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Article ; Online: Comment on: Randomized trial of personalized psychological feedback from a longitudinal online survey and simultaneous evaluation of randomized stepped wedge availability of in-person peer support for hospital staff during the COVID-19 pandemic.

Alizai, Hassam Nasir Khan / Pasha, Aainah / Zia, Namra

2023 Volume 85, Page(s) 249–250

Language	English
Publishing date	2023-08-26
Publishing country	United States
Document type	Letter
ZDB-ID	392299-6
ISSN	1873-7714 ; 0163-8343
ISSN (online)	1873-7714
ISSN	0163-8343
DOI	10.1016/j.genhosppsych.2023.08.008
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Zs.A 1584: Show issues

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Article ; Online: Retraction Note: Ameliorative effect of two structurally divergent hydrazide derivatives against DSS-induced colitis by targeting Nrf2 and NF-κB signaling in mice.

Khan, Ashrafullah / Khan, Adnan / Shal, Bushra / Aziz, Abdul / Ahmad, Sajjad / Amin, Muhammad Usman / Ahmed, Muhammad Naeem / Zia-Ur-Rehman / Khan, Salman

Naunyn-Schmiedeberg's archives of pharmacology

2024 Volume 397, Issue 2, Page(s) 1249

Language	English
Publishing date	2024-01-10
Publishing country	Germany
Document type	Retraction of Publication
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-024-02942-x
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Article ; Online: Insight into the molecular mechanism, cytotoxic, and anticancer activities of phyto-reduced silver nanoparticles in MCF-7 breast cancer cell lines.

Ullah, Ikram / Khalil, Ali Talha / Zia, Asad / Hassan, Ishtiaq / Shinwari, Zabta Khan

Microscopy research and technique

2024

Abstract: This contribution insight on the cytotoxic and anticancer activities and molecular mechanism of phyto-reduced silver nanoparticles (AgNPs) in MCF-7 breast cancer cell lines. A simple, entirely green synthesis process was optimized for the phyto-reduction ...

Abstract	This contribution insight on the cytotoxic and anticancer activities and molecular mechanism of phyto-reduced silver nanoparticles (AgNPs) in MCF-7 breast cancer cell lines. A simple, entirely green synthesis process was optimized for the phyto-reduction of AgNP (~12.7 nm) using aqueous leaf extracts of Indigofera heterantha. The structural and vibrational properties of biosynthesized AgNPs were extensively characterized using UV-Vis spectrophotometer, x-ray diffraction (XRD), dynamic light scattering (DLS), and Fourier transform Infrared spectroscopy (FTIR), while their shape and morphology was studied through scanning electron microscopy (SEM). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell viability assay indicates concentration dependent inhibition with IC
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099714-3
ISSN	1097-0029 ; 1059-910X
ISSN (online)	1097-0029
ISSN	1059-910X
DOI	10.1002/jemt.24540
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Zs.A 2251: Show issues

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Article: IAA-decorated CuO nanocarriers significantly improve Chickpea growth by increasing antioxidative activities.

Hanif, Saad / Javed, Rabia / Khan, Aisha / Sajjad, Anila / Zia, Muhammad

3 Biotech

2023 Volume 13, Issue 3, Page(s) 104

Abstract: Plant growth regulators tagged on metallic oxide nanoparticles (NPs) may function as nanofertilizers with reduced toxicity of NPs. CuO NPs were synthesized to function as nanocarriers of Indole-3-acetic acid (IAA). Powder X-ray diffraction (XRD) and ... ...

Abstract	Plant growth regulators tagged on metallic oxide nanoparticles (NPs) may function as nanofertilizers with reduced toxicity of NPs. CuO NPs were synthesized to function as nanocarriers of Indole-3-acetic acid (IAA). Powder X-ray diffraction (XRD) and scanning electron microscopy (SEM) revealed 30.4 nm size of NPs and sheet-like structure, respectively, of CuO-IAA NPs. Fourier-transform infrared spectroscopy (FTIR) confirmed CuO-IAA formation. IAA-decorated CuO NPs enhanced the physiological parameters of Chickpea plants, i.e., root length, shoot length, and biomass compared to naked CuO NPs. The variation in physiological response was due to change of phytochemical contents in plants. Phenolic content increased up to 17.98 and 18.13 µgGAE/mg DW at 20 and 40 mg/L of CuO-IAA NPs, respectively. However, significant decrease in antioxidant enzymes' activity was recorded compared to control. Presence of CuO-IAA NPs increased the reducing potential of plants at higher concentration of NPs, while decrease in total antioxidant response was observed. This study concludes that IAA conjugation to CuO NPs reduces toxicity of NPs. Furthermore, NPs can be explored as nanocarriers for plant modulators and slow release in future studies.
Language	English
Publishing date	2023-02-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-023-03516-z
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Article ; Online: Prevalence of Crimean Congo Hemorrhagic Fever in Khyber Pakhtunkhwa, Pakistan.

Zia, Asad / Khalil, Ali Talha / Alam, Naz / Khan, Abdul Qadoos / Khan, Mubarak Ali / Yosafzai, Yasar / Ali, Asif / Ullah, Ihsan / Wazir, Ali Rehman

Travel medicine and infectious disease

2024 , Page(s) 102722

Abstract: Background: CCHFV is well recognized as a major public health threat and its prevalence and epidemiological distribution in Pakistan and specifically in KP province is not well documented.: Methods: We used a gold-standard PCR-based diagnostic assay ... ...

Abstract	Background: CCHFV is well recognized as a major public health threat and its prevalence and epidemiological distribution in Pakistan and specifically in KP province is not well documented. Methods: We used a gold-standard PCR-based diagnostic assay for confirmation of CCHFV among suspected patients. A total of 150 patients were enrolled from June 2022 to September 2022 and their blood samples were collected for PCR confirmation. Results: The overall positivity rate for CCHFV was 26.67%, with the virus mostly prevalent in the middle-aged group (21-40 years). In the July of 2022, a significant spike in the prevalence of CCHFV was observed in provincial capital Peshawar with the highest burden (31.57%). Conclusion: Our findings indicate the necessity of strengthening CCHFV monitoring programs and intensifying efforts to identify hotspot regions for effective surveillance and control of CCHFV. The months before the Eid-ul-Adha are crucial in the context of CCHFV control.
Language	English
Publishing date	2024-04-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2170891-5
ISSN	1873-0442 ; 1477-8939
ISSN (online)	1873-0442
ISSN	1477-8939
DOI	10.1016/j.tmaid.2024.102722
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Article ; Online: Nanowarriors from Mentha: Unleashing Nature's Antimicrobial Arsenal with Cerium Oxide Nanoparticles.

Khan, Maarij / Wali, Rahmat / Mashwani, Zia-Ur-Rehman / Raja, Naveed Iqbal / Ullah, Riaz / Bari, Ahmed / Zaman, Shah / Sohail

ACS omega

2024 Volume 9, Issue 13, Page(s) 15449–15462

Abstract: Medicinal plant-based cerium oxide nanoparticles ( ... ...

Abstract	Medicinal plant-based cerium oxide nanoparticles (CeO
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.4c00236
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Article ; Online: Melatonin as a master regulatory hormone for genetic responses to biotic and abiotic stresses in model plant

Ameen, Muaz / Zafar, Asma / Mahmood, Athar / Zia, Muhammad Anjum / Kamran, Kashif / Javaid, Muhammad Mansoor / Yasin, Muhammad / Khan, Bilal Ahmad

Functional plant biology : FPB

2024 Volume 51

Abstract: Melatonin is a naturally occurring biologically active amine produced by plants, animals and microbes. This review explores the biosynthesis of melatonin in plants, with a particular focus on its diverse roles in Arabidopsis thaliana , a model species. ... ...

Abstract	Melatonin is a naturally occurring biologically active amine produced by plants, animals and microbes. This review explores the biosynthesis of melatonin in plants, with a particular focus on its diverse roles in Arabidopsis thaliana , a model species. Melatonin affects abiotic and biotic stress resistance in A. thaliana . Exogenous and endogenous melatonin is addressed in association with various conditions, including cold stress, high light stress, intense heat and infection with Botrytis cinerea or Pseudomonas , as well as in seed germination and lateral root formation. Furthermore, melatonin confers stress resistance in Arabidopsis by initiating the antioxidant system, remedying photosynthesis suppression, regulating transcription factors involved with stress resistance (CBF, DREB, ZAT, CAMTA, WRKY33, MYC2, TGA) and other stress-related hormones (abscisic acid, auxin, ethylene, jasmonic acid and salicylic acid). This article additionally addresses other precursors, metabolic components, expression of genes (COR , CBF , SNAT , ASMT , PIN , PR1 , PDF1.2 and HSFA ) and proteins (JAZ, NPR1) associated with melatonin and reducing both biological and environmental stressors. Furthermore, the future perspective of melatonin rich agri-crops is explored to enhance plant tolerance to abiotic and biotic stresses, maximise crop productivity and enhance nutritional worth, which may help improve food security.
MeSH term(s)	Arabidopsis/genetics ; Melatonin/metabolism ; Plants/genetics ; Arabidopsis Proteins/genetics ; Cold-Shock Response
Chemical Substances	Melatonin (JL5DK93RCL) ; Arabidopsis Proteins
Language	English
Publishing date	2024-02-04
Publishing country	Australia
Document type	Review ; Journal Article
ZDB-ID	2071582-1
ISSN	1445-4416 ; 1445-4408
ISSN (online)	1445-4416
ISSN	1445-4408
DOI	10.1071/FP23248
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Article ; Online: Diagnostic accuracy of intraoperative frozen section for margin evaluation of oral cavity squamous cell carcinoma.

Ali, Javaria P / Mallick, Bakhtawar Allauddin / Rashid, Khushbakht / Malik, Umair Arshad / Hashmi, Atif Ali / Zia, Shamail / Irfan, Muhammad / Khan, Amir / Faridi, Naveen

BMC research notes

2024 Volume 17, Issue 1, Page(s) 43

Abstract: Objectives: Intraoperative frozen-section evaluation is a valuable technique for detecting positive margins intraoperatively for oral squamous cell carcinoma. We conducted this study to determine the diagnostic accuracy of frozen section in detecting ... ...

Abstract	Objectives: Intraoperative frozen-section evaluation is a valuable technique for detecting positive margins intraoperatively for oral squamous cell carcinoma. We conducted this study to determine the diagnostic accuracy of frozen section in detecting margin status and the effect of tumor grade and stage on diagnostic accuracy. Results: A total of 251 biopsy-proven cases of oral squamous cell carcinoma were included in this study. The tissue specimen resected during surgery was sent to the laboratory for frozen section evaluation. The frozen section results were then compared with the permanent section results to determine the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy. The mean age of the patients included in the study was 51.65 ± 10.03 years, with male predominance (55.4%). The overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of frozen section were 88.81%, 94.84%, 95.20%, 88.10%, and 91.63%, respectively. We conclude that frozen section is a useful technique in determining the margin status intraoperatively in oral cancers, with high diagnostic accuracy. Moreover, certain clinical parameters such as age, gender, disease duration, and tumor stage and grade appear to affect the diagnostic accuracy of frozen section.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Female ; Squamous Cell Carcinoma of Head and Neck ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/surgery ; Mouth Neoplasms/pathology ; Frozen Sections/methods ; Retrospective Studies ; Head and Neck Neoplasms
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-024-06698-8
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Article: Health related quality of life in post-acute coronary patient.

Hisam, Aliya / Khan, Aqsa / Zahid, Bisma / Zia, Fatima / Naeem, Aymen / Chaudhry, Hadia

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 72, Issue 10, Page(s) 2069–2073

Abstract: The study aimed to assess the effects of lifestyle-modification counselling on behavioural outcomes among patients after myocardial infarction. This was a quasi-experimental study, conducted at the Armed Forces Institute of Cardiology (AFIC), Rawalpindi, ...

Abstract	The study aimed to assess the effects of lifestyle-modification counselling on behavioural outcomes among patients after myocardial infarction. This was a quasi-experimental study, conducted at the Armed Forces Institute of Cardiology (AFIC), Rawalpindi, from December 2018 to February 2019, on 50 post-myocardial infarction (post-MI) patients. Knowledge, attitude, and practice regarding lifestyle was assessed using a self-designed, pre-tested, validated questionnaire. The participants were given health messages regarding lifestyle modifications for 15-20 minutes based on WHO guidelines on the nature of the disease, diet, exercise, smoking cessation, weight and blood pressure monitoring, and salt intake. The mean age of the patients was 58.68±10.8 years. The MI knowledge sufficiently improved (28,100%), positive attitude was observed (27, 96.4%), and healthy practices were anticipated (24, 85.71%) significantly (p<0.001) after counselling. The lifestyle modification counselling improved the knowledge, attitude, and practice among post- MI patients but significant improvement was seen only in knowledge and practice.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Quality of Life ; Myocardial Infarction/therapy ; Life Style ; Diet ; Exercise/physiology
Language	English
Publishing date	2023-01-24
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.3461
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Article: Copper oxide nanoparticles: In vitro and in vivo toxicity, mechanisms of action and factors influencing their toxicology.

Sajjad, Humna / Sajjad, Anila / Haya, Rida Tul / Khan, Muhammad Mustajab / Zia, Muhammad

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

2023 Volume 271, Page(s) 109682

Abstract: Copper oxide nanoparticles (CuO NPs) have received increasing interest due to their distinctive properties, including small particle size, high surface area, and reactivity. Due to these properties, their applications have been expanded rapidly in ... ...

Abstract	Copper oxide nanoparticles (CuO NPs) have received increasing interest due to their distinctive properties, including small particle size, high surface area, and reactivity. Due to these properties, their applications have been expanded rapidly in various areas such as biomedical properties, industrial catalysts, gas sensors, electronic materials, and environmental remediation. However, because of these widespread uses, there is now an increased risk of human exposure, which could lead to short- and long-term toxicity. This review addresses the underlying toxicity mechanisms of CuO NPs in cells which include reactive oxygen species generation, leaching of Cu ion, coordination effects, non-homeostasis effect, autophagy, and inflammation. In addition, different key factors responsible for toxicity, characterization, surface modification, dissolution, NPs dose, exposure pathways and environment are discussed to understand the toxicological impact of CuO NPs. In vitro and in vivo studies have shown that CuO NPs cause oxidative stress, cytotoxicity, genotoxicity, immunotoxicity, neurotoxicity, and inflammation in bacterial, algal, fish, rodents, and human cell lines. Therefore, to make CuO NPs a more suitable candidate for various applications, it is essential to address their potential toxic effects, and hence, more studies should be done on the long-term and chronic impacts of CuO NPs at different concentrations to assure the safe usage of CuO NPs.
MeSH term(s)	Animals ; Humans ; Copper/toxicity ; Metal Nanoparticles/toxicity ; Nanoparticles ; Inflammation ; Oxides
Chemical Substances	cupric oxide (V1XJQ704R4) ; cuprous oxide (T8BEA5064F) ; Copper (789U1901C5) ; Oxides
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	189285-x
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
DOI	10.1016/j.cbpc.2023.109682
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