cases of COVID-19, cytokine storm, acute respiratory distress syndrome (ARDS), severe systemic inflammatory response and cardiovascular diseases were observed Even if all molecular mechanisms leading to cardiovascular dysfunction in COVID-19 patients remain to be clarified, the evaluation of biomarkers of cardiac injury, stress and inflammation proved to be an excellent tool to identify the COVID-19 patients with worse outcome. However, the number of biomarkers used to manage COVID-19 patients is expected to increase with the increasing knowledge of the pathophysiology of the disease. It is our view that soluble suppressor of tumorigenicity 2 (sST2) can be used as biomarker in COVID-19. sST2 is routinely used as prognostic biomarker in patients with HF. Moreover, high circulating levels of sST2 have also been found in subjects with ARDS, pulmonary fibrosis and sepsis. Keeping in mind these considerations, in this review the possible mechanisms through which the SARS-CoV2 infection could damage the cardiovascular system were summarized and the possible role of sST2 in COVID-19 patients with CVD was discussed.
    Mesh-Begriff(e) Animals ; Biomarkers/metabolism ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/metabolism ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/metabolism ; Cytokine Release Syndrome/diagnosis ; Cytokine Release Syndrome/epidemiology ; Cytokine Release Syndrome/metabolism ; Humans ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Prognosis
    Chemische Substanzen Biomarkers ; IL1RL1 protein, human ; Interleukin-1 Receptor-Like 1 Protein
    Sprache Englisch
    Erscheinungsdatum 2021-03-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2021.106857
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: The Role of Fatigue and Satisfaction of Compassion, and Hopelessness in Healthcare Workers in the Alzheimer's Disease in the Post-COVID-19 Pandemic.

    Conte, Giuseppina / Spiniello, Alessia / Pippa, Federica / Sileno, Rosalba / Basta, Barbara / Manfreda, Erminia / Tavormina, Giuseppe / Franza, Francesco

    Psychiatria Danubina

    2023  Band 35, Heft Suppl 2, Seite(n) 287–291

    Abstract: The COVID-19 pandemic has left emotional consequences for healthcare workers. Dramatic results are obtained on compassion fatigue, burnout, and hopelessness in healthcare workers (HCWs) of older adults with Alzheimer's disease. Our study evaluated ... ...

    Abstract The COVID-19 pandemic has left emotional consequences for healthcare workers. Dramatic results are obtained on compassion fatigue, burnout, and hopelessness in healthcare workers (HCWs) of older adults with Alzheimer's disease. Our study evaluated differences in these factors during and after the pandemic in 48 HCWs. The results showed a statistically significant difference in the Satisfaction of Compassion (P=0.014; during vs post-pandemic) and in the subscale of Secondary Trauma (P=0.005) and Burnout (P=0.49) in CFSS. The results were not statistically significant on the BHS scale (P=0.285). However, hopelessness was found in a higher percentage of HCWs at the end of the pandemic than during the pandemic period (respectively: 35.67% vs 31.67%).
    Mesh-Begriff(e) Humans ; Aged ; COVID-19 ; Pandemics ; Empathy ; Alzheimer Disease/epidemiology ; Compassion Fatigue ; Burnout, Professional/epidemiology ; Burnout, Professional/psychology ; Health Personnel/psychology ; Personal Satisfaction ; Job Satisfaction ; Quality of Life ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2023-08-08
    Erscheinungsland Croatia
    Dokumenttyp Journal Article
    ZDB-ID 1067580-2
    ISSN 0353-5053
    ISSN 0353-5053
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Interaction of Uric Acid and Neutrophil-to-Lymphocyte Ratio for Cardiometabolic Risk Stratification and Prognosis in Coronary Artery Disease Patients.

    Del Turco, Serena / Bastiani, Luca / Minichilli, Fabrizio / Landi, Patrizia / Basta, Giuseppina / Pingitore, Alessandro / Vassalle, Cristina

    Antioxidants (Basel, Switzerland)

    2022  Band 11, Heft 11

    Abstract: Oxidative stress and inflammation are key factors in cardiometabolic diseases. We set out to evaluate the relationship between serum uric acid (UA) and the neutrophil-to-lymphocyte ratio (NLR) with cardiometabolic risk factors in coronary artery disease ( ...

    Abstract Oxidative stress and inflammation are key factors in cardiometabolic diseases. We set out to evaluate the relationship between serum uric acid (UA) and the neutrophil-to-lymphocyte ratio (NLR) with cardiometabolic risk factors in coronary artery disease (CAD) patients, and their additive and multiplicative interactive effects on outcomes (cardiac death/CD and hard events (HE)-death plus reinfarction). A total of 2712 patients (67 ± 11 years, 1960 males) who underwent coronary angiography was retrospectively analyzed and categorized into no-CAD patients (
    Sprache Englisch
    Erscheinungsdatum 2022-10-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11112163
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: The Positive Impact of Early Frailty Levels on Mortality in Elderly Patients with Severe Aortic Stenosis Undergoing Transcatheter/Surgical Aortic Valve Replacement.

    Mazzone, Annamaria / Del Turco, Serena / Trianni, Giuseppe / Quadrelli, Paola / Marotta, Marco / Bastiani, Luca / Gasbarri, Tommaso / D'Agostino, Andreina / Mariani, Massimiliano / Basta, Giuseppina / Foffa, Ilenia / Sbrana, Silverio / Vassalle, Cristina / Ravani, Marcello / Solinas, Marco / Berti, Sergio

    Journal of cardiovascular development and disease

    2023  Band 10, Heft 5

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2023-05-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10050212
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Assessment of RANKL/RANK/osteoprotegerin system expression in patients with hepatocellular carcinoma.

    Cabiati, Manuela / Gaggini, Melania / DE Simone, Paolo / Basta, Giuseppina / Gastaldelli, Amalia / Del Ry, Silvia

    Minerva endocrinology

    2020  Band 46, Heft 3, Seite(n) 367–369

    Mesh-Begriff(e) Carcinoma, Hepatocellular ; Humans ; Liver Neoplasms ; Osteoprotegerin ; RANK Ligand ; Receptor Activator of Nuclear Factor-kappa B
    Chemische Substanzen Osteoprotegerin ; RANK Ligand ; Receptor Activator of Nuclear Factor-kappa B ; TNFRSF11A protein, human ; TNFRSF11B protein, human ; TNFSF11 protein, human
    Sprache Englisch
    Erscheinungsdatum 2020-07-03
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 3062786-2
    ISSN 2724-6116
    ISSN (online) 2724-6116
    DOI 10.23736/S2724-6507.20.03163-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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